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The map label for this gene is hisD [H]

Identifier: 187930296

GI number: 187930296

Start: 3375340

End: 3376668

Strand: Reverse

Name: hisD [H]

Synonym: Rpic_3229

Alternate gene names: 187930296

Gene position: 3376668-3375340 (Counterclockwise)

Preceding gene: 187930297

Following gene: 187930295

Centisome position: 85.65

GC content: 66.82

Gene sequence:

>1329_bases
ATGAGCCTGACCATCCGTAAGCTGGATTCGGCCGAAGCCGGATTCGCGGCGCAACTGCGCCAGGTGCTCGCTTTCGAGGC
GAGCGAAGACGAAGCCATTGACCGGGCGGCCGCGCAGATCCTGGCCGACGTGAAGGCGCGCGGCGACGCCGCTGTGCTGG
AAGCCACGCAGCGCTTTGACCGCATTGAAGCCGATAGCGTGGCCGCGCTGGAACTGTCGCCGGCCACGCTGCAAGCTGCG
CTGGATGGCCTGGAGCCCAAGCGCCGCGCGGCGCTGGAAGCCGCTGCCGCCCGCGTGCGTGCGTATCACGAGAAGCAGAA
GATCGAGTGCGGCACGCACAGCTGGGAATACGCCGAAGCCGACGGCACGGTGCTCGGCCAGAAAGTCACGCCGCTCGATC
GCGTGGGCATCTACGTGCCGGGCGGCAAGGCTGCGTACCCGTCGTCGGTGCTGATGAACGCCATCCCGGCACGTGTGGCC
GGCGTCAAGGAAATCATCATGGTCGTGCCCACGCCCGGTGGCGTGCGCAACGAGCTGGTGCTGGCTGCGGCCTGCATCGC
CGGGGTGGACCGCGTGTTCACCATCGGCGGCGCACAGGCCGTGGGTGCGCTGGCTTATGGCACGGAGACCGTCCCCGCCG
TCGACAAGATCGTCGGCCCCGGCAATGCCTATGTGGCGGCGGCCAAGCGCCGCGTGTTCGGTACGGTGGGCATCGACATG
ATTGCCGGCCCGTCGGAAATCCTCGTCATCTGCGATGGCACGACCGATCCGGACTGGGTGGCGATGGACCTGTTCTCGCA
GGCCGAACACGACGAGCTGGCTCAGTCGATTCTGCTGTGCCCGAACGCCGAGTTCATCGCGCAGGTGGAAGCCAGCATCA
ACCGTCAGCTTGAAGACATGCCCCGCCGAAGCGTGATTGCCGAGTCTCTGTCGGGCCGGGGTGCCCTCATCAAGGTGCGC
GACATGGAAGAGGCGTGCGACATCGCCAACGACATCGCGCCGGAGCATCTGGAGATTTCGGCGGAGAACCCGCGCCAGTG
GGCCGAGCGCATCCGCCACGCCGGTGCGATCTTCCTCGGCAAGTACACCAGCGAGTCGCTGGGCGATTACTGCGCGGGCC
CGAACCATGTGCTGCCCACCTCGCGCACGGCGCGTTTCTCGTCGCCGCTGGGCGTGTACGACTTCATCAAGCGCTCGAGC
CTGATTGAGGTGAGCGAAGCCGGCGCGCAGATGCTGGGCGAGATTGCTGCCGAACTGGCCTACGGCGAAGGCTTGCAGGC
GCATGCCCGCAGCGCCGAATATCGCCTGCAACGCCCAACCTCCGAATAA

Upstream 100 bases:

>100_bases
TCAACCAGGCTGCGCTGAAACTCAAGCGTGACAGGCTGGCGCCCATCCTCGACGCTTTCGAGCGCGCCTCCGCCCAGGAC
GAGCGTGCTGGGGAACCCGC

Downstream 100 bases:

>100_bases
CGCCTGCAGCACGACGATGAACGCCACAGCTCCGGCCCAAGCCTCTCTCGATGACCTGCTCGCCCGCATCGTGCGCGACG
ACGTTCGCGCCATGGGCGCA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSLTIRKLDSAEAGFAAQLRQVLAFEASEDEAIDRAAAQILADVKARGDAAVLEATQRFDRIEADSVAALELSPATLQAA
LDGLEPKRRAALEAAAARVRAYHEKQKIECGTHSWEYAEADGTVLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVA
GVKEIIMVVPTPGGVRNELVLAAACIAGVDRVFTIGGAQAVGALAYGTETVPAVDKIVGPGNAYVAAAKRRVFGTVGIDM
IAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPNAEFIAQVEASINRQLEDMPRRSVIAESLSGRGALIKVR
DMEEACDIANDIAPEHLEISAENPRQWAERIRHAGAIFLGKYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSS
LIEVSEAGAQMLGEIAAELAYGEGLQAHARSAEYRLQRPTSE

Sequences:

>Translated_442_residues
MSLTIRKLDSAEAGFAAQLRQVLAFEASEDEAIDRAAAQILADVKARGDAAVLEATQRFDRIEADSVAALELSPATLQAA
LDGLEPKRRAALEAAAARVRAYHEKQKIECGTHSWEYAEADGTVLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVA
GVKEIIMVVPTPGGVRNELVLAAACIAGVDRVFTIGGAQAVGALAYGTETVPAVDKIVGPGNAYVAAAKRRVFGTVGIDM
IAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPNAEFIAQVEASINRQLEDMPRRSVIAESLSGRGALIKVR
DMEEACDIANDIAPEHLEISAENPRQWAERIRHAGAIFLGKYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSS
LIEVSEAGAQMLGEIAAELAYGEGLQAHARSAEYRLQRPTSE
>Mature_441_residues
SLTIRKLDSAEAGFAAQLRQVLAFEASEDEAIDRAAAQILADVKARGDAAVLEATQRFDRIEADSVAALELSPATLQAAL
DGLEPKRRAALEAAAARVRAYHEKQKIECGTHSWEYAEADGTVLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVAG
VKEIIMVVPTPGGVRNELVLAAACIAGVDRVFTIGGAQAVGALAYGTETVPAVDKIVGPGNAYVAAAKRRVFGTVGIDMI
AGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPNAEFIAQVEASINRQLEDMPRRSVIAESLSGRGALIKVRD
MEEACDIANDIAPEHLEISAENPRQWAERIRHAGAIFLGKYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSL
IEVSEAGAQMLGEIAAELAYGEGLQAHARSAEYRLQRPTSE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=427, Percent_Identity=41.6861826697892, Blast_Score=291, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6319819, Length=408, Percent_Identity=35.5392156862745, Blast_Score=241, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47078; Mature: 46947

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTIRKLDSAEAGFAAQLRQVLAFEASEDEAIDRAAAQILADVKARGDAAVLEATQRFD
CCEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RIEADSVAALELSPATLQAALDGLEPKRRAALEAAAARVRAYHEKQKIECGTHSWEYAEA
CCCCCCEEEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECC
DGTVLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVAGVKEIIMVVPTPGGVRNELV
CCCEECCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHH
LAAACIAGVDRVFTIGGAQAVGALAYGTETVPAVDKIVGPGNAYVAAAKRRVFGTVGIDM
HHHHHHHCCHHEEEECCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPNAEFIAQVEASINRQLEDM
ECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
PRRSVIAESLSGRGALIKVRDMEEACDIANDIAPEHLEISAENPRQWAERIRHAGAIFLG
CHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCEEEEE
KYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSLIEVSEAGAQMLGEIAAELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YGEGLQAHARSAEYRLQRPTSE
HCCCHHHHHCCCHHEECCCCCC
>Mature Secondary Structure 
SLTIRKLDSAEAGFAAQLRQVLAFEASEDEAIDRAAAQILADVKARGDAAVLEATQRFD
CEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RIEADSVAALELSPATLQAALDGLEPKRRAALEAAAARVRAYHEKQKIECGTHSWEYAEA
CCCCCCEEEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECC
DGTVLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVAGVKEIIMVVPTPGGVRNELV
CCCEECCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHH
LAAACIAGVDRVFTIGGAQAVGALAYGTETVPAVDKIVGPGNAYVAAAKRRVFGTVGIDM
HHHHHHHCCHHEEEECCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPNAEFIAQVEASINRQLEDM
ECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
PRRSVIAESLSGRGALIKVRDMEEACDIANDIAPEHLEISAENPRQWAERIRHAGAIFLG
CHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCEEEEE
KYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFIKRSSLIEVSEAGAQMLGEIAAELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YGEGLQAHARSAEYRLQRPTSE
HCCCHHHHHCCCHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]