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The map label for this gene is lpxA

Identifier: 187928379

GI number: 187928379

Start: 1386092

End: 1386907

Strand: Direct

Name: lpxA

Synonym: Rpic_1290

Alternate gene names: 187928379

Gene position: 1386092-1386907 (Clockwise)

Preceding gene: 187928378

Following gene: 187928380

Centisome position: 35.16

GC content: 63.11

Gene sequence:

>816_bases
ATGACGCAAGCACAGAAGATCCATCCGACCGCGCAGATCGATCCGAATGCCGAACTGGATTCGAGCGTCGAGATCGGCGC
GTTTACGGTCGTGGGCCCGAATGTGCGGATGGGCGCGGGCACGCGAGTCGGCCACCACACGGTGATCGAGGGCTACACGA
CGCTGGGTCGTGACAACAGCATTGGCCATTTCGCATCGGTGGGCGGCCGGCCGCAGGACATGAAGTATCGCGACGAGCCG
ACGCAGTTGATCGTCGGCGATCGCAATACCATCCGCGAATTCACCGCGATCCATACTGGCACTGCCCAGGATGCCGGTAT
CACGTCCATCGGCGACGACAACTGGATCATGGCCTACGTGCATATCGCACACGATTGCCGCGTGGGCAACCACACGGTGT
TTTCGAGCAACGCGCAGATCGCGGGCCACGTGGAAGTCGGTGACTGGGCGATCCTCGGTGGCATGTCGGGCGTGCACCAG
TTCGTGCGTATCGGCGCGCATGCCATGCTGGGTGGCGCATCGGCGCTGGTGCAGGATGTGCCGCCGTTCGTGATCGCCGC
AAGCGACAAGGGCGGCAACAAGGCTGCGCCGCACGGCATCAACGTGGAGGGCCTTCGTCGCCGCGGCTTTACGGCCGAGC
AGATCACAGGTCTGCGCCAGGCGTACAAGCTGCTCTACAAGAGCGATCTGAGCTTTGATCAGGCCAAGGCTGAAATCGCC
GCGCAGATCGCTCAGACGGATGACGCCCCGACCCGTGAGGTGTTGACCGCGTTTGCCGATTTCATTGCCGCCACCAAGCG
CGGCATCGTCCGTTGA

Upstream 100 bases:

>100_bases
GTATGTGGAAGTTCAAGGTGTACGGCAAGGTTGACGGTGAAGTCGCCGTGGAAGCCGAAATCATGTGTGCCGTGCGCGAA
GACAAGTCCAAGGGCGAGGC

Downstream 100 bases:

>100_bases
GCGAGCAGCTTCAGAACGCCGCGCCGGTGCGCCGCATCGGCATGGTGGCCGGCGAGGCTTCCGGCGATTTGCTGGCCTCG
CTGCTGCTGAAGGGGCTGCG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTQAQKIHPTAQIDPNAELDSSVEIGAFTVVGPNVRMGAGTRVGHHTVIEGYTTLGRDNSIGHFASVGGRPQDMKYRDEP
TQLIVGDRNTIREFTAIHTGTAQDAGITSIGDDNWIMAYVHIAHDCRVGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQ
FVRIGAHAMLGGASALVQDVPPFVIAASDKGGNKAAPHGINVEGLRRRGFTAEQITGLRQAYKLLYKSDLSFDQAKAEIA
AQIAQTDDAPTREVLTAFADFIAATKRGIVR

Sequences:

>Translated_271_residues
MTQAQKIHPTAQIDPNAELDSSVEIGAFTVVGPNVRMGAGTRVGHHTVIEGYTTLGRDNSIGHFASVGGRPQDMKYRDEP
TQLIVGDRNTIREFTAIHTGTAQDAGITSIGDDNWIMAYVHIAHDCRVGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQ
FVRIGAHAMLGGASALVQDVPPFVIAASDKGGNKAAPHGINVEGLRRRGFTAEQITGLRQAYKLLYKSDLSFDQAKAEIA
AQIAQTDDAPTREVLTAFADFIAATKRGIVR
>Mature_270_residues
TQAQKIHPTAQIDPNAELDSSVEIGAFTVVGPNVRMGAGTRVGHHTVIEGYTTLGRDNSIGHFASVGGRPQDMKYRDEPT
QLIVGDRNTIREFTAIHTGTAQDAGITSIGDDNWIMAYVHIAHDCRVGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQF
VRIGAHAMLGGASALVQDVPPFVIAASDKGGNKAAPHGINVEGLRRRGFTAEQITGLRQAYKLLYKSDLSFDQAKAEIAA
QIAQTDDAPTREVLTAFADFIAATKRGIVR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=265, Percent_Identity=50.188679245283, Blast_Score=275, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_RALPJ (B2UBB3)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001898866.1
- ProteinModelPortal:   B2UBB3
- SMR:   B2UBB3
- GeneID:   6288924
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_1290
- HOGENOM:   HBG659295
- OMA:   GHTSIGE
- ProtClustDB:   PRK05289
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28921; Mature: 28790

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAQKIHPTAQIDPNAELDSSVEIGAFTVVGPNVRMGAGTRVGHHTVIEGYTTLGRDNS
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEECCCCCCCCEEEEECHHCCCCCCC
IGHFASVGGRPQDMKYRDEPTQLIVGDRNTIREFTAIHTGTAQDAGITSIGDDNWIMAYV
CCHHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEE
HIAHDCRVGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQFVRIGAHAMLGGASALVQDV
EEEECCCCCCEEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHCCHHHHHHCC
PPFVIAASDKGGNKAAPHGINVEGLRRRGFTAEQITGLRQAYKLLYKSDLSFDQAKAEIA
CCEEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AQIAQTDDAPTREVLTAFADFIAATKRGIVR
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQAQKIHPTAQIDPNAELDSSVEIGAFTVVGPNVRMGAGTRVGHHTVIEGYTTLGRDNS
CCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEECCCCCCCCEEEEECHHCCCCCCC
IGHFASVGGRPQDMKYRDEPTQLIVGDRNTIREFTAIHTGTAQDAGITSIGDDNWIMAYV
CCHHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEE
HIAHDCRVGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQFVRIGAHAMLGGASALVQDV
EEEECCCCCCEEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHCCHHHHHHCC
PPFVIAASDKGGNKAAPHGINVEGLRRRGFTAEQITGLRQAYKLLYKSDLSFDQAKAEIA
CCEEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AQIAQTDDAPTREVLTAFADFIAATKRGIVR
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA