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The map label for this gene is hemN [H]

Identifier: 187930548

GI number: 187930548

Start: 3641981

End: 3643465

Strand: Reverse

Name: hemN [H]

Synonym: Rpic_3483

Alternate gene names: 187930548

Gene position: 3643465-3641981 (Counterclockwise)

Preceding gene: 187930550

Following gene: 187930542

Centisome position: 92.41

GC content: 64.92

Gene sequence:

>1485_bases
ATGTTTCCGTTCGCCAAGCCGGCCGACAATCCGTCCGCCGCAAATGACACCGCCTTCCGCTGGTCGGCGCCGCAGGTGCG
CGCGCTCGCGCAGCGCTTTGATACGCACGGCCCGCGCTACACCTCGTACCCAACGGCCGACCGCTTTCACAACAAATTCG
GCAACGCCGATTACCTCGACGCCTTGCACCGCCGCGCCGCGATCGCGCCCGCGCTGCATGCGCCGCTGTCGCTGTACATG
CACCTGCCGTTCTGCGCGAACCTTTGCTACTACTGCGGCTGCAACAAGGTCATCACAAAGGATCACTCCCGCAGCGCACG
GTACGTTGAAACGCTCGCCCGCGAGATGGCGATGGTCGCCAACCAGATCGGCCCACTGCGCCGCGTGACGCAGTTGCATT
GGGGCGGCGGCACGCCGACTTTTCTTGCGCACGACGAAATGCGTGCCGTGATGGCCGCCACGCGCGAGCATTTCGACGTG
GCCAACGATGGGGAGATCTCCGTCGAACTCGACCCGCGCCATGCCGACGACGCCACGCTCGAAGTATTGGCCGAGATCGG
TTTCAACCGCGCAAGCCTGGGCATCCAAGACTTTGACCCCGACGTCCAGCGCGCGGTCCACCGCATCCAAAGCGTGGAAG
AGACACGTCGCGTGGTCGACACCGCGCGCCGGCTGGGCTTCGAGTCGATCAGCTTCGACCTGATCTACGGCTTGCCATAT
CAGCGCACGGAAACCTTCAACGCCACGCTGGATCGCGTGCTGGAGATGGCGCCCGATCGGCTGTCCGTCTACAGCTATGC
GCATCTGCCGCACCTGTTCAAGGCGCAGCGCCGCATCGACATGCTCACGCTGCCTACCGCCGACGAAAAGCTCGACTTGC
TCGCCATGACGGTCGAGCGGCTCGTCGCCGAAGGCTATGTCTACATCGGCATGGATCACTTTGCGCGGCCTGACGATGCA
CTCGCCGTCGCACAGCGTGAAGGGCGGCTGCAGCGCAATTTCCAGGGCTATTCCACGCACGCCGATTGCGACATGCTGGC
GTTTGGCGTGTCCGCCATCAGCCGCGTGGGCGATGTGTATGCGCAGAACGAAAAGGATCTCGACGCGTACTACGCTCGCA
TCGACGCAGGCGAGCTGGCCGTGCTGCGCGGCATGTCGCTCACGCCGGACGATCACGTGCGCCGCGCGCTGATCGGCGAG
CTGATGTGCGGATTTGAATTGAACATGCGCGCATTCGGCGCGCGCCACGGGCTGGACTTCAAGCGCAGTTTTGCGGACGA
GTTGCAGGCGCTGGCGCCGCTGGAAGAAGCCGGGCTGGTGAAGGTCGGGGACGAGCGCATCGTCATCACACCGCAAGGGC
GGCTGCTCGTGCGCCGCATCGCGATGGTGTTCGATGCGCACCTGCGCGAGGCGGGCACGGAGCGCGCGATGGAAGCCGAG
GGCAAGCCCGTCACCTTTGTCCCGCGCTACTCCAAGGTGGTCTGA

Upstream 100 bases:

>100_bases
AGGCGCGTTTGAACAGGCGTTGACGGACGTTGACACACATCAACGCGGCGCCCACATCGCAGTTTTAGGATGAGGCATCG
CCCCCACAACGATCGCCCCC

Downstream 100 bases:

>100_bases
CCTTCCTGCTGGCCCGAAGCCACGTCAGACCGTTGCCGGTTCGGGCTGCAGTGCAGTGGTTTGCGTCTGGGCGCTGACCA
ACGTCTGTGGCCATATTTCT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MFPFAKPADNPSAANDTAFRWSAPQVRALAQRFDTHGPRYTSYPTADRFHNKFGNADYLDALHRRAAIAPALHAPLSLYM
HLPFCANLCYYCGCNKVITKDHSRSARYVETLAREMAMVANQIGPLRRVTQLHWGGGTPTFLAHDEMRAVMAATREHFDV
ANDGEISVELDPRHADDATLEVLAEIGFNRASLGIQDFDPDVQRAVHRIQSVEETRRVVDTARRLGFESISFDLIYGLPY
QRTETFNATLDRVLEMAPDRLSVYSYAHLPHLFKAQRRIDMLTLPTADEKLDLLAMTVERLVAEGYVYIGMDHFARPDDA
LAVAQREGRLQRNFQGYSTHADCDMLAFGVSAISRVGDVYAQNEKDLDAYYARIDAGELAVLRGMSLTPDDHVRRALIGE
LMCGFELNMRAFGARHGLDFKRSFADELQALAPLEEAGLVKVGDERIVITPQGRLLVRRIAMVFDAHLREAGTERAMEAE
GKPVTFVPRYSKVV

Sequences:

>Translated_494_residues
MFPFAKPADNPSAANDTAFRWSAPQVRALAQRFDTHGPRYTSYPTADRFHNKFGNADYLDALHRRAAIAPALHAPLSLYM
HLPFCANLCYYCGCNKVITKDHSRSARYVETLAREMAMVANQIGPLRRVTQLHWGGGTPTFLAHDEMRAVMAATREHFDV
ANDGEISVELDPRHADDATLEVLAEIGFNRASLGIQDFDPDVQRAVHRIQSVEETRRVVDTARRLGFESISFDLIYGLPY
QRTETFNATLDRVLEMAPDRLSVYSYAHLPHLFKAQRRIDMLTLPTADEKLDLLAMTVERLVAEGYVYIGMDHFARPDDA
LAVAQREGRLQRNFQGYSTHADCDMLAFGVSAISRVGDVYAQNEKDLDAYYARIDAGELAVLRGMSLTPDDHVRRALIGE
LMCGFELNMRAFGARHGLDFKRSFADELQALAPLEEAGLVKVGDERIVITPQGRLLVRRIAMVFDAHLREAGTERAMEAE
GKPVTFVPRYSKVV
>Mature_494_residues
MFPFAKPADNPSAANDTAFRWSAPQVRALAQRFDTHGPRYTSYPTADRFHNKFGNADYLDALHRRAAIAPALHAPLSLYM
HLPFCANLCYYCGCNKVITKDHSRSARYVETLAREMAMVANQIGPLRRVTQLHWGGGTPTFLAHDEMRAVMAATREHFDV
ANDGEISVELDPRHADDATLEVLAEIGFNRASLGIQDFDPDVQRAVHRIQSVEETRRVVDTARRLGFESISFDLIYGLPY
QRTETFNATLDRVLEMAPDRLSVYSYAHLPHLFKAQRRIDMLTLPTADEKLDLLAMTVERLVAEGYVYIGMDHFARPDDA
LAVAQREGRLQRNFQGYSTHADCDMLAFGVSAISRVGDVYAQNEKDLDAYYARIDAGELAVLRGMSLTPDDHVRRALIGE
LMCGFELNMRAFGARHGLDFKRSFADELQALAPLEEAGLVKVGDERIVITPQGRLLVRRIAMVFDAHLREAGTERAMEAE
GKPVTFVPRYSKVV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=196, Percent_Identity=30.1020408163265, Blast_Score=96, Evalue=9e-20,
Organism=Escherichia coli, GI87082341, Length=446, Percent_Identity=49.1031390134529, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1789325, Length=244, Percent_Identity=30.7377049180328, Blast_Score=115, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 55494; Mature: 55494

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPFAKPADNPSAANDTAFRWSAPQVRALAQRFDTHGPRYTSYPTADRFHNKFGNADYLD
CCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHH
ALHRRAAIAPALHAPLSLYMHLPFCANLCYYCGCNKVITKDHSRSARYVETLAREMAMVA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
NQIGPLRRVTQLHWGGGTPTFLAHDEMRAVMAATREHFDVANDGEISVELDPRHADDATL
HHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHH
EVLAEIGFNRASLGIQDFDPDVQRAVHRIQSVEETRRVVDTARRLGFESISFDLIYGLPY
HHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
QRTETFNATLDRVLEMAPDRLSVYSYAHLPHLFKAQRRIDMLTLPTADEKLDLLAMTVER
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHH
LVAEGYVYIGMDHFARPDDALAVAQREGRLQRNFQGYSTHADCDMLAFGVSAISRVGDVY
HHHCCEEEEECHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AQNEKDLDAYYARIDAGELAVLRGMSLTPDDHVRRALIGELMCGFELNMRAFGARHGLDF
HCCCCCHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCH
KRSFADELQALAPLEEAGLVKVGDERIVITPQGRLLVRRIAMVFDAHLREAGTERAMEAE
HHHHHHHHHHHCCHHHCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GKPVTFVPRYSKVV
CCCEEECCCHHCCC
>Mature Secondary Structure
MFPFAKPADNPSAANDTAFRWSAPQVRALAQRFDTHGPRYTSYPTADRFHNKFGNADYLD
CCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHH
ALHRRAAIAPALHAPLSLYMHLPFCANLCYYCGCNKVITKDHSRSARYVETLAREMAMVA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
NQIGPLRRVTQLHWGGGTPTFLAHDEMRAVMAATREHFDVANDGEISVELDPRHADDATL
HHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHH
EVLAEIGFNRASLGIQDFDPDVQRAVHRIQSVEETRRVVDTARRLGFESISFDLIYGLPY
HHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
QRTETFNATLDRVLEMAPDRLSVYSYAHLPHLFKAQRRIDMLTLPTADEKLDLLAMTVER
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHH
LVAEGYVYIGMDHFARPDDALAVAQREGRLQRNFQGYSTHADCDMLAFGVSAISRVGDVY
HHHCCEEEEECHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AQNEKDLDAYYARIDAGELAVLRGMSLTPDDHVRRALIGELMCGFELNMRAFGARHGLDF
HCCCCCHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCH
KRSFADELQALAPLEEAGLVKVGDERIVITPQGRLLVRRIAMVFDAHLREAGTERAMEAE
HHHHHHHHHHHCCHHHCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GKPVTFVPRYSKVV
CCCEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]