Click here to switch to the map view.

The map label for this gene is fbp

Identifier: 187929345

GI number: 187929345

Start: 2386592

End: 2387608

Strand: Direct

Name: fbp

Synonym: Rpic_2266

Alternate gene names: 187929345

Gene position: 2386592-2387608 (Clockwise)

Preceding gene: 187929344

Following gene: 187929347

Centisome position: 60.53

GC content: 63.13

Gene sequence:

>1017_bases
ATGAAGCGCATCAACCTCACCCGCTACCTGATCGAAGAGCAGCGCGAGCACAACACCATCCCGGCCGAGTTGCGTCTGCT
GCTCGAAGTCGTGGCCCGCGCCTGCAAGGCGATCTCGCACAGCGTCAACAAGGGGGCCCTTGCCGGCGTGCTCGGCTCGG
CCGGCACCGGCAACGTGCAAGGCGAAACCCAGCAGAAGCTGGATGTGATCGCCAACGAAGTCCTGCTCGAAGCCAACGAG
TACGGCGGCAACCTGGCCGCCATGGCCTCGGAAGAGATGGAATCGTTCTATGAGATTCCGCATCGCTATCCGAAGGGCGA
ATACCTGCTGCTGTTCGATCCGCTCGACGGCTCGTCCAACATCGACGTGAATGTGTCGATCGGCACCATCTTCTCGGTGC
TGCACATGCCCAAGGCCGGCGAAGCCGTGACGGAAGCCGATTTCATGCAGCCCGGCTCCAAGCAGGTCGCCGCCGGCTAT
GCCGTGTACGGCCCGCAGACCACGCTGGTGCTGACCGTCGGCAACGGCGTGCACATGTTCACGCTCGACCGTGAAGTCGG
CAGCTTCGTGCTGACCCACCGCGACGTGAAGATTCCGGTCGACACGAAGGAATTCGCCATCAACATGTCGAACATGCGCC
ACTGGGCCCCGCCCGTGCGCCGCTACATCGACGAATGCCTGGCCGGCACCGAAGGCCCGCGCGGCAAGGATTTCAACATG
CGCTGGATCGCCTCGATGGTGGCCGACGTGCATCGCATCCTCACGCGCGGCGGCATCTTCATGTACCCCTGGGACAAGCG
CGAGCCGGGCAAGGCCGGCAAGCTGCGCCTGATGTACGAAGCCAATCCGATGGCCTTCCTGGTGGAACAGGCCGGCGGCG
CGGCTACCAACGGCGAACAACGCATTCTGGATATCCAGCCCGAAAAGCTGCACCAGCGCGTGGCGGTGGTCCTGGGATCG
AAAAACGAGGTGGATCGTGTCACGCAATATCACCTCGAGGCCAAGCAAACGCCGTAA

Upstream 100 bases:

>100_bases
CATCCGAGCCTCTCGCGCGATGTGCGCGAGATCGTTGGCAAGGCGCTGGCCTGAATGTCACCGCTTGTATCGTAAAATCG
CGCCCGTCTCAGGAGAACCC

Downstream 100 bases:

>100_bases
CAACGTCATATAAGGCCGTTGTTCCAGCGGGCCTTGCAGAGCGACAAAAAGTTCTGTTAGAATCGTTGTTTCCGACGCCG
CTGTAGCTCAGTCGGTAGAG

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKRINLTRYLIEEQREHNTIPAELRLLLEVVARACKAISHSVNKGALAGVLGSAGTGNVQGETQQKLDVIANEVLLEANE
YGGNLAAMASEEMESFYEIPHRYPKGEYLLLFDPLDGSSNIDVNVSIGTIFSVLHMPKAGEAVTEADFMQPGSKQVAAGY
AVYGPQTTLVLTVGNGVHMFTLDREVGSFVLTHRDVKIPVDTKEFAINMSNMRHWAPPVRRYIDECLAGTEGPRGKDFNM
RWIASMVADVHRILTRGGIFMYPWDKREPGKAGKLRLMYEANPMAFLVEQAGGAATNGEQRILDIQPEKLHQRVAVVLGS
KNEVDRVTQYHLEAKQTP

Sequences:

>Translated_338_residues
MKRINLTRYLIEEQREHNTIPAELRLLLEVVARACKAISHSVNKGALAGVLGSAGTGNVQGETQQKLDVIANEVLLEANE
YGGNLAAMASEEMESFYEIPHRYPKGEYLLLFDPLDGSSNIDVNVSIGTIFSVLHMPKAGEAVTEADFMQPGSKQVAAGY
AVYGPQTTLVLTVGNGVHMFTLDREVGSFVLTHRDVKIPVDTKEFAINMSNMRHWAPPVRRYIDECLAGTEGPRGKDFNM
RWIASMVADVHRILTRGGIFMYPWDKREPGKAGKLRLMYEANPMAFLVEQAGGAATNGEQRILDIQPEKLHQRVAVVLGS
KNEVDRVTQYHLEAKQTP
>Mature_338_residues
MKRINLTRYLIEEQREHNTIPAELRLLLEVVARACKAISHSVNKGALAGVLGSAGTGNVQGETQQKLDVIANEVLLEANE
YGGNLAAMASEEMESFYEIPHRYPKGEYLLLFDPLDGSSNIDVNVSIGTIFSVLHMPKAGEAVTEADFMQPGSKQVAAGY
AVYGPQTTLVLTVGNGVHMFTLDREVGSFVLTHRDVKIPVDTKEFAINMSNMRHWAPPVRRYIDECLAGTEGPRGKDFNM
RWIASMVADVHRILTRGGIFMYPWDKREPGKAGKLRLMYEANPMAFLVEQAGGAATNGEQRILDIQPEKLHQRVAVVLGS
KNEVDRVTQYHLEAKQTP

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI189083692, Length=322, Percent_Identity=42.8571428571429, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI16579888, Length=322, Percent_Identity=42.8571428571429, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI22907028, Length=321, Percent_Identity=41.7445482866044, Blast_Score=235, Evalue=4e-62,
Organism=Escherichia coli, GI1790679, Length=330, Percent_Identity=45.4545454545455, Blast_Score=276, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17508131, Length=327, Percent_Identity=43.7308868501529, Blast_Score=270, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6323409, Length=329, Percent_Identity=40.1215805471125, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI45550998, Length=327, Percent_Identity=43.4250764525994, Blast_Score=254, Evalue=4e-68,
Organism=Drosophila melanogaster, GI19921562, Length=327, Percent_Identity=43.4250764525994, Blast_Score=254, Evalue=6e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_RALPJ (B2U8C4)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001899832.1
- ProteinModelPortal:   B2U8C4
- SMR:   B2U8C4
- GeneID:   6287673
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_2266
- HOGENOM:   HBG731261
- OMA:   AMSISPE
- ProtClustDB:   PRK09293
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 37433; Mature: 37433

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00124 FBPASE; PS00659 GLYCOSYL_HYDROL_F5

Important sites: BINDING 208-208 BINDING 274-274

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRINLTRYLIEEQREHNTIPAELRLLLEVVARACKAISHSVNKGALAGVLGSAGTGNVQ
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCC
GETQQKLDVIANEVLLEANEYGGNLAAMASEEMESFYEIPHRYPKGEYLLLFDPLDGSSN
CCHHHHHHHHHHHHHEECHHCCCCEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
IDVNVSIGTIFSVLHMPKAGEAVTEADFMQPGSKQVAAGYAVYGPQTTLVLTVGNGVHMF
EEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHCCCEEEECCCEEEEEEECCCEEEE
TLDREVGSFVLTHRDVKIPVDTKEFAINMSNMRHWAPPVRRYIDECLAGTEGPRGKDFNM
EECCCCCCEEEEECCEEECCCHHHHEEEHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
RWIASMVADVHRILTRGGIFMYPWDKREPGKAGKLRLMYEANPMAFLVEQAGGAATNGEQ
HHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCC
RILDIQPEKLHQRVAVVLGSKNEVDRVTQYHLEAKQTP
EEEECCHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKRINLTRYLIEEQREHNTIPAELRLLLEVVARACKAISHSVNKGALAGVLGSAGTGNVQ
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCC
GETQQKLDVIANEVLLEANEYGGNLAAMASEEMESFYEIPHRYPKGEYLLLFDPLDGSSN
CCHHHHHHHHHHHHHEECHHCCCCEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
IDVNVSIGTIFSVLHMPKAGEAVTEADFMQPGSKQVAAGYAVYGPQTTLVLTVGNGVHMF
EEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHCCCEEEECCCEEEEEEECCCEEEE
TLDREVGSFVLTHRDVKIPVDTKEFAINMSNMRHWAPPVRRYIDECLAGTEGPRGKDFNM
EECCCCCCEEEEECCEEECCCHHHHEEEHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
RWIASMVADVHRILTRGGIFMYPWDKREPGKAGKLRLMYEANPMAFLVEQAGGAATNGEQ
HHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCC
RILDIQPEKLHQRVAVVLGSKNEVDRVTQYHLEAKQTP
EEEECCHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA