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The map label for this gene is purM [H]

Identifier: 187929926

GI number: 187929926

Start: 2962773

End: 2963828

Strand: Reverse

Name: purM [H]

Synonym: Rpic_2858

Alternate gene names: 187929926

Gene position: 2963828-2962773 (Counterclockwise)

Preceding gene: 187929936

Following gene: 187929903

Centisome position: 75.18

GC content: 64.87

Gene sequence:

>1056_bases
ATGAGCGCTTCCGATACCCCATCCGCATCGACCGGCCTGTCTTACCGCGACGCGGGCGTCGACATCGAGGCGGGTGACGC
CCTTGTCGACCGCATCAAGCCGTTTGCCAAGCGCACCATGCGCGAAGGCGTGCTGGGCGGCATCGGCGGCTTCGGCGCGC
TGTTCGAGCTGTCCAAGAAGTATCAGGAGCCGGTGCTGGTGTCCGGTACCGACGGCGTGGGCACCAAGCTCAAGCTGGCC
TTTGCGTTGAATCGCCACGACACGGTTGGCCAGGATCTGGTCGCCATGAGCGTGAACGACATCCTGGTGCAGGGCGCCGA
GCCGCTGTTCTTCCTGGATTACTTCGCCTGCGGCAAGCTCGACGTCGACACCGCTGCCACCGTGGTCAAGGGCATCGCCC
AGGGTTGCGAGTTGGCCGGCTGCGCGCTGATCGGCGGCGAAACCGCTGAAATGCCGAGCATGTACCCGGACGGCGAATAC
GACCTGGCCGGCTTTGCCGTCGGCGCCGTCGAAAAGCGCAAGATCATCGACGGCACGACCATTGCCGAGGGCGACGTGGT
GCTGGGCCTGGCTTCGTCGGGTGCGCATTCGAACGGCTACTCGCTGGTGCGCAAGATCATCGAAGTATCGCGCCCGGACT
TGAACGCCGATTTCCACGGCCAGCGCCTGCAGGACGCCATCATGGCGCCGACGCGCATCTACGTGAAGCCGCTGCTGGCA
TTGATGGAGAAGCTGACCGTCAAGGGCATGGCGCACATCACCGGCGGTGGTTTGACCGAAAACGTGCCGCGCGTGCTGCA
AGACAACCTGACCGCCGTGCTGCACAAGAGCGCCTGGACGCTGCCGCCGCTGTTCCAGTGGCTGCAGAAGGCCGGCAACG
TGGCCGATGACGAAATGCATCGCGTGTTCAATTGCGGCATCGGCATGGTGGTGATCGTGTCGGCAGCCGATGCACCGGCC
GCGATCGCGCACCTGAAGGACGCGGGCGAGACGGTCTACCAGATTGGCGAAATCCGCGCACGCCAAGCCGGCGAAGCGCA
GACGATCGTGGTCTGA

Upstream 100 bases:

>100_bases
CCGGTAAAATCGCGATTTTACTGGACCGGCGGGTCCGATTTTTGTGACTTCCCGCTGCCGTCTCGCTTTCTTTCCCGGTT
TTTTCAATTCAGACGACTGT

Downstream 100 bases:

>100_bases
CGCGAAGTTCGCCTCAACAAAAAAACCGCCGATGTGTTCGGCGGTTTTTTTATGCGCGTTGTCTTGCGGGCGCTTATTTC
AGCGGGACGTATTCGCCGCT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSASDTPSASTGLSYRDAGVDIEAGDALVDRIKPFAKRTMREGVLGGIGGFGALFELSKKYQEPVLVSGTDGVGTKLKLA
FALNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVVKGIAQGCELAGCALIGGETAEMPSMYPDGEY
DLAGFAVGAVEKRKIIDGTTIAEGDVVLGLASSGAHSNGYSLVRKIIEVSRPDLNADFHGQRLQDAIMAPTRIYVKPLLA
LMEKLTVKGMAHITGGGLTENVPRVLQDNLTAVLHKSAWTLPPLFQWLQKAGNVADDEMHRVFNCGIGMVVIVSAADAPA
AIAHLKDAGETVYQIGEIRARQAGEAQTIVV

Sequences:

>Translated_351_residues
MSASDTPSASTGLSYRDAGVDIEAGDALVDRIKPFAKRTMREGVLGGIGGFGALFELSKKYQEPVLVSGTDGVGTKLKLA
FALNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVVKGIAQGCELAGCALIGGETAEMPSMYPDGEY
DLAGFAVGAVEKRKIIDGTTIAEGDVVLGLASSGAHSNGYSLVRKIIEVSRPDLNADFHGQRLQDAIMAPTRIYVKPLLA
LMEKLTVKGMAHITGGGLTENVPRVLQDNLTAVLHKSAWTLPPLFQWLQKAGNVADDEMHRVFNCGIGMVVIVSAADAPA
AIAHLKDAGETVYQIGEIRARQAGEAQTIVV
>Mature_350_residues
SASDTPSASTGLSYRDAGVDIEAGDALVDRIKPFAKRTMREGVLGGIGGFGALFELSKKYQEPVLVSGTDGVGTKLKLAF
ALNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVVKGIAQGCELAGCALIGGETAEMPSMYPDGEYD
LAGFAVGAVEKRKIIDGTTIAEGDVVLGLASSGAHSNGYSLVRKIIEVSRPDLNADFHGQRLQDAIMAPTRIYVKPLLAL
MEKLTVKGMAHITGGGLTENVPRVLQDNLTAVLHKSAWTLPPLFQWLQKAGNVADDEMHRVFNCGIGMVVIVSAADAPAA
IAHLKDAGETVYQIGEIRARQAGEAQTIVV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=347, Percent_Identity=53.0259365994236, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI209869995, Length=347, Percent_Identity=53.0259365994236, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI209869993, Length=347, Percent_Identity=53.0259365994236, Blast_Score=360, Evalue=1e-99,
Organism=Escherichia coli, GI1788845, Length=342, Percent_Identity=59.6491228070175, Blast_Score=417, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17567511, Length=354, Percent_Identity=43.5028248587571, Blast_Score=263, Evalue=9e-71,
Organism=Saccharomyces cerevisiae, GI6321203, Length=345, Percent_Identity=48.4057971014493, Blast_Score=321, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24582400, Length=303, Percent_Identity=42.2442244224422, Blast_Score=238, Evalue=3e-63,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37043; Mature: 36912

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASDTPSASTGLSYRDAGVDIEAGDALVDRIKPFAKRTMREGVLGGIGGFGALFELSKK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
YQEPVLVSGTDGVGTKLKLAFALNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKL
HCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCC
DVDTAATVVKGIAQGCELAGCALIGGETAEMPSMYPDGEYDLAGFAVGAVEKRKIIDGTT
CHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCHHEEECCHHHCEEECCCE
IAEGDVVLGLASSGAHSNGYSLVRKIIEVSRPDLNADFHGQRLQDAIMAPTRIYVKPLLA
EECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
LMEKLTVKGMAHITGGGLTENVPRVLQDNLTAVLHKSAWTLPPLFQWLQKAGNVADDEMH
HHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHH
RVFNCGIGMVVIVSAADAPAAIAHLKDAGETVYQIGEIRARQAGEAQTIVV
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
>Mature Secondary Structure 
SASDTPSASTGLSYRDAGVDIEAGDALVDRIKPFAKRTMREGVLGGIGGFGALFELSKK
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
YQEPVLVSGTDGVGTKLKLAFALNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKL
HCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCC
DVDTAATVVKGIAQGCELAGCALIGGETAEMPSMYPDGEYDLAGFAVGAVEKRKIIDGTT
CHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCHHEEECCHHHCEEECCCE
IAEGDVVLGLASSGAHSNGYSLVRKIIEVSRPDLNADFHGQRLQDAIMAPTRIYVKPLLA
EECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
LMEKLTVKGMAHITGGGLTENVPRVLQDNLTAVLHKSAWTLPPLFQWLQKAGNVADDEMH
HHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHH
RVFNCGIGMVVIVSAADAPAAIAHLKDAGETVYQIGEIRARQAGEAQTIVV
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]