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The map label for this gene is dsbD [H]

Identifier: 187930335

GI number: 187930335

Start: 3418278

End: 3420095

Strand: Reverse

Name: dsbD [H]

Synonym: Rpic_3268

Alternate gene names: 187930335

Gene position: 3420095-3418278 (Counterclockwise)

Preceding gene: 187930336

Following gene: 187930332

Centisome position: 86.75

GC content: 64.8

Gene sequence:

>1818_bases
ATGACCTTCTCTTCGTTCGTGTCCGTGCGGCGTGTGATGCAGTTGGCGATGCTGCTGGTCGCGGTGGCGACGCTGTGCAT
GCCTGCACATGCTGCTGACGATTTCCTGCCACCCGAGCAGGCGTTCCGCTTCTCCGCCACGCAGGTCGACGGCCAGACCG
TCGAAGTCAAGTTCGCGATTGCTGATGGCTACTACATGTACCGTGAGCGCTTCGCGGTGGCGGCGGATCCGGCAGCTGTC
GCACTCGCACTCCTCGACATGCCGGCAGGCAAGGTCAAATTCGACGAGACGTTCAACAAGGATGTCGAAACCTATCGCCA
TGAAATCGCATTCCATGTGAAGGCGCGGAACGCGACGGCGCCATTCACGCTGATCGTCACGTCGCAGGGGTGCGCGGATC
AAGGCCTGTGTTATCCGCCGATGAAGAGCCGGTTCCATGTGGAACCCGCAGCGGCTTCCCCGGCGGCGCCTTCCGCCGGC
GGTGGCGACGCACTCGGCCGCATCGCCAGCACGCTGGGTAGCGGCAACCTTGGCGCGATTGCGGCGTTGTTCTTTGGGCT
CGGTCTGTTGCTTACCTTCACGCCGTGTGTGCTCCCGATGCTGCCGATCCTGTCGGCGATCGTGGTCGGCGAGCACGCGA
CGCGTTCGCGCGCAGCGATCGTGTCGGTGGCCTACGTGCTCGGGATGGCCTTCGTCTATACCGCCGTAGGGGTGGCAGCC
GGCTTAGCCGGGCAGGGCCTGCAAGCCGCGCTGCAGAACGCCTGGGTGCTGGGCGCGTTTGCCGTATTGATGGTAGCGCT
GTCGCTGTCGATGTTCGGGCTGTATGAACTGCAGTTGCCGGCAGCTTGGCGCGATCACCTGACAAAAGCCTCCAGCAAGC
ATGGCGGCGGCGAGATTGTTGGCGCGGTCGTGATGGGCGCGCTTTCGGCGTTGATAGTGTCGCCGTGTGTGACGCCGGCG
TTGGCGGGCGCGCTGGCCTATATCGCGCAGACCGGCAACGCCGCGATCGGCGGTATGGCGTTGTTTGCGATGTCGATCGG
CATGGGGGTACCGCTCGTGCTCGTGGGTGTAGGCGCGGGCAACCTGCTGCCGCGCGCGGGCCATTGGTTGATCGTCACCA
AGGCGGTGTTCGGTTTCATCCTGCTGGCTGTGGCGCTGTGGATCGTGCAGCCGGTGTTGCCGGCGTGGGCAGTGATGATT
GCGTGGGGTGGCTTGCTGATCGGTGCGGCCGTGTTTCTGCGGACATTCGATTCGTTGCCCGACGGCGCCGGCAACGTGCA
GCGCTTGGGCAAGGTCGCGGGTGTGGTGCTCGCGCTGGCTGGCGCAGCGCAACTGGTCGGAGTCGCCGCCGGCGGTCGCG
ATCCGCTACAGCCGCTGTCCGGACTGATTCGCGCATCGGCGGGCGCATCCGCGCAAGCTGAGGCACACGGGGTGACATTC
AAGCGGGTGAAGAGCATCGCTGAACTCGATGCCGAAGTGCGCAACGCGAGCGCGTCGGGCCGTGCGGTGATGCTCGATTT
CTACGCCGACTGGTGTGTGAGCTGCAAGGAAATGGAGCGCCTGACCTTTACCGATACGCGGGTGCGCAAGGCGCTTGCCG
ATGTGGTGCTGCTGCAGGCTGACGTGACTGCCAACAGTGCGGATGACCAAGTACTGCTCAAGCGCTTCGGCTTGTTCGGC
CCGCCCGGCACGATCTTCTTCGATGCGCAGGGTCGCGAACTGAAAGCTCGTGTGGTCGGCTATGAGCGCGCCGACACGTT
TCTGGAAAGCCTGCGTCGCACGATCGGCACGACGCAGGCAGCCAAGCCGACGGCCTGA

Upstream 100 bases:

>100_bases
GATCATCGCTGTGCCGGTGGCTGCGGGGTTGCCGGCGTATCTTGCGTGGGTGGCCGACGAAACGCGCATGTCTTCCAATT
GATGTTTGTTTGGCGTTGAT

Downstream 100 bases:

>100_bases
CTACGCGCGCAGCAGGCGGGCGGCGTCCAATGCGAAGTACGTCAGGATGCCGTTCGCGCCGGCGCGCTTGAACGCCAGCA
GCGACTCCAGCACGACCTTG

Product: Protein-disulfide reductase

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 605; Mature: 604

Protein sequence:

>605_residues
MTFSSFVSVRRVMQLAMLLVAVATLCMPAHAADDFLPPEQAFRFSATQVDGQTVEVKFAIADGYYMYRERFAVAADPAAV
ALALLDMPAGKVKFDETFNKDVETYRHEIAFHVKARNATAPFTLIVTSQGCADQGLCYPPMKSRFHVEPAAASPAAPSAG
GGDALGRIASTLGSGNLGAIAALFFGLGLLLTFTPCVLPMLPILSAIVVGEHATRSRAAIVSVAYVLGMAFVYTAVGVAA
GLAGQGLQAALQNAWVLGAFAVLMVALSLSMFGLYELQLPAAWRDHLTKASSKHGGGEIVGAVVMGALSALIVSPCVTPA
LAGALAYIAQTGNAAIGGMALFAMSIGMGVPLVLVGVGAGNLLPRAGHWLIVTKAVFGFILLAVALWIVQPVLPAWAVMI
AWGGLLIGAAVFLRTFDSLPDGAGNVQRLGKVAGVVLALAGAAQLVGVAAGGRDPLQPLSGLIRASAGASAQAEAHGVTF
KRVKSIAELDAEVRNASASGRAVMLDFYADWCVSCKEMERLTFTDTRVRKALADVVLLQADVTANSADDQVLLKRFGLFG
PPGTIFFDAQGRELKARVVGYERADTFLESLRRTIGTTQAAKPTA

Sequences:

>Translated_605_residues
MTFSSFVSVRRVMQLAMLLVAVATLCMPAHAADDFLPPEQAFRFSATQVDGQTVEVKFAIADGYYMYRERFAVAADPAAV
ALALLDMPAGKVKFDETFNKDVETYRHEIAFHVKARNATAPFTLIVTSQGCADQGLCYPPMKSRFHVEPAAASPAAPSAG
GGDALGRIASTLGSGNLGAIAALFFGLGLLLTFTPCVLPMLPILSAIVVGEHATRSRAAIVSVAYVLGMAFVYTAVGVAA
GLAGQGLQAALQNAWVLGAFAVLMVALSLSMFGLYELQLPAAWRDHLTKASSKHGGGEIVGAVVMGALSALIVSPCVTPA
LAGALAYIAQTGNAAIGGMALFAMSIGMGVPLVLVGVGAGNLLPRAGHWLIVTKAVFGFILLAVALWIVQPVLPAWAVMI
AWGGLLIGAAVFLRTFDSLPDGAGNVQRLGKVAGVVLALAGAAQLVGVAAGGRDPLQPLSGLIRASAGASAQAEAHGVTF
KRVKSIAELDAEVRNASASGRAVMLDFYADWCVSCKEMERLTFTDTRVRKALADVVLLQADVTANSADDQVLLKRFGLFG
PPGTIFFDAQGRELKARVVGYERADTFLESLRRTIGTTQAAKPTA
>Mature_604_residues
TFSSFVSVRRVMQLAMLLVAVATLCMPAHAADDFLPPEQAFRFSATQVDGQTVEVKFAIADGYYMYRERFAVAADPAAVA
LALLDMPAGKVKFDETFNKDVETYRHEIAFHVKARNATAPFTLIVTSQGCADQGLCYPPMKSRFHVEPAAASPAAPSAGG
GDALGRIASTLGSGNLGAIAALFFGLGLLLTFTPCVLPMLPILSAIVVGEHATRSRAAIVSVAYVLGMAFVYTAVGVAAG
LAGQGLQAALQNAWVLGAFAVLMVALSLSMFGLYELQLPAAWRDHLTKASSKHGGGEIVGAVVMGALSALIVSPCVTPAL
AGALAYIAQTGNAAIGGMALFAMSIGMGVPLVLVGVGAGNLLPRAGHWLIVTKAVFGFILLAVALWIVQPVLPAWAVMIA
WGGLLIGAAVFLRTFDSLPDGAGNVQRLGKVAGVVLALAGAAQLVGVAAGGRDPLQPLSGLIRASAGASAQAEAHGVTFK
RVKSIAELDAEVRNASASGRAVMLDFYADWCVSCKEMERLTFTDTRVRKALADVVLLQADVTANSADDQVLLKRFGLFGP
PGTIFFDAQGRELKARVVGYERADTFLESLRRTIGTTQAAKPTA

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=590, Percent_Identity=38.8135593220339, Blast_Score=363, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 63007; Mature: 62876

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFSSFVSVRRVMQLAMLLVAVATLCMPAHAADDFLPPEQAFRFSATQVDGQTVEVKFAI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEECCEECCCEEEEEEEEE
ADGYYMYRERFAVAADPAAVALALLDMPAGKVKFDETFNKDVETYRHEIAFHVKARNATA
ECCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHEEEEEECCCCC
PFTLIVTSQGCADQGLCYPPMKSRFHVEPAAASPAAPSAGGGDALGRIASTLGSGNLGAI
CEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
AALFFGLGLLLTFTPCVLPMLPILSAIVVGEHATRSRAAIVSVAYVLGMAFVYTAVGVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLAGQGLQAALQNAWVLGAFAVLMVALSLSMFGLYELQLPAAWRDHLTKASSKHGGGEIV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCCCCHHHH
GAVVMGALSALIVSPCVTPALAGALAYIAQTGNAAIGGMALFAMSIGMGVPLVLVGVGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCC
NLLPRAGHWLIVTKAVFGFILLAVALWIVQPVLPAWAVMIAWGGLLIGAAVFLRTFDSLP
CCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DGAGNVQRLGKVAGVVLALAGAAQLVGVAAGGRDPLQPLSGLIRASAGASAQAEAHGVTF
CCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCCCCHHHCCCHH
KRVKSIAELDAEVRNASASGRAVMLDFYADWCVSCKEMERLTFTDTRVRKALADVVLLQA
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHEE
DVTANSADDQVLLKRFGLFGPPGTIFFDAQGRELKARVVGYERADTFLESLRRTIGTTQA
CCCCCCCCHHHHHHHCCCCCCCCCEEECCCCCEEEHHHHCHHHHHHHHHHHHHHHCCCCC
AKPTA
CCCCC
>Mature Secondary Structure 
TFSSFVSVRRVMQLAMLLVAVATLCMPAHAADDFLPPEQAFRFSATQVDGQTVEVKFAI
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEECCEECCCEEEEEEEEE
ADGYYMYRERFAVAADPAAVALALLDMPAGKVKFDETFNKDVETYRHEIAFHVKARNATA
ECCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHEEEEEECCCCC
PFTLIVTSQGCADQGLCYPPMKSRFHVEPAAASPAAPSAGGGDALGRIASTLGSGNLGAI
CEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHH
AALFFGLGLLLTFTPCVLPMLPILSAIVVGEHATRSRAAIVSVAYVLGMAFVYTAVGVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLAGQGLQAALQNAWVLGAFAVLMVALSLSMFGLYELQLPAAWRDHLTKASSKHGGGEIV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCCCCHHHH
GAVVMGALSALIVSPCVTPALAGALAYIAQTGNAAIGGMALFAMSIGMGVPLVLVGVGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCC
NLLPRAGHWLIVTKAVFGFILLAVALWIVQPVLPAWAVMIAWGGLLIGAAVFLRTFDSLP
CCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DGAGNVQRLGKVAGVVLALAGAAQLVGVAAGGRDPLQPLSGLIRASAGASAQAEAHGVTF
CCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCCCCHHHCCCHH
KRVKSIAELDAEVRNASASGRAVMLDFYADWCVSCKEMERLTFTDTRVRKALADVVLLQA
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHEE
DVTANSADDQVLLKRFGLFGPPGTIFFDAQGRELKARVVGYERADTFLESLRRTIGTTQA
CCCCCCCCHHHHHHHCCCCCCCCCEEECCCCCEEEHHHHCHHHHHHHHHHHHHHHCCCCC
AKPTA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]