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The map label for this gene is guaB [H]

Identifier: 187928395

GI number: 187928395

Start: 1401656

End: 1403119

Strand: Direct

Name: guaB [H]

Synonym: Rpic_1306

Alternate gene names: 187928395

Gene position: 1401656-1403119 (Clockwise)

Preceding gene: 187928392

Following gene: 187928396

Centisome position: 35.55

GC content: 64.28

Gene sequence:

>1464_bases
ATGCGTCTTGTCCAGAAAGCACTCACGTTCGATGATGTGCTGCTCGTCCCGGCCTACTCGGCCGTCCTGCCCCGCGATAC
GTCCCTTCGCACCAAGCTCACCCGTTCGATCGAACTTGCCATTCCGCTCGTCTCCGCCGCCATGGATACGGTTACGGAAG
CGCGGCTCGCCATCGCTATGGCGCAGCAAGGTGGCATCGGTATCGTCCACAAGAACCTGAAGCCCGAAGAACAGGCGCGC
GAAGTCGCCAAGGTCAAGCGCTTTGAATCGGGCGTGCTGCGCGATCCGATCACGATCGGCCCGGACATGAAGGTCCGCGA
CGTGATGGCGCTGTCGGCACAGCACGGCATCTCGGGTTTCCCGGTGCTGGAAGGCAAGAAGGTGGTGGGCATCATCACCA
ACCGCGATCTGCGTTTCGAAGAAGAACTGGACGCCCCGGTGCGCGCCAAGATGACGCCGAGCGAGAAGCTCGTCACCGTC
AAGGAAGGCGCCTCGCTGGAAGAGGCCAAGCGCCTGATGAACAAGCACCGCCTGGAGCGTGTGCTGGTGGTGGGCGAGGC
TTTCGAGCTGCGCGGCCTGATCACCGTCAAGGATATCCAGAAGGCCACCGAATACCCGCTGGCCTCGAAGGACGAGCGCG
GTTCGCTGCGCGTGGGTGCGGCGGTGGGCGTGGGTCCGGATAACGATCTGCGTATCGATTTGCTGGTCAAGGCGGGCGTG
GACGTGATCGTGGTCGACACCGCGCACGGCCACAGCCAGGGCGTGCTGAACCGCGTGCGCTGGATCAAGGACAACTACCC
GCAAGTGCAGGTGATCGGCGGCAACATCGCCACGGGCGACGCGGCCAGGGCGCTGGTCGACCATGGCGCGGATGGCGTCA
AGGTTGGTATCGGCCCGGGTTCGATCTGCACGACACGGATTGTCGCGGGCGTGGGCGTGCCGCAGATCTTTGCCGTGTCC
AATGTGGCCGAGGCCCTCAAGGGCACCGGCGTTCCGCTGATCGCCGACGGCGGTATCCGCTACTCGGGCGATGTGGCCAA
GGCACTGGCTGCCGGCGCACACACCGTGATGATGGGCGGCATGTTTGCCGGCACGGACGAATCTCCCGGTGAGGTGTTCC
TGTTCCAGGGGCGCTCGTACAAGAGCTACCGCGGCATGGGCTCGGTTGGCGCGATGAAGGACGGCGCTGCCGACCGTTAC
TTCCAGGAAGACAACACCGCCAACGTCGACAAGCTGGTGCCCGAAGGTATCGAAGGGCGCGTGCCGTACAAGGGTTCGGC
ACTGCCCATCGTGCATCAACTCACGGGCGGCGTCCGCTCGTCGATGGGCTACTGCGGTTGCGCGTCGATCGCCGAATGGC
ACGAGAAGGCCCAGTTTGTCGAGATCACCGCCGCGGGCATGAACGAATCGCACGTGCACGACGTGCAGATCACGAAGGAA
GCGCCGAACTATCACCGCGACTGA

Upstream 100 bases:

>100_bases
GGTGCGTGCGCGAAGAAAAATTTATCGAGCATAGCACGGGTCTCTACAACCGTGGGGCGAATTCCCGTATAATCCGATTT
TGCGCCTAGAGGAAATTGCT

Downstream 100 bases:

>100_bases
TCGCTTGTCGATCATCGCAAACAACAAACAAGATAGAAGGCAAGCAGTACTGCCGCCGGGGCGCGCGGGCGCTCCGGCCG
ATTCAACCGGTGGCCGAGGC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MRLVQKALTFDDVLLVPAYSAVLPRDTSLRTKLTRSIELAIPLVSAAMDTVTEARLAIAMAQQGGIGIVHKNLKPEEQAR
EVAKVKRFESGVLRDPITIGPDMKVRDVMALSAQHGISGFPVLEGKKVVGIITNRDLRFEEELDAPVRAKMTPSEKLVTV
KEGASLEEAKRLMNKHRLERVLVVGEAFELRGLITVKDIQKATEYPLASKDERGSLRVGAAVGVGPDNDLRIDLLVKAGV
DVIVVDTAHGHSQGVLNRVRWIKDNYPQVQVIGGNIATGDAARALVDHGADGVKVGIGPGSICTTRIVAGVGVPQIFAVS
NVAEALKGTGVPLIADGGIRYSGDVAKALAAGAHTVMMGGMFAGTDESPGEVFLFQGRSYKSYRGMGSVGAMKDGAADRY
FQEDNTANVDKLVPEGIEGRVPYKGSALPIVHQLTGGVRSSMGYCGCASIAEWHEKAQFVEITAAGMNESHVHDVQITKE
APNYHRD

Sequences:

>Translated_487_residues
MRLVQKALTFDDVLLVPAYSAVLPRDTSLRTKLTRSIELAIPLVSAAMDTVTEARLAIAMAQQGGIGIVHKNLKPEEQAR
EVAKVKRFESGVLRDPITIGPDMKVRDVMALSAQHGISGFPVLEGKKVVGIITNRDLRFEEELDAPVRAKMTPSEKLVTV
KEGASLEEAKRLMNKHRLERVLVVGEAFELRGLITVKDIQKATEYPLASKDERGSLRVGAAVGVGPDNDLRIDLLVKAGV
DVIVVDTAHGHSQGVLNRVRWIKDNYPQVQVIGGNIATGDAARALVDHGADGVKVGIGPGSICTTRIVAGVGVPQIFAVS
NVAEALKGTGVPLIADGGIRYSGDVAKALAAGAHTVMMGGMFAGTDESPGEVFLFQGRSYKSYRGMGSVGAMKDGAADRY
FQEDNTANVDKLVPEGIEGRVPYKGSALPIVHQLTGGVRSSMGYCGCASIAEWHEKAQFVEITAAGMNESHVHDVQITKE
APNYHRD
>Mature_487_residues
MRLVQKALTFDDVLLVPAYSAVLPRDTSLRTKLTRSIELAIPLVSAAMDTVTEARLAIAMAQQGGIGIVHKNLKPEEQAR
EVAKVKRFESGVLRDPITIGPDMKVRDVMALSAQHGISGFPVLEGKKVVGIITNRDLRFEEELDAPVRAKMTPSEKLVTV
KEGASLEEAKRLMNKHRLERVLVVGEAFELRGLITVKDIQKATEYPLASKDERGSLRVGAAVGVGPDNDLRIDLLVKAGV
DVIVVDTAHGHSQGVLNRVRWIKDNYPQVQVIGGNIATGDAARALVDHGADGVKVGIGPGSICTTRIVAGVGVPQIFAVS
NVAEALKGTGVPLIADGGIRYSGDVAKALAAGAHTVMMGGMFAGTDESPGEVFLFQGRSYKSYRGMGSVGAMKDGAADRY
FQEDNTANVDKLVPEGIEGRVPYKGSALPIVHQLTGGVRSSMGYCGCASIAEWHEKAQFVEITAAGMNESHVHDVQITKE
APNYHRD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=42.8571428571429, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI217035146, Length=451, Percent_Identity=44.1241685144124, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI34328928, Length=451, Percent_Identity=44.1241685144124, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI156616279, Length=451, Percent_Identity=44.1241685144124, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=42.3799582463466, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI217035152, Length=475, Percent_Identity=42.3157894736842, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI217035148, Length=451, Percent_Identity=43.2372505543237, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI217035150, Length=451, Percent_Identity=40.7982261640798, Blast_Score=318, Evalue=7e-87,
Organism=Homo sapiens, GI50541954, Length=249, Percent_Identity=37.3493975903614, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541952, Length=249, Percent_Identity=37.3493975903614, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541948, Length=249, Percent_Identity=37.3493975903614, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541956, Length=249, Percent_Identity=37.3493975903614, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI156104880, Length=224, Percent_Identity=39.2857142857143, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI1788855, Length=485, Percent_Identity=61.2371134020619, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI1786293, Length=225, Percent_Identity=35.5555555555556, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=38.1052631578947, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI71994389, Length=419, Percent_Identity=39.618138424821, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17560440, Length=280, Percent_Identity=35, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322012, Length=489, Percent_Identity=40.6952965235174, Blast_Score=350, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6323585, Length=485, Percent_Identity=41.0309278350515, Blast_Score=348, Evalue=9e-97,
Organism=Saccharomyces cerevisiae, GI6323464, Length=485, Percent_Identity=40.4123711340206, Blast_Score=333, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=40.9356725146199, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6319353, Length=120, Percent_Identity=41.6666666666667, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=40.7867494824017, Blast_Score=348, Evalue=6e-96,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=40.7867494824017, Blast_Score=348, Evalue=6e-96,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=41.2698412698413, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52038; Mature: 52038

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVQKALTFDDVLLVPAYSAVLPRDTSLRTKLTRSIELAIPLVSAAMDTVTEARLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHEE
AQQGGIGIVHKNLKPEEQAREVAKVKRFESGVLRDPITIGPDMKVRDVMALSAQHGISGF
CCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHCCCCCC
PVLEGKKVVGIITNRDLRFEEELDAPVRAKMTPSEKLVTVKEGASLEEAKRLMNKHRLER
CEECCCEEEEEEECCCCCCHHHCCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHE
VLVVGEAFELRGLITVKDIQKATEYPLASKDERGSLRVGAAVGVGPDNDLRIDLLVKAGV
EEEECCCCHHCEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEEEECCC
DVIVVDTAHGHSQGVLNRVRWIKDNYPQVQVIGGNIATGDAARALVDHGADGVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQIFAVSNVAEALKGTGVPLIADGGIRYSGDVAKALAAGAHTVMMGG
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEECCHHHHHHHCCCCEEEECC
MFAGTDESPGEVFLFQGRSYKSYRGMGSVGAMKDGAADRYFQEDNTANVDKLVPEGIEGR
EEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCHHCCCCCCCCCHHHHCCCCCCCC
VPYKGSALPIVHQLTGGVRSSMGYCGCASIAEWHEKAQFVEITAAGMNESHVHDVQITKE
CCCCCCCCHHHHHHHCHHHHCCCCCCHHHHHHHHHCCEEEEEEECCCCCCCEEEEEEECC
APNYHRD
CCCCCCC
>Mature Secondary Structure
MRLVQKALTFDDVLLVPAYSAVLPRDTSLRTKLTRSIELAIPLVSAAMDTVTEARLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHEE
AQQGGIGIVHKNLKPEEQAREVAKVKRFESGVLRDPITIGPDMKVRDVMALSAQHGISGF
CCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHCCCCCC
PVLEGKKVVGIITNRDLRFEEELDAPVRAKMTPSEKLVTVKEGASLEEAKRLMNKHRLER
CEECCCEEEEEEECCCCCCHHHCCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHE
VLVVGEAFELRGLITVKDIQKATEYPLASKDERGSLRVGAAVGVGPDNDLRIDLLVKAGV
EEEECCCCHHCEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEEEECCC
DVIVVDTAHGHSQGVLNRVRWIKDNYPQVQVIGGNIATGDAARALVDHGADGVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQIFAVSNVAEALKGTGVPLIADGGIRYSGDVAKALAAGAHTVMMGG
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEECCHHHHHHHCCCCEEEECC
MFAGTDESPGEVFLFQGRSYKSYRGMGSVGAMKDGAADRYFQEDNTANVDKLVPEGIEGR
EEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCHHCCCCCCCCCHHHHCCCCCCCC
VPYKGSALPIVHQLTGGVRSSMGYCGCASIAEWHEKAQFVEITAAGMNESHVHDVQITKE
CCCCCCCCHHHHHHHCHHHHCCCCCCHHHHHHHHHCCEEEEEEECCCCCCCEEEEEEECC
APNYHRD
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA