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The map label for this gene is emrY [H]

Identifier: 187928445

GI number: 187928445

Start: 1453843

End: 1455396

Strand: Direct

Name: emrY [H]

Synonym: Rpic_1358

Alternate gene names: 187928445

Gene position: 1453843-1455396 (Clockwise)

Preceding gene: 187928432

Following gene: 187928448

Centisome position: 36.88

GC content: 63.58

Gene sequence:

>1554_bases
ATGAACACGCCAAGCACAGACCACACGGTTTCTCCGCCGCCCGCAGTGCGCAACCCGGTTGCCGAATCGACCGTCGGCAG
CCGGATGGAATTGCGTATGGTAGGCATGGTGATCGGCTTGGCGACGGGCGTGGACTACATGTCCAACCTGATGTTCTCAA
TTGCCGGACCGCATATCGAAGGCGGGGTGCTGGCGTCACAGGATGTCTATCTCTGGGCCGTGACGGCGTATGCAGCAGCG
GCAAGTCTGTCGATTCTGGTGATGGGCCGGCTGGCCGACCACATGACCTACCGCAGGCACACGCTACTGTCGCTGCTGGT
GTTTATTGTCGGCACGCTGATGTGCGCGGCGGCCGAGGGCGGAACGATGCTGATCGTCGGGCGGGCGGTGCAGGGGTTTG
GCGGCGGCCCGATGCTGTCGACTTCGCGCATCTTCGTGCAGCACAGCCCCGCGCACGAACGCCGCACGATGATGAAGGGC
ATGATCTACGGCATCTTCGGGCTGAGCTGCGTGTCGCCGATGCTGTCGGCGGCGCTGACGGAGCAATTCGGCTGGCGCGC
CATCTTCGTCGCGCAGTTGCTGGTGGCCGTGGTGGTATGCGGGCTGGTGGCGGCGTTTTATCCGCATCCGAAGATGCACG
AGCGCCAGGGCGATTTCGCCTCGCTCGATTGGCCCTCAGCCATCGCATTTGGGCTGGCGGCGCTGATTGCGCTGCACGGC
TTTCAGCAGGCCCGCTTCATTCATCCCGATGGTTCGCCTGCCCAGGTGGTGCCGATCATTGCGGTGGTGGCACTCATCAT
CTGGGTCGGCATTCGCCAGACGGCCCACCCATTGCCGTGGGTGGACTTGCGGGCCACGCTGCAGCGGCGCTTCATGATGG
GCATGGTGTTCTACGCCATCTATTACATGTTTGCGAGCGCCTGGGGCTTTCTTTCGTCGAGCCTGCTGCAGAACGGTCTG
GGCTTTCGCTACGAGACCACCGCGCAGTTGATGAGCCTGGGCGGGCTGGTGACGGTGGTGCTCGGCATCCTGAACTTTCA
ATTGACGAACGTGTTGCCGACCAAGCGCGTGCTGATCTCCATCGGCTTTGTGCTGATGGCGACAGCTCTGCTGTGGATGT
CGCATGTGGCCATGCCAGGCGCCTCGGTGGCGGCGGTGGTGCCGGGCTTCATGATCGAAGGCATGGTGGGGGTGTTTGTG
GTGATCCAGGTGGCGGGACTGACCTACGTGGATTTGCCGGCCAAGGATTTCGGCCATGCCTACCAGTTCAAGGGAATCAT
GCGGGCTTGGGCGCAGGCCTTTGGGACGATGGGGGCAACATTGTTGCTGCAGCGCGGACAGGCGCAGCATCGCACCGATC
TGGTGGGGCACGTCAGCGCGCTGACGCCGGCCTGGCAGTGGCCGCATCCGTTGCAGGGGTCGGAGTTGATGCGGATCTCG
TTGGAGATTGATCGGCAGGCGACGTTGCTGGCGGTGGGGGATTTGTTCGCCTGGGGCGCGGTGGTGGCGTTGGTTTGCGC
GGGGGCGATCTGGTTGCAGCGGTCGTTGCGGTGA

Upstream 100 bases:

>100_bases
AAAAGTGTCCCAGTCGTTCCAGTCCGTCGTTCGCATCATTGAACAATGAATTTGTTGGCAGGCGATTTCCGCCGGTTTCG
AGGCAAATTACCATCCCTGC

Downstream 100 bases:

>100_bases
GGGTGCTGTGGGCCGGGTGTTTCGTCCCCTGGCGGGGCCGACTTACTTTCTTTGTCTTGCCAAAGAAAGGTAAGCAAAGA
AAGGCGCGCCCGATGCGGCG

Product: major facilitator superfamily protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MNTPSTDHTVSPPPAVRNPVAESTVGSRMELRMVGMVIGLATGVDYMSNLMFSIAGPHIEGGVLASQDVYLWAVTAYAAA
ASLSILVMGRLADHMTYRRHTLLSLLVFIVGTLMCAAAEGGTMLIVGRAVQGFGGGPMLSTSRIFVQHSPAHERRTMMKG
MIYGIFGLSCVSPMLSAALTEQFGWRAIFVAQLLVAVVVCGLVAAFYPHPKMHERQGDFASLDWPSAIAFGLAALIALHG
FQQARFIHPDGSPAQVVPIIAVVALIIWVGIRQTAHPLPWVDLRATLQRRFMMGMVFYAIYYMFASAWGFLSSSLLQNGL
GFRYETTAQLMSLGGLVTVVLGILNFQLTNVLPTKRVLISIGFVLMATALLWMSHVAMPGASVAAVVPGFMIEGMVGVFV
VIQVAGLTYVDLPAKDFGHAYQFKGIMRAWAQAFGTMGATLLLQRGQAQHRTDLVGHVSALTPAWQWPHPLQGSELMRIS
LEIDRQATLLAVGDLFAWGAVVALVCAGAIWLQRSLR

Sequences:

>Translated_517_residues
MNTPSTDHTVSPPPAVRNPVAESTVGSRMELRMVGMVIGLATGVDYMSNLMFSIAGPHIEGGVLASQDVYLWAVTAYAAA
ASLSILVMGRLADHMTYRRHTLLSLLVFIVGTLMCAAAEGGTMLIVGRAVQGFGGGPMLSTSRIFVQHSPAHERRTMMKG
MIYGIFGLSCVSPMLSAALTEQFGWRAIFVAQLLVAVVVCGLVAAFYPHPKMHERQGDFASLDWPSAIAFGLAALIALHG
FQQARFIHPDGSPAQVVPIIAVVALIIWVGIRQTAHPLPWVDLRATLQRRFMMGMVFYAIYYMFASAWGFLSSSLLQNGL
GFRYETTAQLMSLGGLVTVVLGILNFQLTNVLPTKRVLISIGFVLMATALLWMSHVAMPGASVAAVVPGFMIEGMVGVFV
VIQVAGLTYVDLPAKDFGHAYQFKGIMRAWAQAFGTMGATLLLQRGQAQHRTDLVGHVSALTPAWQWPHPLQGSELMRIS
LEIDRQATLLAVGDLFAWGAVVALVCAGAIWLQRSLR
>Mature_517_residues
MNTPSTDHTVSPPPAVRNPVAESTVGSRMELRMVGMVIGLATGVDYMSNLMFSIAGPHIEGGVLASQDVYLWAVTAYAAA
ASLSILVMGRLADHMTYRRHTLLSLLVFIVGTLMCAAAEGGTMLIVGRAVQGFGGGPMLSTSRIFVQHSPAHERRTMMKG
MIYGIFGLSCVSPMLSAALTEQFGWRAIFVAQLLVAVVVCGLVAAFYPHPKMHERQGDFASLDWPSAIAFGLAALIALHG
FQQARFIHPDGSPAQVVPIIAVVALIIWVGIRQTAHPLPWVDLRATLQRRFMMGMVFYAIYYMFASAWGFLSSSLLQNGL
GFRYETTAQLMSLGGLVTVVLGILNFQLTNVLPTKRVLISIGFVLMATALLWMSHVAMPGASVAAVVPGFMIEGMVGVFV
VIQVAGLTYVDLPAKDFGHAYQFKGIMRAWAQAFGTMGATLLLQRGQAQHRTDLVGHVSALTPAWQWPHPLQGSELMRIS
LEIDRQATLLAVGDLFAWGAVVALVCAGAIWLQRSLR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=503, Percent_Identity=22.8628230616302, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1789042, Length=498, Percent_Identity=22.4899598393574, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87081983, Length=261, Percent_Identity=27.9693486590038, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55827; Mature: 55827

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]