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The map label for this gene is nuoD [H]

Identifier: 187929290

GI number: 187929290

Start: 2321853

End: 2323106

Strand: Reverse

Name: nuoD [H]

Synonym: Rpic_2211

Alternate gene names: 187929290

Gene position: 2323106-2321853 (Counterclockwise)

Preceding gene: 187929291

Following gene: 187929289

Centisome position: 58.92

GC content: 59.09

Gene sequence:

>1254_bases
ATGGCAGATATCAAGAACTACACCCTGAACTTCGGTCCGCAACACCCGGCAGCACACGGCGTGCTGCGCCTGGTGCTTGA
GTTGGACGGTGAAGTCATTCAACGTGCCGACCCGCACATCGGGCTGCTGCACCGCGCGACTGAAAAGCTCGCTGAGCAGA
AGACGTGGATTCAGAGCGTGCCGTACATGGACCGCCTCGACTACGTGTCGATGATGGTCAACGAGCACGCCTACGTGATG
GCAATCGAGCGGCTGCTGGGTCTCGAAGTGCCGCTGCGTGCGCAGTACATCCGCGTCATGTTCGACGAAATCACGCGGAT
CATGAACCACCTGATGTGGATTGGTTCGCACGCGCTGGACGTTGGCGCCATGGCGGTGTTCCTGTACGCCTTCCGCGAGC
GTGAAGACCTGTTCGATATGTATGAGGCGGTGTCGGGCGCGCGCATGCACGCCGCCTACTACCGTCCGGGCGGCGTCTAT
CGCGACCTGCCTGACACGATGCCGCAATACAAGGCATCCAAGGTGCGCAACGAGAAGGCGCTGGCCGCCCTGAACCAAAC
GCGTTCGGGTTCGCTGCTTGATTTCATTGAAGACTTCACCAACCGCTTCCCGAAGTACGTTGACGAGTACGAGACGCTGC
TGACCGACAACCGGATTTGGAAGCAACGTCTCGTTGGTATCGGCGTGGTGAGCCCGGAGCGTGCGCTTAACAAAGGTTTC
TCCGGTGCGATGCTGCGTGGTTCGGGCATCGAATGGGATGTGCGCAAGAAGCAGCCGTATGAGGTGTACGACCGCATCGA
TTTCGACATCCCGGTTGGCGTGAACGGCGATTGCTACGACCGTTATCTGGTGCGCGTGGAAGAAATGCGCCAGAGCAATC
GCATCATTCGCCAGTGCATCGAGTGGCTGCGCAAAAACCCGGGCCCTGTGATCACCGATAACCACAAGGTGGCGCCGCCG
TCGCGTGTGGACATGAAGACCAACATGGAAGAGCTGATTCACCACTTCAAGCTCTTCACGGAAGGTATGCATGTGCCCGA
AGGCGAGGCGTATGCCGCTGTTGAGCACCCGAAGGGCGAGTTCGGCATCTATGCAATCTCCGACGGCGCCAACAAGCCGT
ACCGCTTGAAGATCCGCGCACCGGGCTTCGTTCATCTGGCCGCGCTTGACGAAATGGCGAAGGGTCACATGATTGCCGAT
GCGGTGACGATCATCGGTACGCAAGACATCGTGTTTGGCGAGATCGATCGCTGA

Upstream 100 bases:

>100_bases
GTGGTCTACCAGCCGGTCACCATCGAGCCGCGCGAGATTACGCCGCGTGTGATCCGTGAGGATCAATACGGTGGTCTGAA
GCACTGAAGGGCGCCCGAAC

Downstream 100 bases:

>100_bases
ACCCGCAGGAAACAACGGTTTGACGCGCAGGCAAGCGCGGCTGTGAAACGAGGACGCACGCCGGGGTAAGGTAGTTAGGT
AACACGCCCCGCGTCCCGCA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQSVPYMDRLDYVSMMVNEHAYVM
AIERLLGLEVPLRAQYIRVMFDEITRIMNHLMWIGSHALDVGAMAVFLYAFREREDLFDMYEAVSGARMHAAYYRPGGVY
RDLPDTMPQYKASKVRNEKALAALNQTRSGSLLDFIEDFTNRFPKYVDEYETLLTDNRIWKQRLVGIGVVSPERALNKGF
SGAMLRGSGIEWDVRKKQPYEVYDRIDFDIPVGVNGDCYDRYLVRVEEMRQSNRIIRQCIEWLRKNPGPVITDNHKVAPP
SRVDMKTNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGEFGIYAISDGANKPYRLKIRAPGFVHLAALDEMAKGHMIAD
AVTIIGTQDIVFGEIDR

Sequences:

>Translated_417_residues
MADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQSVPYMDRLDYVSMMVNEHAYVM
AIERLLGLEVPLRAQYIRVMFDEITRIMNHLMWIGSHALDVGAMAVFLYAFREREDLFDMYEAVSGARMHAAYYRPGGVY
RDLPDTMPQYKASKVRNEKALAALNQTRSGSLLDFIEDFTNRFPKYVDEYETLLTDNRIWKQRLVGIGVVSPERALNKGF
SGAMLRGSGIEWDVRKKQPYEVYDRIDFDIPVGVNGDCYDRYLVRVEEMRQSNRIIRQCIEWLRKNPGPVITDNHKVAPP
SRVDMKTNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGEFGIYAISDGANKPYRLKIRAPGFVHLAALDEMAKGHMIAD
AVTIIGTQDIVFGEIDR
>Mature_416_residues
ADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQSVPYMDRLDYVSMMVNEHAYVMA
IERLLGLEVPLRAQYIRVMFDEITRIMNHLMWIGSHALDVGAMAVFLYAFREREDLFDMYEAVSGARMHAAYYRPGGVYR
DLPDTMPQYKASKVRNEKALAALNQTRSGSLLDFIEDFTNRFPKYVDEYETLLTDNRIWKQRLVGIGVVSPERALNKGFS
GAMLRGSGIEWDVRKKQPYEVYDRIDFDIPVGVNGDCYDRYLVRVEEMRQSNRIIRQCIEWLRKNPGPVITDNHKVAPPS
RVDMKTNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGEFGIYAISDGANKPYRLKIRAPGFVHLAALDEMAKGHMIADA
VTIIGTQDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=61.1111111111111, Blast_Score=527, Evalue=1e-150,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=60.2941176470588, Blast_Score=511, Evalue=1e-145,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=38.0487804878049, Blast_Score=301, Evalue=4e-83,
Organism=Escherichia coli, GI1789076, Length=422, Percent_Identity=27.0142180094787, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=25.9803921568627, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17555284, Length=416, Percent_Identity=58.8942307692308, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17568379, Length=416, Percent_Identity=57.6923076923077, Blast_Score=493, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24638644, Length=415, Percent_Identity=60.7228915662651, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI221459469, Length=412, Percent_Identity=54.3689320388349, Blast_Score=464, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47776; Mature: 47644

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQSV
CCCCCCCEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMVNEHAYVMAIERLLGLEVPLRAQYIRVMFDEITRIMNHLMWIGSHALD
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VGAMAVFLYAFREREDLFDMYEAVSGARMHAAYYRPGGVYRDLPDTMPQYKASKVRNEKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHH
LAALNQTRSGSLLDFIEDFTNRFPKYVDEYETLLTDNRIWKQRLVGIGVVSPERALNKGF
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHCCC
SGAMLRGSGIEWDVRKKQPYEVYDRIDFDIPVGVNGDCYDRYLVRVEEMRQSNRIIRQCI
CCCEEECCCCCEECCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EWLRKNPGPVITDNHKVAPPSRVDMKTNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCCCCHHCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGIYAISDGANKPYRLKIRAPGFVHLAALDEMAKGHMIADAVTIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCEEEHHHHHHHHCCCCHHHHHHEECCCCEEECCCCC
>Mature Secondary Structure 
ADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQSV
CCCCCCEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMVNEHAYVMAIERLLGLEVPLRAQYIRVMFDEITRIMNHLMWIGSHALD
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VGAMAVFLYAFREREDLFDMYEAVSGARMHAAYYRPGGVYRDLPDTMPQYKASKVRNEKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHH
LAALNQTRSGSLLDFIEDFTNRFPKYVDEYETLLTDNRIWKQRLVGIGVVSPERALNKGF
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHCCC
SGAMLRGSGIEWDVRKKQPYEVYDRIDFDIPVGVNGDCYDRYLVRVEEMRQSNRIIRQCI
CCCEEECCCCCEECCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EWLRKNPGPVITDNHKVAPPSRVDMKTNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCCCCHHCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGIYAISDGANKPYRLKIRAPGFVHLAALDEMAKGHMIADAVTIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCEEEHHHHHHHHCCCCHHHHHHEECCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA