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The map label for this gene is lpxC

Identifier: 187930150

GI number: 187930150

Start: 3217545

End: 3218462

Strand: Reverse

Name: lpxC

Synonym: Rpic_3082

Alternate gene names: 187930150

Gene position: 3218462-3217545 (Counterclockwise)

Preceding gene: 187930151

Following gene: 187930148

Centisome position: 81.63

GC content: 62.09

Gene sequence:

>918_bases
ATGTTGAAACAACGCACCATCAAGTCCCTCGTCAAGACCGTCGGCATCGGGTTGCACTCGGGCCGCAAGGTGACGTTGAC
GTTGCGCCCGGCGGCCGCAGGCACCGGCATCGTCTTCACGCGTGTTGACCTCGACCCGGCCGTCGAGATTCCGGCCACCG
CCAGCGCCATCGGCGACACCCGCCTTGCATCCGTACTGCAAAAGGATGGCGCCCGCGTGTCGACCGTCGAACATTTGATG
TCCGCTTGCGCAGGCCTTGGCATCGACAATCTCTATGTCGACGTCGACGCCGAAGAAATCCCCATCATGGACGGCAGCGC
GGCCTCGTTCGTGTTTCTGCTGCAATCGGCGGGCATCGAAGAGCAGGGCGCGGCCAAGCGGTTTATCCGCGTGACCAAGC
CGGTGGAAATCCGCGAGGGCGACAAGCTTGCACGCCTCGACCCCTACTTTGGCTTCAAGCTGTCGTTCACCATCGAATTC
CGTCACCCGGCCGTCGACAAGACCGGCCAGACGTTCGAGATCGACTTTGCCGACACCAGCTACACGCGCGAAATCGCGCG
CGCCCGTACGTTTGGTTTTGCCCACGAAGTCGAAATGCTGCGCGAAGTCGGCCTGGCGCGCGGCGGCAGCCTGGACAATG
CCATCGTGCTCGACGAGCACCGCATGCTCAACAACGACGAACTGCGCTACGGCGATGAGTTCGTCCGTCACAAGATCCTC
GACGCCATCGGCGATCTGTATGTGGTCGGTCACCCGCTGATTGCCGCGTATACGGCACACAAGTCGGGGCACGGGCTGAA
CAATGCGCTGCTGCGCGCACTGCTGGCCGATGAAACGGCCTACGAGATCGTGACGTTCGACAAAATCGAAGAGGCGCCGC
GCGCGTTTCTACCTCAGTTGCAACCGGCATTCTCGTGA

Upstream 100 bases:

>100_bases
TTTGAAGGCAGGGACGTGAAAATGGTATGCTTAAGGTTATCACCTATGCAGACTGCATAGATAAAAATAATCGTAGAAAT
TCTGTGAGTTGAGGGCGGCC

Downstream 100 bases:

>100_bases
TCGGCTGATGCGTTTGTACCCATGAAAAAAGCGCCCTGCGGGGCGCTTTTTATTTGGGCCTGGCCGCAGGTGCAACATGC
CGTGCGATCATTTCGGCCAA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MLKQRTIKSLVKTVGIGLHSGRKVTLTLRPAAAGTGIVFTRVDLDPAVEIPATASAIGDTRLASVLQKDGARVSTVEHLM
SACAGLGIDNLYVDVDAEEIPIMDGSAASFVFLLQSAGIEEQGAAKRFIRVTKPVEIREGDKLARLDPYFGFKLSFTIEF
RHPAVDKTGQTFEIDFADTSYTREIARARTFGFAHEVEMLREVGLARGGSLDNAIVLDEHRMLNNDELRYGDEFVRHKIL
DAIGDLYVVGHPLIAAYTAHKSGHGLNNALLRALLADETAYEIVTFDKIEEAPRAFLPQLQPAFS

Sequences:

>Translated_305_residues
MLKQRTIKSLVKTVGIGLHSGRKVTLTLRPAAAGTGIVFTRVDLDPAVEIPATASAIGDTRLASVLQKDGARVSTVEHLM
SACAGLGIDNLYVDVDAEEIPIMDGSAASFVFLLQSAGIEEQGAAKRFIRVTKPVEIREGDKLARLDPYFGFKLSFTIEF
RHPAVDKTGQTFEIDFADTSYTREIARARTFGFAHEVEMLREVGLARGGSLDNAIVLDEHRMLNNDELRYGDEFVRHKIL
DAIGDLYVVGHPLIAAYTAHKSGHGLNNALLRALLADETAYEIVTFDKIEEAPRAFLPQLQPAFS
>Mature_305_residues
MLKQRTIKSLVKTVGIGLHSGRKVTLTLRPAAAGTGIVFTRVDLDPAVEIPATASAIGDTRLASVLQKDGARVSTVEHLM
SACAGLGIDNLYVDVDAEEIPIMDGSAASFVFLLQSAGIEEQGAAKRFIRVTKPVEIREGDKLARLDPYFGFKLSFTIEF
RHPAVDKTGQTFEIDFADTSYTREIARARTFGFAHEVEMLREVGLARGGSLDNAIVLDEHRMLNNDELRYGDEFVRHKIL
DAIGDLYVVGHPLIAAYTAHKSGHGLNNALLRALLADETAYEIVTFDKIEEAPRAFLPQLQPAFS

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=297, Percent_Identity=54.8821548821549, Blast_Score=350, Evalue=9e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_RALPJ (B2UCX0)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001900637.1
- ProteinModelPortal:   B2UCX0
- SMR:   B2UCX0
- GeneID:   6289774
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_3082
- HOGENOM:   HBG482342
- OMA:   ATDPAKE
- ProtClustDB:   PRK13186
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33367; Mature: 33367

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKQRTIKSLVKTVGIGLHSGRKVTLTLRPAAAGTGIVFTRVDLDPAVEIPATASAIGDT
CCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHH
RLASVLQKDGARVSTVEHLMSACAGLGIDNLYVDVDAEEIPIMDGSAASFVFLLQSAGIE
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCC
EQGAAKRFIRVTKPVEIREGDKLARLDPYFGFKLSFTIEFRHPAVDKTGQTFEIDFADTS
CCCHHHHHHEECCCEEECCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCH
YTREIARARTFGFAHEVEMLREVGLARGGSLDNAIVLDEHRMLNNDELRYGDEFVRHKIL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
DAIGDLYVVGHPLIAAYTAHKSGHGLNNALLRALLADETAYEIVTFDKIEEAPRAFLPQL
HHHCCEEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCC
QPAFS
CCCCC
>Mature Secondary Structure
MLKQRTIKSLVKTVGIGLHSGRKVTLTLRPAAAGTGIVFTRVDLDPAVEIPATASAIGDT
CCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHH
RLASVLQKDGARVSTVEHLMSACAGLGIDNLYVDVDAEEIPIMDGSAASFVFLLQSAGIE
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCC
EQGAAKRFIRVTKPVEIREGDKLARLDPYFGFKLSFTIEFRHPAVDKTGQTFEIDFADTS
CCCHHHHHHEECCCEEECCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCH
YTREIARARTFGFAHEVEMLREVGLARGGSLDNAIVLDEHRMLNNDELRYGDEFVRHKIL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
DAIGDLYVVGHPLIAAYTAHKSGHGLNNALLRALLADETAYEIVTFDKIEEAPRAFLPQL
HHHCCEEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCC
QPAFS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA