Click here to switch to the map view.

The map label for this gene is ilvC [H]

Identifier: 187929305

GI number: 187929305

Start: 2336947

End: 2337963

Strand: Reverse

Name: ilvC [H]

Synonym: Rpic_2226

Alternate gene names: 187929305

Gene position: 2337963-2336947 (Counterclockwise)

Preceding gene: 187929306

Following gene: 187929304

Centisome position: 59.3

GC content: 61.46

Gene sequence:

>1017_bases
ATGAAAGTGTTTTACGACAAGGACGCCGACCTCTCCCTGATCAAGGGCAAGAACGTCACCATCATCGGCTATGGCTCGCA
AGGTCACGCCCACGCCCTGAACCTGAACGACTCGGGCGTGAAGGTGACGGTCGGTCTGCGCAAGAACGGCGCGTCGTGGA
ACAAGGCCGTCAACGCCGGCCTGCAGGTCAAGGAAGTGGCCGAGGCAGTGAAGGAAGCCGACGTCGTCATGATCCTGTTG
CCGGACGAGCAGATTGCCGACGTGTACAAGAATGAAGTGCACGGCAACATCAAGCAAGGCGCCGCACTGGCATTCGCCCA
CGGCTTCAACGTGCACTACGGTGCCGTGATCCCGCGCGCAGACCTGGACGTCATCATGATCGCCCCGAAGGCCCCCGGCC
ACACCGTGCGCGGCACGTACACGCAAGGTGGCGGCGTGCCGCACCTGATCGCCGTGCACCAGGACAAGTCGGGCGCCGCA
CGTGATATCGCCCTGTCGTACGCCACTGCCAACGGCGGCGGCCGCGCCGGCATCATCGAGACGAACTTCCGCGAAGAAAC
CGAAACCGACCTGTTCGGCGAACAGGCCGTGCTGTGCGGCGGTACCGTCGAACTGATCAAGGCAGGTTTCGAGACGCTGG
TGGAAGCCGGTTACGCGCCGGAAATGGCGTACTTCGAGTGCCTGCACGAGCTGAAGCTGATCGTCGACCTGATCTATGAA
GGCGGCATCGCCAACATGAACTACTCGATCTCGAACAACGCCGAATACGGCGAATACGTCACCGGCCCGCGCGTTGTGAC
GGAAGAGACCAAGAAGGCCATGAAGCAATGCCTGAAGGACATCCAGACTGGCGAATACGCCAAGAGCTTCCTGTTGGAGT
ACAAGGCAGGCCAGCCGACGCTGATCTCGCGCCGCCGCCTGACCGAAGAGCACCAGATCGAGCAAGTTGGCGCCAAGCTG
CGCGCGATGATGCCGTGGATCGCCAAGAATAAGCTGGTCGACCAGACGAAGAACTGA

Upstream 100 bases:

>100_bases
CGGCGAGCGCATTCTGAAGGTTTGAACCGGCGCGTGCACCAGCGTGTAACAGCGGCCGGACCCCATCGATATTGAAGTAT
TTGAAAATTAGGACATCAAC

Downstream 100 bases:

>100_bases
TCGAGCGCATCTTGTGCGAGAAAGCCAGCCTTCGGGCTGGCTTTTTTTATGCTGTTTCCAGGGAGGCAAACAGTGTTTCA
AGTGATGGCGCGGCCCCGTG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKVFYDKDADLSLIKGKNVTIIGYGSQGHAHALNLNDSGVKVTVGLRKNGASWNKAVNAGLQVKEVAEAVKEADVVMILL
PDEQIADVYKNEVHGNIKQGAALAFAHGFNVHYGAVIPRADLDVIMIAPKAPGHTVRGTYTQGGGVPHLIAVHQDKSGAA
RDIALSYATANGGGRAGIIETNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
GGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLKDIQTGEYAKSFLLEYKAGQPTLISRRRLTEEHQIEQVGAKL
RAMMPWIAKNKLVDQTKN

Sequences:

>Translated_338_residues
MKVFYDKDADLSLIKGKNVTIIGYGSQGHAHALNLNDSGVKVTVGLRKNGASWNKAVNAGLQVKEVAEAVKEADVVMILL
PDEQIADVYKNEVHGNIKQGAALAFAHGFNVHYGAVIPRADLDVIMIAPKAPGHTVRGTYTQGGGVPHLIAVHQDKSGAA
RDIALSYATANGGGRAGIIETNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
GGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLKDIQTGEYAKSFLLEYKAGQPTLISRRRLTEEHQIEQVGAKL
RAMMPWIAKNKLVDQTKN
>Mature_338_residues
MKVFYDKDADLSLIKGKNVTIIGYGSQGHAHALNLNDSGVKVTVGLRKNGASWNKAVNAGLQVKEVAEAVKEADVVMILL
PDEQIADVYKNEVHGNIKQGAALAFAHGFNVHYGAVIPRADLDVIMIAPKAPGHTVRGTYTQGGGVPHLIAVHQDKSGAA
RDIALSYATANGGGRAGIIETNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
GGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLKDIQTGEYAKSFLLEYKAGQPTLISRRRLTEEHQIEQVGAKL
RAMMPWIAKNKLVDQTKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=315, Percent_Identity=38.4126984126984, Blast_Score=177, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6323387, Length=339, Percent_Identity=31.858407079646, Blast_Score=128, Evalue=2e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36720; Mature: 36720

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFYDKDADLSLIKGKNVTIIGYGSQGHAHALNLNDSGVKVTVGLRKNGASWNKAVNAG
CCEEECCCCCEEEECCCCEEEEEECCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHCC
LQVKEVAEAVKEADVVMILLPDEQIADVYKNEVHGNIKQGAALAFAHGFNVHYGAVIPRA
CCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCHHCCEEEEEEECCCEEECEEECCC
DLDVIMIAPKAPGHTVRGTYTQGGGVPHLIAVHQDKSGAARDIALSYATANGGGRAGIIE
CCCEEEECCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCEEEEE
TNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
CCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLKDIQTGEYAKSFLLEYKAGQPT
CCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
LISRRRLTEEHQIEQVGAKLRAMMPWIAKNKLVDQTKN
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVFYDKDADLSLIKGKNVTIIGYGSQGHAHALNLNDSGVKVTVGLRKNGASWNKAVNAG
CCEEECCCCCEEEECCCCEEEEEECCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHCC
LQVKEVAEAVKEADVVMILLPDEQIADVYKNEVHGNIKQGAALAFAHGFNVHYGAVIPRA
CCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCHHCCEEEEEEECCCEEECEEECCC
DLDVIMIAPKAPGHTVRGTYTQGGGVPHLIAVHQDKSGAARDIALSYATANGGGRAGIIE
CCCEEEECCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCEEEEE
TNFREETETDLFGEQAVLCGGTVELIKAGFETLVEAGYAPEMAYFECLHELKLIVDLIYE
CCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEYGEYVTGPRVVTEETKKAMKQCLKDIQTGEYAKSFLLEYKAGQPT
CCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
LISRRRLTEEHQIEQVGAKLRAMMPWIAKNKLVDQTKN
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA