Click here to switch to the map view.

The map label for this gene is ahpC [C]

Identifier: 187928980

GI number: 187928980

Start: 2002794

End: 2003342

Strand: Direct

Name: ahpC [C]

Synonym: Rpic_1900

Alternate gene names: 187928980

Gene position: 2002794-2003342 (Clockwise)

Preceding gene: 187928979

Following gene: 187928981

Centisome position: 50.8

GC content: 59.93

Gene sequence:

>549_bases
ATGAAGACCATTGGTGACAAGCTCGAACCGTTCAAGGTCGTCGGCGTCAAGCCCGGGTTCAACAATCACGAAGAGAACGG
CGAGTCGGCGTTCGAGGACATCACCGAGACCTCGTTCCCGGGCAAATGGAAGGTCATCTTTTTCTATCCGAAGGACTTCA
CGTTCGTCTGCCCGACCGAGATCGTTGCCTTCGCCAAACTGAACGATGACTTTGCCGACCGCGACACCATCGTGCTCGGC
GGCTCGACCGACAATGAATTCGTCAAGCTCGCATGGCGCCGCGAGCACAAAGACCTGAACAAGCTCAACCAATGGTCGTT
TGCCGACTCGACGGGTGCCCTGGTCGACCAGCTTGGCGTACGCGAGCATGAGGCCGGCGTTGCGTTGCGCGCCACCTTCA
TCGTCGACCCGGACAACGTCATCCAGCACGTGTCGGTCAACAACCTGAACGTGGGTCGCAACCCGGACGAAGTGCTGCGC
ATTCTCGACGGCCTGCAGACGGACGAGTTGTGCCCGTGCAACCGCGCAGTCGGCGGTGCGACGCTGTAA

Upstream 100 bases:

>100_bases
TCCGAACATCCTCCAGTCGGACCGGACGGCCGGTGAGCGTGTGTCTGCAAGTCCCCGCTTGGGTTTCGTACCCATTGCCA
CACAACTCAAGGAGAAGCTC

Downstream 100 bases:

>100_bases
CGGCCACGCGGCGCCCTCCGAAGCCGAAGCCCGCCCCTGCGCGGGCTTTCTTTTTCAGCCGCCGCTGACAGGAGACATCG
ATGGAATTTCTGCAGACGAT

Product: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKTIGDKLEPFKVVGVKPGFNNHEENGESAFEDITETSFPGKWKVIFFYPKDFTFVCPTEIVAFAKLNDDFADRDTIVLG
GSTDNEFVKLAWRREHKDLNKLNQWSFADSTGALVDQLGVREHEAGVALRATFIVDPDNVIQHVSVNNLNVGRNPDEVLR
ILDGLQTDELCPCNRAVGGATL

Sequences:

>Translated_182_residues
MKTIGDKLEPFKVVGVKPGFNNHEENGESAFEDITETSFPGKWKVIFFYPKDFTFVCPTEIVAFAKLNDDFADRDTIVLG
GSTDNEFVKLAWRREHKDLNKLNQWSFADSTGALVDQLGVREHEAGVALRATFIVDPDNVIQHVSVNNLNVGRNPDEVLR
ILDGLQTDELCPCNRAVGGATL
>Mature_182_residues
MKTIGDKLEPFKVVGVKPGFNNHEENGESAFEDITETSFPGKWKVIFFYPKDFTFVCPTEIVAFAKLNDDFADRDTIVLG
GSTDNEFVKLAWRREHKDLNKLNQWSFADSTGALVDQLGVREHEAGVALRATFIVDPDNVIQHVSVNNLNVGRNPDEVLR
ILDGLQTDELCPCNRAVGGATL

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5802974, Length=156, Percent_Identity=43.5897435897436, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI32483377, Length=156, Percent_Identity=43.5897435897436, Blast_Score=123, Evalue=8e-29,
Organism=Homo sapiens, GI32189392, Length=162, Percent_Identity=41.358024691358, Blast_Score=120, Evalue=5e-28,
Organism=Homo sapiens, GI4505591, Length=186, Percent_Identity=34.9462365591398, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI32455266, Length=186, Percent_Identity=34.9462365591398, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI32455264, Length=186, Percent_Identity=34.9462365591398, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI5453549, Length=159, Percent_Identity=37.1069182389937, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI33188454, Length=68, Percent_Identity=47.0588235294118, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI4758638, Length=166, Percent_Identity=31.3253012048193, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1786822, Length=187, Percent_Identity=36.3636363636364, Blast_Score=112, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193204376, Length=159, Percent_Identity=38.9937106918239, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32565831, Length=159, Percent_Identity=38.9937106918239, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17554494, Length=151, Percent_Identity=37.7483443708609, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323613, Length=162, Percent_Identity=41.358024691358, Blast_Score=123, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320661, Length=159, Percent_Identity=41.5094339622642, Blast_Score=121, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6319407, Length=160, Percent_Identity=31.25, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17738015, Length=154, Percent_Identity=39.6103896103896, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17157991, Length=159, Percent_Identity=38.9937106918239, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24641739, Length=159, Percent_Identity=38.9937106918239, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI21357347, Length=160, Percent_Identity=35, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24656348, Length=156, Percent_Identity=37.1794871794872, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI17864676, Length=156, Percent_Identity=37.1794871794872, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI17975518, Length=165, Percent_Identity=32.7272727272727, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24652434, Length=165, Percent_Identity=32.7272727272727, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24652436, Length=165, Percent_Identity=32.7272727272727, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20268; Mature: 20268

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIGDKLEPFKVVGVKPGFNNHEENGESAFEDITETSFPGKWKVIFFYPKDFTFVCPTE
CCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEECHHH
IVAFAKLNDDFADRDTIVLGGSTDNEFVKLAWRREHKDLNKLNQWSFADSTGALVDQLGV
HEEEECCCCCCCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
REHEAGVALRATFIVDPDNVIQHVSVNNLNVGRNPDEVLRILDGLQTDELCPCNRAVGGA
CCCCCCEEEEEEEEECCHHHHHEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
TL
CC
>Mature Secondary Structure
MKTIGDKLEPFKVVGVKPGFNNHEENGESAFEDITETSFPGKWKVIFFYPKDFTFVCPTE
CCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEECHHH
IVAFAKLNDDFADRDTIVLGGSTDNEFVKLAWRREHKDLNKLNQWSFADSTGALVDQLGV
HEEEECCCCCCCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
REHEAGVALRATFIVDPDNVIQHVSVNNLNVGRNPDEVLRILDGLQTDELCPCNRAVGGA
CCCCCCEEEEEEEEECCHHHHHEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
TL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA