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The map label for this gene is prlC [H]

Identifier: 187929031

GI number: 187929031

Start: 2061502

End: 2063616

Strand: Direct

Name: prlC [H]

Synonym: Rpic_1951

Alternate gene names: 187929031

Gene position: 2061502-2063616 (Clockwise)

Preceding gene: 187929030

Following gene: 187929032

Centisome position: 52.29

GC content: 65.06

Gene sequence:

>2115_bases
ATGACCGACATTTCGCCCAAGGTTGCCACTCCGGCCAACAATCCGCTGCTCGATTTTTCTGGTCTGCCGCGCTTCGCGGA
CATCCGCCCGGAACACATCACGCCGGCCGTCGACGTGCTGCTCGAGCGTGCCGCATCCGCGGTGGCGCAGGTCAAGGACC
CCGCCACGCCTGTCAGCTGGAACACCGTCGTGACCGCACTGGAAGAGGCCACCGAGCCACTGGGCCGCGCCTGGGGCATC
GTCAGCCACCTGAGCGCCGTCGCCGACACGCCAGAGCTGCGCGAAGCCCATGCCGCCAATCTGCCGCGCGTGACCGAATT
CTGGTCGGGCCTCGGCCAGGATCTGGAGCTGTTCGAGAAGTACAAGGCGATTGCCGACAGCGCGGAATACGCCACGCTGT
CGCCCGCGCGCAAGAAGCTGCTTGAGAACGAACTGCGCGGTTTCCGCCTGGGCGGCGCGGAGCTGCCCGAAGACCAGAAG
CCGCGCTTTGCCGCCATTCAGGAACAGCAGGCGCAACTGACCAAGGCCTTCAGCGATCACGTCCTGGATGCGACCAACGC
CTACGCTCTCGTCATCGACGACGAAGCCCGCCTCGCCGGCTTGCCCGACGACGCCAAGCAGGCTGCGCAGGAAGCTGCAC
GCCGCGACAACCCTGATGCGACGGGCTGGAAGTTCTCGCTGCACTTCCCGTCGTATTTCCCGGTGCTGCAATACGCGGAT
GACCGCGCGCTGCGCCGCACGCTGTACGAAGCCAACGTCACGCGTGCGTCCGAACTGGGCGCGCAGTACGGCGGCGGCAA
GGCCGAGTGGGACAACACCGCCAACATGGCCGAGCAGCTCACGCTGCGCACCGAAGAAGCGCACATGCTGGGCTATCGCA
ATTTTGGCGAAGTGTCCCTCGTGCCCAAGATGGCCGATTCGCCCGAAGACGTGCTGCGCTTCCTAGGTGAACTGGCCGAC
CGCGCCCGTCCGTTTGCCGAGAAGGATTGGGAAGAGCTCCAGGCCTTCGCCAAGACCACGCTCGGCATCGACAAGCTCGA
ACCGTGGGACATGGCCTACGCGTCGGAAAAGCTGCGCGAGGCACGCTACGCATTCTCCGAGCAGGAGGTGAAGCAGTACT
TCCCGGAACCGGCCGTGCTGGATGGCCTGTTCAATGTCGTGCAGACGCTGTTCTCGGTGAAGATCCGGCCAGAGGCAGCG
GCGGTGTGGCACCCCGACGTACGCTTCTTCCGGGTCGAATCGCCCCAGGGTGAGCTGCTCGCACAGTTCTACGTCGACCT
GTACGCGCGCGAAGGCAAGCGTGGCGGTGCATGGATGGACGACGCGCGCGGCCGCAAGCTGCTGGGCGATGCGGGTGTGC
AAACCCCCGTGGCTTACCTCACCTGCAACTTCTCCGGCCCGGTCGGCAACAAGCCCGCGCTGTTCACCCACGACGAGGTC
ATCACGCTCTTCCACGAGTTCGGCCACGGCCTGCACCACATGCTCACGCAGGTGGATGAGCTGGGCGTATCGGGCATCAA
CGGCGTTGAATGGGATGCGGTGGAGCTGCCGTCGCAGTTCATGGAGAACTTCTGCTGGGAATGGGAAGTGCTCTCGCGCA
TGACCCGCCATGTGAATTCCGGCGAACCGCTGCCGCGCAAGCTGTACGACAGCATGCTGGCCGCGAAGAACTTCCAGAAC
GGCATGGCGACGCTGCGCCAGATCGTGTTCTCGACGTTCGACATGCACCTGCACACGGACTTCGACCCGAAGGGCGCGAC
GTCGGTGCTGGAGCTATCGCGCCAGATCAACAATCGCTTCCACGTGGTACCGCAGGCCGAGTTGTCGCGCTGGCCGAACA
CGTTCAGCCACATCTTTGCGGGCGGCTATGCGGCGGGCTACTACAGCTACAAGTGGGCCGAGGTGCTGTCCGCCGATGCC
TATGCGGCGTTCGAAGAGGCCAGTAAGCTGGGCGGCTCGGTGCTCGATGCGGAAACCGGGGCACGCTATCGCCGTGAAGT
ACTGGCCGTTGGTGGCAGCCGCCCGGCCATCGAATCGTTCACGGCTTTCCGCGGCCGCGCTCCCAGCATCGACGCACTGC
TGCGCCATGGCGGCATGATGGCGGAAGCCGCGTAA

Upstream 100 bases:

>100_bases
GCGTAAGCTTCACCCTGATCCAGTTGGAAACGGAAAAAGCGTCCCCACCTGTTGGATCGGACGCTTTTTTTGTCCCCCGA
GTTTCTCTACCGAGCCCGCC

Downstream 100 bases:

>100_bases
CGGCCTGCTCGGCCAGCCGTGACAACGCCGCTTCGCGCCTCGTACCGAAGCGGCGTTTTCATTCGGGCCCGCAGCGCTTG
ATGGCACAATATCGCACCCC

Product: Oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 704; Mature: 703

Protein sequence:

>704_residues
MTDISPKVATPANNPLLDFSGLPRFADIRPEHITPAVDVLLERAASAVAQVKDPATPVSWNTVVTALEEATEPLGRAWGI
VSHLSAVADTPELREAHAANLPRVTEFWSGLGQDLELFEKYKAIADSAEYATLSPARKKLLENELRGFRLGGAELPEDQK
PRFAAIQEQQAQLTKAFSDHVLDATNAYALVIDDEARLAGLPDDAKQAAQEAARRDNPDATGWKFSLHFPSYFPVLQYAD
DRALRRTLYEANVTRASELGAQYGGGKAEWDNTANMAEQLTLRTEEAHMLGYRNFGEVSLVPKMADSPEDVLRFLGELAD
RARPFAEKDWEELQAFAKTTLGIDKLEPWDMAYASEKLREARYAFSEQEVKQYFPEPAVLDGLFNVVQTLFSVKIRPEAA
AVWHPDVRFFRVESPQGELLAQFYVDLYAREGKRGGAWMDDARGRKLLGDAGVQTPVAYLTCNFSGPVGNKPALFTHDEV
ITLFHEFGHGLHHMLTQVDELGVSGINGVEWDAVELPSQFMENFCWEWEVLSRMTRHVNSGEPLPRKLYDSMLAAKNFQN
GMATLRQIVFSTFDMHLHTDFDPKGATSVLELSRQINNRFHVVPQAELSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADA
YAAFEEASKLGGSVLDAETGARYRREVLAVGGSRPAIESFTAFRGRAPSIDALLRHGGMMAEAA

Sequences:

>Translated_704_residues
MTDISPKVATPANNPLLDFSGLPRFADIRPEHITPAVDVLLERAASAVAQVKDPATPVSWNTVVTALEEATEPLGRAWGI
VSHLSAVADTPELREAHAANLPRVTEFWSGLGQDLELFEKYKAIADSAEYATLSPARKKLLENELRGFRLGGAELPEDQK
PRFAAIQEQQAQLTKAFSDHVLDATNAYALVIDDEARLAGLPDDAKQAAQEAARRDNPDATGWKFSLHFPSYFPVLQYAD
DRALRRTLYEANVTRASELGAQYGGGKAEWDNTANMAEQLTLRTEEAHMLGYRNFGEVSLVPKMADSPEDVLRFLGELAD
RARPFAEKDWEELQAFAKTTLGIDKLEPWDMAYASEKLREARYAFSEQEVKQYFPEPAVLDGLFNVVQTLFSVKIRPEAA
AVWHPDVRFFRVESPQGELLAQFYVDLYAREGKRGGAWMDDARGRKLLGDAGVQTPVAYLTCNFSGPVGNKPALFTHDEV
ITLFHEFGHGLHHMLTQVDELGVSGINGVEWDAVELPSQFMENFCWEWEVLSRMTRHVNSGEPLPRKLYDSMLAAKNFQN
GMATLRQIVFSTFDMHLHTDFDPKGATSVLELSRQINNRFHVVPQAELSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADA
YAAFEEASKLGGSVLDAETGARYRREVLAVGGSRPAIESFTAFRGRAPSIDALLRHGGMMAEAA
>Mature_703_residues
TDISPKVATPANNPLLDFSGLPRFADIRPEHITPAVDVLLERAASAVAQVKDPATPVSWNTVVTALEEATEPLGRAWGIV
SHLSAVADTPELREAHAANLPRVTEFWSGLGQDLELFEKYKAIADSAEYATLSPARKKLLENELRGFRLGGAELPEDQKP
RFAAIQEQQAQLTKAFSDHVLDATNAYALVIDDEARLAGLPDDAKQAAQEAARRDNPDATGWKFSLHFPSYFPVLQYADD
RALRRTLYEANVTRASELGAQYGGGKAEWDNTANMAEQLTLRTEEAHMLGYRNFGEVSLVPKMADSPEDVLRFLGELADR
ARPFAEKDWEELQAFAKTTLGIDKLEPWDMAYASEKLREARYAFSEQEVKQYFPEPAVLDGLFNVVQTLFSVKIRPEAAA
VWHPDVRFFRVESPQGELLAQFYVDLYAREGKRGGAWMDDARGRKLLGDAGVQTPVAYLTCNFSGPVGNKPALFTHDEVI
TLFHEFGHGLHHMLTQVDELGVSGINGVEWDAVELPSQFMENFCWEWEVLSRMTRHVNSGEPLPRKLYDSMLAAKNFQNG
MATLRQIVFSTFDMHLHTDFDPKGATSVLELSRQINNRFHVVPQAELSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAY
AAFEEASKLGGSVLDAETGARYRREVLAVGGSRPAIESFTAFRGRAPSIDALLRHGGMMAEAA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=682, Percent_Identity=29.9120234604106, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI14149738, Length=689, Percent_Identity=29.3178519593614, Blast_Score=274, Evalue=2e-73,
Organism=Homo sapiens, GI156105687, Length=661, Percent_Identity=24.6596066565809, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1789913, Length=687, Percent_Identity=47.45269286754, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=697, Percent_Identity=31.5638450502152, Blast_Score=275, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI71999758, Length=576, Percent_Identity=24.1319444444444, Blast_Score=138, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI32565901, Length=597, Percent_Identity=21.608040201005, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319793, Length=692, Percent_Identity=27.3121387283237, Blast_Score=273, Evalue=9e-74,
Organism=Saccharomyces cerevisiae, GI6322715, Length=689, Percent_Identity=22.3512336719884, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI21356111, Length=709, Percent_Identity=28.2087447108604, Blast_Score=251, Evalue=1e-66,
Organism=Drosophila melanogaster, GI20129717, Length=419, Percent_Identity=26.9689737470167, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 78241; Mature: 78109

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDISPKVATPANNPLLDFSGLPRFADIRPEHITPAVDVLLERAASAVAQVKDPATPVSW
CCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCH
NTVVTALEEATEPLGRAWGIVSHLSAVADTPELREAHAANLPRVTEFWSGLGQDLELFEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHH
YKAIADSAEYATLSPARKKLLENELRGFRLGGAELPEDQKPRFAAIQEQQAQLTKAFSDH
HHHHHCCCCCCCCCHHHHHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLDATNAYALVIDDEARLAGLPDDAKQAAQEAARRDNPDATGWKFSLHFPSYFPVLQYAD
HCCCCCCEEEEEECCHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHCC
DRALRRTLYEANVTRASELGAQYGGGKAEWDNTANMAEQLTLRTEEAHMLGYRNFGEVSL
HHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCEEE
VPKMADSPEDVLRFLGELADRARPFAEKDWEELQAFAKTTLGIDKLEPWDMAYASEKLRE
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
ARYAFSEQEVKQYFPEPAVLDGLFNVVQTLFSVKIRPEAAAVWHPDVRFFRVESPQGELL
HHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCEEECCCCEEEEECCCCHHHH
AQFYVDLYAREGKRGGAWMDDARGRKLLGDAGVQTPVAYLTCNFSGPVGNKPALFTHDEV
HHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCEEEEEEECCCCCCCCCCEEEHHHH
ITLFHEFGHGLHHMLTQVDELGVSGINGVEWDAVELPSQFMENFCWEWEVLSRMTRHVNS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
GEPLPRKLYDSMLAAKNFQNGMATLRQIVFSTFDMHLHTDFDPKGATSVLELSRQINNRF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCE
HVVPQAELSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEASKLGGSVLDAETG
EECCCHHHHHCCCHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHH
ARYRREVLAVGGSRPAIESFTAFRGRAPSIDALLRHGGMMAEAA
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TDISPKVATPANNPLLDFSGLPRFADIRPEHITPAVDVLLERAASAVAQVKDPATPVSW
CCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCH
NTVVTALEEATEPLGRAWGIVSHLSAVADTPELREAHAANLPRVTEFWSGLGQDLELFEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHH
YKAIADSAEYATLSPARKKLLENELRGFRLGGAELPEDQKPRFAAIQEQQAQLTKAFSDH
HHHHHCCCCCCCCCHHHHHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLDATNAYALVIDDEARLAGLPDDAKQAAQEAARRDNPDATGWKFSLHFPSYFPVLQYAD
HCCCCCCEEEEEECCHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHCC
DRALRRTLYEANVTRASELGAQYGGGKAEWDNTANMAEQLTLRTEEAHMLGYRNFGEVSL
HHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCEEE
VPKMADSPEDVLRFLGELADRARPFAEKDWEELQAFAKTTLGIDKLEPWDMAYASEKLRE
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
ARYAFSEQEVKQYFPEPAVLDGLFNVVQTLFSVKIRPEAAAVWHPDVRFFRVESPQGELL
HHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCEEECCCCEEEEECCCCHHHH
AQFYVDLYAREGKRGGAWMDDARGRKLLGDAGVQTPVAYLTCNFSGPVGNKPALFTHDEV
HHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCEEEEEEECCCCCCCCCCEEEHHHH
ITLFHEFGHGLHHMLTQVDELGVSGINGVEWDAVELPSQFMENFCWEWEVLSRMTRHVNS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
GEPLPRKLYDSMLAAKNFQNGMATLRQIVFSTFDMHLHTDFDPKGATSVLELSRQINNRF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHCCCE
HVVPQAELSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEASKLGGSVLDAETG
EECCCHHHHHCCCHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHH
ARYRREVLAVGGSRPAIESFTAFRGRAPSIDALLRHGGMMAEAA
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]