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The map label for this gene is pgi

Identifier: 187928942

GI number: 187928942

Start: 1958902

End: 1960521

Strand: Direct

Name: pgi

Synonym: Rpic_1861

Alternate gene names: 187928942

Gene position: 1958902-1960521 (Clockwise)

Preceding gene: 187928941

Following gene: 187928944

Centisome position: 49.69

GC content: 65.62

Gene sequence:

>1620_bases
ATGCCTACAGCCCTACCCGCCTGGCAGTCCCTCACGCAACATGCAGAATCGATCCGCGCGACACATATGCGCGACTGGTT
TGCCGCGCCGGACGCCGAAGAACGGGTACGTGCCTTCACGCTGGAGGCCGCTGGCCTGACGGTCGATTACTCAAAAAACC
GCATCACCCCCGACACGCTTTCCCAACTGCTGCAACTTGCTGAGGAAGCCGGCGTGCTCACCCTGCGCGACGCCATGCTG
CGTGGCGAACGCATCAACAACACCGAGCACCGCGCCGTCTTGCACGTGGCCCTGCGTGGCCGCGCTGAACACGACTATCG
TGCCGACGGCGAGCCCGTCATGCCCGAAGTGCTGCGCGTGCGCGCGCAGATGCGCGACTTTGCCAACCGTGTGCACAGCG
GCGCATGGACAGGCCATTCCGGACGGCGCATCACGGACGTGGTGAACATCGGCATCGGCGGATCGGACCTCGGCCCGCGG
ATGGTATGCCGTGCGCTCGACCACCTTGCCGTGCCGCAGGTGCGCGTGCATTTCGTCTCCAACGTCGACGGCACGGACCT
GGCCGAAACGCTCGACCATCTGAACCCCGACACCACGCTCGCCATCGTCTGTTCCAAGACGTTCACCACGCTGGAAACGA
TGGCCAACGCGCACAGCATGCGCAGGTGGTTTGTCGACCACGGCGTCGCGGAAAGCCAGCTTAAGCACCACTTCGTCGCT
GTCTCCACCAACCGCGAGGCCGTCGTGCAGTTCGGCATCGACCCGGACAACATGTTCACGTTCTGGGATTGGGTTGGCGG
GCGGTTCTCGCTGTGGTCGGCCGTGGGCCTGTCGATCGTGCTGGCGATCGGGCCGCAGCAGTTTGAAGCGATGCTCGACG
GCGCGCGTGCGATGGACCGCCACTTTGCGACGGCCGCGCCGCGCGAGAACCTCCCGCTCATTCTCGGGATGCTGTCGGTC
TGGTATCGCGGCTTCTTCGATGCGGCGAGCGCATGCACCGTGCCCTACTGCGCGCCGCTGGAACTGCTGACCGACTTCAT
GCAACAGTTGGAGATGGAGAGCAACGGCAAATCGGTCCAGCGCAACGGCGCGGCCATCGATACCGACACCGGCCCCATCG
TCTGGGGCACGGCCGGCACCAACGGGCAGCATGCGTATTTCCAGTTGATCCACCAGGGCTCGCAGATCGTGCCGGTGGAT
TTCATCACCACGCTCGAGCCGGTGCGCAACCTGCCTGGCCACCATGCCAAGCTGCTCGCCAACTGCTTCGCGCAGGGCGA
GGCACTGCTGCTGGGGCGCACCGCCGAGGAGGTCCGCGCGGGCGGCGTCACCGACGAAGCGCTGGTGCCGCATATGGTGT
TCGAAGGCAATCGCCCGAGCACGACCATCCTGATGGAGCGGCTGGACGCTGCCTCACTCGGCGCGCTCATCGCCTGCGCC
GAGCACCGCACCTTCGTGCAGGGCGCGGTCTGGAACATCAACTCGTTCGATCAGTGGGGCGTGGAGCTTGGCAAGAAACT
CGCCAAGCCGATCCAGGCGGAACTGGAAGGTGCGCCGGCCTCTGTGGCGCATGATGCGTCGACGGTGGCGTTGATTCGCC
GCGCCAAAGCCGCGCTCTGA

Upstream 100 bases:

>100_bases
CCTTGCTGGCGTCGGACGTTCGCCGATAGAAACACGTCATACAGCACCGTTATACTGCCCACTCGTTTTCCGGCCCCTAC
CTCACGTCACATCACGCCGT

Downstream 100 bases:

>100_bases
CGCAAACGTTCAGAGTTCGGTGACAGCCTCGTCGCCCACGAGATGCCCTGCTTCGATGGTGAGAATGCGGCTGCAACGCG
CCGCCACGGAGCGGTCGTGC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MPTALPAWQSLTQHAESIRATHMRDWFAAPDAEERVRAFTLEAAGLTVDYSKNRITPDTLSQLLQLAEEAGVLTLRDAML
RGERINNTEHRAVLHVALRGRAEHDYRADGEPVMPEVLRVRAQMRDFANRVHSGAWTGHSGRRITDVVNIGIGGSDLGPR
MVCRALDHLAVPQVRVHFVSNVDGTDLAETLDHLNPDTTLAIVCSKTFTTLETMANAHSMRRWFVDHGVAESQLKHHFVA
VSTNREAVVQFGIDPDNMFTFWDWVGGRFSLWSAVGLSIVLAIGPQQFEAMLDGARAMDRHFATAAPRENLPLILGMLSV
WYRGFFDAASACTVPYCAPLELLTDFMQQLEMESNGKSVQRNGAAIDTDTGPIVWGTAGTNGQHAYFQLIHQGSQIVPVD
FITTLEPVRNLPGHHAKLLANCFAQGEALLLGRTAEEVRAGGVTDEALVPHMVFEGNRPSTTILMERLDAASLGALIACA
EHRTFVQGAVWNINSFDQWGVELGKKLAKPIQAELEGAPASVAHDASTVALIRRAKAAL

Sequences:

>Translated_539_residues
MPTALPAWQSLTQHAESIRATHMRDWFAAPDAEERVRAFTLEAAGLTVDYSKNRITPDTLSQLLQLAEEAGVLTLRDAML
RGERINNTEHRAVLHVALRGRAEHDYRADGEPVMPEVLRVRAQMRDFANRVHSGAWTGHSGRRITDVVNIGIGGSDLGPR
MVCRALDHLAVPQVRVHFVSNVDGTDLAETLDHLNPDTTLAIVCSKTFTTLETMANAHSMRRWFVDHGVAESQLKHHFVA
VSTNREAVVQFGIDPDNMFTFWDWVGGRFSLWSAVGLSIVLAIGPQQFEAMLDGARAMDRHFATAAPRENLPLILGMLSV
WYRGFFDAASACTVPYCAPLELLTDFMQQLEMESNGKSVQRNGAAIDTDTGPIVWGTAGTNGQHAYFQLIHQGSQIVPVD
FITTLEPVRNLPGHHAKLLANCFAQGEALLLGRTAEEVRAGGVTDEALVPHMVFEGNRPSTTILMERLDAASLGALIACA
EHRTFVQGAVWNINSFDQWGVELGKKLAKPIQAELEGAPASVAHDASTVALIRRAKAAL
>Mature_538_residues
PTALPAWQSLTQHAESIRATHMRDWFAAPDAEERVRAFTLEAAGLTVDYSKNRITPDTLSQLLQLAEEAGVLTLRDAMLR
GERINNTEHRAVLHVALRGRAEHDYRADGEPVMPEVLRVRAQMRDFANRVHSGAWTGHSGRRITDVVNIGIGGSDLGPRM
VCRALDHLAVPQVRVHFVSNVDGTDLAETLDHLNPDTTLAIVCSKTFTTLETMANAHSMRRWFVDHGVAESQLKHHFVAV
STNREAVVQFGIDPDNMFTFWDWVGGRFSLWSAVGLSIVLAIGPQQFEAMLDGARAMDRHFATAAPRENLPLILGMLSVW
YRGFFDAASACTVPYCAPLELLTDFMQQLEMESNGKSVQRNGAAIDTDTGPIVWGTAGTNGQHAYFQLIHQGSQIVPVDF
ITTLEPVRNLPGHHAKLLANCFAQGEALLLGRTAEEVRAGGVTDEALVPHMVFEGNRPSTTILMERLDAASLGALIACAE
HRTFVQGAVWNINSFDQWGVELGKKLAKPIQAELEGAPASVAHDASTVALIRRAKAAL

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=546, Percent_Identity=49.0842490842491, Blast_Score=518, Evalue=1e-147,
Organism=Homo sapiens, GI296080693, Length=546, Percent_Identity=45.4212454212454, Blast_Score=459, Evalue=1e-129,
Organism=Escherichia coli, GI1790457, Length=547, Percent_Identity=50.6398537477148, Blast_Score=537, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI71996708, Length=514, Percent_Identity=50.5836575875486, Blast_Score=516, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI71996703, Length=514, Percent_Identity=50.5836575875486, Blast_Score=516, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6319673, Length=547, Percent_Identity=49.3601462522852, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24651916, Length=544, Percent_Identity=49.0808823529412, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24651914, Length=544, Percent_Identity=49.0808823529412, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI17737445, Length=544, Percent_Identity=49.0808823529412, Blast_Score=509, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_RALPJ (B2UF65)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001899429.1
- ProteinModelPortal:   B2UF65
- SMR:   B2UF65
- GeneID:   6289858
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_1861
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK00179
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59061; Mature: 58930

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 384-384 ACT_SITE 505-505

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTALPAWQSLTQHAESIRATHMRDWFAAPDAEERVRAFTLEAAGLTVDYSKNRITPDTL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEEEECCEEEECCCCCCCHHHH
SQLLQLAEEAGVLTLRDAMLRGERINNTEHRAVLHVALRGRAEHDYRADGEPVMPEVLRV
HHHHHHHHHCCEEEEHHHHHCCCCCCCCHHHHEEEEEHHCCCCCCCCCCCCCCCHHHHHH
RAQMRDFANRVHSGAWTGHSGRRITDVVNIGIGGSDLGPRMVCRALDHLAVPQVRVHFVS
HHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEC
NVDGTDLAETLDHLNPDTTLAIVCSKTFTTLETMANAHSMRRWFVDHGVAESQLKHHFVA
CCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEE
VSTNREAVVQFGIDPDNMFTFWDWVGGRFSLWSAVGLSIVLAIGPQQFEAMLDGARAMDR
EECCCEEEEEECCCCCCCEEHHHHCCCHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHH
HFATAAPRENLPLILGMLSVWYRGFFDAASACTVPYCAPLELLTDFMQQLEMESNGKSVQ
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHH
RNGAAIDTDTGPIVWGTAGTNGQHAYFQLIHQGSQIVPVDFITTLEPVRNLPGHHAKLLA
CCCCEEECCCCCEEEECCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCHHHHHHH
NCFAQGEALLLGRTAEEVRAGGVTDEALVPHMVFEGNRPSTTILMERLDAASLGALIACA
HHHHCCCEEEEECCHHHHHCCCCCHHHHCCHHEECCCCCCHHHHHHHHCHHHHHHHHHHH
EHRTFVQGAVWNINSFDQWGVELGKKLAKPIQAELEGAPASVAHDASTVALIRRAKAAL
HHHHHHHCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PTALPAWQSLTQHAESIRATHMRDWFAAPDAEERVRAFTLEAAGLTVDYSKNRITPDTL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEEEEECCEEEECCCCCCCHHHH
SQLLQLAEEAGVLTLRDAMLRGERINNTEHRAVLHVALRGRAEHDYRADGEPVMPEVLRV
HHHHHHHHHCCEEEEHHHHHCCCCCCCCHHHHEEEEEHHCCCCCCCCCCCCCCCHHHHHH
RAQMRDFANRVHSGAWTGHSGRRITDVVNIGIGGSDLGPRMVCRALDHLAVPQVRVHFVS
HHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEC
NVDGTDLAETLDHLNPDTTLAIVCSKTFTTLETMANAHSMRRWFVDHGVAESQLKHHFVA
CCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEE
VSTNREAVVQFGIDPDNMFTFWDWVGGRFSLWSAVGLSIVLAIGPQQFEAMLDGARAMDR
EECCCEEEEEECCCCCCCEEHHHHCCCHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHH
HFATAAPRENLPLILGMLSVWYRGFFDAASACTVPYCAPLELLTDFMQQLEMESNGKSVQ
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHH
RNGAAIDTDTGPIVWGTAGTNGQHAYFQLIHQGSQIVPVDFITTLEPVRNLPGHHAKLLA
CCCCEEECCCCCEEEECCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCHHHHHHH
NCFAQGEALLLGRTAEEVRAGGVTDEALVPHMVFEGNRPSTTILMERLDAASLGALIACA
HHHHCCCEEEEECCHHHHHCCCCCHHHHCCHHEECCCCCCHHHHHHHHCHHHHHHHHHHH
EHRTFVQGAVWNINSFDQWGVELGKKLAKPIQAELEGAPASVAHDASTVALIRRAKAAL
HHHHHHHCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA