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The map label for this gene is folC [H]

Identifier: 187929212

GI number: 187929212

Start: 2243486

End: 2244784

Strand: Reverse

Name: folC [H]

Synonym: Rpic_2133

Alternate gene names: 187929212

Gene position: 2244784-2243486 (Counterclockwise)

Preceding gene: 187929213

Following gene: 187929211

Centisome position: 56.94

GC content: 63.97

Gene sequence:

>1299_bases
ATGCCTACATTCGACACGCTGCCCAACTGGCTGGCACACCTGGAAACCGCACACCCTGTCGGCATCGACATGGGCTTGGC
CCGCATCAGTCGCGTGCGCGATGCGCTCGGGCTGGAATTCAAGTCCGTCGTCTTCACGGTGGGCGGCACCAATGGCAAGG
GCTCGACCTGCGCGATGCTGGAGGCGATCCTGCTGGCCGCGGGCTATAAGGTTGGCTGCCATACATCACCGCACCTGATC
GACTTCAACGAGCGTGCTCGCGTGAATGGCGAGATCGCCACCGACGCCATGTTGCTGCCGCACTTCGAGGCAGTGGAGCG
TGCGCGCTGCAGCTTTCCCGAACCCGTCAGCCTGACGTACTTCGAATTCACCACATTGGCGATCATGCATCTGTTCGCCA
ATGCAGGCCTTGATGCTGTGATCCTGGAGGTCGGGCTCGGCGGCCGGCTGGATGCGGTCAACATCGTCGATACCGATTGC
GCCATCATCACCAGCGTCGATCTCGATCACATGGCTTACCTGGGCGATACCCGCGAGGCGATCGGCTTCGAGAAGGCCGG
CATCTTCCGCGCAGGCAAGCCGGCGATCTGCTCTGACCCGGTGCCGCCAATCTCGCTGGTGAAGCACGCTGAAGCCATTG
GCGCAGATCTCTGGCTGATCGGCCGCGATTTCAACTTCCAGGGCGACAAGCAGCAGTGGGGCTTTAGCGGCCGCGGCCGC
CGTTGGCCGAGCCTGGGCTATCCCGCATTGCGCGGGGCGAACCAACTGCTGAACGCATCGGCCGCGCTGGCTGCGCTGGA
ATCGGTGCGCGATCGGTTGCCGATCTCGGCGCAGGACGTGCGTCTGGGCCTGTCGCAGGTGGTACTGCCGGGGCGCTTCC
AGGTTCTGCCGGGCCGTCCGTCCGTCATCCTGGACGTCGCACACAACCCGCACGCGTCGGCGGCGCTGGGCCAGAATCTC
GAGAACATGGGCTTCTACCGTTACACCTACGCGGTGTTCGGTGCGATGCAGGACAAAGATATCGCCGGTGTGCTCGCGCA
CATGCTCGACAAGGTCGACCACTGGTGCCTGACCGATTTGCCGACGCCGCGTGCCGCGAGCGCTTCCAGCTTGGCGCAGG
CGCTCACCGAAGCCGGTTTCCGGGCAGGCAAGGAATCGAGCATGAGCACATTCAGCGATCCCGCCACAGCCTATCGCAAC
GCCATGGAGCGGGCGACCGAGGATGATAGAATCGTGGTCTTCGGATCGTTCTACACCGTTGCCGGCGTGCTGGCGGAGCG
CAAGAGTCGCGCGCACTAA

Upstream 100 bases:

>100_bases
GGCCTGATGCGGCACATCTGTTGAACCGAAGCGCGGGCGAGAGTCCGCGCTTCTTGTTTTTGCGCGGCCCGTTTCCCTGA
AGCCGCGCCACATACTTCGC

Downstream 100 bases:

>100_bases
AACCGGGGCCCTCATGGGACTGTTTTCCATCTTTTCCTCCCGCAAGAACGCTGAAGGCGAACGCACACGCAGCGCAGCCG
CCGGCAGCGCTGCCGATGTG

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpolyglutamate synthase; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase; Dihydrofolate synthase [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MPTFDTLPNWLAHLETAHPVGIDMGLARISRVRDALGLEFKSVVFTVGGTNGKGSTCAMLEAILLAAGYKVGCHTSPHLI
DFNERARVNGEIATDAMLLPHFEAVERARCSFPEPVSLTYFEFTTLAIMHLFANAGLDAVILEVGLGGRLDAVNIVDTDC
AIITSVDLDHMAYLGDTREAIGFEKAGIFRAGKPAICSDPVPPISLVKHAEAIGADLWLIGRDFNFQGDKQQWGFSGRGR
RWPSLGYPALRGANQLLNASAALAALESVRDRLPISAQDVRLGLSQVVLPGRFQVLPGRPSVILDVAHNPHASAALGQNL
ENMGFYRYTYAVFGAMQDKDIAGVLAHMLDKVDHWCLTDLPTPRAASASSLAQALTEAGFRAGKESSMSTFSDPATAYRN
AMERATEDDRIVVFGSFYTVAGVLAERKSRAH

Sequences:

>Translated_432_residues
MPTFDTLPNWLAHLETAHPVGIDMGLARISRVRDALGLEFKSVVFTVGGTNGKGSTCAMLEAILLAAGYKVGCHTSPHLI
DFNERARVNGEIATDAMLLPHFEAVERARCSFPEPVSLTYFEFTTLAIMHLFANAGLDAVILEVGLGGRLDAVNIVDTDC
AIITSVDLDHMAYLGDTREAIGFEKAGIFRAGKPAICSDPVPPISLVKHAEAIGADLWLIGRDFNFQGDKQQWGFSGRGR
RWPSLGYPALRGANQLLNASAALAALESVRDRLPISAQDVRLGLSQVVLPGRFQVLPGRPSVILDVAHNPHASAALGQNL
ENMGFYRYTYAVFGAMQDKDIAGVLAHMLDKVDHWCLTDLPTPRAASASSLAQALTEAGFRAGKESSMSTFSDPATAYRN
AMERATEDDRIVVFGSFYTVAGVLAERKSRAH
>Mature_431_residues
PTFDTLPNWLAHLETAHPVGIDMGLARISRVRDALGLEFKSVVFTVGGTNGKGSTCAMLEAILLAAGYKVGCHTSPHLID
FNERARVNGEIATDAMLLPHFEAVERARCSFPEPVSLTYFEFTTLAIMHLFANAGLDAVILEVGLGGRLDAVNIVDTDCA
IITSVDLDHMAYLGDTREAIGFEKAGIFRAGKPAICSDPVPPISLVKHAEAIGADLWLIGRDFNFQGDKQQWGFSGRGRR
WPSLGYPALRGANQLLNASAALAALESVRDRLPISAQDVRLGLSQVVLPGRFQVLPGRPSVILDVAHNPHASAALGQNLE
NMGFYRYTYAVFGAMQDKDIAGVLAHMLDKVDHWCLTDLPTPRAASASSLAQALTEAGFRAGKESSMSTFSDPATAYRNA
MERATEDDRIVVFGSFYTVAGVLAERKSRAH

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=334, Percent_Identity=31.7365269461078, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI66932990, Length=334, Percent_Identity=31.7365269461078, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI1788654, Length=419, Percent_Identity=43.436754176611, Blast_Score=304, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI71984923, Length=436, Percent_Identity=27.0642201834862, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17553150, Length=436, Percent_Identity=27.0642201834862, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17553148, Length=436, Percent_Identity=27.0642201834862, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323760, Length=361, Percent_Identity=27.4238227146814, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324815, Length=287, Percent_Identity=31.0104529616725, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24641571, Length=152, Percent_Identity=38.1578947368421, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24581568, Length=149, Percent_Identity=35.5704697986577, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17; =6.3.2.12 [H]

Molecular weight: Translated: 46611; Mature: 46479

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTFDTLPNWLAHLETAHPVGIDMGLARISRVRDALGLEFKSVVFTVGGTNGKGSTCAML
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHH
EAILLAAGYKVGCHTSPHLIDFNERARVNGEIATDAMLLPHFEAVERARCSFPEPVSLTY
HHHHHHCCCEECCCCCCCEEECCCCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCEEEH
FEFTTLAIMHLFANAGLDAVILEVGLGGRLDAVNIVDTDCAIITSVDLDHMAYLGDTREA
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCEEEEEECCHHHHHHHCCCHHH
IGFEKAGIFRAGKPAICSDPVPPISLVKHAEAIGADLWLIGRDFNFQGDKQQWGFSGRGR
HCCHHCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHCCCCCCCC
RWPSLGYPALRGANQLLNASAALAALESVRDRLPISAQDVRLGLSQVVLPGRFQVLPGRP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHCCCCCEEEECCCC
SVILDVAHNPHASAALGQNLENMGFYRYTYAVFGAMQDKDIAGVLAHMLDKVDHWCLTDL
CEEEEECCCCCCHHHHHCCHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCC
PTPRAASASSLAQALTEAGFRAGKESSMSTFSDPATAYRNAMERATEDDRIVVFGSFYTV
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECHHHH
AGVLAERKSRAH
HHHHHHHHHCCC
>Mature Secondary Structure 
PTFDTLPNWLAHLETAHPVGIDMGLARISRVRDALGLEFKSVVFTVGGTNGKGSTCAML
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHH
EAILLAAGYKVGCHTSPHLIDFNERARVNGEIATDAMLLPHFEAVERARCSFPEPVSLTY
HHHHHHCCCEECCCCCCCEEECCCCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCEEEH
FEFTTLAIMHLFANAGLDAVILEVGLGGRLDAVNIVDTDCAIITSVDLDHMAYLGDTREA
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCEEEEEECCHHHHHHHCCCHHH
IGFEKAGIFRAGKPAICSDPVPPISLVKHAEAIGADLWLIGRDFNFQGDKQQWGFSGRGR
HCCHHCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHCCCCCCCC
RWPSLGYPALRGANQLLNASAALAALESVRDRLPISAQDVRLGLSQVVLPGRFQVLPGRP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHCCCCCEEEECCCC
SVILDVAHNPHASAALGQNLENMGFYRYTYAVFGAMQDKDIAGVLAHMLDKVDHWCLTDL
CEEEEECCCCCCHHHHHCCHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECCC
PTPRAASASSLAQALTEAGFRAGKESSMSTFSDPATAYRNAMERATEDDRIVVFGSFYTV
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECHHHH
AGVLAERKSRAH
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3040739; 3040734; 9205837; 9278503; 1989505 [H]