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The map label for this gene is fucA [C]

Identifier: 187928525

GI number: 187928525

Start: 1526522

End: 1527370

Strand: Reverse

Name: fucA [C]

Synonym: Rpic_1439

Alternate gene names: 187928525

Gene position: 1527370-1526522 (Counterclockwise)

Preceding gene: 187928526

Following gene: 187928524

Centisome position: 38.74

GC content: 64.43

Gene sequence:

>849_bases
ATGAACGCACCTGCAACCACCCAAGCCAAGCGGCCCGACAGCATGGCCGCCAGTCTCAGCCCCGAGGCTGCCGCGCGCTA
TCGCAACCTGCCGCGCCCGCCGCAATTTGCCACCGTTGAAGAAGAGCGCCTGCATCGCAAACAGCGCCTGGCTGCGGCGT
TTCGCTTGTTCTCCAAATTCGGTTTCGACGAAGGTGTGGCCGGACACATCACGGCGCGCGATCCGGAACACCAGGACAGC
TTCTGGGTGAACCCGTTCGGTGTGCATTTCAGCCAGGTGACGGTATCGAACCTGATCCGCTGCGATCACCACGGCAACGT
GGTGGAAGGGGATTACCCGGTCAACGCCGCAGCGTTTGCGATTCACTCGCGCGTGCACCAGGCGCGCCCCGACCCGGTGG
CCGCTGCGCACTCGCACAGCACGTACGGACGGGCGTGGTCGACGCTCGGCCGCAAACTCGACCCGCTTACGCAAGACGTG
TGCGCCTTTTATGGCGACCACGCTGTGTATGACGATTTCGGCGGCGTAGTGGTCGAGCTGGACGAAGGCCAGCGCATTGC
AGAAGCGCTGGGCGACAACAAGGCCGCCATCCTGCAGAACCATGGCCTGCTGACGGTCGGCAAGACGGTCGACGAAGCAG
CGTGGTGGTTCATCACGATGGAGCGCTCCTGCCAGGTGCAGTTGCTGGCCGAAGCCGCTGCGGCGCGCACCGGCGACGCA
CTACGCACGATTTCCGATGCCGCTGCCCGCCAGGCGTATTCCATCGTCGGATCGGCGCAGGCGGGGTGGTTCCAGTTCCA
GCCGCTGTATGCGCGCATCGTCAAAGAACAACCCGATCTGCTCGACTGA

Upstream 100 bases:

>100_bases
TGAGCTGCGCCGCACGCGGACTGTCAATCGCTTGACAGTCCGCTGGGCGAGGGCCGCCACAGAATGGCCCCACCCACAAC
GAACGCGTGAAGGAGACACC

Downstream 100 bases:

>100_bases
TCGGCAACGCACATTTCTGGAGCCCGCATGACGGACCTGATCCTGCATCACTACGCCACCTCGCCGTTTTCTGAGAAGGT
GCGTTTGATCCTCGGCTACA

Product: hypothetical protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MNAPATTQAKRPDSMAASLSPEAAARYRNLPRPPQFATVEEERLHRKQRLAAAFRLFSKFGFDEGVAGHITARDPEHQDS
FWVNPFGVHFSQVTVSNLIRCDHHGNVVEGDYPVNAAAFAIHSRVHQARPDPVAAAHSHSTYGRAWSTLGRKLDPLTQDV
CAFYGDHAVYDDFGGVVVELDEGQRIAEALGDNKAAILQNHGLLTVGKTVDEAAWWFITMERSCQVQLLAEAAAARTGDA
LRTISDAAARQAYSIVGSAQAGWFQFQPLYARIVKEQPDLLD

Sequences:

>Translated_282_residues
MNAPATTQAKRPDSMAASLSPEAAARYRNLPRPPQFATVEEERLHRKQRLAAAFRLFSKFGFDEGVAGHITARDPEHQDS
FWVNPFGVHFSQVTVSNLIRCDHHGNVVEGDYPVNAAAFAIHSRVHQARPDPVAAAHSHSTYGRAWSTLGRKLDPLTQDV
CAFYGDHAVYDDFGGVVVELDEGQRIAEALGDNKAAILQNHGLLTVGKTVDEAAWWFITMERSCQVQLLAEAAAARTGDA
LRTISDAAARQAYSIVGSAQAGWFQFQPLYARIVKEQPDLLD
>Mature_282_residues
MNAPATTQAKRPDSMAASLSPEAAARYRNLPRPPQFATVEEERLHRKQRLAAAFRLFSKFGFDEGVAGHITARDPEHQDS
FWVNPFGVHFSQVTVSNLIRCDHHGNVVEGDYPVNAAAFAIHSRVHQARPDPVAAAHSHSTYGRAWSTLGRKLDPLTQDV
CAFYGDHAVYDDFGGVVVELDEGQRIAEALGDNKAAILQNHGLLTVGKTVDEAAWWFITMERSCQVQLLAEAAAARTGDA
LRTISDAAARQAYSIVGSAQAGWFQFQPLYARIVKEQPDLLD

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826323, Length=198, Percent_Identity=33.8383838383838, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI29826325, Length=198, Percent_Identity=33.8383838383838, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI29826321, Length=198, Percent_Identity=33.8383838383838, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI29826319, Length=198, Percent_Identity=33.8383838383838, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI297307160, Length=232, Percent_Identity=30.6034482758621, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI89276787, Length=232, Percent_Identity=30.6034482758621, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI9257190, Length=232, Percent_Identity=30.6034482758621, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI297307158, Length=198, Percent_Identity=31.8181818181818, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI9257192, Length=198, Percent_Identity=31.8181818181818, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI9943848, Length=211, Percent_Identity=29.3838862559242, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI9951927, Length=211, Percent_Identity=29.3838862559242, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI62912453, Length=211, Percent_Identity=29.3838862559242, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1789164, Length=175, Percent_Identity=29.7142857142857, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533216, Length=224, Percent_Identity=27.6785714285714, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI115533218, Length=224, Percent_Identity=27.6785714285714, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71989560, Length=218, Percent_Identity=29.3577981651376, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71989541, Length=218, Percent_Identity=29.3577981651376, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71989544, Length=218, Percent_Identity=29.3577981651376, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71989550, Length=218, Percent_Identity=29.3577981651376, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71989555, Length=218, Percent_Identity=29.3577981651376, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281363755, Length=184, Percent_Identity=35.3260869565217, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281363751, Length=184, Percent_Identity=35.3260869565217, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24655690, Length=184, Percent_Identity=35.3260869565217, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281363763, Length=184, Percent_Identity=35.3260869565217, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281363757, Length=184, Percent_Identity=35.3260869565217, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17136738, Length=184, Percent_Identity=35.3260869565217, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24655685, Length=184, Percent_Identity=35.3260869565217, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281363761, Length=184, Percent_Identity=35.3260869565217, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI281363759, Length=184, Percent_Identity=35.3260869565217, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI281363753, Length=184, Percent_Identity=35.3260869565217, Blast_Score=107, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 30977; Mature: 30977

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPATTQAKRPDSMAASLSPEAAARYRNLPRPPQFATVEEERLHRKQRLAAAFRLFSKF
CCCCCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GFDEGVAGHITARDPEHQDSFWVNPFGVHFSQVTVSNLIRCDHHGNVVEGDYPVNAAAFA
CCCCCCCCEEECCCCCCCCCEECCHHCCHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHH
IHSRVHQARPDPVAAAHSHSTYGRAWSTLGRKLDPLTQDVCAFYGDHAVYDDFGGVVVEL
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCEEEEE
DEGQRIAEALGDNKAAILQNHGLLTVGKTVDEAAWWFITMERSCQVQLLAEAAAARTGDA
CCCHHHHHHHCCCCEEEEECCCEEEECCCHHCCEEEEEEECCCCHHHHHHHHHHHHCCHH
LRTISDAAARQAYSIVGSAQAGWFQFQPLYARIVKEQPDLLD
HHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNAPATTQAKRPDSMAASLSPEAAARYRNLPRPPQFATVEEERLHRKQRLAAAFRLFSKF
CCCCCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GFDEGVAGHITARDPEHQDSFWVNPFGVHFSQVTVSNLIRCDHHGNVVEGDYPVNAAAFA
CCCCCCCCEEECCCCCCCCCEECCHHCCHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHH
IHSRVHQARPDPVAAAHSHSTYGRAWSTLGRKLDPLTQDVCAFYGDHAVYDDFGGVVVEL
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCEEEEE
DEGQRIAEALGDNKAAILQNHGLLTVGKTVDEAAWWFITMERSCQVQLLAEAAAARTGDA
CCCHHHHHHHCCCCEEEEECCCEEEECCCHHCCEEEEEEECCCCHHHHHHHHHHHHCCHH
LRTISDAAARQAYSIVGSAQAGWFQFQPLYARIVKEQPDLLD
HHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]