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The map label for this gene is fabG2 [H]

Identifier: 187929698

GI number: 187929698

Start: 2740659

End: 2741441

Strand: Reverse

Name: fabG2 [H]

Synonym: Rpic_2627

Alternate gene names: 187929698

Gene position: 2741441-2740659 (Counterclockwise)

Preceding gene: 187929699

Following gene: 187929688

Centisome position: 69.53

GC content: 63.6

Gene sequence:

>783_bases
ATGCAACTGAACTCCGACATCTCGGCCATCATCACCGGGGGCGCTTCCGGCCTGGGAGCCGCCACGACCCGGCGTTTGGC
CAGCCGTGGCGTCAAAGTCGCCATCTTCGACATGAACGAAACCGTCGGCCAGGCGTTGGCCAGCGAACTCGGCGGCGTTT
ACTGCAATGTGGACGTGACATCTGAGGAGCAGGTGGACACCGCCTTCGCCAAGGCCCGTGCGGCCATCGGGCAGGAGCGC
ATTCTGGTCAACTGCGCCGGTACTGCCGATGCCGTCAAGACTGTCAGCCGCGACAAGAAAACCGGCGAAATCCGCCCATG
CGCGGCAGATCGCTTCAATCGCATCATTCAGATCAACCTGGTGGGCACCTTCCGTTGCATCGCCAAGTCAGCCGCGGGTA
TGTTGACGCTCGCGCCGCTGACCGATGGCGAGCGCGGCGTCATCGTCAACACCGCTTCGGCCGCCGCGCAGGACGGCCAG
GTCGGCCAGGCCAGCTATGCGGCCAGCAAGGCAGCCATCGTGGGCATGACCCTGCCAATCGCGCGCGACATGATGGACGA
AGGGATCCGGATCAACACCATCATGCCGGGGATCTTCGGTACACCGTTGCTGCTGGGTCTGCCGGACAACGTCAAACAGG
CGCTGGCGGCCAGCGTGCCCTTCCCCAAGCGTTTAGGCGACCCCGATGAATTCGCGCAGGCCGTCGAGTTTCTCGTTACT
TGCGGCTACATGAATGCCGAGTCCATTCGTGTGGATGGTGCCATTCGCATGGCGCCGCGCTGA

Upstream 100 bases:

>100_bases
GCCGACAACCTGGAAGGGCAAGCGGCATTCCTGGGCAAGCGCACCCCCCACTTCACGGGCCAATAACGCCTGTCTATCTG
TCATCCATCGAGGAAAAACC

Downstream 100 bases:

>100_bases
CGCTGAAATTTTGATCAATCAGGGAACGTCAGCATGCCTGGAAATCCGGTAATTCTCGAAAAGAATGGTGCCGTCGCGAC
CATAACACTCAACTCGCCAA

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MQLNSDISAIITGGASGLGAATTRRLASRGVKVAIFDMNETVGQALASELGGVYCNVDVTSEEQVDTAFAKARAAIGQER
ILVNCAGTADAVKTVSRDKKTGEIRPCAADRFNRIIQINLVGTFRCIAKSAAGMLTLAPLTDGERGVIVNTASAAAQDGQ
VGQASYAASKAAIVGMTLPIARDMMDEGIRINTIMPGIFGTPLLLGLPDNVKQALAASVPFPKRLGDPDEFAQAVEFLVT
CGYMNAESIRVDGAIRMAPR

Sequences:

>Translated_260_residues
MQLNSDISAIITGGASGLGAATTRRLASRGVKVAIFDMNETVGQALASELGGVYCNVDVTSEEQVDTAFAKARAAIGQER
ILVNCAGTADAVKTVSRDKKTGEIRPCAADRFNRIIQINLVGTFRCIAKSAAGMLTLAPLTDGERGVIVNTASAAAQDGQ
VGQASYAASKAAIVGMTLPIARDMMDEGIRINTIMPGIFGTPLLLGLPDNVKQALAASVPFPKRLGDPDEFAQAVEFLVT
CGYMNAESIRVDGAIRMAPR
>Mature_260_residues
MQLNSDISAIITGGASGLGAATTRRLASRGVKVAIFDMNETVGQALASELGGVYCNVDVTSEEQVDTAFAKARAAIGQER
ILVNCAGTADAVKTVSRDKKTGEIRPCAADRFNRIIQINLVGTFRCIAKSAAGMLTLAPLTDGERGVIVNTASAAAQDGQ
VGQASYAASKAAIVGMTLPIARDMMDEGIRINTIMPGIFGTPLLLGLPDNVKQALAASVPFPKRLGDPDEFAQAVEFLVT
CGYMNAESIRVDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=50.1960784313725, Blast_Score=232, Evalue=3e-61,
Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=47.843137254902, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI15277342, Length=270, Percent_Identity=31.1111111111111, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=28, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI59889578, Length=231, Percent_Identity=29.8701298701299, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI31542939, Length=213, Percent_Identity=30.5164319248826, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI5031737, Length=261, Percent_Identity=28.3524904214559, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI33667109, Length=201, Percent_Identity=28.8557213930348, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=31.6205533596838, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=31.8367346938775, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1789057, Length=266, Percent_Identity=27.8195488721804, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082100, Length=261, Percent_Identity=27.2030651340996, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=27.027027027027, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=27.9527559055118, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790717, Length=258, Percent_Identity=25.5813953488372, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787905, Length=256, Percent_Identity=28.515625, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI2367365, Length=254, Percent_Identity=27.5590551181102, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=249, Percent_Identity=47.7911646586345, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17555706, Length=260, Percent_Identity=30.3846153846154, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=25.2918287937743, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17538486, Length=283, Percent_Identity=28.9752650176678, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=275, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=27.9245283018868, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=272, Percent_Identity=27.9411764705882, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=270, Percent_Identity=25.1851851851852, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=27.037037037037, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=26.6917293233083, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=275, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=263, Percent_Identity=23.574144486692, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320089, Length=227, Percent_Identity=28.1938325991189, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322861, Length=208, Percent_Identity=28.8461538461538, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=51.7786561264822, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=34.6456692913386, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI21355319, Length=256, Percent_Identity=31.25, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28571526, Length=265, Percent_Identity=27.1698113207547, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=28.968253968254, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357041, Length=267, Percent_Identity=27.3408239700375, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 27134; Mature: 27134

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNSDISAIITGGASGLGAATTRRLASRGVKVAIFDMNETVGQALASELGGVYCNVDVT
CCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEECC
SEEQVDTAFAKARAAIGQERILVNCAGTADAVKTVSRDKKTGEIRPCAADRFNRIIQINL
CCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHCCCEEEEEE
VGTFRCIAKSAAGMLTLAPLTDGERGVIVNTASAAAQDGQVGQASYAASKAAIVGMTLPI
EHHHHHHHHHCCCEEEEEECCCCCCEEEEECCHHCCCCCCCCCHHHHHCCCEEEEEEHHH
ARDMMDEGIRINTIMPGIFGTPLLLGLPDNVKQALAASVPFPKRLGDPDEFAQAVEFLVT
HHHHHHCCEEEEEECCCCCCCCEEEECCHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHH
CGYMNAESIRVDGAIRMAPR
CCCCCCCEEEECCEEEECCC
>Mature Secondary Structure
MQLNSDISAIITGGASGLGAATTRRLASRGVKVAIFDMNETVGQALASELGGVYCNVDVT
CCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEECC
SEEQVDTAFAKARAAIGQERILVNCAGTADAVKTVSRDKKTGEIRPCAADRFNRIIQINL
CCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHCCCEEEEEE
VGTFRCIAKSAAGMLTLAPLTDGERGVIVNTASAAAQDGQVGQASYAASKAAIVGMTLPI
EHHHHHHHHHCCCEEEEEECCCCCCEEEEECCHHCCCCCCCCCHHHHHCCCEEEEEEHHH
ARDMMDEGIRINTIMPGIFGTPLLLGLPDNVKQALAASVPFPKRLGDPDEFAQAVEFLVT
HHHHHHCCEEEEEECCCCCCCCEEEECCHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHH
CGYMNAESIRVDGAIRMAPR
CCCCCCCEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]