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The map label for this gene is pyrH [H]

Identifier: 187928369

GI number: 187928369

Start: 1375772

End: 1376482

Strand: Direct

Name: pyrH [H]

Synonym: Rpic_1280

Alternate gene names: 187928369

Gene position: 1375772-1376482 (Clockwise)

Preceding gene: 187928368

Following gene: 187928370

Centisome position: 34.9

GC content: 63.15

Gene sequence:

>711_bases
ATGCCTGCCTATAAGCGCGTTCTACTCAAACTTTCCGGCGAAGCCCTGATGGGCGACGATGCCTTCGGCATCAACCGCAG
CACCATCGAAGGGATGGTCAACGATATCGCCGAAATCGTGAAGCTGGGCGTGCAGGTGGCAGTGGTGATCGGCGGCGGCA
ACATCTTCCGCGGTGTCGCGGGGGGTGCCGCCGGCATGGATCGCGCCACGGCCGATTACATGGGCATGCTGGCCACCATG
ATGAACGCGCTTGCTCTGCAGGACGCCATGCGTCACGCCAATCTCGAAGGCCGTGTGCAATCGGCGCTGCGCCTGGACCA
AGTGGTCGAGCCGTACATCCGCCCCCGTGCGATCCGCCAGTTGGAAGAGGGCAAGATCGTGATTTTCGCGGCCGGCACCG
GCAACCCGTTCTTCACGACCGACACCGCCGCCGCGCTGCGGGGCTCGGAAATCGGCGCCGAGATCGTCCTCAAGGCCACC
AAGGTGGACGGTGTCTATACCGCTGATCCAAAGAAGGACCCGAGCGCCACCCGCTACACCACCATCACGTTCGATGAAGC
CATTTCGCGCAACCTGCAGGTGATGGACGCGACCGCTTTCGCGCTGTGCCGCGACCAGAAGCTGCCGATCAAGGTGTTCT
CCATTCAGAAGCCCGGCGCGCTCAAGCGCGTGATCCTGGGTGAAGACGAAGGCACGCTGGTGCACGTCTGA

Upstream 100 bases:

>100_bases
CGGGATGTGCGAAGTCCCCGCTTTGCACGTCGTTATCATATCCGCAGCGTCATTTCCCCCTTTCCTGTTTCCCGTACCAG
GAATCGTCACGAGGATCTCC

Downstream 100 bases:

>100_bases
AGCCAGCAGCAAGCCTCGTTGCAGGCGCCTTTTTTGCCGTTCGCTGACCCTGCGTAAATGGCGTTGGCGAGCGGCTTCCA
TGTAAAATCGCCTATTGTCT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MPAYKRVLLKLSGEALMGDDAFGINRSTIEGMVNDIAEIVKLGVQVAVVIGGGNIFRGVAGGAAGMDRATADYMGMLATM
MNALALQDAMRHANLEGRVQSALRLDQVVEPYIRPRAIRQLEEGKIVIFAAGTGNPFFTTDTAAALRGSEIGAEIVLKAT
KVDGVYTADPKKDPSATRYTTITFDEAISRNLQVMDATAFALCRDQKLPIKVFSIQKPGALKRVILGEDEGTLVHV

Sequences:

>Translated_236_residues
MPAYKRVLLKLSGEALMGDDAFGINRSTIEGMVNDIAEIVKLGVQVAVVIGGGNIFRGVAGGAAGMDRATADYMGMLATM
MNALALQDAMRHANLEGRVQSALRLDQVVEPYIRPRAIRQLEEGKIVIFAAGTGNPFFTTDTAAALRGSEIGAEIVLKAT
KVDGVYTADPKKDPSATRYTTITFDEAISRNLQVMDATAFALCRDQKLPIKVFSIQKPGALKRVILGEDEGTLVHV
>Mature_235_residues
PAYKRVLLKLSGEALMGDDAFGINRSTIEGMVNDIAEIVKLGVQVAVVIGGGNIFRGVAGGAAGMDRATADYMGMLATMM
NALALQDAMRHANLEGRVQSALRLDQVVEPYIRPRAIRQLEEGKIVIFAAGTGNPFFTTDTAAALRGSEIGAEIVLKATK
VDGVYTADPKKDPSATRYTTITFDEAISRNLQVMDATAFALCRDQKLPIKVFSIQKPGALKRVILGEDEGTLVHV

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=57.5107296137339, Blast_Score=283, Evalue=6e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25270; Mature: 25138

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYKRVLLKLSGEALMGDDAFGINRSTIEGMVNDIAEIVKLGVQVAVVIGGGNIFRGVA
CCHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEHHCC
GGAAGMDRATADYMGMLATMMNALALQDAMRHANLEGRVQSALRLDQVVEPYIRPRAIRQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHH
LEEGKIVIFAAGTGNPFFTTDTAAALRGSEIGAEIVLKATKVDGVYTADPKKDPSATRYT
HCCCCEEEEEECCCCCCEECCHHHHHCCCCCCEEEEEEEEECCCEEECCCCCCCCCCEEE
TITFDEAISRNLQVMDATAFALCRDQKLPIKVFSIQKPGALKRVILGEDEGTLVHV
EEEEHHHHCCCCEEEHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEC
>Mature Secondary Structure 
PAYKRVLLKLSGEALMGDDAFGINRSTIEGMVNDIAEIVKLGVQVAVVIGGGNIFRGVA
CHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEHHCC
GGAAGMDRATADYMGMLATMMNALALQDAMRHANLEGRVQSALRLDQVVEPYIRPRAIRQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHH
LEEGKIVIFAAGTGNPFFTTDTAAALRGSEIGAEIVLKATKVDGVYTADPKKDPSATRYT
HCCCCEEEEEECCCCCCEECCHHHHHCCCCCCEEEEEEEEECCCEEECCCCCCCCCCEEE
TITFDEAISRNLQVMDATAFALCRDQKLPIKVFSIQKPGALKRVILGEDEGTLVHV
EEEEHHHHCCCCEEEHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA