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The map label for this gene is hutH [H]

Identifier: 187929948

GI number: 187929948

Start: 2984454

End: 2986010

Strand: Reverse

Name: hutH [H]

Synonym: Rpic_2880

Alternate gene names: 187929948

Gene position: 2986010-2984454 (Counterclockwise)

Preceding gene: 187929949

Following gene: 187929947

Centisome position: 75.74

GC content: 68.02

Gene sequence:

>1557_bases
ATGAACACCATGACCACGCCCCCCATCATCACGTTGCAGCCGGGCGCAATGTCCTTTGCCGACCTGCGCCGCGTCTGGCT
CGCCCCCACGCCTGTTGCGCTGTCGGGCGATTGCGCTGCCGCCATCGAAGCCTCGGCAGCCACCGTGCAGGCCATCGTCG
CCAAGGGCGCGCCGGCCTACGGCATCAACACCGGTTTCGGCCTGCTGGCCAAGACGCAGATCGCCACGCACGAGCTGGAG
CGCCTGCAACGCAACCTGATCCTGTCGCACGCTGTCGGCACCGGTGAAGACTTGAGCGACAACGTGGCGCGATTGGTGCT
GCTGATGAAGGCAGCGAGCCTGGCGCGCGGTTATTCGGGCGTGCGCCGTGTTGTGATCGACACGCTGTTGGCACTGCTGA
ACGCCGGCATCGTGCCCTGCATTCCGTCGAAGGGTTCGGTGGGCGCGTCGGGCGATCTGGCGCCGCTGGCGCACATGACG
CTGGCCCTGCTGGGCGAAGGCGACGTGCGCGTGAACGGCGTACGCACCCCGGCACGTGCGGCACTGGCTGCCGCGGGCAT
CGAGCCGATCGCGCTGGCCGCCAAGGAAGGCCTGGCACTCATCAACGGCACGCAGGTGTCGACCGCGTTGGCGCTCAACG
GCCTGTTCCTGGCCGAGCGACTGCTGCAAGCCGCCACGGTGTCGGGTGCGTTGTCGGTGGATGCCGCCAAGGGCAGCGAC
GCGCCGTTCGATCCGCGCGTGCACACTGTGCGTGGGCAAGCCGGCCAGATCGCCACCGCGGCCGTGTACCGCAACCTGCT
TGCCGGCAGCGCCATCCGTCAGTCTCACCTCGTGGGCGACAAGCGCGTGCAAGACCCATACAGCCTGCGCTGCCAGCCGC
AAGTCATGGGTGCATGTTTCGATCTGATCCGCCAGGCCGGCGCCACGCTGCTCACCGAAGCCAACGCAGTGACCGACAAC
CCGCTGGTCTACGCCGACGCCGGTGAAGTGATCTCGGGCGGTAACTTCCATGCCGAGCCGGTGGCGTTTGCCGCCGACAT
GCTCGCGCTGGCGATTGCCGAGATCGGTGCGCTGTCCGAGCGCCGCATCGCGCTGCTGATCGACTCCACGCTGTCGGGCT
TGCCGCCGTTCCTGGTCGAGCAGCCGGGCCTGAACTCGGGCTTCATGATCGCCCACGTCACGGCCGCCGCGCTGGCGTCG
GAAAACAAGACGTTCGCCCACCCGGCCAGCGTCGACAGCCTGCCGACTTCCGCCAACCAGGAAGACCACGTCAGCATGGC
AACCTTTGCAGGCCGCCGTTTGCAGGACATGGCTGAGAACACCGCCACCATCGTCGGCATCGAAGCGCTGGCGGCGGCGC
AGGGCATCGACTTCCACAAGCCGCTGGCGACGTCCGACACGCTGCAGAAGGCACATGGCTGCATCCGTGCGCGCGTGGCG
TACTACGGTGAAGATCGCCTGTTCGCCCCCGACATCGAAGCCGCCCGCCGCCTCGTGCTCGACGGTGCCCTCGGCGATTC
GTGCCGCGCGCACGTCGGCGAACTCGCACTCGTCTGA

Upstream 100 bases:

>100_bases
CATGCCGATGCCGGCTACGAAACCGCCATTGCCTGCGCCAAGCGCAACGGTTTGAACCTGCCGATGATCGGCTAAGTTAA
AGACATCCTCTCGCATTGCT

Downstream 100 bases:

>100_bases
CCATGCTCGCCCAAGCCGAACCGAACGTCTGGCAAGGCCGCGTCGATGCGGAGGAAGGCCCGCTGGGCTTGCGTTGGCAC
CAGACGGTGCGCCGCATCGA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MNTMTTPPIITLQPGAMSFADLRRVWLAPTPVALSGDCAAAIEASAATVQAIVAKGAPAYGINTGFGLLAKTQIATHELE
RLQRNLILSHAVGTGEDLSDNVARLVLLMKAASLARGYSGVRRVVIDTLLALLNAGIVPCIPSKGSVGASGDLAPLAHMT
LALLGEGDVRVNGVRTPARAALAAAGIEPIALAAKEGLALINGTQVSTALALNGLFLAERLLQAATVSGALSVDAAKGSD
APFDPRVHTVRGQAGQIATAAVYRNLLAGSAIRQSHLVGDKRVQDPYSLRCQPQVMGACFDLIRQAGATLLTEANAVTDN
PLVYADAGEVISGGNFHAEPVAFAADMLALAIAEIGALSERRIALLIDSTLSGLPPFLVEQPGLNSGFMIAHVTAAALAS
ENKTFAHPASVDSLPTSANQEDHVSMATFAGRRLQDMAENTATIVGIEALAAAQGIDFHKPLATSDTLQKAHGCIRARVA
YYGEDRLFAPDIEAARRLVLDGALGDSCRAHVGELALV

Sequences:

>Translated_518_residues
MNTMTTPPIITLQPGAMSFADLRRVWLAPTPVALSGDCAAAIEASAATVQAIVAKGAPAYGINTGFGLLAKTQIATHELE
RLQRNLILSHAVGTGEDLSDNVARLVLLMKAASLARGYSGVRRVVIDTLLALLNAGIVPCIPSKGSVGASGDLAPLAHMT
LALLGEGDVRVNGVRTPARAALAAAGIEPIALAAKEGLALINGTQVSTALALNGLFLAERLLQAATVSGALSVDAAKGSD
APFDPRVHTVRGQAGQIATAAVYRNLLAGSAIRQSHLVGDKRVQDPYSLRCQPQVMGACFDLIRQAGATLLTEANAVTDN
PLVYADAGEVISGGNFHAEPVAFAADMLALAIAEIGALSERRIALLIDSTLSGLPPFLVEQPGLNSGFMIAHVTAAALAS
ENKTFAHPASVDSLPTSANQEDHVSMATFAGRRLQDMAENTATIVGIEALAAAQGIDFHKPLATSDTLQKAHGCIRARVA
YYGEDRLFAPDIEAARRLVLDGALGDSCRAHVGELALV
>Mature_518_residues
MNTMTTPPIITLQPGAMSFADLRRVWLAPTPVALSGDCAAAIEASAATVQAIVAKGAPAYGINTGFGLLAKTQIATHELE
RLQRNLILSHAVGTGEDLSDNVARLVLLMKAASLARGYSGVRRVVIDTLLALLNAGIVPCIPSKGSVGASGDLAPLAHMT
LALLGEGDVRVNGVRTPARAALAAAGIEPIALAAKEGLALINGTQVSTALALNGLFLAERLLQAATVSGALSVDAAKGSD
APFDPRVHTVRGQAGQIATAAVYRNLLAGSAIRQSHLVGDKRVQDPYSLRCQPQVMGACFDLIRQAGATLLTEANAVTDN
PLVYADAGEVISGGNFHAEPVAFAADMLALAIAEIGALSERRIALLIDSTLSGLPPFLVEQPGLNSGFMIAHVTAAALAS
ENKTFAHPASVDSLPTSANQEDHVSMATFAGRRLQDMAENTATIVGIEALAAAQGIDFHKPLATSDTLQKAHGCIRARVA
YYGEDRLFAPDIEAARRLVLDGALGDSCRAHVGELALV

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=480, Percent_Identity=44.5833333333333, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17567831, Length=517, Percent_Identity=42.1663442940039, Blast_Score=359, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53530; Mature: 53530

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTMTTPPIITLQPGAMSFADLRRVWLAPTPVALSGDCAAAIEASAATVQAIVAKGAPAY
CCCCCCCCEEEECCCCCCHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCC
GINTGFGLLAKTQIATHELERLQRNLILSHAVGTGEDLSDNVARLVLLMKAASLARGYSG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VRRVVIDTLLALLNAGIVPCIPSKGSVGASGDLAPLAHMTLALLGEGDVRVNGVRTPARA
HHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHH
ALAAAGIEPIALAAKEGLALINGTQVSTALALNGLFLAERLLQAATVSGALSVDAAKGSD
HHHHCCCCHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
APFDPRVHTVRGQAGQIATAAVYRNLLAGSAIRQSHLVGDKRVQDPYSLRCQPQVMGACF
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHHHHH
DLIRQAGATLLTEANAVTDNPLVYADAGEVISGGNFHAEPVAFAADMLALAIAEIGALSE
HHHHHCCCEEEECCCCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCC
RRIALLIDSTLSGLPPFLVEQPGLNSGFMIAHVTAAALASENKTFAHPASVDSLPTSANQ
CEEEEEEECHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
EDHVSMATFAGRRLQDMAENTATIVGIEALAAAQGIDFHKPLATSDTLQKAHGCIRARVA
CCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHE
YYGEDRLFAPDIEAARRLVLDGALGDSCRAHVGELALV
EECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHEECC
>Mature Secondary Structure
MNTMTTPPIITLQPGAMSFADLRRVWLAPTPVALSGDCAAAIEASAATVQAIVAKGAPAY
CCCCCCCCEEEECCCCCCHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCC
GINTGFGLLAKTQIATHELERLQRNLILSHAVGTGEDLSDNVARLVLLMKAASLARGYSG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VRRVVIDTLLALLNAGIVPCIPSKGSVGASGDLAPLAHMTLALLGEGDVRVNGVRTPARA
HHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHH
ALAAAGIEPIALAAKEGLALINGTQVSTALALNGLFLAERLLQAATVSGALSVDAAKGSD
HHHHCCCCHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
APFDPRVHTVRGQAGQIATAAVYRNLLAGSAIRQSHLVGDKRVQDPYSLRCQPQVMGACF
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHHHHH
DLIRQAGATLLTEANAVTDNPLVYADAGEVISGGNFHAEPVAFAADMLALAIAEIGALSE
HHHHHCCCEEEECCCCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCC
RRIALLIDSTLSGLPPFLVEQPGLNSGFMIAHVTAAALASENKTFAHPASVDSLPTSANQ
CEEEEEEECHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
EDHVSMATFAGRRLQDMAENTATIVGIEALAAAQGIDFHKPLATSDTLQKAHGCIRARVA
CCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHE
YYGEDRLFAPDIEAARRLVLDGALGDSCRAHVGELALV
EECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]