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The map label for this gene is bigR [H]

Identifier: 187929093

GI number: 187929093

Start: 2119588

End: 2119953

Strand: Direct

Name: bigR [H]

Synonym: Rpic_2014

Alternate gene names: 187929093

Gene position: 2119588-2119953 (Clockwise)

Preceding gene: 187929091

Following gene: 187929094

Centisome position: 53.76

GC content: 63.66

Gene sequence:

>366_bases
ATGAGCCATTCCACTGCCAGTCCCGATGTTGTGCCGCTGCCTGAGGCGGCCATTTCCATGCTGCGCGCCTCTGCGTCGCA
GGCGTGTGCCGTGCTCAAGGCCATGGCCCACGAAGACCGCCTGCTGCTGCTCTGCCAGCTCACGCAGGGCGAGCGCAATG
TCGGCGAGCTGGAGGCGCTGGTCGGTCTGCATCAACCCAGCCTGTCGCAGCAATTGGGCGTGTTGCGCGACGAGGGCCTT
GTCGCCACGCGGCGCGAAGGCAAATACATCTACTACCGGCTCGCCAGCTTCGAGGTCATCCAGATCATGCAGACGCTGTC
CGAGCTTTACTGCGGCAAGGTCATGAAGAAGATGGCGGGACGCTGA

Upstream 100 bases:

>100_bases
GTGGACTTTCCCGAACAATCTATATTTTTATAGAATATCGTCTGACATTCTGTCTGCCAATAGCGCAAACAGCATGAATA
AACCCTCGCACCACGCCCCG

Downstream 100 bases:

>100_bases
CCATGTCGCCGATGGAAGCGGGTTGGATCATCAGTGCGGGGCTGGGCTCCGTGGTTGGCCTGATCCTGGCGCTGACGGGC
GCAGGCGGCGCCATTGTCGC

Product: ArsR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 121; Mature: 120

Protein sequence:

>121_residues
MSHSTASPDVVPLPEAAISMLRASASQACAVLKAMAHEDRLLLLCQLTQGERNVGELEALVGLHQPSLSQQLGVLRDEGL
VATRREGKYIYYRLASFEVIQIMQTLSELYCGKVMKKMAGR

Sequences:

>Translated_121_residues
MSHSTASPDVVPLPEAAISMLRASASQACAVLKAMAHEDRLLLLCQLTQGERNVGELEALVGLHQPSLSQQLGVLRDEGL
VATRREGKYIYYRLASFEVIQIMQTLSELYCGKVMKKMAGR
>Mature_120_residues
SHSTASPDVVPLPEAAISMLRASASQACAVLKAMAHEDRLLLLCQLTQGERNVGELEALVGLHQPSLSQQLGVLRDEGLV
ATRREGKYIYYRLASFEVIQIMQTLSELYCGKVMKKMAGR

Specific function: Represses an operon that comprises at least itself and blh. Binds to a palindromic AT-rich sequence spanning the -10 region of the blh promoter and blocks transcription of the operon [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789021, Length=95, Percent_Identity=42.1052631578947, Blast_Score=75, Evalue=1e-15,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 13289; Mature: 13158

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSTASPDVVPLPEAAISMLRASASQACAVLKAMAHEDRLLLLCQLTQGERNVGELEAL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHH
VGLHQPSLSQQLGVLRDEGLVATRREGKYIYYRLASFEVIQIMQTLSELYCGKVMKKMAG
HHCCCCCHHHHHCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
R
C
>Mature Secondary Structure 
SHSTASPDVVPLPEAAISMLRASASQACAVLKAMAHEDRLLLLCQLTQGERNVGELEAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHH
VGLHQPSLSQQLGVLRDEGLVATRREGKYIYYRLASFEVIQIMQTLSELYCGKVMKKMAG
HHCCCCCHHHHHCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]