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The map label for this gene is iciA [H]

Identifier: 187929091

GI number: 187929091

Start: 2117725

End: 2118621

Strand: Direct

Name: iciA [H]

Synonym: Rpic_2012

Alternate gene names: 187929091

Gene position: 2117725-2118621 (Clockwise)

Preceding gene: 187929089

Following gene: 187929093

Centisome position: 53.71

GC content: 68.23

Gene sequence:

>897_bases
GTGCTGGATTATTCCGCCCTGGCGGCGTTGGCTGCCGTCATCCGAGAAGGCAGTTTCGAGCGGGCAGCCCGCGCACTGCA
TGTCACGCCGTCGGCCATTTCGCAGCGCATCCGGTTGCTGGAAGAACGCGTCGGCTGCGCGCTGGTCGTGCGCGACCAGC
CGTGCCGCCCCACCGAGACCGGCCGGCGGCTTTGCCAGCACGTCGACCGCGTGCGCCTGCTCGAACAGGAACTGCAAGGC
ACGTTGCCGACGCTGGCGCCAGAGGACGCGGCGCGTGTTGCGCTGCCCATTGCCGTGAACGCCGACAGCCTGGCGACGTG
GCTCGCGCCAGCGATCGCCACATTCGCAGCAGCCCACCCGGTGCTGATGGAGGTGGCGGTGGATGATCAGGATCACACCG
GTGAATGGCTGCGCAGCGGCGCCGTGCTGGCAGCCGTTACCGCCACCGCGCGGCCGGCCACAGGGTGCAACAGCCGTCCT
CTTGGAGCCATGCGTTATCTGGCTGCGGCCAGCCCCGCTTTCGTACAGCAACATTTCGCAGACGGCGTCCGCGCAGGAGA
ACTGGCGCAAGCGCCCTGCCTCGTGTTCAACACCAAGGATGCGTTGCAGGCCACCTGGGCCAGGCGCCTGTGCCATCGAC
ATGTGGAACTGCCGCGCCATCTGCTGCCGTCGTCGCAGGCGTTTGTGACCGCGGCCGTGGCCGGCATGGGCTGGGGGCTG
CATCCGCATGCGCTGATTGCGCAGCATCTTGAAGACGGCTCGCTGGTCGAGCTGGTGCCGGATACGCCGTTGGACGTTCC
GCTGTATTGGCAGCATGCGCGGGCGGCCTCGGCGCTGCTCGATGAACTCAGCCGCCAAGTGCTGACTGCTGCGCGTGCCG
CGCTGCTCGCTCCCTGA

Upstream 100 bases:

>100_bases
GAGGAAGTCGCTATCGAGGTCGTCATGCGCGCAGCTTGCCGGCCCGATTGAATGAAGACAAACTATCTTTTCTTCATTTG
ATTCAGTTTTCCTAACTCAC

Downstream 100 bases:

>100_bases
GCCGTTACAGCGCGTTCAGAGGAATCTTGAGGTACTGCACGCCGTTTGGCTCGGCCGGAGGCAACATGCCCGCGCGAATG
TTCACCTGAATGGCCGGCAG

Product: chromosome replication initiation inhibitor protein

Products: NA

Alternate protein names: OriC replication inhibitor [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MLDYSALAALAAVIREGSFERAARALHVTPSAISQRIRLLEERVGCALVVRDQPCRPTETGRRLCQHVDRVRLLEQELQG
TLPTLAPEDAARVALPIAVNADSLATWLAPAIATFAAAHPVLMEVAVDDQDHTGEWLRSGAVLAAVTATARPATGCNSRP
LGAMRYLAAASPAFVQQHFADGVRAGELAQAPCLVFNTKDALQATWARRLCHRHVELPRHLLPSSQAFVTAAVAGMGWGL
HPHALIAQHLEDGSLVELVPDTPLDVPLYWQHARAASALLDELSRQVLTAARAALLAP

Sequences:

>Translated_298_residues
MLDYSALAALAAVIREGSFERAARALHVTPSAISQRIRLLEERVGCALVVRDQPCRPTETGRRLCQHVDRVRLLEQELQG
TLPTLAPEDAARVALPIAVNADSLATWLAPAIATFAAAHPVLMEVAVDDQDHTGEWLRSGAVLAAVTATARPATGCNSRP
LGAMRYLAAASPAFVQQHFADGVRAGELAQAPCLVFNTKDALQATWARRLCHRHVELPRHLLPSSQAFVTAAVAGMGWGL
HPHALIAQHLEDGSLVELVPDTPLDVPLYWQHARAASALLDELSRQVLTAARAALLAP
>Mature_298_residues
MLDYSALAALAAVIREGSFERAARALHVTPSAISQRIRLLEERVGCALVVRDQPCRPTETGRRLCQHVDRVRLLEQELQG
TLPTLAPEDAARVALPIAVNADSLATWLAPAIATFAAAHPVLMEVAVDDQDHTGEWLRSGAVLAAVTATARPATGCNSRP
LGAMRYLAAASPAFVQQHFADGVRAGELAQAPCLVFNTKDALQATWARRLCHRHVELPRHLLPSSQAFVTAAVAGMGWGL
HPHALIAQHLEDGSLVELVPDTPLDVPLYWQHARAASALLDELSRQVLTAARAALLAP

Specific function: Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789283, Length=294, Percent_Identity=37.7551020408163, Blast_Score=171, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR017685
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31971; Mature: 31971

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDYSALAALAAVIREGSFERAARALHVTPSAISQRIRLLEERVGCALVVRDQPCRPTET
CCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCHH
GRRLCQHVDRVRLLEQELQGTLPTLAPEDAARVALPIAVNADSLATWLAPAIATFAAAHP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCH
VLMEVAVDDQDHTGEWLRSGAVLAAVTATARPATGCNSRPLGAMRYLAAASPAFVQQHFA
HHEEEEECCCCCHHHHHHCCCHHEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHH
DGVRAGELAQAPCLVFNTKDALQATWARRLCHRHVELPRHLLPSSQAFVTAAVAGMGWGL
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
HPHALIAQHLEDGSLVELVPDTPLDVPLYWQHARAASALLDELSRQVLTAARAALLAP
CHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDYSALAALAAVIREGSFERAARALHVTPSAISQRIRLLEERVGCALVVRDQPCRPTET
CCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCHH
GRRLCQHVDRVRLLEQELQGTLPTLAPEDAARVALPIAVNADSLATWLAPAIATFAAAHP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCH
VLMEVAVDDQDHTGEWLRSGAVLAAVTATARPATGCNSRPLGAMRYLAAASPAFVQQHFA
HHEEEEECCCCCHHHHHHCCCHHEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHH
DGVRAGELAQAPCLVFNTKDALQATWARRLCHRHVELPRHLLPSSQAFVTAAVAGMGWGL
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
HPHALIAQHLEDGSLVELVPDTPLDVPLYWQHARAASALLDELSRQVLTAARAALLAP
CHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA