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The map label for this gene is deoA [C]

Identifier: 187928792

GI number: 187928792

Start: 1800860

End: 1802374

Strand: Direct

Name: deoA [C]

Synonym: Rpic_1709

Alternate gene names: 187928792

Gene position: 1800860-1802374 (Clockwise)

Preceding gene: 187928791

Following gene: 187928793

Centisome position: 45.68

GC content: 65.02

Gene sequence:

>1515_bases
ATGAGGAACCCTCGCCACAGGGCAAGTCTTGCCGTGCGTCGGATGGGCATCGAGACGCAGCAGGAATATGTCGTCTACAT
GCATCGAGACTGCCATGTTTGCCGCTCCGAGGGTTTCGAGGCGCAGACGCGAGTACTGATTAGCCTGAACGGACGCTCGA
TCATCGCCACGCTGAACGTTGTCGATCCGACCTTGCTGGAGTTGGGGGAGGCGGCGCTTTCGAACAGCGCGTGGCGAGCG
CTGGCGCCCGCGCCGGGCGACCGGATCACGATCTCGCATGCCCCGACGCTGGACTCAATGAGCCAGGTGCGGGCGAAGAT
CTACGGCCACAGGCTCGACGCGTCGGCTCTGGACTCGATCATTAGTGACGTCGCCGCTGGCAGCTACCCTGGGACACATA
TCGCCGCTTTTCTAAGCGCCTGCGCCGGCGGGCGGATGGATTTGCAGGAGACGATCGATCTGACGCGAGCGATGCTGGCC
GCGGGCAAGCGGCTCGACTGGGGGCATGCACCGATCGCGGACAAGCACTGTGTGGGTGGATTGCCGGGAAACCGCACGAC
GCCGATTGTCGTGTCGATCATCACCGCGGCCGGGCTCACGATGCCGAAGACGTCGTCAAGGGCCATTACCTCGCCGGCTG
GCACCGCCGACGTGATCGAAACGATGACGCCGGTGGCGCTCGATTTGGAGCAGATGCGCCGCGTTGTCCAACGCGAGGGC
GGCTGCTTTGTCTGGGGAGGCTCGCTGGCGCTCAGCCCGGCCGACGACATGTTGATCCGCGTCGAGCGCCCGCTGGACCT
CGACAGCGACGCGCAGCTCGTGGCATCTGTGCTGTCGAAGAAGATCGCTGCCGGCGCTACCCACTCCGTGATCGATGTGC
CGGTCGGGCCGACCGCCAAGGTGCGCAGTGACGCAGACTACGAGTGCCTGAAGCAAATGCTGGAGCAGGTAGCGCAGGCC
TTTGATTTGCACTTGCAGGTAGTGCGTACGGACGGGACGCAGCCGGTGGGCCGTGGCATTGGTCCCTCACTGGAGGCGCA
CGACGTGCTGGCAGTCCTTCAGCGTGCCGAGCGCGCGCCCGAGGATCTGAGCGTGCGCGCTGTCGCATTGGCTGGACAAC
TGTTGGAATTTTGCGGTCACAGCGAGCCGGGTACTGGCGTCTTGGTCGCTCAGCGGTTGCTTGATAGCGGCGCCGCGTGG
GCCAAATTCCAGGCGATCTGCAAAGCGCAAGGGGGCTTACGCGAGCCGCAGCGGGCGCGGCTACGCGAGCCTGTGCTGGC
CGAACGTGACGGGATGGTACGTGAGATCGACAGCCGGCGGTTGGCTCGCGTGGCCAAGCTCGCCGGGGCACCGAAGGCAC
CCGCTGCCGGGCTCGAACTGCATGTCAAGCTGGGGGATCGCGTCGAGCGAGGTATGCCGCTGTTCACCGTGCATGCCGAA
GCGCTCGGCGAGTTGGACTACGCGTTCGACTACCTGGAGGCTCACCCGCTGATCGATGTGGGAGATTCGAGATGA

Upstream 100 bases:

>100_bases
GCGAGCCGGGGCCGGCTGATGCGATGCGCCAGCGCATCGAGCGGGAACTTGGGTGGTCCGCCAGCGTTCCGTTGTTGGGA
CAGCACGTGGAGTTCGATGT

Downstream 100 bases:

>100_bases
CGCCACTGATTTTTGCCATGCCGGGCAATGAAGCGATGGCAGAGAAGCTGGCTTCGGCGTTGGGCGCAGAGCGCGGGACT
ACGACGGTGCGGCGCTTTCC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase 2 [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MRNPRHRASLAVRRMGIETQQEYVVYMHRDCHVCRSEGFEAQTRVLISLNGRSIIATLNVVDPTLLELGEAALSNSAWRA
LAPAPGDRITISHAPTLDSMSQVRAKIYGHRLDASALDSIISDVAAGSYPGTHIAAFLSACAGGRMDLQETIDLTRAMLA
AGKRLDWGHAPIADKHCVGGLPGNRTTPIVVSIITAAGLTMPKTSSRAITSPAGTADVIETMTPVALDLEQMRRVVQREG
GCFVWGGSLALSPADDMLIRVERPLDLDSDAQLVASVLSKKIAAGATHSVIDVPVGPTAKVRSDADYECLKQMLEQVAQA
FDLHLQVVRTDGTQPVGRGIGPSLEAHDVLAVLQRAERAPEDLSVRAVALAGQLLEFCGHSEPGTGVLVAQRLLDSGAAW
AKFQAICKAQGGLREPQRARLREPVLAERDGMVREIDSRRLARVAKLAGAPKAPAAGLELHVKLGDRVERGMPLFTVHAE
ALGELDYAFDYLEAHPLIDVGDSR

Sequences:

>Translated_504_residues
MRNPRHRASLAVRRMGIETQQEYVVYMHRDCHVCRSEGFEAQTRVLISLNGRSIIATLNVVDPTLLELGEAALSNSAWRA
LAPAPGDRITISHAPTLDSMSQVRAKIYGHRLDASALDSIISDVAAGSYPGTHIAAFLSACAGGRMDLQETIDLTRAMLA
AGKRLDWGHAPIADKHCVGGLPGNRTTPIVVSIITAAGLTMPKTSSRAITSPAGTADVIETMTPVALDLEQMRRVVQREG
GCFVWGGSLALSPADDMLIRVERPLDLDSDAQLVASVLSKKIAAGATHSVIDVPVGPTAKVRSDADYECLKQMLEQVAQA
FDLHLQVVRTDGTQPVGRGIGPSLEAHDVLAVLQRAERAPEDLSVRAVALAGQLLEFCGHSEPGTGVLVAQRLLDSGAAW
AKFQAICKAQGGLREPQRARLREPVLAERDGMVREIDSRRLARVAKLAGAPKAPAAGLELHVKLGDRVERGMPLFTVHAE
ALGELDYAFDYLEAHPLIDVGDSR
>Mature_504_residues
MRNPRHRASLAVRRMGIETQQEYVVYMHRDCHVCRSEGFEAQTRVLISLNGRSIIATLNVVDPTLLELGEAALSNSAWRA
LAPAPGDRITISHAPTLDSMSQVRAKIYGHRLDASALDSIISDVAAGSYPGTHIAAFLSACAGGRMDLQETIDLTRAMLA
AGKRLDWGHAPIADKHCVGGLPGNRTTPIVVSIITAAGLTMPKTSSRAITSPAGTADVIETMTPVALDLEQMRRVVQREG
GCFVWGGSLALSPADDMLIRVERPLDLDSDAQLVASVLSKKIAAGATHSVIDVPVGPTAKVRSDADYECLKQMLEQVAQA
FDLHLQVVRTDGTQPVGRGIGPSLEAHDVLAVLQRAERAPEDLSVRAVALAGQLLEFCGHSEPGTGVLVAQRLLDSGAAW
AKFQAICKAQGGLREPQRARLREPVLAERDGMVREIDSRRLARVAKLAGAPKAPAAGLELHVKLGDRVERGMPLFTVHAE
ALGELDYAFDYLEAHPLIDVGDSR

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=408, Percent_Identity=31.6176470588235, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI4503445, Length=408, Percent_Identity=31.6176470588235, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI166158922, Length=408, Percent_Identity=31.6176470588235, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1790842, Length=400, Percent_Identity=26, Blast_Score=102, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 54014; Mature: 54014

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNPRHRASLAVRRMGIETQQEYVVYMHRDCHVCRSEGFEAQTRVLISLNGRSIIATLNV
CCCCHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHCCCCCEEEEEEEECCCEEEEEEEC
VDPTLLELGEAALSNSAWRALAPAPGDRITISHAPTLDSMSQVRAKIYGHRLDASALDSI
CCHHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHH
ISDVAAGSYPGTHIAAFLSACAGGRMDLQETIDLTRAMLAAGKRLDWGHAPIADKHCVGG
HHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
LPGNRTTPIVVSIITAAGLTMPKTSSRAITSPAGTADVIETMTPVALDLEQMRRVVQREG
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHCHHHHHHHHHHCC
GCFVWGGSLALSPADDMLIRVERPLDLDSDAQLVASVLSKKIAAGATHSVIDVPVGPTAK
CEEEECCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCC
VRSDADYECLKQMLEQVAQAFDLHLQVVRTDGTQPVGRGIGPSLEAHDVLAVLQRAERAP
CCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
EDLSVRAVALAGQLLEFCGHSEPGTGVLVAQRLLDSGAAWAKFQAICKAQGGLREPQRAR
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHH
LREPVLAERDGMVREIDSRRLARVAKLAGAPKAPAAGLELHVKLGDRVERGMPLFTVHAE
HCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHCCCCEEEEEHH
ALGELDYAFDYLEAHPLIDVGDSR
HHHHHHHHHHHHHCCCCEECCCCC
>Mature Secondary Structure
MRNPRHRASLAVRRMGIETQQEYVVYMHRDCHVCRSEGFEAQTRVLISLNGRSIIATLNV
CCCCHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHCCCCCEEEEEEEECCCEEEEEEEC
VDPTLLELGEAALSNSAWRALAPAPGDRITISHAPTLDSMSQVRAKIYGHRLDASALDSI
CCHHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHH
ISDVAAGSYPGTHIAAFLSACAGGRMDLQETIDLTRAMLAAGKRLDWGHAPIADKHCVGG
HHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
LPGNRTTPIVVSIITAAGLTMPKTSSRAITSPAGTADVIETMTPVALDLEQMRRVVQREG
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHCHHHHHHHHHHCC
GCFVWGGSLALSPADDMLIRVERPLDLDSDAQLVASVLSKKIAAGATHSVIDVPVGPTAK
CEEEECCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCC
VRSDADYECLKQMLEQVAQAFDLHLQVVRTDGTQPVGRGIGPSLEAHDVLAVLQRAERAP
CCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
EDLSVRAVALAGQLLEFCGHSEPGTGVLVAQRLLDSGAAWAKFQAICKAQGGLREPQRAR
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHH
LREPVLAERDGMVREIDSRRLARVAKLAGAPKAPAAGLELHVKLGDRVERGMPLFTVHAE
HCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHCCCCEEEEEHH
ALGELDYAFDYLEAHPLIDVGDSR
HHHHHHHHHHHHHCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA