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The map label for this gene is hisC1 [H]

Identifier: 187930295

GI number: 187930295

Start: 3374199

End: 3375323

Strand: Reverse

Name: hisC1 [H]

Synonym: Rpic_3228

Alternate gene names: 187930295

Gene position: 3375323-3374199 (Counterclockwise)

Preceding gene: 187930296

Following gene: 187930294

Centisome position: 85.61

GC content: 64.18

Gene sequence:

>1125_bases
ATGAACGCCACAGCTCCGGCCCAAGCCTCTCTCGATGACCTGCTCGCCCGCATCGTGCGCGACGACGTTCGCGCCATGGG
CGCATACCACGTGCCCGACGCGACCGGCATGGTCAAGCTGGACGCGATGGAAAACCCATATCTGCTGCCGGCGATGCTGC
GCGACGCGCTGGGCAAGCGCCTGGCCGAAGTCGCGCTCAACCGCTACCCGGTGCCGACGGCCGACGCGTTAAAGGCGCAG
CTCAAGCAGGTGATGCATGTGCCGGCCGGTGCCGAGGTGCTGCTGGGCAATGGTTCGGACGAGATCATCAGCCTGATCGC
CATTGCGGCGGCCAAGCCGGGCGCGACCGTGCTGGCGCCGGTGCCGGGTTTCGTGATGTACGCGATGTCGGCGCAGCTGC
TGGGCTTGAACTTTGTCGGCGTACCGCTCAAGGCGGACCTGACGCTTGACCGTGAAGCGATGCTGGCGGCCATGGCCGAA
CACCAGCCCGCCGTCATCTACCTGGCGTATCCGAACAACCCGACGGGCAATCTGTTCGACGCGGCGGACATGGACGCGAT
CATCCGTGCCGCACGTGGCCCGGTGTGCCAAAGCCTGGTGGTAGTCGACGAGGCCTACCAGCCATTCGCGCAACATAGCT
GGATGCCGCGCCTGCGCGATTTCGATCATCTTCTGGTGATGCGCACCGTCTCCAAGCTGGGCCTGGCCGGCATCCGCCTC
GGCTACGTGGCCGGCCACCCGAAGTGGATCGCCGAGCTGGACAAGGTGCGCCCGCCGTATAACGTGAATGTGCTGACCGA
GGCGACCGCCCAGTTCATGCTCGAACACGTGGACGTGCTGGATGCCCAGGCAGCGACCCTGCGTGCCGAGCGCACCAAGC
TGATCGATGTGCTGTCGGCTCAGCCGGGCGTGACGGTGTTCCCAAGCGCGGCGAATTTCATCCTGCTGCGCGTGCCGAAT
GCCGCCACCTTGTTCGAGCGCCTGCTCAATCGGCGGATTCTGATTAAAAACGTCAGTAAAATGCACCCGTTGCTGGCCAA
CTGTCTGCGCGTGACGGTCAGCAATCCCGAAGAAAACGCGCAATTTATCGATGCCTTTGTCGCATCGATGCAGGAAGCCC
CATGA

Upstream 100 bases:

>100_bases
GCTGCCGAACTGGCCTACGGCGAAGGCTTGCAGGCGCATGCCCGCAGCGCCGAATATCGCCTGCAACGCCCAACCTCCGA
ATAACGCCTGCAGCACGACG

Downstream 100 bases:

>100_bases
GCCGCCGTGCCGAGGTCACTCGTAACACCTCTGAAACGCAGATCCGCGTCGCCCTTGATTTGGACGGCACGGGCAAGCAG
ACGCTGAACACCGGCGTCCC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MNATAPAQASLDDLLARIVRDDVRAMGAYHVPDATGMVKLDAMENPYLLPAMLRDALGKRLAEVALNRYPVPTADALKAQ
LKQVMHVPAGAEVLLGNGSDEIISLIAIAAAKPGATVLAPVPGFVMYAMSAQLLGLNFVGVPLKADLTLDREAMLAAMAE
HQPAVIYLAYPNNPTGNLFDAADMDAIIRAARGPVCQSLVVVDEAYQPFAQHSWMPRLRDFDHLLVMRTVSKLGLAGIRL
GYVAGHPKWIAELDKVRPPYNVNVLTEATAQFMLEHVDVLDAQAATLRAERTKLIDVLSAQPGVTVFPSAANFILLRVPN
AATLFERLLNRRILIKNVSKMHPLLANCLRVTVSNPEENAQFIDAFVASMQEAP

Sequences:

>Translated_374_residues
MNATAPAQASLDDLLARIVRDDVRAMGAYHVPDATGMVKLDAMENPYLLPAMLRDALGKRLAEVALNRYPVPTADALKAQ
LKQVMHVPAGAEVLLGNGSDEIISLIAIAAAKPGATVLAPVPGFVMYAMSAQLLGLNFVGVPLKADLTLDREAMLAAMAE
HQPAVIYLAYPNNPTGNLFDAADMDAIIRAARGPVCQSLVVVDEAYQPFAQHSWMPRLRDFDHLLVMRTVSKLGLAGIRL
GYVAGHPKWIAELDKVRPPYNVNVLTEATAQFMLEHVDVLDAQAATLRAERTKLIDVLSAQPGVTVFPSAANFILLRVPN
AATLFERLLNRRILIKNVSKMHPLLANCLRVTVSNPEENAQFIDAFVASMQEAP
>Mature_374_residues
MNATAPAQASLDDLLARIVRDDVRAMGAYHVPDATGMVKLDAMENPYLLPAMLRDALGKRLAEVALNRYPVPTADALKAQ
LKQVMHVPAGAEVLLGNGSDEIISLIAIAAAKPGATVLAPVPGFVMYAMSAQLLGLNFVGVPLKADLTLDREAMLAAMAE
HQPAVIYLAYPNNPTGNLFDAADMDAIIRAARGPVCQSLVVVDEAYQPFAQHSWMPRLRDFDHLLVMRTVSKLGLAGIRL
GYVAGHPKWIAELDKVRPPYNVNVLTEATAQFMLEHVDVLDAQAATLRAERTKLIDVLSAQPGVTVFPSAANFILLRVPN
AATLFERLLNRRILIKNVSKMHPLLANCLRVTVSNPEENAQFIDAFVASMQEAP

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=361, Percent_Identity=31.8559556786704, Blast_Score=143, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322075, Length=386, Percent_Identity=26.4248704663212, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40521; Mature: 40521

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATAPAQASLDDLLARIVRDDVRAMGAYHVPDATGMVKLDAMENPYLLPAMLRDALGKR
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCEEEEECCCCCEEHHHHHHHHHHHH
LAEVALNRYPVPTADALKAQLKQVMHVPAGAEVLLGNGSDEIISLIAIAAAKPGATVLAP
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCCEEEEC
VPGFVMYAMSAQLLGLNFVGVPLKADLTLDREAMLAAMAEHQPAVIYLAYPNNPTGNLFD
CCHHHHHHHHHHHHCCEEECCCEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
AADMDAIIRAARGPVCQSLVVVDEAYQPFAQHSWMPRLRDFDHLLVMRTVSKLGLAGIRL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHEEE
GYVAGHPKWIAELDKVRPPYNVNVLTEATAQFMLEHVDVLDAQAATLRAERTKLIDVLSA
EEECCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPGVTVFPSAANFILLRVPNAATLFERLLNRRILIKNVSKMHPLLANCLRVTVSNPEENA
CCCCEEECCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEECCCCHHH
QFIDAFVASMQEAP
HHHHHHHHHHHCCC
>Mature Secondary Structure
MNATAPAQASLDDLLARIVRDDVRAMGAYHVPDATGMVKLDAMENPYLLPAMLRDALGKR
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCEEEEECCCCCEEHHHHHHHHHHHH
LAEVALNRYPVPTADALKAQLKQVMHVPAGAEVLLGNGSDEIISLIAIAAAKPGATVLAP
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCCEEEEC
VPGFVMYAMSAQLLGLNFVGVPLKADLTLDREAMLAAMAEHQPAVIYLAYPNNPTGNLFD
CCHHHHHHHHHHHHCCEEECCCEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
AADMDAIIRAARGPVCQSLVVVDEAYQPFAQHSWMPRLRDFDHLLVMRTVSKLGLAGIRL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHEEE
GYVAGHPKWIAELDKVRPPYNVNVLTEATAQFMLEHVDVLDAQAATLRAERTKLIDVLSA
EEECCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPGVTVFPSAANFILLRVPNAATLFERLLNRRILIKNVSKMHPLLANCLRVTVSNPEENA
CCCCEEECCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEECCCCHHH
QFIDAFVASMQEAP
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]