Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 187929786

GI number: 187929786

Start: 2829051

End: 2829950

Strand: Reverse

Name: nadC [H]

Synonym: Rpic_2716

Alternate gene names: 187929786

Gene position: 2829950-2829051 (Counterclockwise)

Preceding gene: 187929787

Following gene: 187929781

Centisome position: 71.78

GC content: 67.0

Gene sequence:

>900_bases
ATGACGGCAACACAGATGAACACGACGCGTCTCGCCCCTGCGGCTGAGGCAATTTTCGATGGCTTTGGCCCGGCACTGCG
CGAGGCGTTGTCCGCGAATGTGGCCGCAGCCATTGCCGAGGACGTTGGCACGGGCGACCGCACTGGCTTGCTGATCCCCG
CCGATCGCCTTGCGCGCGCGCGCGTGATCGTGCGTGAGCACGCCGTGCTCTGCGGCACACCCTGGTTCGATGCGTGCATG
CGCGCCGTTGACCCGACGCTGCGGGTCACGTGGCGTCAGCACGAAGGCGATCGCATGGCGCCCGATTCCGTGGTGTGCGA
GATCGAGGGCCCGGCGCGTTCGCTGTTGACGGCTGAGCGCCCGTCGCTGAACTTCCTGCAGTTGCTGTCCGGTGTGGCGA
CGGCGACTTCGCGTTACGCCGCAGCCGTCGAAGGCACGCGCGCCCGCGTGCTCGACACACGTAAGACGCTGCCGGGCCTG
CGCCTGGCGCAGAAGTACGCCGTGCGGATCGGTGGCGGCGAGAATCAGCGCTTAGCCTTGTACGACGGCATCCTGATCAA
GGAAAACCACATCGCTGCGGCAGGTGGCGTGACAGCGGCCCTGCGTGCGGCGCAGGCGCTGAACGCAGGCGTGACGATTC
AGGTTGAGGTGGAAACGCTCGCGCAGCTGGATGAAGCACTGGCGGCAGGTGCCACGTCCGTGCTGCTCGACAACTTCGAA
CCGCCCGCGATGCGCGAGGCTGTGCGCGTAACGGCGGGCAGGGCGCTGCTCGAGGTGTCCGGCGGCGTAAACATCGAGAC
GATCCGCACCTTTGCCGAGACCGGCGTGGACCGAATCTCCGTCGGCGCGCTCACGAAGGACGTGCGCGCAACCGACTTCT
CTTTGCGGATCGTCGACTAA

Upstream 100 bases:

>100_bases
TCGATCGCATGCTGGACTTTGCCGCGCGCGAGAAAGCCACGGTTCGCCCGCAAGGCGACCTGGCCGCGAACGCACAACTC
TTTCAAGGAATCGGCCCGGC

Downstream 100 bases:

>100_bases
GGCTAAGCCTCAGCGTTTCCGGGCGATCTGCCGATGGGTCGGCTGCATGACCGTCGGCAGTGCCTTGGGTAGCGTTTCGG
GGTAGTCGCGCGAGAAATGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTATQMNTTRLAPAAEAIFDGFGPALREALSANVAAAIAEDVGTGDRTGLLIPADRLARARVIVREHAVLCGTPWFDACM
RAVDPTLRVTWRQHEGDRMAPDSVVCEIEGPARSLLTAERPSLNFLQLLSGVATATSRYAAAVEGTRARVLDTRKTLPGL
RLAQKYAVRIGGGENQRLALYDGILIKENHIAAAGGVTAALRAAQALNAGVTIQVEVETLAQLDEALAAGATSVLLDNFE
PPAMREAVRVTAGRALLEVSGGVNIETIRTFAETGVDRISVGALTKDVRATDFSLRIVD

Sequences:

>Translated_299_residues
MTATQMNTTRLAPAAEAIFDGFGPALREALSANVAAAIAEDVGTGDRTGLLIPADRLARARVIVREHAVLCGTPWFDACM
RAVDPTLRVTWRQHEGDRMAPDSVVCEIEGPARSLLTAERPSLNFLQLLSGVATATSRYAAAVEGTRARVLDTRKTLPGL
RLAQKYAVRIGGGENQRLALYDGILIKENHIAAAGGVTAALRAAQALNAGVTIQVEVETLAQLDEALAAGATSVLLDNFE
PPAMREAVRVTAGRALLEVSGGVNIETIRTFAETGVDRISVGALTKDVRATDFSLRIVD
>Mature_298_residues
TATQMNTTRLAPAAEAIFDGFGPALREALSANVAAAIAEDVGTGDRTGLLIPADRLARARVIVREHAVLCGTPWFDACMR
AVDPTLRVTWRQHEGDRMAPDSVVCEIEGPARSLLTAERPSLNFLQLLSGVATATSRYAAAVEGTRARVLDTRKTLPGLR
LAQKYAVRIGGGENQRLALYDGILIKENHIAAAGGVTAALRAAQALNAGVTIQVEVETLAQLDEALAAGATSVLLDNFEP
PAMREAVRVTAGRALLEVSGGVNIETIRTFAETGVDRISVGALTKDVRATDFSLRIVD

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=246, Percent_Identity=36.9918699186992, Blast_Score=147, Evalue=9e-36,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=50.7407407407407, Blast_Score=236, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6321162, Length=289, Percent_Identity=32.8719723183391, Blast_Score=151, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31650; Mature: 31518

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATQMNTTRLAPAAEAIFDGFGPALREALSANVAAAIAEDVGTGDRTGLLIPADRLARA
CCCCCCCCHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHH
RVIVREHAVLCGTPWFDACMRAVDPTLRVTWRQHEGDRMAPDSVVCEIEGPARSLLTAER
HHHHHHCEEEECCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEECCCHHHHHHCCC
PSLNFLQLLSGVATATSRYAAAVEGTRARVLDTRKTLPGLRLAQKYAVRIGGGENQRLAL
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEE
YDGILIKENHIAAAGGVTAALRAAQALNAGVTIQVEVETLAQLDEALAAGATSVLLDNFE
ECCEEEECCCEEECCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCHHHHHCCCC
PPAMREAVRVTAGRALLEVSGGVNIETIRTFAETGVDRISVGALTKDVRATDFSLRIVD
CHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure 
TATQMNTTRLAPAAEAIFDGFGPALREALSANVAAAIAEDVGTGDRTGLLIPADRLARA
CCCCCCCHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHH
RVIVREHAVLCGTPWFDACMRAVDPTLRVTWRQHEGDRMAPDSVVCEIEGPARSLLTAER
HHHHHHCEEEECCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEECCCHHHHHHCCC
PSLNFLQLLSGVATATSRYAAAVEGTRARVLDTRKTLPGLRLAQKYAVRIGGGENQRLAL
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEE
YDGILIKENHIAAAGGVTAALRAAQALNAGVTIQVEVETLAQLDEALAAGATSVLLDNFE
ECCEEEECCCEEECCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCHHHHHCCCC
PPAMREAVRVTAGRALLEVSGGVNIETIRTFAETGVDRISVGALTKDVRATDFSLRIVD
CHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]