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The map label for this gene is groEL

Identifier: 188526820

GI number: 188526820

Start: 7356

End: 8996

Strand: Reverse

Name: groEL

Synonym: HPSH_00050

Alternate gene names: 188526820

Gene position: 8996-7356 (Counterclockwise)

Preceding gene: 188526821

Following gene: 188526819

Centisome position: 0.56

GC content: 44.91

Gene sequence:

>1641_bases
ATGGCAAAAGAAATCAAATTTTCAGATAGCGCAAGAAACCTTTTGTTTGAAGGCGTGAGACAACTCCATGACGCTGTCAA
AGTAACCATGGGGCCAAGAGGTAGGAATGTGTTGATCCAAAAAAGCTATGGCGCTCCAAGCATCACCAAAGACGGCGTGA
GCGTGGCTAAAGAGATTGAATTAAGTTGCCCAGTGGCTAATATGGGTGCTCAACTCGTTAAAGAAGTAGCGAGCAAAACC
GCTGATGCTGCCGGCGATGGCACGACCACAGCGACCGTGCTTGCTTATAGCATTTTTAAAGAGGGCTTGAGGAATATCAC
GGCTGGGGCTAACCCTATTGAAGTGAAACGAGGCATGGATAAAGCCGCTGAAGCCATTATTAATGAGCTTAAAAAAGCGA
GCAAAAAAGTAGGCGGTAAAGAAGAAATCACCCAAGTAGCGACCATTTCTGCAAACTCTGATCACAATATCGGGAAACTC
ATCGCTGACGCTATGGAAAAAGTGGGTAAAGACGGCGTGATCACCGTTGAAGAAGCTAAGGGCATTGAAGATGAATTAGA
TGTCGTAGAGGGCATGCAATTTGATAGAGGCTATCTCTCCCCTTATTTTGTAACAAACGCTGAGAAAATGACCGCTCAAT
TGGATAACGCTTACATCCTTTTAACGGATAAAAAAATCTCTAGCATGAAAGACATTCTCCCACTACTAGAAAAAACCATG
AAAGAGGGCAAACCGCTTTTAATCATCGCTGAAGACATTGAGGGCGAAGCTTTAACGACTCTAGTGGTGAATAAATTAAG
AGGCGTGTTGAATATCGCAGCGGTTAAGGCTCCAGGCTTTGGGGACAGAAGAAAAGAAATGCTCAAAGACATCGCTGTTT
TAACCGGCGGTCAAGTTATTAGCGAAGAATTAGGCTTGACTTTAGAAAACGCTGAAGTGGAGTTTTTAGGCAAAGCCGGA
AGGATTGTGATTGACAAAGACAACACCACGATCGTAGATGGCAAAGGCCATAGCCATGATGTCAAAGACAGAGTCGCGCA
AATCAAAACCCAAATTGCAAGCACGACAAGCGATTATGACAAAGAAAAATTGCAAGAAAGATTGGCTAAACTCTCTGGCG
GTGTGGCTGTGATTAAAGTGGGCGCTGCGAGTGAAGTGGAAATGAAAGAGAAAAAAGACCGGGTTGATGACGCGTTGAGC
GCGACTAAAGCGGCTGTTGAAGAAGGCATTGTTATTGGCGGCGGTGCGGCTCTCATTCGTGCGGCTCAAAAAGTGCATTT
GAATTTACACGATGATGAAAAAGTGGGCTATGAAATCATCATGCGCGCCATTAAAGCCCCATTAGCTCAAATCGCTATCA
ATGCCGGTTATGATGGCGGTGTGGTCGTGAATGAAGTGCAAAAACACGAAGGGCATTTTGGTTTTAACGCTAGCAATGGC
AAGTATGTGGATATGTTTAAAGAAGGCATTATTGACCCCTTAAAAGTAGAAAGGATCGCTTTGCAAAATGCGGTTTCGGT
TTCAAGCCTGCTTTTAACCACAGAAGCCACCGTGCATGAAATCAAAGAAGAAAAAGCAACCCCAGCAATGCCTGATATGG
GTGGCATGGGCGGTATGGGAGGCATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
TTGTCATACAAATAGTCATGACCATAAACATGCCAAAGAGCATGAAGCTTGCTGTCATGATCACAAAAAACACTAAAAAC
ATTATTATTAAGGATACAAA

Downstream 100 bases:

>100_bases
GCCCCCTTGCTTTTCTTGATAAAAGCCCTCTTTTTGGGGGCTTTTGTTTGACAAAACCGCTCATTCTAAAAATAAAACGC
ACAACAAAAAGACAAAACCT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIELSCPVANMGAQLVKEVASKT
ADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMDKAAEAIINELKKASKKVGGKEEITQVATISANSDHNIGKL
IADAMEKVGKDGVITVEEAKGIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTM
KEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAVLTGGQVISEELGLTLENAEVEFLGKAG
RIVIDKDNTTIVDGKGHSHDVKDRVAQIKTQIASTTSDYDKEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALS
ATKAAVEEGIVIGGGAALIRAAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVQKHEGHFGFNASNG
KYVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKATPAMPDMGGMGGMGGMGGMM

Sequences:

>Translated_546_residues
MAKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIELSCPVANMGAQLVKEVASKT
ADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMDKAAEAIINELKKASKKVGGKEEITQVATISANSDHNIGKL
IADAMEKVGKDGVITVEEAKGIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTM
KEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAVLTGGQVISEELGLTLENAEVEFLGKAG
RIVIDKDNTTIVDGKGHSHDVKDRVAQIKTQIASTTSDYDKEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALS
ATKAAVEEGIVIGGGAALIRAAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVQKHEGHFGFNASNG
KYVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKATPAMPDMGGMGGMGGMGGMM
>Mature_545_residues
AKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIELSCPVANMGAQLVKEVASKTA
DAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMDKAAEAIINELKKASKKVGGKEEITQVATISANSDHNIGKLI
ADAMEKVGKDGVITVEEAKGIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTMK
EGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAVLTGGQVISEELGLTLENAEVEFLGKAGR
IVIDKDNTTIVDGKGHSHDVKDRVAQIKTQIASTTSDYDKEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALSA
TKAAVEEGIVIGGGAALIRAAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVQKHEGHFGFNASNGK
YVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKATPAMPDMGGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=53.0188679245283, Blast_Score=544, Evalue=1e-155,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=53.0188679245283, Blast_Score=544, Evalue=1e-155,
Organism=Homo sapiens, GI38455427, Length=569, Percent_Identity=23.3743409490334, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790586, Length=527, Percent_Identity=60.5313092979127, Blast_Score=630, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=51.6068052930057, Blast_Score=525, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=50.7177033492823, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17564182, Length=553, Percent_Identity=22.4231464737794, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532603, Length=558, Percent_Identity=24.3727598566308, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32566944, Length=124, Percent_Identity=32.258064516129, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=522, Percent_Identity=52.8735632183908, Blast_Score=528, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6322350, Length=563, Percent_Identity=24.3339253996448, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322524, Length=123, Percent_Identity=30.0813008130081, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=53.8022813688213, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=53.8022813688213, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=51.0436432637571, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=51.0436432637571, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=51.0436432637571, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI17864606, Length=539, Percent_Identity=43.2282003710575, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24584129, Length=536, Percent_Identity=35.0746268656716, Blast_Score=306, Evalue=3e-83,
Organism=Drosophila melanogaster, GI19921262, Length=536, Percent_Identity=35.0746268656716, Blast_Score=306, Evalue=3e-83,
Organism=Drosophila melanogaster, GI24583944, Length=546, Percent_Identity=23.8095238095238, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58294; Mature: 58163

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIE
CCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHH
LSCPVANMGAQLVKEVASKTADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMD
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHH
KAAEAIINELKKASKKVGGKEEITQVATISANSDHNIGKLIADAMEKVGKDGVITVEEAK
HHHHHHHHHHHHHHHHCCCHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEHHHC
GIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTM
CCHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHH
KEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAVLTGGQVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCHHH
SEELGLTLENAEVEFLGKAGRIVIDKDNTTIVDGKGHSHDVKDRVAQIKTQIASTTSDYD
HHHHCCEEECCCEEEECCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCH
KEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIR
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHH
AAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVQKHEGHFGFNASNG
HHHHHEEECCCCHHHHHHHHHHHHHCCHHHHEEECCCCCCEEHHHHHHCCCCCCCCCCCC
KYVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKATPAMPDMGGMGGMG
CCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GMGGMM
CCCCCC
>Mature Secondary Structure 
AKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIE
CCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHH
LSCPVANMGAQLVKEVASKTADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMD
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHH
KAAEAIINELKKASKKVGGKEEITQVATISANSDHNIGKLIADAMEKVGKDGVITVEEAK
HHHHHHHHHHHHHHHHCCCHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEHHHC
GIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTM
CCHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHH
KEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAVLTGGQVI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCHHH
SEELGLTLENAEVEFLGKAGRIVIDKDNTTIVDGKGHSHDVKDRVAQIKTQIASTTSDYD
HHHHCCEEECCCEEEECCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCH
KEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIR
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHH
AAQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVQKHEGHFGFNASNG
HHHHHEEECCCCHHHHHHHHHHHHHCCHHHHEEECCCCCCEEHHHHHHCCCCCCCCCCCC
KYVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKATPAMPDMGGMGGMG
CCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GMGGMM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA