Click here to switch to the map view.

The map label for this gene is hutU [H]

Identifier: 187929949

GI number: 187929949

Start: 2986036

End: 2987754

Strand: Reverse

Name: hutU [H]

Synonym: Rpic_2881

Alternate gene names: 187929949

Gene position: 2987754-2986036 (Counterclockwise)

Preceding gene: 187929951

Following gene: 187929948

Centisome position: 75.78

GC content: 65.04

Gene sequence:

>1719_bases
ATGAACGCCCCGACCCACGCTGCCCACCTGACCAACGATCCGCGCTACGACGCCTCGCGCGAAATCCGTGCCCCGCGTGG
CACCGAGCTGCACTGCAAGAGCTGGCTGACCGAGGCGGCCTATCGCATGCTGCAGAACAACCTCGACCCGGATGTGGCCG
AGAACCCCAAGCACCTCGTCGTCTACGGCGGTATTGGCCGCGCTGCGCGCGACTGGGCCTGCTTTGACAAGATCCTGGAA
ACGCTGCGCGAGCTGAACGACGACGAATCGCTGCTCGTGCAATCGGGCAAGCCGGTGGGCGTGTTCAAGACCCACCCGGA
TGCACCGCGCGTCTTGATCGCCAACTCCAACCTGGTGCCCAAGTGGGCGAACTGGGAGCACTTCAACGAGCTGGATCGCA
AGGGCCTGTTCATGTATGGCCAGATGACTGCCGGCAGTTGGATCTACATCGGTAGCCAGGGCATTGTGCAAGGCACGTAT
GAGACGTTTGCCGAAGCCGGTCGTCAACATTACGACGGCAAGCTGGCTGGCCGCTGGATTCTCACGGCGGGCCTGGGCGG
CATGGGCGGCGCGCAGCCGCTGGCCGCCACGCTGGCCGGCGCCGTGTCGCTGAACATCGAGTGCCAGCAATCGAGCATCG
ATTTCCGCCTGCGTACGCGCTACCTCGACAAGCAGGCAAAGGACATCGACGACGCATTCAACCTGATTCGCCACCATTGC
GAGCGCGGCGAGGCCGTGTCCATCGGTCTGCTCGGCAATGCGGCGGAAATCTTGCCGGAGCTGGTCAAGCGTGCCCGCGC
CGGCGGCCTGAAGCCGGATCTGGTGACCGACCAGACCTCGGCGCATGATCTGGTCAACGGCTACCTGCCGATTGGCTGGA
CGGTCGAGCAATGGCGTGCTGCGCAACGCGACCCGTCGCAGCACGCCCGCCTGACCGACGAGGCCGCCAAGTCGTGCGCC
GTACACGTGCAGGCCATGCTTGACTTCCAGGCCATGGGCATTCCGACCGTCGACTACGGCAACAACATCCGCCAGGTCGC
GTTCGACCAGGGCGTGAAGAACGCCTTCGACTTCCCGGGTTTCGTGCCGGCCTACATCCGACCGCTGTTCTGCGAAGGCA
AGGGCCCATTCCGCTGGGTGGCGCTGTCGGGCGATCCGGAAGACATCTACAAGACCGACGCCAAGATCAAGGAACTCTTC
CCGCACAACACGCACGTCCATCGCTGGCTCGACATGGCGCGTGATCGCATCGCCTTCCAAGGGTTGCCCGCACGGATCTG
CTGGCTCGGCCTGGGCGAGCGTCACCTGGCCGGTCTGGCTTTCAACGAGATGGTCAAGAATGGCGAGCTGAAGGCGCCGA
TCGTGATCGGTCGCGATCACCTCGACACCGGCTCCGTCGCCAGCCCCAACCGTGAAACCGAAGCCATGCGCGACGGCACC
GATGCCGTGTCGGACTGGCCGCTGCTCAACGCGCTGCTCAACACGGCCGGCGGTGCGACGTGGGTGTCGCTGCACCACGG
AGGCGGTGTCGGCATGGGCTATTCGCAGCACTCGGGCGTGGTGATCGTCGCCGACGGCACGGACGCTGCGGCCAAGCGTC
TGGGTCGTGTGCTCGTCAACGATTCCGGCTCGGGCGTCATGCGCCATGCCGATGCCGGCTACGAAACCGCCATTGCCTGC
GCCAAGCGCAACGGTTTGAACCTGCCGATGATCGGCTAA

Upstream 100 bases:

>100_bases
ATCATCAGGGTTTGCTCTTAGCTTGTAAAGTTTTCTTGCCTAAGTTGTATATACAACATAAGATGCGCTCCATGACAAAG
GAGTTCGCAGGAGACCTCAC

Downstream 100 bases:

>100_bases
GTTAAAGACATCCTCTCGCATTGCTATGAACACCATGACCACGCCCCCCATCATCACGTTGCAGCCGGGCGCAATGTCCT
TTGCCGACCTGCGCCGCGTC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 572; Mature: 572

Protein sequence:

>572_residues
MNAPTHAAHLTNDPRYDASREIRAPRGTELHCKSWLTEAAYRMLQNNLDPDVAENPKHLVVYGGIGRAARDWACFDKILE
TLRELNDDESLLVQSGKPVGVFKTHPDAPRVLIANSNLVPKWANWEHFNELDRKGLFMYGQMTAGSWIYIGSQGIVQGTY
ETFAEAGRQHYDGKLAGRWILTAGLGGMGGAQPLAATLAGAVSLNIECQQSSIDFRLRTRYLDKQAKDIDDAFNLIRHHC
ERGEAVSIGLLGNAAEILPELVKRARAGGLKPDLVTDQTSAHDLVNGYLPIGWTVEQWRAAQRDPSQHARLTDEAAKSCA
VHVQAMLDFQAMGIPTVDYGNNIRQVAFDQGVKNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKIKELF
PHNTHVHRWLDMARDRIAFQGLPARICWLGLGERHLAGLAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETEAMRDGT
DAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHSGVVIVADGTDAAAKRLGRVLVNDSGSGVMRHADAGYETAIAC
AKRNGLNLPMIG

Sequences:

>Translated_572_residues
MNAPTHAAHLTNDPRYDASREIRAPRGTELHCKSWLTEAAYRMLQNNLDPDVAENPKHLVVYGGIGRAARDWACFDKILE
TLRELNDDESLLVQSGKPVGVFKTHPDAPRVLIANSNLVPKWANWEHFNELDRKGLFMYGQMTAGSWIYIGSQGIVQGTY
ETFAEAGRQHYDGKLAGRWILTAGLGGMGGAQPLAATLAGAVSLNIECQQSSIDFRLRTRYLDKQAKDIDDAFNLIRHHC
ERGEAVSIGLLGNAAEILPELVKRARAGGLKPDLVTDQTSAHDLVNGYLPIGWTVEQWRAAQRDPSQHARLTDEAAKSCA
VHVQAMLDFQAMGIPTVDYGNNIRQVAFDQGVKNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKIKELF
PHNTHVHRWLDMARDRIAFQGLPARICWLGLGERHLAGLAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETEAMRDGT
DAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHSGVVIVADGTDAAAKRLGRVLVNDSGSGVMRHADAGYETAIAC
AKRNGLNLPMIG
>Mature_572_residues
MNAPTHAAHLTNDPRYDASREIRAPRGTELHCKSWLTEAAYRMLQNNLDPDVAENPKHLVVYGGIGRAARDWACFDKILE
TLRELNDDESLLVQSGKPVGVFKTHPDAPRVLIANSNLVPKWANWEHFNELDRKGLFMYGQMTAGSWIYIGSQGIVQGTY
ETFAEAGRQHYDGKLAGRWILTAGLGGMGGAQPLAATLAGAVSLNIECQQSSIDFRLRTRYLDKQAKDIDDAFNLIRHHC
ERGEAVSIGLLGNAAEILPELVKRARAGGLKPDLVTDQTSAHDLVNGYLPIGWTVEQWRAAQRDPSQHARLTDEAAKSCA
VHVQAMLDFQAMGIPTVDYGNNIRQVAFDQGVKNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKIKELF
PHNTHVHRWLDMARDRIAFQGLPARICWLGLGERHLAGLAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETEAMRDGT
DAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHSGVVIVADGTDAAAKRLGRVLVNDSGSGVMRHADAGYETAIAC
AKRNGLNLPMIG

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=573, Percent_Identity=33.3333333333333, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI260306182, Length=224, Percent_Identity=36.1607142857143, Blast_Score=154, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71997891, Length=581, Percent_Identity=34.7676419965577, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 62531; Mature: 62531

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPTHAAHLTNDPRYDASREIRAPRGTELHCKSWLTEAAYRMLQNNLDPDVAENPKHLV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
VYGGIGRAARDWACFDKILETLRELNDDESLLVQSGKPVGVFKTHPDAPRVLIANSNLVP
EECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCEEEEECCCCCC
KWANWEHFNELDRKGLFMYGQMTAGSWIYIGSQGIVQGTYETFAEAGRQHYDGKLAGRWI
CCCCCHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
LTAGLGGMGGAQPLAATLAGAVSLNIECQQSSIDFRLRTRYLDKQAKDIDDAFNLIRHHC
EEECCCCCCCCHHHHHHHHHEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
ERGEAVSIGLLGNAAEILPELVKRARAGGLKPDLVTDQTSAHDLVNGYLPIGWTVEQWRA
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHH
AQRDPSQHARLTDEAAKSCAVHVQAMLDFQAMGIPTVDYGNNIRQVAFDQGVKNAFDFPG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHCHHHHCCCCC
FVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKIKELFPHNTHVHRWLDMARDRIAFQ
CCHHHHCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GLPARICWLGLGERHLAGLAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETEAMRDGT
CCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCC
DAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHSGVVIVADGTDAAAKRLGRVLVN
CHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHCEEEEC
DSGSGVMRHADAGYETAIACAKRNGLNLPMIG
CCCCCEEEECCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNAPTHAAHLTNDPRYDASREIRAPRGTELHCKSWLTEAAYRMLQNNLDPDVAENPKHLV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
VYGGIGRAARDWACFDKILETLRELNDDESLLVQSGKPVGVFKTHPDAPRVLIANSNLVP
EECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCEEEEECCCCCC
KWANWEHFNELDRKGLFMYGQMTAGSWIYIGSQGIVQGTYETFAEAGRQHYDGKLAGRWI
CCCCCHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
LTAGLGGMGGAQPLAATLAGAVSLNIECQQSSIDFRLRTRYLDKQAKDIDDAFNLIRHHC
EEECCCCCCCCHHHHHHHHHEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
ERGEAVSIGLLGNAAEILPELVKRARAGGLKPDLVTDQTSAHDLVNGYLPIGWTVEQWRA
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHH
AQRDPSQHARLTDEAAKSCAVHVQAMLDFQAMGIPTVDYGNNIRQVAFDQGVKNAFDFPG
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHCHHHHCCCCC
FVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKIKELFPHNTHVHRWLDMARDRIAFQ
CCHHHHCEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GLPARICWLGLGERHLAGLAFNEMVKNGELKAPIVIGRDHLDTGSVASPNRETEAMRDGT
CCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCC
DAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHSGVVIVADGTDAAAKRLGRVLVN
CHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHCEEEEC
DSGSGVMRHADAGYETAIACAKRNGLNLPMIG
CCCCCEEEECCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]