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The map label for this gene is hemC [H]

Identifier: 187929644

GI number: 187929644

Start: 2678845

End: 2679861

Strand: Reverse

Name: hemC [H]

Synonym: Rpic_2571

Alternate gene names: 187929644

Gene position: 2679861-2678845 (Counterclockwise)

Preceding gene: 187929646

Following gene: 187929643

Centisome position: 67.97

GC content: 66.86

Gene sequence:

>1017_bases
ATGTCTTCCAACGCCCGCCCGACTTCCCGTCAATCCCAGCTTGCAACGACTCCTGCAGCCCAGGCGCCGACCAAGCTGGT
CATTGCCTCGCGCGAGAGCCGGCTAGCCCTCTGGCAAGCCGAACACGTGCGTGCTGCATTGCAAAAATACTATCCCGCGT
GCGACGTGTCCATCCTTGGAATGACCACGCGCGGCGACCAGATTCTCGACCGCTCCCTCGCGAAGGTGGGGGGCAAGGGT
TTGTTCGTGAAGGAACTGGAAGTCGCGCTGGCCGAGGGGCGCGCAGATCTCGCCGTACATTCGCTCAAGGATGTGCCGAT
GGAATTGCCGGAAGGCTTTGCGCTGTCGGCCATCCTCGAACGCGAAGACCCGCGCGACGCCTTTATTTCCAACGACTACG
CTGATCTGGCCTCGCTGCCTGCCGGCGCCGTGGTGGGCACGTCGAGCCTGCGCCGCGAGGCCTCGTTGAGGGCTCGGTTT
CCGCATCTGGTGATCCAGCCGCTGCGGGGCAACCTCGATACGCGCCTCGGCAAGCTCGATCGCGGCGACTACGCTGCCAT
CATCCTGGCCGCTGCGGGGCTCAAGCGGCTGGGGTTGGTCGATCGCATTCGCTCGACCATCGCGCCGGAAGAATCGCTAC
CGGCAGCCGGGCAAGGTGCGCTCGGCATCGAAATTCGCGCCGATCGCGCAGACGTGCGAGCCTGCCTCGCGCCCCTGCAC
GATGAGCCCACTGCACTGGCCGTGACGGCTGAACGCGCTGTTTCGCGCATTCTCGGCGGTTCGTGCCAGGTGCCACTCGC
CTCGTTCGCGCAGTGGTCGGACGGCGGCACGCTGCGCCTGCGCGCCTTTGTTGCTTCGCAGGACGGCACCCGCAAACTCG
CCGCGGATGGCGAAGCCACGCCATCTACGCTGGCCGAAGCCGACGCACTGGGCGTGCGCGTCGCCCAGCAGATGCTGGCC
GGCGGCGCACGCGACATCCTTGCCATGCTGGGCGCCGACGCCCCACCCGCTACCTGA

Upstream 100 bases:

>100_bases
TAGGTTGGGTGCTCGAAGGTGCCTGAACGGCCCTCGTTTCTGTATCACTTCAACGTGATAGCCGGACTGTCGCGAAAATG
CTGCGTGCTACCATTGCCGC

Downstream 100 bases:

>100_bases
ATCCCACGGCTCGCCATGGACGACCACTTGCCACCGCGCTTGTCACCATCGTCGCCCGCTTCCAGCACGCCGCCTGTTCA
ATCGGCAACCCCGCCCGTGG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSSNARPTSRQSQLATTPAAQAPTKLVIASRESRLALWQAEHVRAALQKYYPACDVSILGMTTRGDQILDRSLAKVGGKG
LFVKELEVALAEGRADLAVHSLKDVPMELPEGFALSAILEREDPRDAFISNDYADLASLPAGAVVGTSSLRREASLRARF
PHLVIQPLRGNLDTRLGKLDRGDYAAIILAAAGLKRLGLVDRIRSTIAPEESLPAAGQGALGIEIRADRADVRACLAPLH
DEPTALAVTAERAVSRILGGSCQVPLASFAQWSDGGTLRLRAFVASQDGTRKLAADGEATPSTLAEADALGVRVAQQMLA
GGARDILAMLGADAPPAT

Sequences:

>Translated_338_residues
MSSNARPTSRQSQLATTPAAQAPTKLVIASRESRLALWQAEHVRAALQKYYPACDVSILGMTTRGDQILDRSLAKVGGKG
LFVKELEVALAEGRADLAVHSLKDVPMELPEGFALSAILEREDPRDAFISNDYADLASLPAGAVVGTSSLRREASLRARF
PHLVIQPLRGNLDTRLGKLDRGDYAAIILAAAGLKRLGLVDRIRSTIAPEESLPAAGQGALGIEIRADRADVRACLAPLH
DEPTALAVTAERAVSRILGGSCQVPLASFAQWSDGGTLRLRAFVASQDGTRKLAADGEATPSTLAEADALGVRVAQQMLA
GGARDILAMLGADAPPAT
>Mature_337_residues
SSNARPTSRQSQLATTPAAQAPTKLVIASRESRLALWQAEHVRAALQKYYPACDVSILGMTTRGDQILDRSLAKVGGKGL
FVKELEVALAEGRADLAVHSLKDVPMELPEGFALSAILEREDPRDAFISNDYADLASLPAGAVVGTSSLRREASLRARFP
HLVIQPLRGNLDTRLGKLDRGDYAAIILAAAGLKRLGLVDRIRSTIAPEESLPAAGQGALGIEIRADRADVRACLAPLHD
EPTALAVTAERAVSRILGGSCQVPLASFAQWSDGGTLRLRAFVASQDGTRKLAADGEATPSTLAEADALGVRVAQQMLAG
GARDILAMLGADAPPAT

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=345, Percent_Identity=41.7391304347826, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI66933009, Length=330, Percent_Identity=42.1212121212121, Blast_Score=234, Evalue=7e-62,
Organism=Escherichia coli, GI48994974, Length=311, Percent_Identity=55.9485530546624, Blast_Score=323, Evalue=8e-90,
Organism=Saccharomyces cerevisiae, GI6319996, Length=323, Percent_Identity=39.3188854489164, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI20130425, Length=295, Percent_Identity=42.7118644067797, Blast_Score=218, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35564; Mature: 35433

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNARPTSRQSQLATTPAAQAPTKLVIASRESRLALWQAEHVRAALQKYYPACDVSILG
CCCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
MTTRGDQILDRSLAKVGGKGLFVKELEVALAEGRADLAVHSLKDVPMELPEGFALSAILE
ECCCCHHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
REDPRDAFISNDYADLASLPAGAVVGTSSLRREASLRARFPHLVIQPLRGNLDTRLGKLD
CCCCCHHHHCCCHHHHHHCCCCCEECCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHCCCC
RGDYAAIILAAAGLKRLGLVDRIRSTIAPEESLPAAGQGALGIEIRADRADVRACLAPLH
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCC
DEPTALAVTAERAVSRILGGSCQVPLASFAQWSDGGTLRLRAFVASQDGTRKLAADGEAT
CCCCEEEEEHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEEEEEECCCCCEEECCCCCCC
PSTLAEADALGVRVAQQMLAGGARDILAMLGADAPPAT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSNARPTSRQSQLATTPAAQAPTKLVIASRESRLALWQAEHVRAALQKYYPACDVSILG
CCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
MTTRGDQILDRSLAKVGGKGLFVKELEVALAEGRADLAVHSLKDVPMELPEGFALSAILE
ECCCCHHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
REDPRDAFISNDYADLASLPAGAVVGTSSLRREASLRARFPHLVIQPLRGNLDTRLGKLD
CCCCCHHHHCCCHHHHHHCCCCCEECCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHCCCC
RGDYAAIILAAAGLKRLGLVDRIRSTIAPEESLPAAGQGALGIEIRADRADVRACLAPLH
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCC
DEPTALAVTAERAVSRILGGSCQVPLASFAQWSDGGTLRLRAFVASQDGTRKLAADGEAT
CCCCEEEEEHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEEEEEECCCCCEEECCCCCCC
PSTLAEADALGVRVAQQMLAGGARDILAMLGADAPPAT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]