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The map label for this gene is cusS [H]

Identifier: 187928923

GI number: 187928923

Start: 1932078

End: 1933448

Strand: Direct

Name: cusS [H]

Synonym: Rpic_1842

Alternate gene names: 187928923

Gene position: 1932078-1933448 (Clockwise)

Preceding gene: 187928922

Following gene: 187928924

Centisome position: 49.01

GC content: 60.69

Gene sequence:

>1371_bases
ATGAGGCGCCATTCACTAACGGCGCGGCTGACCGCGTATTTCTCCTTGTCATCAGCGGCCATGTTGTTGGGCCTCGGCAT
TCTGATCGCCCTGGCCATGGAGGAGCATTTTGCAGTGGAAGACTTTACGGCGTTGGGCGAGAACGTGAACGTTATTCGCC
GGGTGGTTGAGAGTAGCTCTGCACCCGAGGTCTCTAGTCGGCTCAACGACGTGCTACAGCACCGCACGGATCTGATTGTG
CGAGTCCAGGCGCCACAGGGTCAGGCCTTGTTTGCCACCCCCGACTTTGACTTTGCGGAGGTGTTGGCCGTGCTACGCAA
GGCAGGCCGTCATTCCGGGGCCCTTGTTTGGCAGCAGGGCGACAAGCAATACCGGGGGGTGCATATGCAAGTGCCGCTGC
GCGACGACGGTGCGCTGGATGTATTGGTGGGCATCAATACTGAGATCCATGCGCATTTCCTACGCGCGTTTCGGAAGACG
TTGACGCTCTACATCGCATTGGCCGCCCTGGCGAGCGGCCTATTTGGATGGTGGGCGGCCCGGCGGGGGCTGTTGCCGCT
GCGCGCGATGGCTTCGCGGGCGAAGTCTGTGACGGCGGACCGCCTGGACGAACGGATGCCGGTCGATATGGTACCGGTCG
AGGTTGCCGATCTTGGCGTGACGTTGAACGGCATGCTCGCGCGCTTGCAGGGCGATTTCCAGCGACTCACCGACTTCTCG
ACCGATATCGCACACGAGCTACGCACACCGATCACCAACCTGCTGACGCAAACCGAAGTGGCTCTCTCACAAATTCGCGA
ACCTGCAAAGTACAGAGACGTCCTTGCTTCAAACGTAGAAGAGCTGCAGCGTTTGGCTCGGATGGTGTCGGACATGCTCT
ACCTGGCCAAGATGGAGCACAACCTGACGCTGCCCAGTGCCGAGATGATCGAGCTTGCCGGCGAGGTGCGCGCACTCTTT
GAGTTTTACGACGCGTTCGCGGAGGACAAAGCCGTGCAGTTGCAAGTGGAAGGACAAGCGCAACTGCGTGGCGATCGGCT
CATGCTCAGACGCGCCTTCAGCAATCTGTTGTCGAATGCGATACGGCACACACCCAGGCGCGGCCGTGTGATCGTTTCCA
TCACGCCAACCGAGGAGGGCCTCGCCGTGACGATCGACAACGACGGCGAGGCGATTGCTCCCGACGTGCTGCCGTTCATC
TTCGAGCGCTTCTTTCGCGCAGACAAGTCGCGTGCGCGCCCAGAATCGGACGGAGCAGGCCTTGGCTTGGCTATCACCAA
AGCAATCGTTCTCGCCCATGGGGGAACCATTTCTGCCACACGCGTGCACGATCGCACTCGATTCACCGTCCGGCTGCCGA
TCCGCTGCTGA

Upstream 100 bases:

>100_bases
GACGCCTGCGCGCCAAAATCGACGATAACTTCGAACCTAAATTGATCCATACCGTCCGTGGCATGGGCTATGTCCTCGAA
GGTCCGGAGGACGGGGAGTA

Downstream 100 bases:

>100_bases
ACTTTGGGGGGGCACGCTCGCTGACATCATCCGTCAGGTCGGCCCCTATGGCGGCCAATGTGTCGTGCAAGCTGCCCGAA
GTCTTGCGTGAGCATGACGC

Product: heavy metal sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MRRHSLTARLTAYFSLSSAAMLLGLGILIALAMEEHFAVEDFTALGENVNVIRRVVESSSAPEVSSRLNDVLQHRTDLIV
RVQAPQGQALFATPDFDFAEVLAVLRKAGRHSGALVWQQGDKQYRGVHMQVPLRDDGALDVLVGINTEIHAHFLRAFRKT
LTLYIALAALASGLFGWWAARRGLLPLRAMASRAKSVTADRLDERMPVDMVPVEVADLGVTLNGMLARLQGDFQRLTDFS
TDIAHELRTPITNLLTQTEVALSQIREPAKYRDVLASNVEELQRLARMVSDMLYLAKMEHNLTLPSAEMIELAGEVRALF
EFYDAFAEDKAVQLQVEGQAQLRGDRLMLRRAFSNLLSNAIRHTPRRGRVIVSITPTEEGLAVTIDNDGEAIAPDVLPFI
FERFFRADKSRARPESDGAGLGLAITKAIVLAHGGTISATRVHDRTRFTVRLPIRC

Sequences:

>Translated_456_residues
MRRHSLTARLTAYFSLSSAAMLLGLGILIALAMEEHFAVEDFTALGENVNVIRRVVESSSAPEVSSRLNDVLQHRTDLIV
RVQAPQGQALFATPDFDFAEVLAVLRKAGRHSGALVWQQGDKQYRGVHMQVPLRDDGALDVLVGINTEIHAHFLRAFRKT
LTLYIALAALASGLFGWWAARRGLLPLRAMASRAKSVTADRLDERMPVDMVPVEVADLGVTLNGMLARLQGDFQRLTDFS
TDIAHELRTPITNLLTQTEVALSQIREPAKYRDVLASNVEELQRLARMVSDMLYLAKMEHNLTLPSAEMIELAGEVRALF
EFYDAFAEDKAVQLQVEGQAQLRGDRLMLRRAFSNLLSNAIRHTPRRGRVIVSITPTEEGLAVTIDNDGEAIAPDVLPFI
FERFFRADKSRARPESDGAGLGLAITKAIVLAHGGTISATRVHDRTRFTVRLPIRC
>Mature_456_residues
MRRHSLTARLTAYFSLSSAAMLLGLGILIALAMEEHFAVEDFTALGENVNVIRRVVESSSAPEVSSRLNDVLQHRTDLIV
RVQAPQGQALFATPDFDFAEVLAVLRKAGRHSGALVWQQGDKQYRGVHMQVPLRDDGALDVLVGINTEIHAHFLRAFRKT
LTLYIALAALASGLFGWWAARRGLLPLRAMASRAKSVTADRLDERMPVDMVPVEVADLGVTLNGMLARLQGDFQRLTDFS
TDIAHELRTPITNLLTQTEVALSQIREPAKYRDVLASNVEELQRLARMVSDMLYLAKMEHNLTLPSAEMIELAGEVRALF
EFYDAFAEDKAVQLQVEGQAQLRGDRLMLRRAFSNLLSNAIRHTPRRGRVIVSITPTEEGLAVTIDNDGEAIAPDVLPFI
FERFFRADKSRARPESDGAGLGLAITKAIVLAHGGTISATRVHDRTRFTVRLPIRC

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=475, Percent_Identity=34.9473684210526, Blast_Score=281, Evalue=8e-77,
Organism=Escherichia coli, GI1788279, Length=308, Percent_Identity=33.7662337662338, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=31.3636363636364, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790346, Length=264, Percent_Identity=30.6818181818182, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1788393, Length=249, Percent_Identity=30.9236947791165, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787894, Length=315, Percent_Identity=31.1111111111111, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789403, Length=346, Percent_Identity=29.1907514450867, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=25.7777777777778, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=216, Percent_Identity=28.2407407407407, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790551, Length=286, Percent_Identity=24.8251748251748, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788549, Length=228, Percent_Identity=24.5614035087719, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=312, Percent_Identity=22.7564102564103, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081816, Length=227, Percent_Identity=27.7533039647577, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790861, Length=268, Percent_Identity=25.3731343283582, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1789808, Length=195, Percent_Identity=26.6666666666667, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI145693157, Length=230, Percent_Identity=27.3913043478261, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50578; Mature: 50578

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRHSLTARLTAYFSLSSAAMLLGLGILIALAMEEHFAVEDFTALGENVNVIRRVVESSS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
APEVSSRLNDVLQHRTDLIVRVQAPQGQALFATPDFDFAEVLAVLRKAGRHSGALVWQQG
CCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHCCCCCCEEEEECC
DKQYRGVHMQVPLRDDGALDVLVGINTEIHAHFLRAFRKTLTLYIALAALASGLFGWWAA
CCCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRGLLPLRAMASRAKSVTADRLDERMPVDMVPVEVADLGVTLNGMLARLQGDFQRLTDFS
HCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHH
TDIAHELRTPITNLLTQTEVALSQIREPAKYRDVLASNVEELQRLARMVSDMLYLAKMEH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NLTLPSAEMIELAGEVRALFEFYDAFAEDKAVQLQVEGQAQLRGDRLMLRRAFSNLLSNA
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
IRHTPRRGRVIVSITPTEEGLAVTIDNDGEAIAPDVLPFIFERFFRADKSRARPESDGAG
HHCCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
LGLAITKAIVLAHGGTISATRVHDRTRFTVRLPIRC
CHHHHHHHHHHCCCCEEEEEEEECCEEEEEEECCCC
>Mature Secondary Structure
MRRHSLTARLTAYFSLSSAAMLLGLGILIALAMEEHFAVEDFTALGENVNVIRRVVESSS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
APEVSSRLNDVLQHRTDLIVRVQAPQGQALFATPDFDFAEVLAVLRKAGRHSGALVWQQG
CCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHCCCCCCEEEEECC
DKQYRGVHMQVPLRDDGALDVLVGINTEIHAHFLRAFRKTLTLYIALAALASGLFGWWAA
CCCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRGLLPLRAMASRAKSVTADRLDERMPVDMVPVEVADLGVTLNGMLARLQGDFQRLTDFS
HCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHH
TDIAHELRTPITNLLTQTEVALSQIREPAKYRDVLASNVEELQRLARMVSDMLYLAKMEH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NLTLPSAEMIELAGEVRALFEFYDAFAEDKAVQLQVEGQAQLRGDRLMLRRAFSNLLSNA
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
IRHTPRRGRVIVSITPTEEGLAVTIDNDGEAIAPDVLPFIFERFFRADKSRARPESDGAG
HHCCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
LGLAITKAIVLAHGGTISATRVHDRTRFTVRLPIRC
CHHHHHHHHHHCCCCEEEEEEEECCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]