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The map label for this gene is nuoF2 [H]

Identifier: 187929288

GI number: 187929288

Start: 2319938

End: 2321233

Strand: Reverse

Name: nuoF2 [H]

Synonym: Rpic_2209

Alternate gene names: 187929288

Gene position: 2321233-2319938 (Counterclockwise)

Preceding gene: 187929289

Following gene: 187929287

Centisome position: 58.88

GC content: 61.88

Gene sequence:

>1296_bases
ATGACCTCTCTGCACGATCGACATATCCAGCCGTTGATTCTTGCCGGCCTGAACGGCGACAACTGGCACCTCGAAGATTA
CGTCAAGCGTGGCGGCTATCAACAGCTCAAGCGCATCCTCACCGAGAAGATCACCCCAGAGCAGGTCATTGCCGACGTGA
AGGCGTCGGGCCTGCGTGGCCGGGGCGGTGCGGGCTTCCCGACCGGTCTGAAGTGGAGTTTCATGCCGCGCCAGTTCCCG
GGCCAGAAGTATCTAGTCTGCAACACGGACGAAGGCGAGCCGGGGACGTTCAAGGATCGCGACATCATCCGTTACAACCC
GCACGCGCTGATCGAAGGCATGGCCATCGGCGGCTACGCGATGGGCATCACCGTTGGCTACAACTACATCCACGGCGAGA
TCTGGAACGAATACAAGATCTTCGAGCAGGCCCTAGAAGAGGCGCGCGCTGCAGGCTTCCTCGGTGACAACATCCTGGGG
TCCGGCTTCAACTTCCAGCTGCATGCGCACCATGGCTATGGCGCGTACATCTGCGGCGAAGAGACCGCGCTGCTCGAGTC
GCTGGAAGGCAAGAAGGGCCAGCCGCGCTTCAAGCCGCCGTTCCCGGCAAGCTTTGGCCTGTACGGCAAGCCGACCACCA
TCAACAACACCGAAACCTTTGCCGCGGTGCCGTTCCTGCTCGCGATCGGTCCGGACAACTACCTGAAGATGGGCAAGCCG
AACAACGGTGGCTCGAAGATCTTCTCTGTGTCCGGCGACGTGGAGCGTCCGGGCAACTACGAGATTCCGCTCGGCACGCC
GTTCTCCAAGCTGCTGGAGCTGGCCGGTGGCATGCGCGGTGGCAAGAAACTCAAGGCGGTCATCCCGGGTGGTTCGTCGG
CGCCCGTGGTGCCGGCCGACCTGATGATGGCCTCCGACATGGACTACGACTCGATCGCCAAGGCTGGTTCGATGCTGGGC
TCGGGTGCAGTGATCGTGATGGACGAAACGCGTTGCATGGTGAAGTCGCTGCTGCGCCTGTCGTACTTCTATTTCGAAGA
GTCGTGCGGCCAGTGCACACCGTGCCGCGAAGGCACGGGCTGGCTGTACCGCGTGGTCGACCGCATCGAGCACGGCAAGG
GCCGCCAGGAAGACCTGGACCTGCTGAACAACGTGGCCGAAAACATCATGGGCCGGACCATCTGCGCACTCGGCGATGCC
GCTGCGATGCCGGTCCGCGGCATGCTCAAGCACTACTGGGATGAGTTCGCGTATCACGTCGAACACAAGCAGTGCATGGT
GCCCACCTACATTTAA

Upstream 100 bases:

>100_bases
CAACAACACCCACATGTGCAGCTTCATGAGCAACGAGAAGCTCGACGCGCTGATCGCCGACCTCCAGTCGAAGGCGCCGA
CCAACGGAGCAGGCAAGTAA

Downstream 100 bases:

>100_bases
GCGTGGCAGAACATGGTTGAAATCGAAATCGATGGCAAGAAGGTCGAGGTTGCCGAAGGCAGCCTGGTGATGGAGGCGGC
TCGCCAGACGGGCACCTACA

Product: NADH-quinone oxidoreductase subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MTSLHDRHIQPLILAGLNGDNWHLEDYVKRGGYQQLKRILTEKITPEQVIADVKASGLRGRGGAGFPTGLKWSFMPRQFP
GQKYLVCNTDEGEPGTFKDRDIIRYNPHALIEGMAIGGYAMGITVGYNYIHGEIWNEYKIFEQALEEARAAGFLGDNILG
SGFNFQLHAHHGYGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETFAAVPFLLAIGPDNYLKMGKP
NNGGSKIFSVSGDVERPGNYEIPLGTPFSKLLELAGGMRGGKKLKAVIPGGSSAPVVPADLMMASDMDYDSIAKAGSMLG
SGAVIVMDETRCMVKSLLRLSYFYFEESCGQCTPCREGTGWLYRVVDRIEHGKGRQEDLDLLNNVAENIMGRTICALGDA
AAMPVRGMLKHYWDEFAYHVEHKQCMVPTYI

Sequences:

>Translated_431_residues
MTSLHDRHIQPLILAGLNGDNWHLEDYVKRGGYQQLKRILTEKITPEQVIADVKASGLRGRGGAGFPTGLKWSFMPRQFP
GQKYLVCNTDEGEPGTFKDRDIIRYNPHALIEGMAIGGYAMGITVGYNYIHGEIWNEYKIFEQALEEARAAGFLGDNILG
SGFNFQLHAHHGYGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETFAAVPFLLAIGPDNYLKMGKP
NNGGSKIFSVSGDVERPGNYEIPLGTPFSKLLELAGGMRGGKKLKAVIPGGSSAPVVPADLMMASDMDYDSIAKAGSMLG
SGAVIVMDETRCMVKSLLRLSYFYFEESCGQCTPCREGTGWLYRVVDRIEHGKGRQEDLDLLNNVAENIMGRTICALGDA
AAMPVRGMLKHYWDEFAYHVEHKQCMVPTYI
>Mature_430_residues
TSLHDRHIQPLILAGLNGDNWHLEDYVKRGGYQQLKRILTEKITPEQVIADVKASGLRGRGGAGFPTGLKWSFMPRQFPG
QKYLVCNTDEGEPGTFKDRDIIRYNPHALIEGMAIGGYAMGITVGYNYIHGEIWNEYKIFEQALEEARAAGFLGDNILGS
GFNFQLHAHHGYGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETFAAVPFLLAIGPDNYLKMGKPN
NGGSKIFSVSGDVERPGNYEIPLGTPFSKLLELAGGMRGGKKLKAVIPGGSSAPVVPADLMMASDMDYDSIAKAGSMLGS
GAVIVMDETRCMVKSLLRLSYFYFEESCGQCTPCREGTGWLYRVVDRIEHGKGRQEDLDLLNNVAENIMGRTICALGDAA
AMPVRGMLKHYWDEFAYHVEHKQCMVPTYI

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=425, Percent_Identity=46.5882352941176, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI260656005, Length=425, Percent_Identity=46.5882352941176, Blast_Score=388, Evalue=1e-108,
Organism=Escherichia coli, GI1788620, Length=402, Percent_Identity=42.0398009950249, Blast_Score=329, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17531727, Length=431, Percent_Identity=47.0997679814385, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI19920794, Length=424, Percent_Identity=45.2830188679245, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI45550452, Length=415, Percent_Identity=45.0602409638554, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24653819, Length=398, Percent_Identity=37.1859296482412, Blast_Score=258, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24653817, Length=398, Percent_Identity=33.4170854271357, Blast_Score=220, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47412; Mature: 47281

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLHDRHIQPLILAGLNGDNWHLEDYVKRGGYQQLKRILTEKITPEQVIADVKASGLRG
CCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCC
RGGAGFPTGLKWSFMPRQFPGQKYLVCNTDEGEPGTFKDRDIIRYNPHALIEGMAIGGYA
CCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCHHHHEEEEECCEE
MGITVGYNYIHGEIWNEYKIFEQALEEARAAGFLGDNILGSGFNFQLHAHHGYGAYICGE
EEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEEECC
ETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETFAAVPFLLAIGPDNYLKMGKP
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCEECCCC
NNGGSKIFSVSGDVERPGNYEIPLGTPFSKLLELAGGMRGGKKLKAVIPGGSSAPVVPAD
CCCCCEEEEECCCCCCCCCEECCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHH
LMMASDMDYDSIAKAGSMLGSGAVIVMDETRCMVKSLLRLSYFYFEESCGQCTPCREGTG
HHHCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
WLYRVVDRIEHGKGRQEDLDLLNNVAENIMGRTICALGDAAAMPVRGMLKHYWDEFAYHV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHH
EHKQCMVPTYI
CCCEEECCCCC
>Mature Secondary Structure 
TSLHDRHIQPLILAGLNGDNWHLEDYVKRGGYQQLKRILTEKITPEQVIADVKASGLRG
CCCCCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCC
RGGAGFPTGLKWSFMPRQFPGQKYLVCNTDEGEPGTFKDRDIIRYNPHALIEGMAIGGYA
CCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCHHHHEEEEECCEE
MGITVGYNYIHGEIWNEYKIFEQALEEARAAGFLGDNILGSGFNFQLHAHHGYGAYICGE
EEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEEECC
ETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETFAAVPFLLAIGPDNYLKMGKP
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCEECCCC
NNGGSKIFSVSGDVERPGNYEIPLGTPFSKLLELAGGMRGGKKLKAVIPGGSSAPVVPAD
CCCCCEEEEECCCCCCCCCEECCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHH
LMMASDMDYDSIAKAGSMLGSGAVIVMDETRCMVKSLLRLSYFYFEESCGQCTPCREGTG
HHHCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
WLYRVVDRIEHGKGRQEDLDLLNNVAENIMGRTICALGDAAAMPVRGMLKHYWDEFAYHV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHH
EHKQCMVPTYI
CCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]