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The map label for this gene is dxs

Identifier: 187929505

GI number: 187929505

Start: 2531041

End: 2532951

Strand: Reverse

Name: dxs

Synonym: Rpic_2426

Alternate gene names: 187929505

Gene position: 2532951-2531041 (Counterclockwise)

Preceding gene: 187929506

Following gene: 187929504

Centisome position: 64.25

GC content: 65.62

Gene sequence:

>1911_bases
ATGACGTACGAACTTCTGAACACCATCGACGATCCGGCCGACCTGCGCCGACTGGACCGCCGCCAACTCGGGCCGCTGGC
CAACGAGTTGCGCGCCTTCGTGCTCGATTCCGTCTCGCAAACGGGCGGCCATCTGTCGTCGAACCTGGGCACGGTCGAAT
TGACCATCGCACTGCACTACGTCTTCAACACGCCGGAAGACCGCATCGTGTGGGACGTCGGCCACCAGAGCTATCCGCAC
AAGATCCTCACGGGCCGCCGCGACCAGATGGGCTCGCTGCGCCAGCTGGACGGCATCTCCGGTTTCCCGCGCCGCAGCGA
GAGCCCGTACGACACGTTCGGCACCGCGCACTCGTCCACGTCGATTTCGGCTGCGCTTGGCATGGCCCTGGGCGCCAAGA
CCAAGGGTGAAGACCGCGTCGCCATTGCGGTGATCGGCGACGGTGCGATGAGCGCCGGCATGGCCTTCGAGGCGATGAAC
AACGCGGGCGTCTATAAAGACCTGCCGCTGGTGGTCGTGCTCAACGACAACGACATGTCGATCTCGCCGCCGGTGGGCGC
GCTGAATCGCTATCTGGCGCGGCTGATGAGCGGGCAGTTTTACGCGGCCACCAAGAAGGGCGTGGAAAAACTGCTGTCGG
TGGCGCCGCCGGTGCTCGAGTTTGCCAAGCGCTTCGAGGAACACACCAAGGGCATGTTCGTGCCGGCCACGATGTTCGAG
GAGTTCGGCTTTAACTACATCGGCCCGATCGACGGGCACGATCTCGAATCGCTGGTGCCGACGCTGCAGAACATCCGCCA
GCGCGCGCGTGAAGGCGGCGGGCCGCAGTTCCTCCACGTCGTCACCAAGAAGGGCCAGGGTTACAAGCTGGCCGAGGCCG
ATCCGATCCTTTATCACGGCCCGGGCAAGTTCAACCCGCAGGAAGGCATCAAGCCTTCGGGGCGCCCAGCCAAGGTGACG
TATACGCAGGTGTTTGGCCAGTGGCTGTGCGATATGGCGGCGGCCGACAAGCGCTTGGTGGGTATCACGCCGGCCATGCG
AGAAGGCTCCGGGATGGTGGAGTTCGAGCAGCGCTTTCCCGACCGCTATTACGACGTCGGCATCGCCGAGCAGCACGCCG
TCACCTTCGCCGGCGGTCTGGCATGCGAGGGGCTGAAGCCCGTCGTCGCCATCTATTCGACGTTCCTGCAGCGGGGCTAT
GACCAGTTGATCCACGATGTGGCGCTGCAGAACTTGCCGGTGGTATTCGCGCTGGACCGTGCGGGTCTGGTGGGCGCAGA
CGGCGCCACGCACGCGGGTGCCTACGACATTGCCTACCTGCGCTGCATCCCCAACATGATGGTGATGACGCCGGCCGACG
AGAACGAATGCCGCCAGCTTTTGAGTACCGCGTTCGCGCAGGACTGCCCGACAGCGGTGCGCTATCCGCGTGGTGCCGGT
ACGGGCGTGACGGTGCAGCCGACGCTGGAGCCGCTGCCTGTGGGCAAGGCCGAAGTGCGCCGCACGTCCACGGCTCCGGC
CGGCCAGCGCGTTGCGATTCTGGCGTTTGGTTCGATGGTTGCCCCTGCTTCGGCAGCAGCTGAGCGTTTGGATGCGACCG
TTGTCAACATGCGCTTCGTCAAGCCGCTCGACGTGGCCTGCGTGCTGGAAATGGCTCGCACGCACGATTTCGTGGTCACG
GCAGAGGAAGGTTGCGTGATGGGCGGCGCCGGCAGCGCCTGCCTGGAAGCGCTGGCTGCCGCCGGTGTTGCAACGCCGGT
ATTGCAGCTCGGCCTGCCCGACCGCTTTGTCGATCACGGTGATCACGCGGCGCTGCTGGCGCAGTGCGGGCTGGATGCCA
ATGGCATCCTCGCTTCCATCCGCGAGCGTTTTGCCGTGCAGCCGCGCGCTGCAGCCCCGCGCGTCGCCTGA

Upstream 100 bases:

>100_bases
GATTGGCCGAGATGGCCGACCTGATCGTGCGGCGTGGCCACTGAACAACATTGCATCGACGTTAGAAGTCTTTGCCAAAA
CGCCTGAGCGGCGGTCCCAC

Downstream 100 bases:

>100_bases
GGCACTTTGGCGCCGTGCCATAGGCAGAATCAATCACCCGCATTGCAGCCGCGGGTTTGAGTAGTTGACTGCAAAGGTAG
GAAATTTCTTTTACACTCCG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MTYELLNTIDDPADLRRLDRRQLGPLANELRAFVLDSVSQTGGHLSSNLGTVELTIALHYVFNTPEDRIVWDVGHQSYPH
KILTGRRDQMGSLRQLDGISGFPRRSESPYDTFGTAHSSTSISAALGMALGAKTKGEDRVAIAVIGDGAMSAGMAFEAMN
NAGVYKDLPLVVVLNDNDMSISPPVGALNRYLARLMSGQFYAATKKGVEKLLSVAPPVLEFAKRFEEHTKGMFVPATMFE
EFGFNYIGPIDGHDLESLVPTLQNIRQRAREGGGPQFLHVVTKKGQGYKLAEADPILYHGPGKFNPQEGIKPSGRPAKVT
YTQVFGQWLCDMAAADKRLVGITPAMREGSGMVEFEQRFPDRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGY
DQLIHDVALQNLPVVFALDRAGLVGADGATHAGAYDIAYLRCIPNMMVMTPADENECRQLLSTAFAQDCPTAVRYPRGAG
TGVTVQPTLEPLPVGKAEVRRTSTAPAGQRVAILAFGSMVAPASAAAERLDATVVNMRFVKPLDVACVLEMARTHDFVVT
AEEGCVMGGAGSACLEALAAAGVATPVLQLGLPDRFVDHGDHAALLAQCGLDANGILASIRERFAVQPRAAAPRVA

Sequences:

>Translated_636_residues
MTYELLNTIDDPADLRRLDRRQLGPLANELRAFVLDSVSQTGGHLSSNLGTVELTIALHYVFNTPEDRIVWDVGHQSYPH
KILTGRRDQMGSLRQLDGISGFPRRSESPYDTFGTAHSSTSISAALGMALGAKTKGEDRVAIAVIGDGAMSAGMAFEAMN
NAGVYKDLPLVVVLNDNDMSISPPVGALNRYLARLMSGQFYAATKKGVEKLLSVAPPVLEFAKRFEEHTKGMFVPATMFE
EFGFNYIGPIDGHDLESLVPTLQNIRQRAREGGGPQFLHVVTKKGQGYKLAEADPILYHGPGKFNPQEGIKPSGRPAKVT
YTQVFGQWLCDMAAADKRLVGITPAMREGSGMVEFEQRFPDRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGY
DQLIHDVALQNLPVVFALDRAGLVGADGATHAGAYDIAYLRCIPNMMVMTPADENECRQLLSTAFAQDCPTAVRYPRGAG
TGVTVQPTLEPLPVGKAEVRRTSTAPAGQRVAILAFGSMVAPASAAAERLDATVVNMRFVKPLDVACVLEMARTHDFVVT
AEEGCVMGGAGSACLEALAAAGVATPVLQLGLPDRFVDHGDHAALLAQCGLDANGILASIRERFAVQPRAAAPRVA
>Mature_635_residues
TYELLNTIDDPADLRRLDRRQLGPLANELRAFVLDSVSQTGGHLSSNLGTVELTIALHYVFNTPEDRIVWDVGHQSYPHK
ILTGRRDQMGSLRQLDGISGFPRRSESPYDTFGTAHSSTSISAALGMALGAKTKGEDRVAIAVIGDGAMSAGMAFEAMNN
AGVYKDLPLVVVLNDNDMSISPPVGALNRYLARLMSGQFYAATKKGVEKLLSVAPPVLEFAKRFEEHTKGMFVPATMFEE
FGFNYIGPIDGHDLESLVPTLQNIRQRAREGGGPQFLHVVTKKGQGYKLAEADPILYHGPGKFNPQEGIKPSGRPAKVTY
TQVFGQWLCDMAAADKRLVGITPAMREGSGMVEFEQRFPDRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGYD
QLIHDVALQNLPVVFALDRAGLVGADGATHAGAYDIAYLRCIPNMMVMTPADENECRQLLSTAFAQDCPTAVRYPRGAGT
GVTVQPTLEPLPVGKAEVRRTSTAPAGQRVAILAFGSMVAPASAAAERLDATVVNMRFVKPLDVACVLEMARTHDFVVTA
EEGCVMGGAGSACLEALAAAGVATPVLQLGLPDRFVDHGDHAALLAQCGLDANGILASIRERFAVQPRAAAPRVA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=652, Percent_Identity=25, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI4507521, Length=652, Percent_Identity=25, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI225637459, Length=533, Percent_Identity=25.891181988743, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI225637461, Length=533, Percent_Identity=25.891181988743, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI225637463, Length=533, Percent_Identity=25.891181988743, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI133778974, Length=664, Percent_Identity=23.9457831325301, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786622, Length=624, Percent_Identity=56.5705128205128, Blast_Score=735, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=626, Percent_Identity=24.2811501597444, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24666278, Length=611, Percent_Identity=24.0589198036007, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45551847, Length=605, Percent_Identity=24.7933884297521, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45550715, Length=605, Percent_Identity=24.7933884297521, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24645119, Length=518, Percent_Identity=25.4826254826255, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21358145, Length=279, Percent_Identity=26.5232974910394, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650940, Length=279, Percent_Identity=26.5232974910394, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_RALPJ (B2U930)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001899992.1
- GeneID:   6287217
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_2426
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68244; Mature: 68113

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYELLNTIDDPADLRRLDRRQLGPLANELRAFVLDSVSQTGGHLSSNLGTVELTIALHY
CCHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEEEEEEE
VFNTPEDRIVWDVGHQSYPHKILTGRRDQMGSLRQLDGISGFPRRSESPYDTFGTAHSST
EECCCCCCEEEECCCCCCCCHHHCCCCHHHCCHHHHCCCCCCCCCCCCCCHHCCCCCCCC
SISAALGMALGAKTKGEDRVAIAVIGDGAMSAGMAFEAMNNAGVYKDLPLVVVLNDNDMS
HHHHHHHHHHCCCCCCCCEEEEEEEECCCHHCCHHHHHHCCCCCEECCCEEEEECCCCCC
ISPPVGALNRYLARLMSGQFYAATKKGVEKLLSVAPPVLEFAKRFEEHTKGMFVPATMFE
CCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEHHHHHH
EFGFNYIGPIDGHDLESLVPTLQNIRQRAREGGGPQFLHVVTKKGQGYKLAEADPILYHG
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCCEEEEC
PGKFNPQEGIKPSGRPAKVTYTQVFGQWLCDMAAADKRLVGITPAMREGSGMVEFEQRFP
CCCCCHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCEEEECCCHHHCCCCCCHHHHHCC
DRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLPVVFALDR
HHHEECCCCCHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGLVGADGATHAGAYDIAYLRCIPNMMVMTPADENECRQLLSTAFAQDCPTAVRYPRGAG
CCEECCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHCCCCCCC
TGVTVQPTLEPLPVGKAEVRRTSTAPAGQRVAILAFGSMVAPASAAAERLDATVVNMRFV
CCEEECCCCCCCCCCHHHHHHCCCCCCCCEEEEEEECCHHCCHHHHHHHHHHHHEEEEEC
KPLDVACVLEMARTHDFVVTAEEGCVMGGAGSACLEALAAAGVATPVLQLGLPDRFVDHG
CCHHHHHHHHHHHCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
DHAALLAQCGLDANGILASIRERFAVQPRAAAPRVA
CHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TYELLNTIDDPADLRRLDRRQLGPLANELRAFVLDSVSQTGGHLSSNLGTVELTIALHY
CHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEEEEEEE
VFNTPEDRIVWDVGHQSYPHKILTGRRDQMGSLRQLDGISGFPRRSESPYDTFGTAHSST
EECCCCCCEEEECCCCCCCCHHHCCCCHHHCCHHHHCCCCCCCCCCCCCCHHCCCCCCCC
SISAALGMALGAKTKGEDRVAIAVIGDGAMSAGMAFEAMNNAGVYKDLPLVVVLNDNDMS
HHHHHHHHHHCCCCCCCCEEEEEEEECCCHHCCHHHHHHCCCCCEECCCEEEEECCCCCC
ISPPVGALNRYLARLMSGQFYAATKKGVEKLLSVAPPVLEFAKRFEEHTKGMFVPATMFE
CCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEHHHHHH
EFGFNYIGPIDGHDLESLVPTLQNIRQRAREGGGPQFLHVVTKKGQGYKLAEADPILYHG
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCCEEEEC
PGKFNPQEGIKPSGRPAKVTYTQVFGQWLCDMAAADKRLVGITPAMREGSGMVEFEQRFP
CCCCCHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCEEEECCCHHHCCCCCCHHHHHCC
DRYYDVGIAEQHAVTFAGGLACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLPVVFALDR
HHHEECCCCCHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGLVGADGATHAGAYDIAYLRCIPNMMVMTPADENECRQLLSTAFAQDCPTAVRYPRGAG
CCEECCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHCCCCCCC
TGVTVQPTLEPLPVGKAEVRRTSTAPAGQRVAILAFGSMVAPASAAAERLDATVVNMRFV
CCEEECCCCCCCCCCHHHHHHCCCCCCCCEEEEEEECCHHCCHHHHHHHHHHHHEEEEEC
KPLDVACVLEMARTHDFVVTAEEGCVMGGAGSACLEALAAAGVATPVLQLGLPDRFVDHG
CCHHHHHHHHHHHCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
DHAALLAQCGLDANGILASIRERFAVQPRAAAPRVA
CHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA