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The map label for this gene is cusR [H]

Identifier: 187928922

GI number: 187928922

Start: 1931392

End: 1932078

Strand: Direct

Name: cusR [H]

Synonym: Rpic_1841

Alternate gene names: 187928922

Gene position: 1931392-1932078 (Clockwise)

Preceding gene: 187928916

Following gene: 187928923

Centisome position: 48.99

GC content: 57.93

Gene sequence:

>687_bases
ATGAAGCTCCTTGTTGTCGAAGACGAATCCAAGACCGGCGAATATTTGCAGCAGGGGTTGTCGGAAGCCGGCTTTGTTGT
GGACCTTGCCCGCAATGGCTTGGACGGCCGACATCTTGCAATGACGGGCGACTATGACCTCTTGATTCTTGACGTGATGT
TGCCCGATCTCGAAGGGTGGCAGATCCTGCACGCACTGCGCTCAACTGAACTGGCTGTGCCGGTGCTGTTTCTGACCGCG
CGCGATAGCGTCGCTGATCGGGTCAAGGGCTTGGAGCTGGGCGCGGATGACTACATGGTCAAACCATTTGCATTTGCGGA
ATTGCTCGCGCGTGTTCGAACTCTGCTTCGACGAGGCAGTGCGCCATCGCTTGCAGAACGCATCCAGGTGGCCGACCTGG
TGCTGGATCTGACTCGCCGTCGTGCTTCCCGTGGCGGTCAGCGAATCACGTTGACCAGTAAGGAGTTCTCGCTGCTGGAA
CTGCTAGCCCGCCGTCATGGCGAGGTGTTGCCCCGGTCCCTGATCGCCTCCCAAGTCTGGGACATGAATTTCGACAGCGA
CACTAACGTGATCGACGTCGCCATTCGACGCCTGCGCGCCAAAATCGACGATAACTTCGAACCTAAATTGATCCATACCG
TCCGTGGCATGGGCTATGTCCTCGAAGGTCCGGAGGACGGGGAGTAA

Upstream 100 bases:

>100_bases
ATTACATATTGGTCAGGTTGGTCAGCAACCATGCCGCTCCATGTACGCTACACGATACCGGTCGCACTTTTCGTGCGCCA
TAAGTAATAAAGAGACAGAC

Downstream 100 bases:

>100_bases
TGAGGCGCCATTCACTAACGGCGCGGCTGACCGCGTATTTCTCCTTGTCATCAGCGGCCATGTTGTTGGGCCTCGGCATT
CTGATCGCCCTGGCCATGGA

Product: winged helix family two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKLLVVEDESKTGEYLQQGLSEAGFVVDLARNGLDGRHLAMTGDYDLLILDVMLPDLEGWQILHALRSTELAVPVLFLTA
RDSVADRVKGLELGADDYMVKPFAFAELLARVRTLLRRGSAPSLAERIQVADLVLDLTRRRASRGGQRITLTSKEFSLLE
LLARRHGEVLPRSLIASQVWDMNFDSDTNVIDVAIRRLRAKIDDNFEPKLIHTVRGMGYVLEGPEDGE

Sequences:

>Translated_228_residues
MKLLVVEDESKTGEYLQQGLSEAGFVVDLARNGLDGRHLAMTGDYDLLILDVMLPDLEGWQILHALRSTELAVPVLFLTA
RDSVADRVKGLELGADDYMVKPFAFAELLARVRTLLRRGSAPSLAERIQVADLVLDLTRRRASRGGQRITLTSKEFSLLE
LLARRHGEVLPRSLIASQVWDMNFDSDTNVIDVAIRRLRAKIDDNFEPKLIHTVRGMGYVLEGPEDGE
>Mature_228_residues
MKLLVVEDESKTGEYLQQGLSEAGFVVDLARNGLDGRHLAMTGDYDLLILDVMLPDLEGWQILHALRSTELAVPVLFLTA
RDSVADRVKGLELGADDYMVKPFAFAELLARVRTLLRRGSAPSLAERIQVADLVLDLTRRRASRGGQRITLTSKEFSLLE
LLARRHGEVLPRSLIASQVWDMNFDSDTNVIDVAIRRLRAKIDDNFEPKLIHTVRGMGYVLEGPEDGE

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=71.4912280701754, Blast_Score=334, Evalue=2e-93,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=57.0776255707763, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=40.7239819004525, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=37.0044052863436, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=35.1351351351351, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=40, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=35.4545454545455, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=37.0044052863436, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=36.3636363636364, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=39.0350877192982, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=33.4821428571429, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=32.7433628318584, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=30, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.7359307359307, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790437, Length=116, Percent_Identity=32.7586206896552, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25481; Mature: 25481

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVVEDESKTGEYLQQGLSEAGFVVDLARNGLDGRHLAMTGDYDLLILDVMLPDLEGW
CEEEEEECCCCHHHHHHHHHHHCCEEEEHHHCCCCCCEEEEECCCCEEEEEECCCCCCHH
QILHALRSTELAVPVLFLTARDSVADRVKGLELGADDYMVKPFAFAELLARVRTLLRRGS
HHHHHHHHCCHHHEEEEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
APSLAERIQVADLVLDLTRRRASRGGQRITLTSKEFSLLELLARRHGEVLPRSLIASQVW
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHH
DMNFDSDTNVIDVAIRRLRAKIDDNFEPKLIHTVRGMGYVLEGPEDGE
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure
MKLLVVEDESKTGEYLQQGLSEAGFVVDLARNGLDGRHLAMTGDYDLLILDVMLPDLEGW
CEEEEEECCCCHHHHHHHHHHHCCEEEEHHHCCCCCCEEEEECCCCEEEEEECCCCCCHH
QILHALRSTELAVPVLFLTARDSVADRVKGLELGADDYMVKPFAFAELLARVRTLLRRGS
HHHHHHHHCCHHHEEEEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
APSLAERIQVADLVLDLTRRRASRGGQRITLTSKEFSLLELLARRHGEVLPRSLIASQVW
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHH
DMNFDSDTNVIDVAIRRLRAKIDDNFEPKLIHTVRGMGYVLEGPEDGE
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]