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The map label for this gene is nuoL [H]

Identifier: 187929282

GI number: 187929282

Start: 2312791

End: 2314851

Strand: Reverse

Name: nuoL [H]

Synonym: Rpic_2203

Alternate gene names: 187929282

Gene position: 2314851-2312791 (Counterclockwise)

Preceding gene: 187929283

Following gene: 187929281

Centisome position: 58.71

GC content: 59.78

Gene sequence:

>2061_bases
ATGGCTACCACGCTCAATCCCAACCTGCTGCTGGCGATCCCGCTCGCGCCGCTGGCCGGCGCGGCGATCGCCGGGCTGTT
CGGCACCAAGTTCTTTGGCGAGAAGATCGGCCGCACGGCATCCCACAGCGTCACCATCCTCGGTGTCGCGATCGCCTTCA
TTCTGTCAGCGCTGACGCTGTCCGACGTCATCAATGGCGCCGGTTACAACGGCACCGTCTATGGATGGATGACGGTTGGC
TCGCTGAAGATGGAAATCGGCTTCCTCATCGATTCGCTCACGGCGATGATGATGTGCGTGGTGACCTTCGTCTCGCTGAT
GGTGCATATCTACACCATTGGCTACATGGCGGAAGACGACGGCTATAACCGTTTCTTCGCGTACATCTCGCTGTTCACCT
TTTCGATGTTGATGCTCGTGATGAGCAACAATTTCCTGCAGCTGTTCTTCGGCTGGGAGGCGGTGGGTTTGGTGTCGTAC
CTGCTGATCGGCTTCTGGTTCAAGCGTCCGACGGCCATCTACGCCAACATGAAAGCGTTCCTGGTCAACCGCGTGGGTGA
CTTCGGCTTCGTGCTCGGTATCGGCCTGTTGCTGGCGTACAGCGGTAGCCTGAGCTACGCCGATGTGTTCGCTGCCCGCG
ACAACCTGGCCACGATTGGCTTCCCGGGTACTGACTGGCACATGCTGACGGTCGCTTGTATCTGCTTGTTTATCGGCGCG
ATGGGTAAATCGGCGCAGTTCCCGCTGCACGTGTGGCTGCCGGACTCGATGGAAGGCCCGACCCCGATCTCCGCACTGAT
TCACGCGGCCACCATGGTGACCGCCGGTATCTTCATGGTCGCGCGCATGTCGCCGCTGTTCGAACTGTCGGACACCGCGC
TGTCGTTCGTGCTGATCATCGGCGCCATTACCGCGCTGTTCATGGGCTTCCTGGGCATCATCCAGACCGATATCAAGCGT
GTGGTGGCGTACTCGACGCTGTCTCAACTCGGTTACATGACCGTCGCGCTGGGCGCGTCGGCTTACCAAGTCGCGGTGTT
CCACCTGATGACGCACGCGTTCTTCAAGGCGCTGCTGTTCCTCGGCGCGGGCTCGGTCATCATCGGCATGCACCACGATC
AGGACATGCGCAACATGGGCGGCTTGCGCAAGTACATGCCGGTCACGTGGCTGACATCGCTGGTGGGGTCGCTGGCGCTG
ATTGGCACGCCGTTCTTTGCAGGTTTCTACTCGAAGGACTCGATCATCGAAGCGGTGCGCGAATCGCACCTGCCGGGCGC
CAGCTTTGCCTACTGGGCTGTGCTGGCTGGCGTGTTCGTGACCGCGTTCTACTCGTTCCGCATGTATTTCCTGGTGTTCC
ACGGTGAAGAGCGTTTCGGCAAGGAACACTCGCATCACGAAGGCAATCACGTGGACGAAGAGGAAACCGCTGACCATCAC
CACGGCCTGGCTCCGGGTCAGAAGCCGCACGAGTCGCCGTGGGTGGTGACGGTCCCCCTGGTGCTGCTCGCGATTCCTTC
GGTCATCATCGGTGCGATGGCAATCCAGCCGATGCTGTTCGGCGAGTTCTTCAAGCACGGTGTTGTGTTCTCGGAGGTCA
TCTTCAATGCTGACAACCACGAAGCAATGAAGGTGCTGGCCGAAGACTTCCACGGTTGGGTCGAGATGGCGCTGCACGGC
TTTACGTCGGCACCGTTCATCCTGCTGCTGGCGGGTGTGGTGCTGTCGTGGTTCTTCTACTTGAAGCGCCCGGATATTCC
GGCAGCAATCGCCAAGCGGTTCTCCGGCGTCTACAAGCTGCTGGACAACAAGTACTACATGGACAAGATCAACGAGATCG
TCTTTGCCAACGGTGCGGTCAAGTTTGGCCGTGGCCTGTGGAAGGGCGGCGATCAAGGTGTGATCGACGGTGTTGTCGTC
AACGGCAGCGCGCGTCTGGTGGGCTGGTTCGCGACCGTCGTGCGCCTGCTCCAGTCCGGCTTCATCTATGACTATGCGTT
CGCGATGATCATCGGCACGGTTGGGCTGCTGACGTATTTCGTGTTTCTGGCAGGCAAATAA

Upstream 100 bases:

>100_bases
CCATCCTGGTGGTGCTGTTCCGTAATCTGGACACCATCAACGTCGACGATCTGGACAGCCTCAAGGGCTGACCTCCGCAT
CCACCTAAAAGAAGCGTTCC

Downstream 100 bases:

>100_bases
GGGATTACAAAAATGGTTCTGTCTTTTGCGATCTGGCTGCCGATCTTCTTCGGCGTGCTGGTGCTGGCCTCGGGCTCAGA
CCGCAATCCCGGTTATGTCC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 686; Mature: 685

Protein sequence:

>686_residues
MATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGEKIGRTASHSVTILGVAIAFILSALTLSDVINGAGYNGTVYGWMTVG
SLKMEIGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMAEDDGYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSY
LLIGFWFKRPTAIYANMKAFLVNRVGDFGFVLGIGLLLAYSGSLSYADVFAARDNLATIGFPGTDWHMLTVACICLFIGA
MGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALSFVLIIGAITALFMGFLGIIQTDIKR
VVAYSTLSQLGYMTVALGASAYQVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPVTWLTSLVGSLAL
IGTPFFAGFYSKDSIIEAVRESHLPGASFAYWAVLAGVFVTAFYSFRMYFLVFHGEERFGKEHSHHEGNHVDEEETADHH
HGLAPGQKPHESPWVVTVPLVLLAIPSVIIGAMAIQPMLFGEFFKHGVVFSEVIFNADNHEAMKVLAEDFHGWVEMALHG
FTSAPFILLLAGVVLSWFFYLKRPDIPAAIAKRFSGVYKLLDNKYYMDKINEIVFANGAVKFGRGLWKGGDQGVIDGVVV
NGSARLVGWFATVVRLLQSGFIYDYAFAMIIGTVGLLTYFVFLAGK

Sequences:

>Translated_686_residues
MATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGEKIGRTASHSVTILGVAIAFILSALTLSDVINGAGYNGTVYGWMTVG
SLKMEIGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMAEDDGYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSY
LLIGFWFKRPTAIYANMKAFLVNRVGDFGFVLGIGLLLAYSGSLSYADVFAARDNLATIGFPGTDWHMLTVACICLFIGA
MGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALSFVLIIGAITALFMGFLGIIQTDIKR
VVAYSTLSQLGYMTVALGASAYQVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPVTWLTSLVGSLAL
IGTPFFAGFYSKDSIIEAVRESHLPGASFAYWAVLAGVFVTAFYSFRMYFLVFHGEERFGKEHSHHEGNHVDEEETADHH
HGLAPGQKPHESPWVVTVPLVLLAIPSVIIGAMAIQPMLFGEFFKHGVVFSEVIFNADNHEAMKVLAEDFHGWVEMALHG
FTSAPFILLLAGVVLSWFFYLKRPDIPAAIAKRFSGVYKLLDNKYYMDKINEIVFANGAVKFGRGLWKGGDQGVIDGVVV
NGSARLVGWFATVVRLLQSGFIYDYAFAMIIGTVGLLTYFVFLAGK
>Mature_685_residues
ATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGEKIGRTASHSVTILGVAIAFILSALTLSDVINGAGYNGTVYGWMTVGS
LKMEIGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMAEDDGYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYL
LIGFWFKRPTAIYANMKAFLVNRVGDFGFVLGIGLLLAYSGSLSYADVFAARDNLATIGFPGTDWHMLTVACICLFIGAM
GKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALSFVLIIGAITALFMGFLGIIQTDIKRV
VAYSTLSQLGYMTVALGASAYQVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLRKYMPVTWLTSLVGSLALI
GTPFFAGFYSKDSIIEAVRESHLPGASFAYWAVLAGVFVTAFYSFRMYFLVFHGEERFGKEHSHHEGNHVDEEETADHHH
GLAPGQKPHESPWVVTVPLVLLAIPSVIIGAMAIQPMLFGEFFKHGVVFSEVIFNADNHEAMKVLAEDFHGWVEMALHGF
TSAPFILLLAGVVLSWFFYLKRPDIPAAIAKRFSGVYKLLDNKYYMDKINEIVFANGAVKFGRGLWKGGDQGVIDGVVVN
GSARLVGWFATVVRLLQSGFIYDYAFAMIIGTVGLLTYFVFLAGK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=396, Percent_Identity=40.9090909090909, Blast_Score=298, Evalue=1e-80,
Organism=Escherichia coli, GI1788614, Length=452, Percent_Identity=44.0265486725664, Blast_Score=351, Evalue=8e-98,
Organism=Escherichia coli, GI1788829, Length=339, Percent_Identity=30.6784660766962, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1788831, Length=354, Percent_Identity=29.0960451977401, Blast_Score=126, Evalue=5e-30,
Organism=Escherichia coli, GI1788827, Length=418, Percent_Identity=29.9043062200957, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI145693160, Length=366, Percent_Identity=26.775956284153, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788613, Length=272, Percent_Identity=28.3088235294118, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI2367154, Length=136, Percent_Identity=33.8235294117647, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 75014; Mature: 74883

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGEKIGRTASHSVTILGVAIAFILSALTL
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
SDVINGAGYNGTVYGWMTVGSLKMEIGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMAEDD
HHHHCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
GYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWFKRPTAIYANMKAF
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LVNRVGDFGFVLGIGLLLAYSGSLSYADVFAARDNLATIGFPGTDWHMLTVACICLFIGA
HHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHC
MGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALSFVLII
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
GAITALFMGFLGIIQTDIKRVVAYSTLSQLGYMTVALGASAYQVAVFHLMTHAFFKALLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGAGSVIIGMHHDQDMRNMGGLRKYMPVTWLTSLVGSLALIGTPFFAGFYSKDSIIEAVR
HCCCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHH
ESHLPGASFAYWAVLAGVFVTAFYSFRMYFLVFHGEERFGKEHSHHEGNHVDEEETADHH
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHCCCCCCCCCCCCCCHHCCHHH
HGLAPGQKPHESPWVVTVPLVLLAIPSVIIGAMAIQPMLFGEFFKHGVVFSEVIFNADNH
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCH
EAMKVLAEDFHGWVEMALHGFTSAPFILLLAGVVLSWFFYLKRPDIPAAIAKRFSGVYKL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LDNKYYMDKINEIVFANGAVKFGRGLWKGGDQGVIDGVVVNGSARLVGWFATVVRLLQSG
HCCCHHHHHHHHHHEECCCHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCC
FIYDYAFAMIIGTVGLLTYFVFLAGK
CHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATTLNPNLLLAIPLAPLAGAAIAGLFGTKFFGEKIGRTASHSVTILGVAIAFILSALTL
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
SDVINGAGYNGTVYGWMTVGSLKMEIGFLIDSLTAMMMCVVTFVSLMVHIYTIGYMAEDD
HHHHCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
GYNRFFAYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWFKRPTAIYANMKAF
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LVNRVGDFGFVLGIGLLLAYSGSLSYADVFAARDNLATIGFPGTDWHMLTVACICLFIGA
HHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHC
MGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDTALSFVLII
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
GAITALFMGFLGIIQTDIKRVVAYSTLSQLGYMTVALGASAYQVAVFHLMTHAFFKALLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGAGSVIIGMHHDQDMRNMGGLRKYMPVTWLTSLVGSLALIGTPFFAGFYSKDSIIEAVR
HCCCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHH
ESHLPGASFAYWAVLAGVFVTAFYSFRMYFLVFHGEERFGKEHSHHEGNHVDEEETADHH
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHCCCCCCCCCCCCCCHHCCHHH
HGLAPGQKPHESPWVVTVPLVLLAIPSVIIGAMAIQPMLFGEFFKHGVVFSEVIFNADNH
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCH
EAMKVLAEDFHGWVEMALHGFTSAPFILLLAGVVLSWFFYLKRPDIPAAIAKRFSGVYKL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LDNKYYMDKINEIVFANGAVKFGRGLWKGGDQGVIDGVVVNGSARLVGWFATVVRLLQSG
HCCCHHHHHHHHHHEECCCHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCC
FIYDYAFAMIIGTVGLLTYFVFLAGK
CHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]