| Definition | Ralstonia pickettii 12J chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_010682 |
| Length | 3,942,557 |
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The map label for this gene is hemD [H]
Identifier: 187929643
GI number: 187929643
Start: 2676721
End: 2678829
Strand: Reverse
Name: hemD [H]
Synonym: Rpic_2570
Alternate gene names: 187929643
Gene position: 2678829-2676721 (Counterclockwise)
Preceding gene: 187929644
Following gene: 187929642
Centisome position: 67.95
GC content: 67.85
Gene sequence:
>2109_bases ATGGACGACCACTTGCCACCGCGCTTGTCACCATCGTCGCCCGCTTCCAGCACGCCGCCTGTTCAATCGGCAACCCCGCC CGTGGTGGTGGTCACGCGTCCGCGCGCACAGGCGCCCATGCTGGTGGCGGCGCTTGAGCGCCACGGCCTGCGCACGCACC AGTTTCCGCTGCTCGACATTGCGCCGACGCCCAATCTCGACGACTTGCGTGCCGCGCTGGGCGATCCGTCGCGCTATGCG CTGGTCGTGTTCGTCAGCCCCAACGCCGTGCAGCAGGCATTTTCCGCCATGCCGGAAGGCTTCCGCTGGCCGCAGGAAGT ACCGGTGGCAGTAGTGGGGCCCGCGAGCGCACAGGCGCTTGCCACGCACGGGGTCGCGCCGCCCGCGCACCGTGTGATCA AGCCCGACACGCATGCCGACGACGCCCGCCAGGATTCCGAGGCGCTCTACGCGCGGCTGGATGTGCCCTCGCTGAGCGGC CGTGAAGTGCTGATCGTGCGCGGCAACGGTGGCCGTGAGTGGCTGGCCGATCAGCTGCGCGAAGCCGGTGCATCGGTCCG TACGGCGGAAGCCTATCGCCGCAGCGTACCGGTGCCCGATGCCGCTGCGTGGCTTGCGTTGCGTGCCGTGCTTTCGTCCC GCCACGCCTGGACGCTCACCAGCTCCGAGGCCGTCCGCAATCTTGATGAGCTGGCCCGCGCCAATCTGTCGCCCGCTGAT CTCGATACGCTGCACGGCGCGCCATGCTTTGCTTCGCACGCCCGCATCGTCGAACAGGCCGAATCGCTGGGTTTCCGCGA TGTGACGCTGACCGGCGCCGGCGACGACCGGCTCCTCGCCAGCGTGCTCGCCTGGGCCGGGCCGATATGGGCTCCCGAGC ATGCCCCAGCAACGGTGCCGGATGATTCAAACCCGTCTACTTCTTCTTCCACTGTGACGCAGACTCCCGTTCCCTCGTCC GCTCCCGCTTCAACGCCAGCGCCCGCAGCCGTCAAGCCGAGTCCTGCGCCTGCTGCTCCGCCGGCTGCGTTTGCGCCCAC CATGACGGTCAACCATGCGCCGCGCCGTGGCGGTTGGCTCATCTGGGTGGCGCTGGTCGCGGTCGTGGCGGCAGTGGCCG CGCTACAGGTGCGCAACGAACGCCTTGCACGCGAGATCCGTCAGCGCGCCCAAACGAATGAGGCGCTGGCGCAGGAGATG CGCGTGCTCTCGCGGGCCGATCAGGATTCGGTTTCCCAGCTGCAGCAGAAGTTTGGCGCGCTGGATGCCCGCACCGCTGA AACGCGCGATCGCCAGGCAGCGCTGGAGCAGGCCAATCAAGACCTCCTGCGCAACCGCGATGACTGGCAGCGCGCCGAGA TCCAGCGTTCGCTGGAAGTGACCGCTGAACAACTGCAACTGACCGGCAACGTCGCGGGTGCATTGGCTGCGCTGCAAACG ATCGACGCGCGCCTGGCCACGCTCGACAAGCCGCAGTTCAACGCCGTGCGTCGGGCGGTATCGCGCGACATGGCCAAGCT CAAGGCGATGCCGTCGTTTGATCTGGCCGGTGCTGCGCTGCGGTTGGATGACGCCATCAACGCGGTCGATACGCTGCCGC TCGTCTCGTCGGCCCAGCCGCTGGAGGCGGAACAGGCTGCGCAGGCGCCGCATACTGTGGCGAAACCCTCGAAGAATGCC AAGGCACACGCTGCGTCGGCGCCCGTTGCCTCGACGCCGCCAAACGCCGGATGGTCGGCAGGCGTGCGCGCTTGGTGGGG CCGCCTGTGGAACGACGTGCGCGGCGAACTCGGCCAGATCGTACAGGTGCGCCGCGTCGATCAGACCGAGGCACTGCTGC TGTCTTCCGACCAAGCGTGGTTCCTGCGCGAAAACCTCAAGCTGCGCCTGATGAATGCGCGCCTGGCGTTGCTCTCGCGC AATGAAGCCGTGTTCCGCGCCGATCTGGGGCGCGCTGATACGCTGCTCGCGCGCTACTTTGATACGCAGTCTTCGCGCGT GACCACAGTGCAGAATCAACTGTCGCAGGCGCGCGCGACGGTTGGCACGCTGCAGGTTCCAACGCTAGCTGACAGCCTTG CCGCCGTGCGCGGTTCGGGCAAGGAGTGA
Upstream 100 bases:
>100_bases CGTGCGCGTCGCCCAGCAGATGCTGGCCGGCGGCGCACGCGACATCCTTGCCATGCTGGGCGCCGACGCCCCACCCGCTA CCTGAATCCCACGGCTCGCC
Downstream 100 bases:
>100_bases GCATGCGCTGGGTATTCTGGGTCGCGCTCCTGTTTGCCGCCGCCGTGGGGCTGGCGCTGTTTACCGAACTCAATCTGAGC AACGTCGTGCTGTTCTACCC
Product: bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase
Products: NA
Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]
Number of amino acids: Translated: 702; Mature: 702
Protein sequence:
>702_residues MDDHLPPRLSPSSPASSTPPVQSATPPVVVVTRPRAQAPMLVAALERHGLRTHQFPLLDIAPTPNLDDLRAALGDPSRYA LVVFVSPNAVQQAFSAMPEGFRWPQEVPVAVVGPASAQALATHGVAPPAHRVIKPDTHADDARQDSEALYARLDVPSLSG REVLIVRGNGGREWLADQLREAGASVRTAEAYRRSVPVPDAAAWLALRAVLSSRHAWTLTSSEAVRNLDELARANLSPAD LDTLHGAPCFASHARIVEQAESLGFRDVTLTGAGDDRLLASVLAWAGPIWAPEHAPATVPDDSNPSTSSSTVTQTPVPSS APASTPAPAAVKPSPAPAAPPAAFAPTMTVNHAPRRGGWLIWVALVAVVAAVAALQVRNERLAREIRQRAQTNEALAQEM RVLSRADQDSVSQLQQKFGALDARTAETRDRQAALEQANQDLLRNRDDWQRAEIQRSLEVTAEQLQLTGNVAGALAALQT IDARLATLDKPQFNAVRRAVSRDMAKLKAMPSFDLAGAALRLDDAINAVDTLPLVSSAQPLEAEQAAQAPHTVAKPSKNA KAHAASAPVASTPPNAGWSAGVRAWWGRLWNDVRGELGQIVQVRRVDQTEALLLSSDQAWFLRENLKLRLMNARLALLSR NEAVFRADLGRADTLLARYFDTQSSRVTTVQNQLSQARATVGTLQVPTLADSLAAVRGSGKE
Sequences:
>Translated_702_residues MDDHLPPRLSPSSPASSTPPVQSATPPVVVVTRPRAQAPMLVAALERHGLRTHQFPLLDIAPTPNLDDLRAALGDPSRYA LVVFVSPNAVQQAFSAMPEGFRWPQEVPVAVVGPASAQALATHGVAPPAHRVIKPDTHADDARQDSEALYARLDVPSLSG REVLIVRGNGGREWLADQLREAGASVRTAEAYRRSVPVPDAAAWLALRAVLSSRHAWTLTSSEAVRNLDELARANLSPAD LDTLHGAPCFASHARIVEQAESLGFRDVTLTGAGDDRLLASVLAWAGPIWAPEHAPATVPDDSNPSTSSSTVTQTPVPSS APASTPAPAAVKPSPAPAAPPAAFAPTMTVNHAPRRGGWLIWVALVAVVAAVAALQVRNERLAREIRQRAQTNEALAQEM RVLSRADQDSVSQLQQKFGALDARTAETRDRQAALEQANQDLLRNRDDWQRAEIQRSLEVTAEQLQLTGNVAGALAALQT IDARLATLDKPQFNAVRRAVSRDMAKLKAMPSFDLAGAALRLDDAINAVDTLPLVSSAQPLEAEQAAQAPHTVAKPSKNA KAHAASAPVASTPPNAGWSAGVRAWWGRLWNDVRGELGQIVQVRRVDQTEALLLSSDQAWFLRENLKLRLMNARLALLSR NEAVFRADLGRADTLLARYFDTQSSRVTTVQNQLSQARATVGTLQVPTLADSLAAVRGSGKE >Mature_702_residues MDDHLPPRLSPSSPASSTPPVQSATPPVVVVTRPRAQAPMLVAALERHGLRTHQFPLLDIAPTPNLDDLRAALGDPSRYA LVVFVSPNAVQQAFSAMPEGFRWPQEVPVAVVGPASAQALATHGVAPPAHRVIKPDTHADDARQDSEALYARLDVPSLSG REVLIVRGNGGREWLADQLREAGASVRTAEAYRRSVPVPDAAAWLALRAVLSSRHAWTLTSSEAVRNLDELARANLSPAD LDTLHGAPCFASHARIVEQAESLGFRDVTLTGAGDDRLLASVLAWAGPIWAPEHAPATVPDDSNPSTSSSTVTQTPVPSS APASTPAPAAVKPSPAPAAPPAAFAPTMTVNHAPRRGGWLIWVALVAVVAAVAALQVRNERLAREIRQRAQTNEALAQEM RVLSRADQDSVSQLQQKFGALDARTAETRDRQAALEQANQDLLRNRDDWQRAEIQRSLEVTAEQLQLTGNVAGALAALQT IDARLATLDKPQFNAVRRAVSRDMAKLKAMPSFDLAGAALRLDDAINAVDTLPLVSSAQPLEAEQAAQAPHTVAKPSKNA KAHAASAPVASTPPNAGWSAGVRAWWGRLWNDVRGELGQIVQVRRVDQTEALLLSSDQAWFLRENLKLRLMNARLALLSR NEAVFRADLGRADTLLARYFDTQSSRVTTVQNQLSQARATVGTLQVPTLADSLAAVRGSGKE
Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]
COG id: COG2959
COG function: function code H; Uncharacterized enzyme of heme biosynthesis
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the uroporphyrinogen-III synthase family [H]
Homologues:
Organism=Escherichia coli, GI1790236, Length=256, Percent_Identity=29.6875, Blast_Score=72, Evalue=8e-14,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003754 [H]
Pfam domain/function: PF02602 HEM4 [H]
EC number: =4.2.1.75 [H]
Molecular weight: Translated: 75098; Mature: 75098
Theoretical pI: Translated: 8.52; Mature: 8.52
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.1 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.3 %Cys+Met (Translated Protein) 0.1 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDDHLPPRLSPSSPASSTPPVQSATPPVVVVTRPRAQAPMLVAALERHGLRTHQFPLLDI CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCEEEE APTPNLDDLRAALGDPSRYALVVFVSPNAVQQAFSAMPEGFRWPQEVPVAVVGPASAQAL CCCCCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHH ATHGVAPPAHRVIKPDTHADDARQDSEALYARLDVPSLSGREVLIVRGNGGREWLADQLR HHCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCEEEEEECCCCHHHHHHHHH EAGASVRTAEAYRRSVPVPDAAAWLALRAVLSSRHAWTLTSSEAVRNLDELARANLSPAD HCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCC LDTLHGAPCFASHARIVEQAESLGFRDVTLTGAGDDRLLASVLAWAGPIWAPEHAPATVP HHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCC DDSNPSTSSSTVTQTPVPSSAPASTPAPAAVKPSPAPAAPPAAFAPTMTVNHAPRRGGWL CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHH IWVALVAVVAAVAALQVRNERLAREIRQRAQTNEALAQEMRVLSRADQDSVSQLQQKFGA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC LDARTAETRDRQAALEQANQDLLRNRDDWQRAEIQRSLEVTAEQLQLTGNVAGALAALQT CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH IDARLATLDKPQFNAVRRAVSRDMAKLKAMPSFDLAGAALRLDDAINAVDTLPLVSSAQP HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEHHHHHHHHHHCCCCCCCCC LEAEQAAQAPHTVAKPSKNAKAHAASAPVASTPPNAGWSAGVRAWWGRLWNDVRGELGQI CCHHHHHCCCCHHCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH VQVRRVDQTEALLLSSDQAWFLRENLKLRLMNARLALLSRNEAVFRADLGRADTLLARYF HHHHHCCHHHHEEECCCCCEEECCCCEEEEEHHHHHHHCCCCHHHHHHCCHHHHHHHHHH DTQSSRVTTVQNQLSQARATVGTLQVPTLADSLAAVRGSGKE CCCCCHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHCCCCC >Mature Secondary Structure MDDHLPPRLSPSSPASSTPPVQSATPPVVVVTRPRAQAPMLVAALERHGLRTHQFPLLDI CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCEEEE APTPNLDDLRAALGDPSRYALVVFVSPNAVQQAFSAMPEGFRWPQEVPVAVVGPASAQAL CCCCCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHH ATHGVAPPAHRVIKPDTHADDARQDSEALYARLDVPSLSGREVLIVRGNGGREWLADQLR HHCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCEEEEEECCCCHHHHHHHHH EAGASVRTAEAYRRSVPVPDAAAWLALRAVLSSRHAWTLTSSEAVRNLDELARANLSPAD HCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCC LDTLHGAPCFASHARIVEQAESLGFRDVTLTGAGDDRLLASVLAWAGPIWAPEHAPATVP HHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCC DDSNPSTSSSTVTQTPVPSSAPASTPAPAAVKPSPAPAAPPAAFAPTMTVNHAPRRGGWL CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHH IWVALVAVVAAVAALQVRNERLAREIRQRAQTNEALAQEMRVLSRADQDSVSQLQQKFGA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC LDARTAETRDRQAALEQANQDLLRNRDDWQRAEIQRSLEVTAEQLQLTGNVAGALAALQT CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH IDARLATLDKPQFNAVRRAVSRDMAKLKAMPSFDLAGAALRLDDAINAVDTLPLVSSAQP HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEHHHHHHHHHHCCCCCCCCC LEAEQAAQAPHTVAKPSKNAKAHAASAPVASTPPNAGWSAGVRAWWGRLWNDVRGELGQI CCHHHHHCCCCHHCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH VQVRRVDQTEALLLSSDQAWFLRENLKLRLMNARLALLSRNEAVFRADLGRADTLLARYF HHHHHCCHHHHEEECCCCCEEECCCCEEEEEHHHHHHHCCCCHHHHHHCCHHHHHHHHHH DTQSSRVTTVQNQLSQARATVGTLQVPTLADSLAAVRGSGKE CCCCCHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8159168; 10984043 [H]