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The map label for this gene is zitB [H]

Identifier: 187928760

GI number: 187928760

Start: 1766121

End: 1767425

Strand: Reverse

Name: zitB [H]

Synonym: Rpic_1677

Alternate gene names: 187928760

Gene position: 1767425-1766121 (Counterclockwise)

Preceding gene: 187928761

Following gene: 187928759

Centisome position: 44.83

GC content: 62.68

Gene sequence:

>1305_bases
ATGAGCAATTTCTACGACACGCCGTTCGGTATCGGTCATGACCACGTGTTCCTGGGCGCAGGGCACGAGAAAAACGAGCG
CAAGACATGGGCCGTGATCGTGCTGTGCACGCTGATGATGGCCGCTGAGATCATCGGCGGCAGCATGTTTGGCTCGCTGG
CCCTGGTGGCCGATGGGCTGCATATGTCGACGCACGCAGGCGCCATGCTGATCGCGGCGCTGGCCTACACATATGCGCGG
CGCCACGCGAACGACTCACGCTTCGTGTTCGGTACAGGCAAGCTCGGCGACCTGGCCGGCTTCACCAGCGCCATCATCCT
GGCGATGATCGCGCTGCTGATCGGCTACGAGGCTGTGGTGCGATTCCTCTCGCCGGTGCCGATCCACTTTAGTGAGGCGA
TCCCGATTGCGGTGGTCGGCCTGCTGGTGAACATCGCCAGTGCCTGGCTGCTGAGCGGTGGCGACCACGATGGCCACAGC
CATGGCCACAGTCATCACCATGGTCATGCCCACGGACACGATCACGGCCCAGCCGGACTTGGCGACAAACATGCACACGG
CAAGGAAGTGCAGCACATCAACGCGCCAGCAGGGGTGTTCGCGCTGTCGATCTTTGAAGACGACGTACCGCCAGTTTTCC
GCTTGGCTGGAGAAACCATCCCGCTGCCCAGCGACGTGGCGACGGTGACCACCATCCGGCCGGACGGCAGCCGCCAGGAA
TTCCTGATGGTCCGCAAGGCGAACTACCTAGAATCCACCACAGAGATTCCGGAGCCGCATGCCTTTACTGCCGTGCTCGG
CATCGGCGGCCAGGAATACAGCGTGGCCTTCGAAGAGCATGAGCACGATCACGCCGATGGACACGGGGCGCACCATCGCG
ACCACAACATGCGCGCGGCCTATGTGCACGTCTTGGCCGACGCCGCCATCTCTGTCCTGGCCATCATCGGGCTGTTGCTG
GCCAAAACCTTCGGCTGGCTCTGGATGGACCCGCTTGCAGGTATCGTCGGTGCGCTGGTCATCGCCAACTGGGCGTACGG
ACTGATGCGCGACACGGGTGGCATCCTGGTCGACATGACACCAGACAAGCAAATCGGCGGCCGCATCAAGACTGCACTGG
AAACCGATGGCGACGCGCTGCTCGATCTGCACGTCTGGCGCATCGGCCCTGGGCACCTGGGCGTGGTGGTCTCGGTCGGC
ACACGCCAGGCGCATCGCGGGCCGCAGTTTTATCACGAACGGCTGCGGCGATTCCAAGCGCTGTCACACGTTACGATCGA
GGTTCATTCGTTACCGACCAAATAA

Upstream 100 bases:

>100_bases
ACCCACCTGACCGAGGTGGATGACGAACATGAACACGCCGAAGGCAGCGCCAAGGAGCAGCTGATCGAGGTCGTGCACAG
CTATTTCAAATGAGCCAGCC

Downstream 100 bases:

>100_bases
CCTGACGTCCGACCTGGACATATCCTCCGGACGATTAGAACGGGGGCGGTACCCCGCCATGTGGGTGCCGCATTCGCCCA
ACCAAAACAAGAAAACATTG

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSNFYDTPFGIGHDHVFLGAGHEKNERKTWAVIVLCTLMMAAEIIGGSMFGSLALVADGLHMSTHAGAMLIAALAYTYAR
RHANDSRFVFGTGKLGDLAGFTSAIILAMIALLIGYEAVVRFLSPVPIHFSEAIPIAVVGLLVNIASAWLLSGGDHDGHS
HGHSHHHGHAHGHDHGPAGLGDKHAHGKEVQHINAPAGVFALSIFEDDVPPVFRLAGETIPLPSDVATVTTIRPDGSRQE
FLMVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVAFEEHEHDHADGHGAHHRDHNMRAAYVHVLADAAISVLAIIGLLL
AKTFGWLWMDPLAGIVGALVIANWAYGLMRDTGGILVDMTPDKQIGGRIKTALETDGDALLDLHVWRIGPGHLGVVVSVG
TRQAHRGPQFYHERLRRFQALSHVTIEVHSLPTK

Sequences:

>Translated_434_residues
MSNFYDTPFGIGHDHVFLGAGHEKNERKTWAVIVLCTLMMAAEIIGGSMFGSLALVADGLHMSTHAGAMLIAALAYTYAR
RHANDSRFVFGTGKLGDLAGFTSAIILAMIALLIGYEAVVRFLSPVPIHFSEAIPIAVVGLLVNIASAWLLSGGDHDGHS
HGHSHHHGHAHGHDHGPAGLGDKHAHGKEVQHINAPAGVFALSIFEDDVPPVFRLAGETIPLPSDVATVTTIRPDGSRQE
FLMVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVAFEEHEHDHADGHGAHHRDHNMRAAYVHVLADAAISVLAIIGLLL
AKTFGWLWMDPLAGIVGALVIANWAYGLMRDTGGILVDMTPDKQIGGRIKTALETDGDALLDLHVWRIGPGHLGVVVSVG
TRQAHRGPQFYHERLRRFQALSHVTIEVHSLPTK
>Mature_433_residues
SNFYDTPFGIGHDHVFLGAGHEKNERKTWAVIVLCTLMMAAEIIGGSMFGSLALVADGLHMSTHAGAMLIAALAYTYARR
HANDSRFVFGTGKLGDLAGFTSAIILAMIALLIGYEAVVRFLSPVPIHFSEAIPIAVVGLLVNIASAWLLSGGDHDGHSH
GHSHHHGHAHGHDHGPAGLGDKHAHGKEVQHINAPAGVFALSIFEDDVPPVFRLAGETIPLPSDVATVTTIRPDGSRQEF
LMVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVAFEEHEHDHADGHGAHHRDHNMRAAYVHVLADAAISVLAIIGLLLA
KTFGWLWMDPLAGIVGALVIANWAYGLMRDTGGILVDMTPDKQIGGRIKTALETDGDALLDLHVWRIGPGHLGVVVSVGT
RQAHRGPQFYHERLRRFQALSHVTIEVHSLPTK

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=150, Percent_Identity=28.6666666666667, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786966, Length=137, Percent_Identity=40.1459854014599, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=374, Percent_Identity=24.331550802139, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=412, Percent_Identity=22.3300970873786, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320411, Length=152, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 46726; Mature: 46595

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFYDTPFGIGHDHVFLGAGHEKNERKTWAVIVLCTLMMAAEIIGGSMFGSLALVADGL
CCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
HMSTHAGAMLIAALAYTYARRHANDSRFVFGTGKLGDLAGFTSAIILAMIALLIGYEAVV
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RFLSPVPIHFSEAIPIAVVGLLVNIASAWLLSGGDHDGHSHGHSHHHGHAHGHDHGPAGL
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GDKHAHGKEVQHINAPAGVFALSIFEDDVPPVFRLAGETIPLPSDVATVTTIRPDGSRQE
CCCCCCCCCHHCCCCCCHHEEEEECCCCCCHHHHHCCCCCCCCCCCEEEEEECCCCCCCC
FLMVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVAFEEHEHDHADGHGAHHRDHNMRAA
EEEEHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEHHCCCCCCCCCCCCCCCCCCHHH
YVHVLADAAISVLAIIGLLLAKTFGWLWMDPLAGIVGALVIANWAYGLMRDTGGILVDMT
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PDKQIGGRIKTALETDGDALLDLHVWRIGPGHLGVVVSVGTRQAHRGPQFYHERLRRFQA
CCHHHCCCCHHHCCCCCCEEEEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
LSHVTIEVHSLPTK
HHHEEEEEECCCCC
>Mature Secondary Structure 
SNFYDTPFGIGHDHVFLGAGHEKNERKTWAVIVLCTLMMAAEIIGGSMFGSLALVADGL
CCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
HMSTHAGAMLIAALAYTYARRHANDSRFVFGTGKLGDLAGFTSAIILAMIALLIGYEAVV
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RFLSPVPIHFSEAIPIAVVGLLVNIASAWLLSGGDHDGHSHGHSHHHGHAHGHDHGPAGL
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GDKHAHGKEVQHINAPAGVFALSIFEDDVPPVFRLAGETIPLPSDVATVTTIRPDGSRQE
CCCCCCCCCHHCCCCCCHHEEEEECCCCCCHHHHHCCCCCCCCCCCEEEEEECCCCCCCC
FLMVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVAFEEHEHDHADGHGAHHRDHNMRAA
EEEEHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEHHCCCCCCCCCCCCCCCCCCHHH
YVHVLADAAISVLAIIGLLLAKTFGWLWMDPLAGIVGALVIANWAYGLMRDTGGILVDMT
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PDKQIGGRIKTALETDGDALLDLHVWRIGPGHLGVVVSVGTRQAHRGPQFYHERLRRFQA
CCHHHCCCCHHHCCCCCCEEEEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
LSHVTIEVHSLPTK
HHHEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]