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The map label for this gene is 187928791

Identifier: 187928791

GI number: 187928791

Start: 1799499

End: 1800863

Strand: Direct

Name: 187928791

Synonym: Rpic_1708

Alternate gene names: NA

Gene position: 1799499-1800863 (Clockwise)

Preceding gene: 187928790

Following gene: 187928792

Centisome position: 45.64

GC content: 63.59

Gene sequence:

>1365_bases
ATGAAGCTCAGTTTTCACGGTGCGGCCGGCACAGTGACCGGCTCAAAGTATTTGGTGGAGCATCAGGGGCAGCGCCTGCT
GGTTGATTGCGGGTTGTTCCAGGGCTACAAGCAGTTGCGATTGCTGAACTGGGAGCCGTTGCCGTTCAGCGCCGCCGACA
TCGATGCGGTGGTGCTGACACACTCCCATCTGGACCATGCCGGTGCGTTACCGTTGCTCGTGAAACAGGGCTTCCGGGGC
CGGATTCTGGCGACGCCCTCGACAATCGAACTATGCGGTCTGCTGTTGCCCGACAGCGGGAGAATCCAGGAGGAGGACGC
CGCCTATGCGAACCGGCATCACACCTCCAAGCACGCCACGGCTTTGCCGCTGTACACGGAGGACGACGCACGTCGCGCAA
TGGAACAGTTGCACCGATTGCCTTTCGACCAGTGTGTGGACGTCGTCCCCGACGTTACGGTGACCTTGCGCCCGGCTGGG
CATATTCTCGGCGCGGCCTCGGCCGAACTGACAGCGGGGCAGACGACAGTGCTGTTCTCCGGAGACGTTGGCCGCCCCGA
CGACCCGGTGATGCGTGCGCCTGCGCCGGCTCCCAAGGCAGACTACATCGTTGTCGAATCGACTTATGGGGACCGGCTAC
ACGAACCGGTACCCAATGCGCAGGCCGTGCTCGGTGAGGCGATTGCTCGCACAGCACACCGTGGCGGCATGGTCGTGATT
CCGGCGTTTGCGGTGGGGCGTGCACAGTTGCTGCTGCATTTGATCCACAAGCTGAAGCAACAGGGCGCGATTCCAGACCT
GCCTGTTTTTCTCGACAGCCCGATGGCAATAGATGCAACCGAGATCTATCACCGCCATCACGCCGAACATAAGCTGTCGC
TCGAAGATTGCCTCGGGATGTACAAAGCTGCGCGCATGATCAGGACCCCGGAGGAATCGCGGGCGCTGGCTGGGCTGGCC
CTCCCGGCTGTGATCATCTCGGCCAGCGGCATGGCCACCGGCGGCCGCGTGCTGCACCATCTGAAGCATCTGGCGCCGGA
CCGGCGCAACACCATCATCCTGGCCGGTTATCAGGCTGGGGGGACACGCGGCGCGCGGCTGCAGGCTGGTGAGCGAAGCC
TGCGCATTCACGGTGAGGACGTCGCCGTGCGTGCCGAAGTGATTTCACTGCAGGGCATGTCGGCGCATGCCGATGCAAGC
CAATTGATCGAGTGGCTGGGCAGTGCGCCAGCGGCGCCGCGCTCGGTGTTCGTCACCCATGGCGAGCCGGGGCCGGCTGA
TGCGATGCGCCAGCGCATCGAGCGGGAACTTGGGTGGTCCGCCAGCGTTCCGTTGTTGGGACAGCACGTGGAGTTCGATG
TATGA

Upstream 100 bases:

>100_bases
GAGTGGGCGCACTATGCGTCGCACACCCCGCGGTTCATCCCGAATTTTGGCGACAAGCAAGCGGATCGCCACCACCACGC
ATGACAAAAAGGGGGAGGCG

Downstream 100 bases:

>100_bases
GGAACCCTCGCCACAGGGCAAGTCTTGCCGTGCGTCGGATGGGCATCGAGACGCAGCAGGAATATGTCGTCTACATGCAT
CGAGACTGCCATGTTTGCCG

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MKLSFHGAAGTVTGSKYLVEHQGQRLLVDCGLFQGYKQLRLLNWEPLPFSAADIDAVVLTHSHLDHAGALPLLVKQGFRG
RILATPSTIELCGLLLPDSGRIQEEDAAYANRHHTSKHATALPLYTEDDARRAMEQLHRLPFDQCVDVVPDVTVTLRPAG
HILGAASAELTAGQTTVLFSGDVGRPDDPVMRAPAPAPKADYIVVESTYGDRLHEPVPNAQAVLGEAIARTAHRGGMVVI
PAFAVGRAQLLLHLIHKLKQQGAIPDLPVFLDSPMAIDATEIYHRHHAEHKLSLEDCLGMYKAARMIRTPEESRALAGLA
LPAVIISASGMATGGRVLHHLKHLAPDRRNTIILAGYQAGGTRGARLQAGERSLRIHGEDVAVRAEVISLQGMSAHADAS
QLIEWLGSAPAAPRSVFVTHGEPGPADAMRQRIERELGWSASVPLLGQHVEFDV

Sequences:

>Translated_454_residues
MKLSFHGAAGTVTGSKYLVEHQGQRLLVDCGLFQGYKQLRLLNWEPLPFSAADIDAVVLTHSHLDHAGALPLLVKQGFRG
RILATPSTIELCGLLLPDSGRIQEEDAAYANRHHTSKHATALPLYTEDDARRAMEQLHRLPFDQCVDVVPDVTVTLRPAG
HILGAASAELTAGQTTVLFSGDVGRPDDPVMRAPAPAPKADYIVVESTYGDRLHEPVPNAQAVLGEAIARTAHRGGMVVI
PAFAVGRAQLLLHLIHKLKQQGAIPDLPVFLDSPMAIDATEIYHRHHAEHKLSLEDCLGMYKAARMIRTPEESRALAGLA
LPAVIISASGMATGGRVLHHLKHLAPDRRNTIILAGYQAGGTRGARLQAGERSLRIHGEDVAVRAEVISLQGMSAHADAS
QLIEWLGSAPAAPRSVFVTHGEPGPADAMRQRIERELGWSASVPLLGQHVEFDV
>Mature_454_residues
MKLSFHGAAGTVTGSKYLVEHQGQRLLVDCGLFQGYKQLRLLNWEPLPFSAADIDAVVLTHSHLDHAGALPLLVKQGFRG
RILATPSTIELCGLLLPDSGRIQEEDAAYANRHHTSKHATALPLYTEDDARRAMEQLHRLPFDQCVDVVPDVTVTLRPAG
HILGAASAELTAGQTTVLFSGDVGRPDDPVMRAPAPAPKADYIVVESTYGDRLHEPVPNAQAVLGEAIARTAHRGGMVVI
PAFAVGRAQLLLHLIHKLKQQGAIPDLPVFLDSPMAIDATEIYHRHHAEHKLSLEDCLGMYKAARMIRTPEESRALAGLA
LPAVIISASGMATGGRVLHHLKHLAPDRRNTIILAGYQAGGTRGARLQAGERSLRIHGEDVAVRAEVISLQGMSAHADAS
QLIEWLGSAPAAPRSVFVTHGEPGPADAMRQRIERELGWSASVPLLGQHVEFDV

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=452, Percent_Identity=26.5486725663717, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI7706427, Length=442, Percent_Identity=27.8280542986425, Blast_Score=159, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI32564696, Length=455, Percent_Identity=26.3736263736264, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI32566029, Length=445, Percent_Identity=27.8651685393258, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323307, Length=435, Percent_Identity=25.2873563218391, Blast_Score=139, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24648013, Length=453, Percent_Identity=28.6975717439294, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI21358523, Length=458, Percent_Identity=24.4541484716157, Blast_Score=144, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 48940; Mature: 48940

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSFHGAAGTVTGSKYLVEHQGQRLLVDCGLFQGYKQLRLLNWEPLPFSAADIDAVVLT
CEEEECCCCCCCCCCHHHEECCCCEEEEECHHHHHHHHHEEECCCCCCCCCCCCEEEEEE
HSHLDHAGALPLLVKQGFRGRILATPSTIELCGLLLPDSGRIQEEDAAYANRHHTSKHAT
ECCCCCCCCCHHHHHCCCCCEEEECCCHHHHHEEECCCCCCCCCHHHHHHHHCCCCCCCE
ALPLYTEDDARRAMEQLHRLPFDQCVDVVPDVTVTLRPAGHILGAASAELTAGQTTVLFS
EECEECCHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCEEECCCCEECCCCEEEEEE
GDVGRPDDPVMRAPAPAPKADYIVVESTYGDRLHEPVPNAQAVLGEAIARTAHRGGMVVI
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHCCCCCCHHHHHHHHHHHHHHCCCEEEE
PAFAVGRAQLLLHLIHKLKQQGAIPDLPVFLDSPMAIDATEIYHRHHAEHKLSLEDCLGM
ECHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCEECHHHHHHHHHHHCCCCHHHHHHH
YKAARMIRTPEESRALAGLALPAVIISASGMATGGRVLHHLKHLAPDRRNTIILAGYQAG
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCC
GTRGARLQAGERSLRIHGEDVAVRAEVISLQGMSAHADASQLIEWLGSAPAAPRSVFVTH
CCCCCEEECCCCEEEEECCCEEEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEEC
GEPGPADAMRQRIERELGWSASVPLLGQHVEFDV
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLSFHGAAGTVTGSKYLVEHQGQRLLVDCGLFQGYKQLRLLNWEPLPFSAADIDAVVLT
CEEEECCCCCCCCCCHHHEECCCCEEEEECHHHHHHHHHEEECCCCCCCCCCCCEEEEEE
HSHLDHAGALPLLVKQGFRGRILATPSTIELCGLLLPDSGRIQEEDAAYANRHHTSKHAT
ECCCCCCCCCHHHHHCCCCCEEEECCCHHHHHEEECCCCCCCCCHHHHHHHHCCCCCCCE
ALPLYTEDDARRAMEQLHRLPFDQCVDVVPDVTVTLRPAGHILGAASAELTAGQTTVLFS
EECEECCHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCEEECCCCEECCCCEEEEEE
GDVGRPDDPVMRAPAPAPKADYIVVESTYGDRLHEPVPNAQAVLGEAIARTAHRGGMVVI
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHCCCCCCHHHHHHHHHHHHHHCCCEEEE
PAFAVGRAQLLLHLIHKLKQQGAIPDLPVFLDSPMAIDATEIYHRHHAEHKLSLEDCLGM
ECHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCEECHHHHHHHHHHHCCCCHHHHHHH
YKAARMIRTPEESRALAGLALPAVIISASGMATGGRVLHHLKHLAPDRRNTIILAGYQAG
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCC
GTRGARLQAGERSLRIHGEDVAVRAEVISLQGMSAHADASQLIEWLGSAPAAPRSVFVTH
CCCCCEEECCCCEEEEECCCEEEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEEC
GEPGPADAMRQRIERELGWSASVPLLGQHVEFDV
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA