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The map label for this gene is xdhA [H]

Identifier: 187929326

GI number: 187929326

Start: 2357530

End: 2359896

Strand: Direct

Name: xdhA [H]

Synonym: Rpic_2247

Alternate gene names: 187929326

Gene position: 2357530-2359896 (Clockwise)

Preceding gene: 187929325

Following gene: 187929327

Centisome position: 59.8

GC content: 64.81

Gene sequence:

>2367_bases
ATGAACAAGCAAACCGAAGCCTTCCTGCTGGCGGAAGCCGATATTGCTGCCGCCATGCCTGATCAGCGCGGTGCTGTGGT
GGGCATTTCGCGCCCGCACGAATCTGCGCACCTGCATGTTGCTGGCACCGCCACCTACACCGACGACATCCCCGAGCTGG
CCGGCACGCTGCACGCGGCGCTCGGCATGAGCACGCAGGCGCATGCGCGCATCGTCAACATGGATCTGGAACGCGTGAAG
GCTGCGCCGGGCGTCGTGGCGGTATTCACGTCAGCCGACATTCCGGGCACGAACGATTGCGGCCCGATCATCCATGACGA
TCCCATCCTGGCGATCGACACGGTGCACTTTATCGGCCAGCCGATGTTCATCGTGGTGGCCACGTCGCACGATGCGGCGC
GCCGTGCAGCGCGTCTGGGCAATATCGAATACGAAGTGCTGCCCCCGCTGCTGACGCCTGAAGAGGCACGCGCTGCCGGC
AAGTCCGTGCTGCCGCCGATGCACCTCAAGCGCGGCGAACCCGCCGAGCGCATCGCTGCCGCGCCGCACTCCGAAGCCGG
CAAGATGTCATTGGGCGGCCAGGAGCAGTTCTACCTCGAAAGCCAGATCTCGTACGCGGTGCCGAAGGAAGACAACGGCA
TGCACGTTTGGTGCTCGACGCAGCATCCGACCGAGATGCAGCACATGGTGTCGCACATGCTGGGCTGGCACGCCAACCAG
GTGCTGGTTGAATGCCGTCGCATGGGCGGCGGTTTCGGCGGGAAGGAGTCGCAATCGGGCCTGTTCGCCTGCTGCGCTTC
GCTGGCGGCATGGAAACTCGCCTGCCCCGTCAAGCTGCGTCCGGACCGCGACGACGACATGATGATCACCGGCAAGCGGC
ATGACTTCCGCTTTGCCTACGAAGCCGGCTACGACGACGATGGGCGCATCCAGGGCGTCAAGGTCGACATGACCTCGCGC
GCCGGTTTCTCGGCCGACCTGTCGGGCCCGGTGATGACGCGCGCCATCTGCCACTTCGACAACGCCTACTGGCTGCCTGA
GGTGGAAATCGACGGCTTCTGCGCGCGCACCAACACGCAGTCGAACACCGCGTTCCGAGGCTTTGGCGGCCCGCAGGGCG
CGTTTGCCATCGAGTACATCATGGACAACATCGCGCGCTCGGTCGGCAAGGATGCGCTCGACGTACGCCGCGCCAATCTG
TACGGCAAGGACAAGAACAACGTCACGCCATACGGCCAGACGGTGGAGGACAACGTCATCCATGAACTGCTGGACGAGCT
GGAAGCGACGTCCGACTATCGCGCCCGCCGAGAAGCGATTCGCGCGTTCAATGCGACCAGCCCGGTGCTCAAGCGTGGCC
TTGCGCTGACGCCGGTGAAGTTCGGCATCTCGTTCAACGTGAAGCACTTCAACCAGGCCGGCGCCCTTGTGCACGTCTAC
AACGACGGCTCGATCCTCGTGAACCACGGCGGCACCGAAATGGGCCAGGGCCTGAACACGAAGGTCGCGCAGGTCGTGGC
ACACGAACTGGGCGTGTCGTTCACGCGCATCCGCGTCACGGCGACCGACACCAGCAAGGTGGCAAACACCTCCGCCACGG
CGGCATCCACAGGCAGCGACCTGAACGGCAAGGCTGCACAAGACGCCGCACGCCAGATCCGCCAGCGCCTGATCGCGTTT
GCGGCCGAGCATTACGAAGCGCCCATCGAGACGGTGGCGATCGTGGGCGACCATCTGGAAATCGGTACGCGCCGCGTGCC
CTTCGACGAGCTGATCGGCAAAGCCTACGTTGCCCGCGTGCAGTTGTGGTCCGACGGCTTCTACGCCACGCCCAAGCTGC
ACTGGGATCAATCCAAGCTCAAGGGCCGCCCGTTCTACTACTACGCGTATGGCGCAGCCGTGTCGGAAGTGGTGGTCGAT
ACGCTGACCGGCGAATGGCGCCTGCTGCGCGCCGACGTGCTGCACGACGCCGGCCGCTCGATCAACCCGGCCATCGACAT
CGGCCAGGTGGAAGGCGCGTTCATCCAGGGCATGGGCTGGCTCACGACCGAAGAGCTGTGGTGGAACAAGAACGGCAAGC
TGATGACGCACGCGCCGTCCACCTACAAGATCCCGACGGTCAACGACTGCCCGCCGGACTTCCGCGTGAATCTGTTCAAC
AACGCCAACGTGGAAGACAGCATCCACCGCTCCAAGGCACTTGGCGAACCGCCGCTGCTGCTGCCGTTCTCGGTGTTCTT
CGCCATTCGCGATGCGGTGGCCGCCGTGGGCGACGGCCGGACGAATCCGCCGCTGAACGCACCGGCCACCAGCGAAGAAA
TCCTCAAGGCCGTGGATGCTATCCGCAGCGCCCCGCTGTCCGCCTGA

Upstream 100 bases:

>100_bases
TACCGCTTCTGGCTGGAAACCCGCACCGATGCGCCGCTCGGGCCCCAACAGATCAATGTGCGCGCAGTCGAATTGAATAC
CCTCACGGCAGCCTAAGAAC

Downstream 100 bases:

>100_bases
GTTCGGAGAACAGACCATGGACCACACGCAACTGCGTCCATTCCGCTTCGCCGACGTGCTCGCCACCGTGCAAGCGGCGC
AGCCGTGCGTGCTGGTCACG

Product: xanthine dehydrogenase, molybdopterin binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 788; Mature: 788

Protein sequence:

>788_residues
MNKQTEAFLLAEADIAAAMPDQRGAVVGISRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSTQAHARIVNMDLERVK
AAPGVVAVFTSADIPGTNDCGPIIHDDPILAIDTVHFIGQPMFIVVATSHDAARRAARLGNIEYEVLPPLLTPEEARAAG
KSVLPPMHLKRGEPAERIAAAPHSEAGKMSLGGQEQFYLESQISYAVPKEDNGMHVWCSTQHPTEMQHMVSHMLGWHANQ
VLVECRRMGGGFGGKESQSGLFACCASLAAWKLACPVKLRPDRDDDMMITGKRHDFRFAYEAGYDDDGRIQGVKVDMTSR
AGFSADLSGPVMTRAICHFDNAYWLPEVEIDGFCARTNTQSNTAFRGFGGPQGAFAIEYIMDNIARSVGKDALDVRRANL
YGKDKNNVTPYGQTVEDNVIHELLDELEATSDYRARREAIRAFNATSPVLKRGLALTPVKFGISFNVKHFNQAGALVHVY
NDGSILVNHGGTEMGQGLNTKVAQVVAHELGVSFTRIRVTATDTSKVANTSATAASTGSDLNGKAAQDAARQIRQRLIAF
AAEHYEAPIETVAIVGDHLEIGTRRVPFDELIGKAYVARVQLWSDGFYATPKLHWDQSKLKGRPFYYYAYGAAVSEVVVD
TLTGEWRLLRADVLHDAGRSINPAIDIGQVEGAFIQGMGWLTTEELWWNKNGKLMTHAPSTYKIPTVNDCPPDFRVNLFN
NANVEDSIHRSKALGEPPLLLPFSVFFAIRDAVAAVGDGRTNPPLNAPATSEEILKAVDAIRSAPLSA

Sequences:

>Translated_788_residues
MNKQTEAFLLAEADIAAAMPDQRGAVVGISRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSTQAHARIVNMDLERVK
AAPGVVAVFTSADIPGTNDCGPIIHDDPILAIDTVHFIGQPMFIVVATSHDAARRAARLGNIEYEVLPPLLTPEEARAAG
KSVLPPMHLKRGEPAERIAAAPHSEAGKMSLGGQEQFYLESQISYAVPKEDNGMHVWCSTQHPTEMQHMVSHMLGWHANQ
VLVECRRMGGGFGGKESQSGLFACCASLAAWKLACPVKLRPDRDDDMMITGKRHDFRFAYEAGYDDDGRIQGVKVDMTSR
AGFSADLSGPVMTRAICHFDNAYWLPEVEIDGFCARTNTQSNTAFRGFGGPQGAFAIEYIMDNIARSVGKDALDVRRANL
YGKDKNNVTPYGQTVEDNVIHELLDELEATSDYRARREAIRAFNATSPVLKRGLALTPVKFGISFNVKHFNQAGALVHVY
NDGSILVNHGGTEMGQGLNTKVAQVVAHELGVSFTRIRVTATDTSKVANTSATAASTGSDLNGKAAQDAARQIRQRLIAF
AAEHYEAPIETVAIVGDHLEIGTRRVPFDELIGKAYVARVQLWSDGFYATPKLHWDQSKLKGRPFYYYAYGAAVSEVVVD
TLTGEWRLLRADVLHDAGRSINPAIDIGQVEGAFIQGMGWLTTEELWWNKNGKLMTHAPSTYKIPTVNDCPPDFRVNLFN
NANVEDSIHRSKALGEPPLLLPFSVFFAIRDAVAAVGDGRTNPPLNAPATSEEILKAVDAIRSAPLSA
>Mature_788_residues
MNKQTEAFLLAEADIAAAMPDQRGAVVGISRPHESAHLHVAGTATYTDDIPELAGTLHAALGMSTQAHARIVNMDLERVK
AAPGVVAVFTSADIPGTNDCGPIIHDDPILAIDTVHFIGQPMFIVVATSHDAARRAARLGNIEYEVLPPLLTPEEARAAG
KSVLPPMHLKRGEPAERIAAAPHSEAGKMSLGGQEQFYLESQISYAVPKEDNGMHVWCSTQHPTEMQHMVSHMLGWHANQ
VLVECRRMGGGFGGKESQSGLFACCASLAAWKLACPVKLRPDRDDDMMITGKRHDFRFAYEAGYDDDGRIQGVKVDMTSR
AGFSADLSGPVMTRAICHFDNAYWLPEVEIDGFCARTNTQSNTAFRGFGGPQGAFAIEYIMDNIARSVGKDALDVRRANL
YGKDKNNVTPYGQTVEDNVIHELLDELEATSDYRARREAIRAFNATSPVLKRGLALTPVKFGISFNVKHFNQAGALVHVY
NDGSILVNHGGTEMGQGLNTKVAQVVAHELGVSFTRIRVTATDTSKVANTSATAASTGSDLNGKAAQDAARQIRQRLIAF
AAEHYEAPIETVAIVGDHLEIGTRRVPFDELIGKAYVARVQLWSDGFYATPKLHWDQSKLKGRPFYYYAYGAAVSEVVVD
TLTGEWRLLRADVLHDAGRSINPAIDIGQVEGAFIQGMGWLTTEELWWNKNGKLMTHAPSTYKIPTVNDCPPDFRVNLFN
NANVEDSIHRSKALGEPPLLLPFSVFFAIRDAVAAVGDGRTNPPLNAPATSEEILKAVDAIRSAPLSA

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=760, Percent_Identity=41.3157894736842, Blast_Score=578, Evalue=1e-165,
Organism=Homo sapiens, GI71773480, Length=752, Percent_Identity=38.1648936170213, Blast_Score=479, Evalue=1e-135,
Organism=Escherichia coli, GI1789230, Length=760, Percent_Identity=28.5526315789474, Blast_Score=208, Evalue=1e-54,
Organism=Escherichia coli, GI1789246, Length=779, Percent_Identity=26.1874197689345, Blast_Score=204, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17540638, Length=764, Percent_Identity=39.9214659685864, Blast_Score=509, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17539860, Length=720, Percent_Identity=34.8611111111111, Blast_Score=342, Evalue=6e-94,
Organism=Caenorhabditis elegans, GI32566215, Length=710, Percent_Identity=32.2535211267606, Blast_Score=341, Evalue=9e-94,
Organism=Drosophila melanogaster, GI17737937, Length=755, Percent_Identity=41.5894039735099, Blast_Score=582, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24647199, Length=764, Percent_Identity=32.7225130890052, Blast_Score=342, Evalue=7e-94,
Organism=Drosophila melanogaster, GI24647193, Length=782, Percent_Identity=31.2020460358056, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24647201, Length=757, Percent_Identity=31.3077939233818, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24647195, Length=765, Percent_Identity=29.281045751634, Blast_Score=295, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24647197, Length=765, Percent_Identity=29.281045751634, Blast_Score=294, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 85626; Mature: 85626

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQTEAFLLAEADIAAAMPDQRGAVVGISRPHESAHLHVAGTATYTDDIPELAGTLHAA
CCCCCCEEEEEECCHHHCCCCCCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
LGMSTQAHARIVNMDLERVKAAPGVVAVFTSADIPGTNDCGPIIHDDPILAIDTVHFIGQ
HCCCCHHHEEEEECCHHHHHCCCCEEEEEECCCCCCCCCCCCCEECCCEEEEEHHHHHCC
PMFIVVATSHDAARRAARLGNIEYEVLPPLLTPEEARAAGKSVLPPMHLKRGEPAERIAA
CEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCCCCCHHCCCCCCHHHHHC
APHSEAGKMSLGGQEQFYLESQISYAVPKEDNGMHVWCSTQHPTEMQHMVSHMLGWHANQ
CCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHH
VLVECRRMGGGFGGKESQSGLFACCASLAAWKLACPVKLRPDRDDDMMITGKRHDFRFAY
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEECCEEECCCCCCCEEEECCCCCEEEEE
EAGYDDDGRIQGVKVDMTSRAGFSADLSGPVMTRAICHFDNAYWLPEVEIDGFCARTNTQ
ECCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCEEEECCCC
SNTAFRGFGGPQGAFAIEYIMDNIARSVGKDALDVRRANLYGKDKNNVTPYGQTVEDNVI
CCCEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
HELLDELEATSDYRARREAIRAFNATSPVLKRGLALTPVKFGISFNVKHFNQAGALVHVY
HHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCEECEEEECEEEEEEEECCCCCEEEEE
NDGSILVNHGGTEMGQGLNTKVAQVVAHELGVSFTRIRVTATDTSKVANTSATAASTGSD
ECCEEEEECCCHHHCCCCCHHHHHHHHHHHCCEEEEEEEEECCCHHHCCCCCCCCCCCCC
LNGKAAQDAARQIRQRLIAFAAEHYEAPIETVAIVGDHLEIGTRRVPFDELIGKAYVARV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHEEEE
QLWSDGFYATPKLHWDQSKLKGRPFYYYAYGAAVSEVVVDTLTGEWRLLRADVLHDAGRS
EEECCCEEECCEEECCHHHHCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEHHHHHHCCCC
INPAIDIGQVEGAFIQGMGWLTTEELWWNKNGKLMTHAPSTYKIPTVNDCPPDFRVNLFN
CCCCEECCCCCCHHCCCCCCCEEHHHEECCCCCEEEECCCCEECCCCCCCCCCCEEEEEC
NANVEDSIHRSKALGEPPLLLPFSVFFAIRDAVAAVGDGRTNPPLNAPATSEEILKAVDA
CCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
IRSAPLSA
HHCCCCCC
>Mature Secondary Structure
MNKQTEAFLLAEADIAAAMPDQRGAVVGISRPHESAHLHVAGTATYTDDIPELAGTLHAA
CCCCCCEEEEEECCHHHCCCCCCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
LGMSTQAHARIVNMDLERVKAAPGVVAVFTSADIPGTNDCGPIIHDDPILAIDTVHFIGQ
HCCCCHHHEEEEECCHHHHHCCCCEEEEEECCCCCCCCCCCCCEECCCEEEEEHHHHHCC
PMFIVVATSHDAARRAARLGNIEYEVLPPLLTPEEARAAGKSVLPPMHLKRGEPAERIAA
CEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCCCCCHHCCCCCCHHHHHC
APHSEAGKMSLGGQEQFYLESQISYAVPKEDNGMHVWCSTQHPTEMQHMVSHMLGWHANQ
CCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHH
VLVECRRMGGGFGGKESQSGLFACCASLAAWKLACPVKLRPDRDDDMMITGKRHDFRFAY
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEECCEEECCCCCCCEEEECCCCCEEEEE
EAGYDDDGRIQGVKVDMTSRAGFSADLSGPVMTRAICHFDNAYWLPEVEIDGFCARTNTQ
ECCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCEEEECCCC
SNTAFRGFGGPQGAFAIEYIMDNIARSVGKDALDVRRANLYGKDKNNVTPYGQTVEDNVI
CCCEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
HELLDELEATSDYRARREAIRAFNATSPVLKRGLALTPVKFGISFNVKHFNQAGALVHVY
HHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCEECEEEECEEEEEEEECCCCCEEEEE
NDGSILVNHGGTEMGQGLNTKVAQVVAHELGVSFTRIRVTATDTSKVANTSATAASTGSD
ECCEEEEECCCHHHCCCCCHHHHHHHHHHHCCEEEEEEEEECCCHHHCCCCCCCCCCCCC
LNGKAAQDAARQIRQRLIAFAAEHYEAPIETVAIVGDHLEIGTRRVPFDELIGKAYVARV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHEEEE
QLWSDGFYATPKLHWDQSKLKGRPFYYYAYGAAVSEVVVDTLTGEWRLLRADVLHDAGRS
EEECCCEEECCEEECCHHHHCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEHHHHHHCCCC
INPAIDIGQVEGAFIQGMGWLTTEELWWNKNGKLMTHAPSTYKIPTVNDCPPDFRVNLFN
CCCCEECCCCCCHHCCCCCCCEEHHHEECCCCCEEEECCCCEECCCCCCCCCCCEEEEEC
NANVEDSIHRSKALGEPPLLLPFSVFFAIRDAVAAVGDGRTNPPLNAPATSEEILKAVDA
CCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
IRSAPLSA
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]