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The map label for this gene is paaH [H]

Identifier: 187929247

GI number: 187929247

Start: 2281097

End: 2282605

Strand: Direct

Name: paaH [H]

Synonym: Rpic_2168

Alternate gene names: 187929247

Gene position: 2281097-2282605 (Clockwise)

Preceding gene: 187929245

Following gene: 187929248

Centisome position: 57.86

GC content: 66.34

Gene sequence:

>1509_bases
ATGCAGACTATCGGGATTGTGGGCACCGGCGCCATGGGGCGCGGCATTGCACAGATCGCGGCCCAGGCAGGTTTGCGCGT
CAAACTGTTCGACGCCAATCCGCAAGCCGTGGAAGCGGCGCGCACGGCGCTGGCCGACACGCTGGCCAAGCTGGCCGCCA
AGGGCAAGCTCACAGCAGATGAAGCTGACGCCACAATCGCCCGCCTGATTCCGGCCGGCGCCCTCTCCGACCTGGCCGAC
TGCGATCTGGTGGTCGAGGCCATCGTCGAGAAGCTCGACGTCAAGCGCGACCTCTTCCGTCAACTCGAAGACATCGTCCG
CGCGGATGCCATCCTGGCGTCGAATACCTCATCGCTGTCGATCACCGCGATTGCCGCGACATGCAAACACCCGGAGCGCG
TCGCTGGTTTCCACTTCTTCAACCCGGTTCCGCTGATGAAGGTGGTCGAAGTCATCGACGGCCTGCGCAGCGCACCCGCC
ACCGGTGACGCCCTGGCCGCACTGGCCAAGCGCATGGGTCACACCGCCGTGCGCTGCATCGACATGCCGGGCTTCATCGT
CAACCACGCCGGGCGCGGCATGAATACCGAAGGGCTGCGCGTGGCGCAGGAAAGTGTGGCGGCCTATGCGGACATCGACG
CCATCATGCGCGAGCAGGCCGGCTTCCGCATGGGGCCGTTCGAGTTGATGGACCTCACAGGGCTGGATGTTTCGCACCCG
GTGATGGAATCGGTCTACCGCCAGTTCTACGACGAGCCGCGCTATCGTCCGTCGCAGATCACGGCGTTGCGCTTTGCCGG
CAGCATTCTGGGCCGCAAGACGGGCGAAGGGTTCTACCGCTATCCGGAAGGACAGAAACAGGTGCCGGCTGAAGCGCCCG
CCCCGTCCGCGCGCCCGTCTTCAGTGTGGATCAGCCGCGCGCATGACGCCGGCCACGCCGCAGCGCAGCGCCTGTTGCTC
GATCTGGGCATTACGCCCGAAGGCGGTTCCAAACCGTCCGCCGACGCATTGATCATCGTCACGCCGCGCGGGCTGGATGC
CACGGCCTGCGTGACCGCCGAGGGGCTCGACGCACGCCGCACCGTGGCGCTCGACACGCTCTATCCGTTTGCCGCCACCA
AGCGCCGCACGCTGATGACCACACCCGCCACCGACGCAGCCTACCGCGATGCCGCACACGGCTTGCTCGCGTCCGACGGC
GTACCGGTCACGGTGATCCGCGATTCGGGTGGCTTTGTCGCGCAGCGCATCGTCGCATGCATCGTCAACATCGCGTGCGA
TATCGCACAGCAGCGCATTGCTACGCCCACCGACATCGACCTCGCCGTCACGCTGGGGCTCGGTTATCCCAAAGGGCCGC
TGGCACTCGGCGATACGCTGGGCACGAACGCCATCCTGGAAGTCCTGCAGAATCTCTACGCGCTTTATGGCGATCCGCGC
TATCGCCCGAGCCCGTGGCTGCTGCGCCGTGCCCGTCTGGGCATGTCGCTGCTCACGCCTGATGCCTGA

Upstream 100 bases:

>100_bases
TCCTTGGTAATTTGGCCGTCCGTTATGGTCGGTGCGGATGCCAGAAATCGCACGCTCGTGCTATTTTAGCCAGACTTCTT
TCGATCGCAGCGGATTTCAT

Downstream 100 bases:

>100_bases
CGCCTGATTGCCGCTTACCCTGACGAGGCCGCCATGACCGCGCAACTGCTCTCCAAACGCATCGGTTCGACGCTGGTGCT
GACGCTGTCCAACCCTGACG

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MQTIGIVGTGAMGRGIAQIAAQAGLRVKLFDANPQAVEAARTALADTLAKLAAKGKLTADEADATIARLIPAGALSDLAD
CDLVVEAIVEKLDVKRDLFRQLEDIVRADAILASNTSSLSITAIAATCKHPERVAGFHFFNPVPLMKVVEVIDGLRSAPA
TGDALAALAKRMGHTAVRCIDMPGFIVNHAGRGMNTEGLRVAQESVAAYADIDAIMREQAGFRMGPFELMDLTGLDVSHP
VMESVYRQFYDEPRYRPSQITALRFAGSILGRKTGEGFYRYPEGQKQVPAEAPAPSARPSSVWISRAHDAGHAAAQRLLL
DLGITPEGGSKPSADALIIVTPRGLDATACVTAEGLDARRTVALDTLYPFAATKRRTLMTTPATDAAYRDAAHGLLASDG
VPVTVIRDSGGFVAQRIVACIVNIACDIAQQRIATPTDIDLAVTLGLGYPKGPLALGDTLGTNAILEVLQNLYALYGDPR
YRPSPWLLRRARLGMSLLTPDA

Sequences:

>Translated_502_residues
MQTIGIVGTGAMGRGIAQIAAQAGLRVKLFDANPQAVEAARTALADTLAKLAAKGKLTADEADATIARLIPAGALSDLAD
CDLVVEAIVEKLDVKRDLFRQLEDIVRADAILASNTSSLSITAIAATCKHPERVAGFHFFNPVPLMKVVEVIDGLRSAPA
TGDALAALAKRMGHTAVRCIDMPGFIVNHAGRGMNTEGLRVAQESVAAYADIDAIMREQAGFRMGPFELMDLTGLDVSHP
VMESVYRQFYDEPRYRPSQITALRFAGSILGRKTGEGFYRYPEGQKQVPAEAPAPSARPSSVWISRAHDAGHAAAQRLLL
DLGITPEGGSKPSADALIIVTPRGLDATACVTAEGLDARRTVALDTLYPFAATKRRTLMTTPATDAAYRDAAHGLLASDG
VPVTVIRDSGGFVAQRIVACIVNIACDIAQQRIATPTDIDLAVTLGLGYPKGPLALGDTLGTNAILEVLQNLYALYGDPR
YRPSPWLLRRARLGMSLLTPDA
>Mature_502_residues
MQTIGIVGTGAMGRGIAQIAAQAGLRVKLFDANPQAVEAARTALADTLAKLAAKGKLTADEADATIARLIPAGALSDLAD
CDLVVEAIVEKLDVKRDLFRQLEDIVRADAILASNTSSLSITAIAATCKHPERVAGFHFFNPVPLMKVVEVIDGLRSAPA
TGDALAALAKRMGHTAVRCIDMPGFIVNHAGRGMNTEGLRVAQESVAAYADIDAIMREQAGFRMGPFELMDLTGLDVSHP
VMESVYRQFYDEPRYRPSQITALRFAGSILGRKTGEGFYRYPEGQKQVPAEAPAPSARPSSVWISRAHDAGHAAAQRLLL
DLGITPEGGSKPSADALIIVTPRGLDATACVTAEGLDARRTVALDTLYPFAATKRRTLMTTPATDAAYRDAAHGLLASDG
VPVTVIRDSGGFVAQRIVACIVNIACDIAQQRIATPTDIDLAVTLGLGYPKGPLALGDTLGTNAILEVLQNLYALYGDPR
YRPSPWLLRRARLGMSLLTPDA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=38.4083044982699, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=37.2549019607843, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI20127408, Length=290, Percent_Identity=32.4137931034483, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI261878539, Length=295, Percent_Identity=29.8305084745763, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI68989263, Length=295, Percent_Identity=29.8305084745763, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI115430219, Length=241, Percent_Identity=29.045643153527, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1787661, Length=495, Percent_Identity=39.7979797979798, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1790281, Length=275, Percent_Identity=34.5454545454545, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI1788682, Length=270, Percent_Identity=34.4444444444444, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=39.4463667820069, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=37.5, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17563036, Length=291, Percent_Identity=32.6460481099656, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25144276, Length=317, Percent_Identity=33.7539432176656, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17508951, Length=289, Percent_Identity=34.2560553633218, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17508953, Length=289, Percent_Identity=34.2560553633218, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17558304, Length=298, Percent_Identity=33.2214765100671, Blast_Score=138, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI71985923, Length=289, Percent_Identity=29.757785467128, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=28.3687943262411, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24583077, Length=290, Percent_Identity=30.6896551724138, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24583079, Length=290, Percent_Identity=30.6896551724138, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI19921000, Length=290, Percent_Identity=30.6896551724138, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI45549573, Length=241, Percent_Identity=30.7053941908714, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI20129993, Length=227, Percent_Identity=25.5506607929515, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 53284; Mature: 53284

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIGIVGTGAMGRGIAQIAAQAGLRVKLFDANPQAVEAARTALADTLAKLAAKGKLTAD
CCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
EADATIARLIPAGALSDLADCDLVVEAIVEKLDVKRDLFRQLEDIVRADAILASNTSSLS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
ITAIAATCKHPERVAGFHFFNPVPLMKVVEVIDGLRSAPATGDALAALAKRMGHTAVRCI
EEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEE
DMPGFIVNHAGRGMNTEGLRVAQESVAAYADIDAIMREQAGFRMGPFELMDLTGLDVSHP
CCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCCCCCHH
VMESVYRQFYDEPRYRPSQITALRFAGSILGRKTGEGFYRYPEGQKQVPAEAPAPSARPS
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCC
SVWISRAHDAGHAAAQRLLLDLGITPEGGSKPSADALIIVTPRGLDATACVTAEGLDARR
CCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCC
TVALDTLYPFAATKRRTLMTTPATDAAYRDAAHGLLASDGVPVTVIRDSGGFVAQRIVAC
EEEHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCEECCCCCEEEEECCCCHHHHHHHHH
IVNIACDIAQQRIATPTDIDLAVTLGLGYPKGPLALGDTLGTNAILEVLQNLYALYGDPR
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
YRPSPWLLRRARLGMSLLTPDA
CCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQTIGIVGTGAMGRGIAQIAAQAGLRVKLFDANPQAVEAARTALADTLAKLAAKGKLTAD
CCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
EADATIARLIPAGALSDLADCDLVVEAIVEKLDVKRDLFRQLEDIVRADAILASNTSSLS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
ITAIAATCKHPERVAGFHFFNPVPLMKVVEVIDGLRSAPATGDALAALAKRMGHTAVRCI
EEEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEE
DMPGFIVNHAGRGMNTEGLRVAQESVAAYADIDAIMREQAGFRMGPFELMDLTGLDVSHP
CCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCCCCCHH
VMESVYRQFYDEPRYRPSQITALRFAGSILGRKTGEGFYRYPEGQKQVPAEAPAPSARPS
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCC
SVWISRAHDAGHAAAQRLLLDLGITPEGGSKPSADALIIVTPRGLDATACVTAEGLDARR
CCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCC
TVALDTLYPFAATKRRTLMTTPATDAAYRDAAHGLLASDGVPVTVIRDSGGFVAQRIVAC
EEEHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCEECCCCCEEEEECCCCHHHHHHHHH
IVNIACDIAQQRIATPTDIDLAVTLGLGYPKGPLALGDTLGTNAILEVLQNLYALYGDPR
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
YRPSPWLLRRARLGMSLLTPDA
CCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]