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The map label for this gene is frlR [H]

Identifier: 187929231

GI number: 187929231

Start: 2263838

End: 2264647

Strand: Reverse

Name: frlR [H]

Synonym: Rpic_2152

Alternate gene names: 187929231

Gene position: 2264647-2263838 (Counterclockwise)

Preceding gene: 187929242

Following gene: 187929230

Centisome position: 57.44

GC content: 63.83

Gene sequence:

>810_bases
ATGTCGAGCACGCCAAGCCCTCTATCCGCTGCGATGCCGCCTTCAGGCGGCGAAGGCGGCGCATCGCCCGCTTCTGCGGG
CGGCGCAGGCGGCTCTCCCACGTTCAGCCCGCTGTATCAGCAGATCAAGACGCTGATCCTGCAAAGCTTGCAGGCCGGCG
AGTGGAAGCCCGGCGAGATGATCCCCAGTGAGATGGAGTTGGCGGCCCGCTACAAGGTCAGCCAGGGGACCGTGCGCAAG
GCGATCGACGAATTGGCGGCAGAAAACCTGGTCGCGCGGCGCCAGGGCAAGGGCACCTTCGTTACCACGCATTACGAAGA
AGGGGTGCAGTTCCGTTTCTTGCGTCTGATGCCGGAGCAGGGCGAGCAGCACTATCCCAGCAGCCGTGTGCTGGAGTGCA
AGCGCATGCGCGCCCCGGCTGAGATCGCCCGTCTGCTCGAGCTCAAGGCCGGTGACAGCGTCGTGCAGATCCGCCGCATC
CTGTTCTTTTCGGGTGAGCCGACCGTGCTGGAGGAAATCTGGTTGCCGGGGGCGAGCTTCAAAGGGCTGACGGCTGAAAA
GCTGACCGAGTGGAAGGGTCCGATGTACGCATTTTTCGAGGCGGAGTTTGGCGTGCGCATGTTGCGTGCCACCGAGCGCA
TCCGTGCGGTGGCCGCTGACCCGACCACGGCGGAGTTGCTGTCGGTGGCCGCTGAATCGCCGCTGCTGTCAGTGGAGCGC
GTGTCGCATACGTTCGGCGACAAACCGGTGGAGATACGCCGTGGCCTGTACGTCACGACGCGGCACTACTACCAGAACGA
ATTGAATTAA

Upstream 100 bases:

>100_bases
CTTGCTAGAAAGTCAATGAATCTTCTGTCTTATATAAGACATAAGACATTCTATAAACGGGCTGGACGCCTTTGTCGCTT
TTGTGGTGAAATCGGCGGTT

Downstream 100 bases:

>100_bases
TGACGCGTCGCCGGGCCCGATTCATGCGGGCCGTCGCCGCTTCGGCTGCGTCTTGATTTGTGCGGCGCGCAACAGCGTAT
TGCGCGTCATGAAGGCGGTG

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MSSTPSPLSAAMPPSGGEGGASPASAGGAGGSPTFSPLYQQIKTLILQSLQAGEWKPGEMIPSEMELAARYKVSQGTVRK
AIDELAAENLVARRQGKGTFVTTHYEEGVQFRFLRLMPEQGEQHYPSSRVLECKRMRAPAEIARLLELKAGDSVVQIRRI
LFFSGEPTVLEEIWLPGASFKGLTAEKLTEWKGPMYAFFEAEFGVRMLRATERIRAVAADPTTAELLSVAAESPLLSVER
VSHTFGDKPVEIRRGLYVTTRHYYQNELN

Sequences:

>Translated_269_residues
MSSTPSPLSAAMPPSGGEGGASPASAGGAGGSPTFSPLYQQIKTLILQSLQAGEWKPGEMIPSEMELAARYKVSQGTVRK
AIDELAAENLVARRQGKGTFVTTHYEEGVQFRFLRLMPEQGEQHYPSSRVLECKRMRAPAEIARLLELKAGDSVVQIRRI
LFFSGEPTVLEEIWLPGASFKGLTAEKLTEWKGPMYAFFEAEFGVRMLRATERIRAVAADPTTAELLSVAAESPLLSVER
VSHTFGDKPVEIRRGLYVTTRHYYQNELN
>Mature_268_residues
SSTPSPLSAAMPPSGGEGGASPASAGGAGGSPTFSPLYQQIKTLILQSLQAGEWKPGEMIPSEMELAARYKVSQGTVRKA
IDELAAENLVARRQGKGTFVTTHYEEGVQFRFLRLMPEQGEQHYPSSRVLECKRMRAPAEIARLLELKAGDSVVQIRRIL
FFSGEPTVLEEIWLPGASFKGLTAEKLTEWKGPMYAFFEAEFGVRMLRATERIRAVAADPTTAELLSVAAESPLLSVERV
SHTFGDKPVEIRRGLYVTTRHYYQNELN

Specific function: May regulate the transcription of the frlABCD operon [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=218, Percent_Identity=27.0642201834862, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1790118, Length=210, Percent_Identity=29.0476190476191, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790540, Length=226, Percent_Identity=28.7610619469027, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786950, Length=213, Percent_Identity=29.1079812206573, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788418, Length=233, Percent_Identity=24.4635193133047, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 29591; Mature: 29460

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTPSPLSAAMPPSGGEGGASPASAGGAGGSPTFSPLYQQIKTLILQSLQAGEWKPGEM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
IPSEMELAARYKVSQGTVRKAIDELAAENLVARRQGKGTFVTTHYEEGVQFRFLRLMPEQ
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCC
GEQHYPSSRVLECKRMRAPAEIARLLELKAGDSVVQIRRILFFSGEPTVLEEIWLPGASF
CCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCC
KGLTAEKLTEWKGPMYAFFEAEFGVRMLRATERIRAVAADPTTAELLSVAAESPLLSVER
CCCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHH
VSHTFGDKPVEIRRGLYVTTRHYYQNELN
HHHHHCCCCHHHHCCEEEEEHHHHHCCCC
>Mature Secondary Structure 
SSTPSPLSAAMPPSGGEGGASPASAGGAGGSPTFSPLYQQIKTLILQSLQAGEWKPGEM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
IPSEMELAARYKVSQGTVRKAIDELAAENLVARRQGKGTFVTTHYEEGVQFRFLRLMPEQ
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCC
GEQHYPSSRVLECKRMRAPAEIARLLELKAGDSVVQIRRILFFSGEPTVLEEIWLPGASF
CCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCC
KGLTAEKLTEWKGPMYAFFEAEFGVRMLRATERIRAVAADPTTAELLSVAAESPLLSVER
CCCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHH
VSHTFGDKPVEIRRGLYVTTRHYYQNELN
HHHHHCCCCHHHHCCEEEEEHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]