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The map label for this gene is nuoN [H]

Identifier: 187929280

GI number: 187929280

Start: 2309820

End: 2311295

Strand: Reverse

Name: nuoN [H]

Synonym: Rpic_2201

Alternate gene names: 187929280

Gene position: 2311295-2309820 (Counterclockwise)

Preceding gene: 187929281

Following gene: 187929279

Centisome position: 58.62

GC content: 60.43

Gene sequence:

>1476_bases
ATGCAATCGTCCTCCTCTATTGCGGCTTTTGCCCCAATCGTTTTTCTCGCGCTGGGCATTGGTGCCGTCAACTGGATTGA
CTTGGCACGCGGCCAGAAACGAAGCAGCGTGGCCTATCCGGTTTCGTTGGTGATTACGCTGGTGCTGGCGGTGTGGTTTG
CGCTGAACGCTGCGAACGGTGAGACGCACTACGTCTTCGGCAACATGGCGGTGATCGATCCGATGGCCAACGTGCTGGCG
TCGTTCTGTGCGCTGACGCTGTTTGCCACGCTGGTGTACACGCGCCGCTATCTGGCCGACCGTGACATGTATGCGGGTGA
GTTCTACATGTTCGCCCTGTTCACACTGGGCGGCCAGGTGGTGATGATCACCGGCAACAACTTCCTCGTGCTCTATCTGG
GCCTTGAATTGTTGTCGCTGGCGTCGTACACACTGGTTGCGCTGCGTCGCCGTTCGAACGTGTCGTCCGAATCGGCCATG
AAGTATTTCATCCTGGGTGCGCTGGCCTCGGGCCTGCTGCTGTATGGCATGTCGATGCTGTATGGCGCCACCGGCTCGCT
GGAACTGGGCAAGGTGTTTGACGCCATCAAGAACGGCGAGATCAACAAGACGATTCTCGTGTTCGGCGTAGTGTTCATCG
TTGCCGGGCTCGGCTTCAAGCTGGGTGTGGCACCGTTCCACATGTGGGTGCCGGACGTGTACCAAGGCTCGCCGACGGCC
GTGACGTTGCTGATTGCCGGCGCCCCGAAGGTTGCTGCGTTCGCGATGACGCTGCGCATTCTGGTTGAAGGCCTGCTGCC
GCTGGCGTTCGACTGGCAGAACATGCTGATTGTGCTGGCCGTTGTGTCGCTGGCCATCGGCAATATCACCGGCGTTGTGC
AAACCAACTTCAAGCGTCTGCTGGGCTACTCGACCGTCTCGCATATGGGCTTCCTGCTGCTGGGCCTCGTGTCGGGCGTC
AGTTCCGGCAAGCCGGATCTGACGGCACAGGCCTACAGTGCGTCGATGTTCTACGCCATCACCTACGTACTGACTGCGCT
GGGCGCGTTCGGCATCATCCTGCTGCTGGCGCGCAAAGGCTACGAGGCGGAAGAGATTGCCGACCTCAAGGGCTTGTCGA
AGAAGAGCCCGTGGTTTGCCCTGCTGATGCTGTTCATCATGATGTCGCTGGCAGGCCTGCCGCCGACGGTTGGCTTCTAC
GCCAAGCTGTCGGTCCTGGGTGCGGTGGTCGATGCCGGTATGCCGTGGCTGGCCGTTGTGGCGGTGCTGTTTTCGTTGGT
GGGTGCGTTCTACTACCTGCGTGTCATCAAGGTCATGTACTTCGATGTGCCGGCTGACGAAGGCCCCGTTGAAGCCTCCT
TCGGCCTGCGCTCGCTGCTGTCGGTCAATGGCTTGCTGGTGCTGTTGCTGGGTATCTTCCCGGCTGGCCTGATGGCCGTG
TGCTATCAGGCCATCCGCCTGACGCTGGCTTCGTAA

Upstream 100 bases:

>100_bases
GGCCTGTATCCGAAGCCCTTCACCGATGTCATGCATGCGTCCGTGGTCAATCTGCTGACCCACGTGGCTCAGTCGAAGCT
GTAAGCAGCGAGAAGAAACT

Downstream 100 bases:

>100_bases
AACGCGGAGCGCCATGAACACATCGACGGGCGGTCTATTTGTCATCGTGTTGGCACTGATTTGTGCCAACCTGCCGTTCG
TCAATCAACGCGTGCTGGCG

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MQSSSSIAAFAPIVFLALGIGAVNWIDLARGQKRSSVAYPVSLVITLVLAVWFALNAANGETHYVFGNMAVIDPMANVLA
SFCALTLFATLVYTRRYLADRDMYAGEFYMFALFTLGGQVVMITGNNFLVLYLGLELLSLASYTLVALRRRSNVSSESAM
KYFILGALASGLLLYGMSMLYGATGSLELGKVFDAIKNGEINKTILVFGVVFIVAGLGFKLGVAPFHMWVPDVYQGSPTA
VTLLIAGAPKVAAFAMTLRILVEGLLPLAFDWQNMLIVLAVVSLAIGNITGVVQTNFKRLLGYSTVSHMGFLLLGLVSGV
SSGKPDLTAQAYSASMFYAITYVLTALGAFGIILLLARKGYEAEEIADLKGLSKKSPWFALLMLFIMMSLAGLPPTVGFY
AKLSVLGAVVDAGMPWLAVVAVLFSLVGAFYYLRVIKVMYFDVPADEGPVEASFGLRSLLSVNGLLVLLLGIFPAGLMAV
CYQAIRLTLAS

Sequences:

>Translated_491_residues
MQSSSSIAAFAPIVFLALGIGAVNWIDLARGQKRSSVAYPVSLVITLVLAVWFALNAANGETHYVFGNMAVIDPMANVLA
SFCALTLFATLVYTRRYLADRDMYAGEFYMFALFTLGGQVVMITGNNFLVLYLGLELLSLASYTLVALRRRSNVSSESAM
KYFILGALASGLLLYGMSMLYGATGSLELGKVFDAIKNGEINKTILVFGVVFIVAGLGFKLGVAPFHMWVPDVYQGSPTA
VTLLIAGAPKVAAFAMTLRILVEGLLPLAFDWQNMLIVLAVVSLAIGNITGVVQTNFKRLLGYSTVSHMGFLLLGLVSGV
SSGKPDLTAQAYSASMFYAITYVLTALGAFGIILLLARKGYEAEEIADLKGLSKKSPWFALLMLFIMMSLAGLPPTVGFY
AKLSVLGAVVDAGMPWLAVVAVLFSLVGAFYYLRVIKVMYFDVPADEGPVEASFGLRSLLSVNGLLVLLLGIFPAGLMAV
CYQAIRLTLAS
>Mature_491_residues
MQSSSSIAAFAPIVFLALGIGAVNWIDLARGQKRSSVAYPVSLVITLVLAVWFALNAANGETHYVFGNMAVIDPMANVLA
SFCALTLFATLVYTRRYLADRDMYAGEFYMFALFTLGGQVVMITGNNFLVLYLGLELLSLASYTLVALRRRSNVSSESAM
KYFILGALASGLLLYGMSMLYGATGSLELGKVFDAIKNGEINKTILVFGVVFIVAGLGFKLGVAPFHMWVPDVYQGSPTA
VTLLIAGAPKVAAFAMTLRILVEGLLPLAFDWQNMLIVLAVVSLAIGNITGVVQTNFKRLLGYSTVSHMGFLLLGLVSGV
SSGKPDLTAQAYSASMFYAITYVLTALGAFGIILLLARKGYEAEEIADLKGLSKKSPWFALLMLFIMMSLAGLPPTVGFY
AKLSVLGAVVDAGMPWLAVVAVLFSLVGAFYYLRVIKVMYFDVPADEGPVEASFGLRSLLSVNGLLVLLLGIFPAGLMAV
CYQAIRLTLAS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=323, Percent_Identity=24.7678018575851, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI145693160, Length=425, Percent_Identity=34.1176470588235, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1788831, Length=382, Percent_Identity=24.869109947644, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788614, Length=377, Percent_Identity=25.1989389920424, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788827, Length=326, Percent_Identity=25.7668711656442, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1788613, Length=437, Percent_Identity=24.4851258581236, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI2367154, Length=255, Percent_Identity=27.843137254902, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 52539; Mature: 52539

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSSSSIAAFAPIVFLALGIGAVNWIDLARGQKRSSVAYPVSLVITLVLAVWFALNAANG
CCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
ETHYVFGNMAVIDPMANVLASFCALTLFATLVYTRRYLADRDMYAGEFYMFALFTLGGQV
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEE
VMITGNNFLVLYLGLELLSLASYTLVALRRRSNVSSESAMKYFILGALASGLLLYGMSML
EEEECCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YGATGSLELGKVFDAIKNGEINKTILVFGVVFIVAGLGFKLGVAPFHMWVPDVYQGSPTA
HCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHCCCHHHHCCCCCCCCCCCE
VTLLIAGAPKVAAFAMTLRILVEGLLPLAFDWQNMLIVLAVVSLAIGNITGVVQTNFKRL
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
LGYSTVSHMGFLLLGLVSGVSSGKPDLTAQAYSASMFYAITYVLTALGAFGIILLLARKG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YEAEEIADLKGLSKKSPWFALLMLFIMMSLAGLPPTVGFYAKLSVLGAVVDAGMPWLAVV
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
AVLFSLVGAFYYLRVIKVMYFDVPADEGPVEASFGLRSLLSVNGLLVLLLGIFPAGLMAV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CYQAIRLTLAS
HHHHHHHHHCC
>Mature Secondary Structure
MQSSSSIAAFAPIVFLALGIGAVNWIDLARGQKRSSVAYPVSLVITLVLAVWFALNAANG
CCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
ETHYVFGNMAVIDPMANVLASFCALTLFATLVYTRRYLADRDMYAGEFYMFALFTLGGQV
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEE
VMITGNNFLVLYLGLELLSLASYTLVALRRRSNVSSESAMKYFILGALASGLLLYGMSML
EEEECCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YGATGSLELGKVFDAIKNGEINKTILVFGVVFIVAGLGFKLGVAPFHMWVPDVYQGSPTA
HCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHCCCHHHHCCCCCCCCCCCE
VTLLIAGAPKVAAFAMTLRILVEGLLPLAFDWQNMLIVLAVVSLAIGNITGVVQTNFKRL
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
LGYSTVSHMGFLLLGLVSGVSSGKPDLTAQAYSASMFYAITYVLTALGAFGIILLLARKG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YEAEEIADLKGLSKKSPWFALLMLFIMMSLAGLPPTVGFYAKLSVLGAVVDAGMPWLAVV
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
AVLFSLVGAFYYLRVIKVMYFDVPADEGPVEASFGLRSLLSVNGLLVLLLGIFPAGLMAV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CYQAIRLTLAS
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA