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The map label for this gene is frr

Identifier: 187928370

GI number: 187928370

Start: 1376659

End: 1377219

Strand: Direct

Name: frr

Synonym: Rpic_1281

Alternate gene names: 187928370

Gene position: 1376659-1377219 (Clockwise)

Preceding gene: 187928369

Following gene: 187928371

Centisome position: 34.92

GC content: 59.71

Gene sequence:

>561_bases
ATGAGCGTCGCCGATGTCAAAAAGAATGCCGAGCAGAAGATGCAGAAGTCGATTGAGGCTCTGAAGACGGATCTGGCCAA
GATCCGTACTGGCCGTGCCCACACCGGTCTGCTCGATCACGTGCAAGTCGACTACTACGGCTCGATGGTGCCGATCAGCC
AGGTTGCCAACGTGACCCTGGTGGATGCACGCACGATTGGCGTGCAACCGTGGGAAAAGAAGATGGTGCAAGCCGTCGAG
AAGGCCATCCGTGAAGCGGACCTCGGCCTGAATCCCGCCACCATGGGCGACATCATTCGCGTGCCGACGCCTGCGCTGAC
CGAAGAGCGCCGCAAGGAGCTGACCAAGGTAGTGAAGGGCGAGGGCGAAGATGCCAAGGTCGCCGTGCGCAACCTGCGCC
GCGATGCCAACGAACAGCTCAAGAAGCTGGTGAAGGACAAGGCCATCTCGGAAGACGACGAGCGTCGCGGCGGAGACGAG
GTTCAGAAGCTGACCGACAAGTTCGTCGCCGAGATCGACAAGCTGGTCGCCGAGAAAGACAAGGAAATCATGACGGTGTA
A

Upstream 100 bases:

>100_bases
TCCATGTAAAATCGCCTATTGTCTTTTTGGTCTTGCCGGTGTCCTGTGTCGTTTTCCGGGGCGCAAGTTCGGCAGACCGC
CGTTATCGTTCGGAGGAAGT

Downstream 100 bases:

>100_bases
GGCCGTCTCCCGCCGCCGGCGCATTGGGCGCATGCGGTGGGAAGCCCGATTCATGCATATCAGTTCCACACTGGCGGTGC
CCGACACCGCCGATACGCCG

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MSVADVKKNAEQKMQKSIEALKTDLAKIRTGRAHTGLLDHVQVDYYGSMVPISQVANVTLVDARTIGVQPWEKKMVQAVE
KAIREADLGLNPATMGDIIRVPTPALTEERRKELTKVVKGEGEDAKVAVRNLRRDANEQLKKLVKDKAISEDDERRGGDE
VQKLTDKFVAEIDKLVAEKDKEIMTV

Sequences:

>Translated_186_residues
MSVADVKKNAEQKMQKSIEALKTDLAKIRTGRAHTGLLDHVQVDYYGSMVPISQVANVTLVDARTIGVQPWEKKMVQAVE
KAIREADLGLNPATMGDIIRVPTPALTEERRKELTKVVKGEGEDAKVAVRNLRRDANEQLKKLVKDKAISEDDERRGGDE
VQKLTDKFVAEIDKLVAEKDKEIMTV
>Mature_185_residues
SVADVKKNAEQKMQKSIEALKTDLAKIRTGRAHTGLLDHVQVDYYGSMVPISQVANVTLVDARTIGVQPWEKKMVQAVEK
AIREADLGLNPATMGDIIRVPTPALTEERRKELTKVVKGEGEDAKVAVRNLRRDANEQLKKLVKDKAISEDDERRGGDEV
QKLTDKFVAEIDKLVAEKDKEIMTV

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Homo sapiens, GI20270317, Length=174, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI291042689, Length=150, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1786368, Length=182, Percent_Identity=54.9450549450549, Blast_Score=209, Evalue=8e-56,
Organism=Drosophila melanogaster, GI24661488, Length=173, Percent_Identity=29.4797687861272, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_RALPJ (B2UB09)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001898857.1
- ProteinModelPortal:   B2UB09
- SMR:   B2UB09
- GeneID:   6289427
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_1281
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- ProtClustDB:   PRK00083
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- PANTHER:   PTHR20982:SF3
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 20746; Mature: 20615

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVADVKKNAEQKMQKSIEALKTDLAKIRTGRAHTGLLDHVQVDYYGSMVPISQVANVTL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHCCCCE
VDARTIGVQPWEKKMVQAVEKAIREADLGLNPATMGDIIRVPTPALTEERRKELTKVVKG
ECCHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHC
EGEDAKVAVRNLRRDANEQLKKLVKDKAISEDDERRGGDEVQKLTDKFVAEIDKLVAEKD
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCC
KEIMTV
HHHCCC
>Mature Secondary Structure 
SVADVKKNAEQKMQKSIEALKTDLAKIRTGRAHTGLLDHVQVDYYGSMVPISQVANVTL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHCCCCE
VDARTIGVQPWEKKMVQAVEKAIREADLGLNPATMGDIIRVPTPALTEERRKELTKVVKG
ECCHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHC
EGEDAKVAVRNLRRDANEQLKKLVKDKAISEDDERRGGDEVQKLTDKFVAEIDKLVAEKD
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCC
KEIMTV
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA