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The map label for this gene is cpg2 [H]

Identifier: 187930443

GI number: 187930443

Start: 3539037

End: 3540347

Strand: Reverse

Name: cpg2 [H]

Synonym: Rpic_3377

Alternate gene names: 187930443

Gene position: 3540347-3539037 (Counterclockwise)

Preceding gene: 187930445

Following gene: 187930442

Centisome position: 89.8

GC content: 64.61

Gene sequence:

>1311_bases
ATGAGAGCCCCGTTGTTGCCCAAGGGTTTGCGCCCTGCAGTGCTGGCCGCCGTCGCACTGGTCGGTGCGCTGGCTGCCGG
CCACGCTGCCGCCGTGCCGCCGGCTGAAATCTACAAGCGCGCCCAGCAGGAAAAACCCGCGCTGATCGACACCATGAAGA
CTTTGGTCTCGATCGAATCGGGCAGCAAGGACATCGAAGGCCTGGACAAGATTGCCGGCGTGATTGCCGAGCGCCTGCGC
GGCATGGGCGGCGACGTCAAGCTCATCGACCCCAGCGACCACGCTTACCGCATGGCCGATACCCCCGAGAAGATCGGCAA
GATGGTGCTCGCGCGCTTCAAGGGCGATGGCAAGCGCAACATCATGCTAATTGCGCACATGGATACCGTGTATCTCAAGG
GCATGCTCGCGCAGCAGCCATTCCGCATCGACGGTGAACGCGCCTACGGTCTGGGCATTGCCGACGACAAGAACGGCGTC
GCGGTCATCCTCCACACGGTGTCGATCCTGCAGGCCGTCAATTTCAAGCAATACGGCACGCTCACGGTGCTGATCAACGG
CGATGAAGAAATCAGCTCGCCGGGCGCGCGGGCCATGCAGGCCAAGCTGGGCGCCGAGCAGGACGCCGTGTTCTCGTGCG
AAGGCACGCGCGTGACGTCGGACAAGCTGTCGGTGGCCACCAGCGGCATCGGCGCGATCCTGCTGGATGTGAAGGGCAAG
GCTTCGCACGCCGGCGGCGCGCCGGAGCAGGGCCGCAACGCGCTGTACGAACTGTCGCACCAGGTGCTGCAGATGCGCGA
TCTGTCCAAGCCCGAAACGGGCCTCAAGGTGAACTGGACAGTGGCGCAGGCAGGCACGAACCGCAACGTGATCCCGGCCG
CGGCCAGCGCTCAGGCCGATGTGCGCCTGCTGCGCGCAGCCGACGCCGACAAGTTGGAAGAAACCGTCAACGAACGCATC
AAGAACAAACTGATCCCGGATACGCAGGTCACAGCCAAGTTCGAGCGCCGTCGCCCGCCGCTGGAAGCCACGCCGGCGTC
GCGCGCGCTGGCCGAACACGCTCAGAAGATCTATGGCGAACTCGGCAAGACGCTGGAGATTGACGACAAGGCCGAAGGCG
GCGGCACCGATGCCGCGTTTGCCGCGTCGAAGACGAAGGCGCCCGTGATCGAGCGTTTTGGCCTGGCGAGCTTTGGCGCG
CACTCGAATGACGCCGAATATGTCGACCTGAACTCCATCGTGCCGCGCCTGTACCTGTTGACGCGCATGATCATGGACGT
GTCGCGCGATCGCGTCGGCCCGGCCAAGTAA

Upstream 100 bases:

>100_bases
CTATCCGAAGGGGGGATAGCCCTCGGGCAATCCTCAGGCTGGCGTGAGAAAATCGCGGTTTTGTTGCAGACCATAACTAA
GAACAGGTGAGGAAACATCC

Downstream 100 bases:

>100_bases
CCGCACTGCAATGCGGCGCGTAAGCCTTACACGCGCCGCAGCAGCTCTCTTGCGCGAAGCCGCTGCCCTGCGGCTTCCCA
CCGCCCGGGTGCCGGGTATT

Product: glutamate carboxypeptidase

Products: NA

Alternate protein names: CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MRAPLLPKGLRPAVLAAVALVGALAAGHAAAVPPAEIYKRAQQEKPALIDTMKTLVSIESGSKDIEGLDKIAGVIAERLR
GMGGDVKLIDPSDHAYRMADTPEKIGKMVLARFKGDGKRNIMLIAHMDTVYLKGMLAQQPFRIDGERAYGLGIADDKNGV
AVILHTVSILQAVNFKQYGTLTVLINGDEEISSPGARAMQAKLGAEQDAVFSCEGTRVTSDKLSVATSGIGAILLDVKGK
ASHAGGAPEQGRNALYELSHQVLQMRDLSKPETGLKVNWTVAQAGTNRNVIPAAASAQADVRLLRAADADKLEETVNERI
KNKLIPDTQVTAKFERRRPPLEATPASRALAEHAQKIYGELGKTLEIDDKAEGGGTDAAFAASKTKAPVIERFGLASFGA
HSNDAEYVDLNSIVPRLYLLTRMIMDVSRDRVGPAK

Sequences:

>Translated_436_residues
MRAPLLPKGLRPAVLAAVALVGALAAGHAAAVPPAEIYKRAQQEKPALIDTMKTLVSIESGSKDIEGLDKIAGVIAERLR
GMGGDVKLIDPSDHAYRMADTPEKIGKMVLARFKGDGKRNIMLIAHMDTVYLKGMLAQQPFRIDGERAYGLGIADDKNGV
AVILHTVSILQAVNFKQYGTLTVLINGDEEISSPGARAMQAKLGAEQDAVFSCEGTRVTSDKLSVATSGIGAILLDVKGK
ASHAGGAPEQGRNALYELSHQVLQMRDLSKPETGLKVNWTVAQAGTNRNVIPAAASAQADVRLLRAADADKLEETVNERI
KNKLIPDTQVTAKFERRRPPLEATPASRALAEHAQKIYGELGKTLEIDDKAEGGGTDAAFAASKTKAPVIERFGLASFGA
HSNDAEYVDLNSIVPRLYLLTRMIMDVSRDRVGPAK
>Mature_436_residues
MRAPLLPKGLRPAVLAAVALVGALAAGHAAAVPPAEIYKRAQQEKPALIDTMKTLVSIESGSKDIEGLDKIAGVIAERLR
GMGGDVKLIDPSDHAYRMADTPEKIGKMVLARFKGDGKRNIMLIAHMDTVYLKGMLAQQPFRIDGERAYGLGIADDKNGV
AVILHTVSILQAVNFKQYGTLTVLINGDEEISSPGARAMQAKLGAEQDAVFSCEGTRVTSDKLSVATSGIGAILLDVKGK
ASHAGGAPEQGRNALYELSHQVLQMRDLSKPETGLKVNWTVAQAGTNRNVIPAAASAQADVRLLRAADADKLEETVNERI
KNKLIPDTQVTAKFERRRPPLEATPASRALAEHAQKIYGELGKTLEIDDKAEGGGTDAAFAASKTKAPVIERFGLASFGA
HSNDAEYVDLNSIVPRLYLLTRMIMDVSRDRVGPAK

Specific function: Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity [H]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR017150
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.17.11 [H]

Molecular weight: Translated: 46567; Mature: 46567

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00758 ARGE_DAPE_CPG2_1 ; PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPLLPKGLRPAVLAAVALVGALAAGHAAAVPPAEIYKRAQQEKPALIDTMKTLVSIES
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
GSKDIEGLDKIAGVIAERLRGMGGDVKLIDPSDHAYRMADTPEKIGKMVLARFKGDGKRN
CCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEECCCCHHHHHHHHHHHHCCCCCCE
IMLIAHMDTVYLKGMLAQQPFRIDGERAYGLGIADDKNGVAVILHTVSILQAVNFKQYGT
EEEEEECHHHHHHHHHHCCCCEECCCEEEECCCCCCCCCCEEHHHHHHHHHHHCCCCCCE
LTVLINGDEEISSPGARAMQAKLGAEQDAVFSCEGTRVTSDKLSVATSGIGAILLDVKGK
EEEEECCCHHHCCCCHHHHHHHCCCCCCCEEEECCCEEECCHHHHHHCCCEEEEEEECCC
ASHAGGAPEQGRNALYELSHQVLQMRDLSKPETGLKVNWTVAQAGTNRNVIPAAASAQAD
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHH
VRLLRAADADKLEETVNERIKNKLIPDTQVTAKFERRRPPLEATPASRALAEHAQKIYGE
HHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LGKTLEIDDKAEGGGTDAAFAASKTKAPVIERFGLASFGAHSNDAEYVDLNSIVPRLYLL
HCCEEEECCCCCCCCCCHHHHCCCCCCHHHHHCCCHHCCCCCCCCCEEEHHHHHHHHHHH
TRMIMDVSRDRVGPAK
HHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRAPLLPKGLRPAVLAAVALVGALAAGHAAAVPPAEIYKRAQQEKPALIDTMKTLVSIES
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCC
GSKDIEGLDKIAGVIAERLRGMGGDVKLIDPSDHAYRMADTPEKIGKMVLARFKGDGKRN
CCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEECCCCHHHHHHHHHHHHCCCCCCE
IMLIAHMDTVYLKGMLAQQPFRIDGERAYGLGIADDKNGVAVILHTVSILQAVNFKQYGT
EEEEEECHHHHHHHHHHCCCCEECCCEEEECCCCCCCCCCEEHHHHHHHHHHHCCCCCCE
LTVLINGDEEISSPGARAMQAKLGAEQDAVFSCEGTRVTSDKLSVATSGIGAILLDVKGK
EEEEECCCHHHCCCCHHHHHHHCCCCCCCEEEECCCEEECCHHHHHHCCCEEEEEEECCC
ASHAGGAPEQGRNALYELSHQVLQMRDLSKPETGLKVNWTVAQAGTNRNVIPAAASAQAD
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHH
VRLLRAADADKLEETVNERIKNKLIPDTQVTAKFERRRPPLEATPASRALAEHAQKIYGE
HHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LGKTLEIDDKAEGGGTDAAFAASKTKAPVIERFGLASFGAHSNDAEYVDLNSIVPRLYLL
HCCEEEECCCCCCCCCCHHHHCCCCCCHHHHHCCCHHCCCCCCCCCEEEHHHHHHHHHHH
TRMIMDVSRDRVGPAK
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6396165; 3838935; 9083113 [H]