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The map label for this gene is obgE [H]

Identifier: 187930133

GI number: 187930133

Start: 3199608

End: 3200702

Strand: Reverse

Name: obgE [H]

Synonym: Rpic_3065

Alternate gene names: 187930133

Gene position: 3200702-3199608 (Counterclockwise)

Preceding gene: 187930134

Following gene: 187930132

Centisome position: 81.18

GC content: 65.39

Gene sequence:

>1095_bases
ATGAAGTTCATCGACGAAGCCCGGATCGAAGTGATCGCTGGTGACGGCGGCAACGGCAGCGCCTCGATGCGCCGCGAGAA
ATTCGTCCCGTTTGGCGGGCCCGACGGCGGCGACGGTGGGCGTGGCGGCAGCGTGTGGGCCGTGGCTGACCGCAACATCA
ACACCCTGATCGACTACCGCTTTGCCAAGAAGCATCTCGCGCGCAACGGTGAGAACGGCCGTGGTGCGGACTGCTACGGC
GCTGCTGGCGACGACATTACCCTGCGCATGCCGGTGGGCACGGCCATCTACGATGCCGACACGGAAGAGCTGATCGCCGA
CCTGACGATCGACGGCCAGCGCCTGTGCCTCGCGCAGGGCGGCGAAGGCGGTTGGGGCAACATCCACTTCAAGTCGAGCA
CTAACCGCGCTCCGCGCCAGAAGACCGACGGGAAGGCCGGTGAGCGTCGCAACCTGCGCCTGGAGTTGAAGGTGCTGGCC
GACGTGGGTCTGCTCGGCATGCCGAATGCCGGCAAGTCGACGCTGATCACCGCCATTTCGAACGCGCGCCCGAAGATTGC
CGACTACCCGTTCACGACGCTGCACCCGAACCTGGGCGTGGTCCGGACGGGCCCGTCGAAATCGTTCGTGGTGGCCGACA
TCCCTGGCCTGATCGAAGGCGCAGCGGAAGGCGCCGGTCTGGGTCACCAGTTCCTGCGGCACCTGCAACGCACGCGCGTG
CTGCTGCACGTGGTGGATCTCGCCCCGTTCGACGAGAGCGTCGACCCGGTTGCCGAAGCCAAGGCGATCGTCGGCGAGCT
GAAGAAATACGACGCTGAACTCTTCGACAAGCCGCGCTGGCTCGTGCTTAACAAGCTCGACATGGTGCCCGAGGACGAAC
GCGAGGCGCGCGTGAAGGATTTCGTGAAGCGCTTCAAGTGGAAGGGCCCGGTGCACCGGATTTCTGCGTTGACGCACGAT
GGCACGCAGGCGCTTGTGCACGCGATCCAGGAATACCTCGACGAGCTGCGCGCCGAAGAGGATGCAGCCGCAGCCGCACC
CGACCAGCGTCTGGACCCGACACTGCACAACGTCGACCACGACGATCAAGCCTAA

Upstream 100 bases:

>100_bases
GTCTTGGCGCATGTTTCCAGGCGCGTTCTGTTAGCGATGGCGCGAGTGGCGCCGATTTCCTTTTACCTGCCGTGCGCACG
CCGCACGGGCGGAGACCTCC

Downstream 100 bases:

>100_bases
ACACAACAAACATCCTTCGGAGACGCGCCCACCATGGCCCTGCATTCGCTGATTGCCGATGCGCGCCGCCTTGTCGTCAA
GGTCGGTTCCAGCCTGGTTA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKFIDEARIEVIAGDGGNGSASMRREKFVPFGGPDGGDGGRGGSVWAVADRNINTLIDYRFAKKHLARNGENGRGADCYG
AAGDDITLRMPVGTAIYDADTEELIADLTIDGQRLCLAQGGEGGWGNIHFKSSTNRAPRQKTDGKAGERRNLRLELKVLA
DVGLLGMPNAGKSTLITAISNARPKIADYPFTTLHPNLGVVRTGPSKSFVVADIPGLIEGAAEGAGLGHQFLRHLQRTRV
LLHVVDLAPFDESVDPVAEAKAIVGELKKYDAELFDKPRWLVLNKLDMVPEDEREARVKDFVKRFKWKGPVHRISALTHD
GTQALVHAIQEYLDELRAEEDAAAAAPDQRLDPTLHNVDHDDQA

Sequences:

>Translated_364_residues
MKFIDEARIEVIAGDGGNGSASMRREKFVPFGGPDGGDGGRGGSVWAVADRNINTLIDYRFAKKHLARNGENGRGADCYG
AAGDDITLRMPVGTAIYDADTEELIADLTIDGQRLCLAQGGEGGWGNIHFKSSTNRAPRQKTDGKAGERRNLRLELKVLA
DVGLLGMPNAGKSTLITAISNARPKIADYPFTTLHPNLGVVRTGPSKSFVVADIPGLIEGAAEGAGLGHQFLRHLQRTRV
LLHVVDLAPFDESVDPVAEAKAIVGELKKYDAELFDKPRWLVLNKLDMVPEDEREARVKDFVKRFKWKGPVHRISALTHD
GTQALVHAIQEYLDELRAEEDAAAAAPDQRLDPTLHNVDHDDQA
>Mature_364_residues
MKFIDEARIEVIAGDGGNGSASMRREKFVPFGGPDGGDGGRGGSVWAVADRNINTLIDYRFAKKHLARNGENGRGADCYG
AAGDDITLRMPVGTAIYDADTEELIADLTIDGQRLCLAQGGEGGWGNIHFKSSTNRAPRQKTDGKAGERRNLRLELKVLA
DVGLLGMPNAGKSTLITAISNARPKIADYPFTTLHPNLGVVRTGPSKSFVVADIPGLIEGAAEGAGLGHQFLRHLQRTRV
LLHVVDLAPFDESVDPVAEAKAIVGELKKYDAELFDKPRWLVLNKLDMVPEDEREARVKDFVKRFKWKGPVHRISALTHD
GTQALVHAIQEYLDELRAEEDAAAAAPDQRLDPTLHNVDHDDQA

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=332, Percent_Identity=38.855421686747, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI111955139, Length=364, Percent_Identity=35.4395604395604, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI111955063, Length=198, Percent_Identity=38.3838383838384, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI58761500, Length=205, Percent_Identity=27.3170731707317, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4758796, Length=156, Percent_Identity=31.4102564102564, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789574, Length=349, Percent_Identity=55.5873925501433, Blast_Score=348, Evalue=2e-97,
Organism=Escherichia coli, GI1787454, Length=101, Percent_Identity=39.6039603960396, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790615, Length=169, Percent_Identity=35.5029585798817, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=336, Percent_Identity=38.6904761904762, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17552324, Length=312, Percent_Identity=31.7307692307692, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17509631, Length=139, Percent_Identity=32.3741007194245, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321962, Length=186, Percent_Identity=37.6344086021505, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321773, Length=156, Percent_Identity=30.1282051282051, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24585318, Length=311, Percent_Identity=38.2636655948553, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI20129375, Length=332, Percent_Identity=35.5421686746988, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24640873, Length=135, Percent_Identity=31.8518518518519, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640877, Length=135, Percent_Identity=31.8518518518519, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640875, Length=135, Percent_Identity=31.8518518518519, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17981711, Length=172, Percent_Identity=29.0697674418605, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917 [H]

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 39564; Mature: 39564

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFIDEARIEVIAGDGGNGSASMRREKFVPFGGPDGGDGGRGGSVWAVADRNINTLIDYR
CCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHH
FAKKHLARNGENGRGADCYGAAGDDITLRMPVGTAIYDADTEELIADLTIDGQRLCLAQG
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCHHHHHHHEECCCCEEEEEEC
GEGGWGNIHFKSSTNRAPRQKTDGKAGERRNLRLELKVLADVGLLGMPNAGKSTLITAIS
CCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHEEEEHH
NARPKIADYPFTTLHPNLGVVRTGPSKSFVVADIPGLIEGAAEGAGLGHQFLRHLQRTRV
CCCCCCCCCCCEEECCCCCEEEECCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHH
LLHVVDLAPFDESVDPVAEAKAIVGELKKYDAELFDKPRWLVLNKLDMVPEDEREARVKD
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCHHHHHHHH
FVKRFKWKGPVHRISALTHDGTQALVHAIQEYLDELRAEEDAAAAAPDQRLDPTLHNVDH
HHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHCCCC
DDQA
CCCC
>Mature Secondary Structure
MKFIDEARIEVIAGDGGNGSASMRREKFVPFGGPDGGDGGRGGSVWAVADRNINTLIDYR
CCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHH
FAKKHLARNGENGRGADCYGAAGDDITLRMPVGTAIYDADTEELIADLTIDGQRLCLAQG
HHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCHHHHHHHEECCCCEEEEEEC
GEGGWGNIHFKSSTNRAPRQKTDGKAGERRNLRLELKVLADVGLLGMPNAGKSTLITAIS
CCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHEEEEHH
NARPKIADYPFTTLHPNLGVVRTGPSKSFVVADIPGLIEGAAEGAGLGHQFLRHLQRTRV
CCCCCCCCCCCEEECCCCCEEEECCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHH
LLHVVDLAPFDESVDPVAEAKAIVGELKKYDAELFDKPRWLVLNKLDMVPEDEREARVKD
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCCHHHHHHHH
FVKRFKWKGPVHRISALTHDGTQALVHAIQEYLDELRAEEDAAAAAPDQRLDPTLHNVDH
HHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHCCCC
DDQA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]