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The map label for this gene is hemH

Identifier: 187929945

GI number: 187929945

Start: 2981074

End: 2982189

Strand: Reverse

Name: hemH

Synonym: Rpic_2877

Alternate gene names: 187929945

Gene position: 2982189-2981074 (Counterclockwise)

Preceding gene: 187929946

Following gene: 187929944

Centisome position: 75.64

GC content: 64.34

Gene sequence:

>1116_bases
ATGCCCTTCTTGCCCGAACCCCTGTTCCAGCACGGCCAGCCCGATCGCACGGCGATCCTGCTCGTCAACCTCGGTACGCC
CGACGGTACGTCGCCACGCGAGGTCGGCCGCTACCTGCGTCAGTTCCTGTCCGACCCCCGCGTTGTGGAAATTCCGCGCG
CCGTGTGGTGGTTCATCCTCAACGTGCTGATCGTGCCGCTACGCTCGCGGGCGTCGGCGCACAAGTACGAAAGCATATGG
CTGCGCGAGGCCAACATGACGGGCTCGCCGCTGCTCGTCTACAGCGAGCGCCAGGCGCATGCGCTGCAGCAGTTGCTGAA
CGCCCAGGGCCACGATGTGGTGGTTGCCTGTGCGATGCGCTATGGCAATCCTTCGATTCCGTCCGTCATGCAGGCGCTGC
GCAAGCAGGGCGTCGAGCGTATCCTCGTGTTGCCGATGTATCCGCAGTATTCCGGCACCACCACCGCGACGGCCTTCGAT
GAGGTCTTCCGCGTGCTGGGCGAAATGCGCAATCAGCCGGAGTTGCGGCTGGTCAAGCATTTCCACGATGACCCTGCCTA
CATCAATGCGCTGCACCAGCAGGTGGGGGCGTATTGGGCACAGCACGGCGCACCCGATTTCGCGCACGGCGACAAGCTGG
TGCTGTCGTTTCATGGTGTGCCGCGACGGACGCTGGAATTGGGCGATCCGTATCACTGCGAATGCCTGAAGACCGGGCGC
TTGCTGGGAGAAGCGCTCGGCCTGCAGCCGGGTCAGTACCTGGTCACGTTCCAGTCACGCTTTGGCCGAGCCGAATGGTT
GCAACCATACACCGCGCCCACGCTGGAAGAGCTTGGCCGAGTCGGCACCAACCGCGTCGATGTGTTCTGCCCGGGCTTCC
CGGCCGATTGCCTGGAGACGCTGGAAGAGATCGCCATGGAAGGGCAGTCGACCTTCCGTGTCGCCGGCGGCAAGGAATTC
CATTACATCCCGTGCCTCAATGACAGCGAAGCCTGGATCGCCGGCATTGCCGACATCGCGCTTGCGCATCTGCAGGGCTG
GCCGCTCACGCTTACGCATCCGCACGTGCTGGAAGCCAGCCGCACGCGTGCGCAGAGCAAGGGAGCGGCCGCATGA

Upstream 100 bases:

>100_bases
ACCCGTGTGTTGGTGTGGTCAAGGACGGCGCCGTGGTGGCGTAAGGAACACGCGATGAATCGGCTCGTATAATCGGCCGG
TCTATCGCGAACCCGCGCCC

Downstream 100 bases:

>100_bases
AGGTGAGCACGGACGCGGCCGATCGCGTGCGTATCGACAAATGGCTGTGGGCGGCGCGCTTCTTCAAGACGCGTTCGCAG
GCGACGGACGCGGTGGAGCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MPFLPEPLFQHGQPDRTAILLVNLGTPDGTSPREVGRYLRQFLSDPRVVEIPRAVWWFILNVLIVPLRSRASAHKYESIW
LREANMTGSPLLVYSERQAHALQQLLNAQGHDVVVACAMRYGNPSIPSVMQALRKQGVERILVLPMYPQYSGTTTATAFD
EVFRVLGEMRNQPELRLVKHFHDDPAYINALHQQVGAYWAQHGAPDFAHGDKLVLSFHGVPRRTLELGDPYHCECLKTGR
LLGEALGLQPGQYLVTFQSRFGRAEWLQPYTAPTLEELGRVGTNRVDVFCPGFPADCLETLEEIAMEGQSTFRVAGGKEF
HYIPCLNDSEAWIAGIADIALAHLQGWPLTLTHPHVLEASRTRAQSKGAAA

Sequences:

>Translated_371_residues
MPFLPEPLFQHGQPDRTAILLVNLGTPDGTSPREVGRYLRQFLSDPRVVEIPRAVWWFILNVLIVPLRSRASAHKYESIW
LREANMTGSPLLVYSERQAHALQQLLNAQGHDVVVACAMRYGNPSIPSVMQALRKQGVERILVLPMYPQYSGTTTATAFD
EVFRVLGEMRNQPELRLVKHFHDDPAYINALHQQVGAYWAQHGAPDFAHGDKLVLSFHGVPRRTLELGDPYHCECLKTGR
LLGEALGLQPGQYLVTFQSRFGRAEWLQPYTAPTLEELGRVGTNRVDVFCPGFPADCLETLEEIAMEGQSTFRVAGGKEF
HYIPCLNDSEAWIAGIADIALAHLQGWPLTLTHPHVLEASRTRAQSKGAAA
>Mature_370_residues
PFLPEPLFQHGQPDRTAILLVNLGTPDGTSPREVGRYLRQFLSDPRVVEIPRAVWWFILNVLIVPLRSRASAHKYESIWL
REANMTGSPLLVYSERQAHALQQLLNAQGHDVVVACAMRYGNPSIPSVMQALRKQGVERILVLPMYPQYSGTTTATAFDE
VFRVLGEMRNQPELRLVKHFHDDPAYINALHQQVGAYWAQHGAPDFAHGDKLVLSFHGVPRRTLELGDPYHCECLKTGRL
LGEALGLQPGQYLVTFQSRFGRAEWLQPYTAPTLEELGRVGTNRVDVFCPGFPADCLETLEEIAMEGQSTFRVAGGKEFH
YIPCLNDSEAWIAGIADIALAHLQGWPLTLTHPHVLEASRTRAQSKGAAA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=274, Percent_Identity=23.7226277372263, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI60499025, Length=274, Percent_Identity=23.7226277372263, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1786681, Length=328, Percent_Identity=45.7317073170732, Blast_Score=278, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6324750, Length=342, Percent_Identity=25.7309941520468, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17864156, Length=342, Percent_Identity=23.3918128654971, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24651774, Length=271, Percent_Identity=24.3542435424354, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_RALPJ (B2UBQ0)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001900432.1
- ProteinModelPortal:   B2UBQ0
- SMR:   B2UBQ0
- GeneID:   6287773
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_2877
- HOGENOM:   HBG697135
- OMA:   TIEEIGM
- ProtClustDB:   PRK00035
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 41445; Mature: 41314

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFLPEPLFQHGQPDRTAILLVNLGTPDGTSPREVGRYLRQFLSDPRVVEIPRAVWWFIL
CCCCCCHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
NVLIVPLRSRASAHKYESIWLREANMTGSPLLVYSERQAHALQQLLNAQGHDVVVACAMR
HHHHHHHHHHCCHHHHHHEEEEECCCCCCEEEEECCHHHHHHHHHHCCCCCCEEEEEEHH
YGNPSIPSVMQALRKQGVERILVLPMYPQYSGTTTATAFDEVFRVLGEMRNQPELRLVKH
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
FHDDPAYINALHQQVGAYWAQHGAPDFAHGDKLVLSFHGVPRRTLELGDPYHCECLKTGR
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHCCCCCCCHHHHHHHH
LLGEALGLQPGQYLVTFQSRFGRAEWLQPYTAPTLEELGRVGTNRVDVFCPGFPADCLET
HHHHHHCCCCCCEEEEEHHHCCCHHHCCCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHH
LEEIAMEGQSTFRVAGGKEFHYIPCLNDSEAWIAGIADIALAHLQGWPLTLTHPHVLEAS
HHHHHHCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHH
RTRAQSKGAAA
HHHHCCCCCCC
>Mature Secondary Structure 
PFLPEPLFQHGQPDRTAILLVNLGTPDGTSPREVGRYLRQFLSDPRVVEIPRAVWWFIL
CCCCCHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
NVLIVPLRSRASAHKYESIWLREANMTGSPLLVYSERQAHALQQLLNAQGHDVVVACAMR
HHHHHHHHHHCCHHHHHHEEEEECCCCCCEEEEECCHHHHHHHHHHCCCCCCEEEEEEHH
YGNPSIPSVMQALRKQGVERILVLPMYPQYSGTTTATAFDEVFRVLGEMRNQPELRLVKH
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
FHDDPAYINALHQQVGAYWAQHGAPDFAHGDKLVLSFHGVPRRTLELGDPYHCECLKTGR
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHCCCCCCCHHHHHHHH
LLGEALGLQPGQYLVTFQSRFGRAEWLQPYTAPTLEELGRVGTNRVDVFCPGFPADCLET
HHHHHHCCCCCCEEEEEHHHCCCHHHCCCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHH
LEEIAMEGQSTFRVAGGKEFHYIPCLNDSEAWIAGIADIALAHLQGWPLTLTHPHVLEAS
HHHHHHCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHH
RTRAQSKGAAA
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA