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The map label for this gene is kbl [C]

Identifier: 187928235

GI number: 187928235

Start: 1218099

End: 1219460

Strand: Reverse

Name: kbl [C]

Synonym: Rpic_1144

Alternate gene names: 187928235

Gene position: 1219460-1218099 (Counterclockwise)

Preceding gene: 187928236

Following gene: 187928234

Centisome position: 30.93

GC content: 64.39

Gene sequence:

>1362_bases
ATGAGACTGGGCGACCAGTTGCGACAGCAGCTTGCTGCTAAGGCCCTGAAGCGGCAGCTTGATCGGGTCACGAAAGAAAT
GGAGACGGGAGCCGAACGGGCGGCAGTTGCGGCCCATACCGGTGAAGCGTCGGCAGCACAGCCGGTCAATCCGGCGGACT
ATGCGGCACTGTGCCGCTTCGACACGCTGCCTGCGTACCAGCAGGTCTCGATCATCCGCGAGGTAAGCGAGCGTTTGGGC
ATTGCGTCGCCGTTCTTCCGCGTCCACGAAGGCGTGGCCGGGGCCACCACGCAGATCAACGGCCAGTCCTATATCAACTT
CGCCAACTACAATTATCTCGGCCTATCCGGGGATGCTGAGGTATCGGCCAGCGCCAAAGCCGCAGTCGACCAGTATGGCA
CCTCGGCGTCGGCAAGCCGCATGGTGGCCGGCGAGCGGCCGGTCCAGCGCGAGCTAGAGCGCGCGCTGGCAAGCGTCTAC
GAGGTCGACGACTGCGTCGCCTTCGTCAGCGGGCATGCCACCAACGTCACCGTGATCGGATGCCTGTTTGGCCCCGGCGA
CCTGATCGTGCATGACGCGTTGGCGCACAACAGCATCGTGCAGGGGGCGCAGCTCAGCGGCGCCAAGCGGCTGAACTTCC
CGCATAACGACTGGGCAGCGCTTGACGCCCTGCTCACGCGCGTGCGGCGCGACTACCGCCGTGTGCTGATCGCCGTGGAA
GGCATCTACAGCATGGATGGAGACTTCCCCGAGCTGGAACGCTTCATCGACATCAAGCGCCGCCACGGTGCCTTCCTCAT
GGTCGACGAAGCGCACTCGTTCGGCGTGCTCGGTGCGACAGGCAAAGGCATCCGGGAGCATTTCGGGCTGGCCGGCCGCG
ACGTCGATATCTGGATGGGGACTTTCAGCAAGACGCTGGCGGGCTGCGGCGGGTACATCGCCGGCGAGCAGGCGCTGATC
GACATCCTGCGCCACCTGGCACCCGGTTTCCTGTACAGCGTTGGATTGTCACCGGTGCTGGCCGCCACCTCGCTGACCGC
TCTTCGGCGCATGCTGGATGAGCCGCAACGAGTCGCCAAGCTGCGCGAGCGCGGACGTCAGTTCCTGGACGCCGCACGTG
AAGCGGGCCTCAACACGGGGCTGAGCGCCGGATACTCGGTCGTGCCAGTGATTATCGGCAGTTCGCTCAAGGCCGCGCAA
TGGGCCAATGCACTGTTCGAGAAAGGCATCAACACGCAGCCGATCTTTTATCCCGCGGTGGAGGAGAAAGCCGCGCGGCT
GCGCTTCTTTATCTGCTCCACCCACACGCCGGAACAGATCGCTTATACGATAGCGTCCGTTGCGCAGCTGGCACGGCGTT
AG

Upstream 100 bases:

>100_bases
CCCAGCCACGAAATGAATTACCGGCTTTGTGCCGCCCTGCTCGCCCGGCCCGATGCCTGGGAATGGGCATACCCCACACA
CTGACGAAGGAATCCGCAGT

Downstream 100 bases:

>100_bases
CACTATGGACACGATGCTGCAGATGGATCAGTCATCGGGCTCGGCACTCACGTTCCGTCGCGCTGCGGCTAGCGATGCCG
CTGCGCTGGCGCCGTTGGTG

Product: Glycine C-acetyltransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MRLGDQLRQQLAAKALKRQLDRVTKEMETGAERAAVAAHTGEASAAQPVNPADYAALCRFDTLPAYQQVSIIREVSERLG
IASPFFRVHEGVAGATTQINGQSYINFANYNYLGLSGDAEVSASAKAAVDQYGTSASASRMVAGERPVQRELERALASVY
EVDDCVAFVSGHATNVTVIGCLFGPGDLIVHDALAHNSIVQGAQLSGAKRLNFPHNDWAALDALLTRVRRDYRRVLIAVE
GIYSMDGDFPELERFIDIKRRHGAFLMVDEAHSFGVLGATGKGIREHFGLAGRDVDIWMGTFSKTLAGCGGYIAGEQALI
DILRHLAPGFLYSVGLSPVLAATSLTALRRMLDEPQRVAKLRERGRQFLDAAREAGLNTGLSAGYSVVPVIIGSSLKAAQ
WANALFEKGINTQPIFYPAVEEKAARLRFFICSTHTPEQIAYTIASVAQLARR

Sequences:

>Translated_453_residues
MRLGDQLRQQLAAKALKRQLDRVTKEMETGAERAAVAAHTGEASAAQPVNPADYAALCRFDTLPAYQQVSIIREVSERLG
IASPFFRVHEGVAGATTQINGQSYINFANYNYLGLSGDAEVSASAKAAVDQYGTSASASRMVAGERPVQRELERALASVY
EVDDCVAFVSGHATNVTVIGCLFGPGDLIVHDALAHNSIVQGAQLSGAKRLNFPHNDWAALDALLTRVRRDYRRVLIAVE
GIYSMDGDFPELERFIDIKRRHGAFLMVDEAHSFGVLGATGKGIREHFGLAGRDVDIWMGTFSKTLAGCGGYIAGEQALI
DILRHLAPGFLYSVGLSPVLAATSLTALRRMLDEPQRVAKLRERGRQFLDAAREAGLNTGLSAGYSVVPVIIGSSLKAAQ
WANALFEKGINTQPIFYPAVEEKAARLRFFICSTHTPEQIAYTIASVAQLARR
>Mature_453_residues
MRLGDQLRQQLAAKALKRQLDRVTKEMETGAERAAVAAHTGEASAAQPVNPADYAALCRFDTLPAYQQVSIIREVSERLG
IASPFFRVHEGVAGATTQINGQSYINFANYNYLGLSGDAEVSASAKAAVDQYGTSASASRMVAGERPVQRELERALASVY
EVDDCVAFVSGHATNVTVIGCLFGPGDLIVHDALAHNSIVQGAQLSGAKRLNFPHNDWAALDALLTRVRRDYRRVLIAVE
GIYSMDGDFPELERFIDIKRRHGAFLMVDEAHSFGVLGATGKGIREHFGLAGRDVDIWMGTFSKTLAGCGGYIAGEQALI
DILRHLAPGFLYSVGLSPVLAATSLTALRRMLDEPQRVAKLRERGRQFLDAAREAGLNTGLSAGYSVVPVIIGSSLKAAQ
WANALFEKGINTQPIFYPAVEEKAARLRFFICSTHTPEQIAYTIASVAQLARR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI119220554, Length=389, Percent_Identity=34.1902313624679, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4758668, Length=362, Percent_Identity=33.9779005524862, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI7657118, Length=381, Percent_Identity=29.9212598425197, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI284448556, Length=349, Percent_Identity=30.0859598853868, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI83977442, Length=340, Percent_Identity=29.7058823529412, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI83977440, Length=340, Percent_Identity=29.7058823529412, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI83977444, Length=340, Percent_Identity=29.7058823529412, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI4502025, Length=347, Percent_Identity=30.2593659942363, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI40316939, Length=347, Percent_Identity=30.2593659942363, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI5454084, Length=296, Percent_Identity=32.4324324324324, Blast_Score=139, Evalue=7e-33,
Organism=Escherichia coli, GI1790046, Length=390, Percent_Identity=32.3076923076923, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1786993, Length=351, Percent_Identity=28.4900284900285, Blast_Score=123, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32566772, Length=362, Percent_Identity=34.8066298342541, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17560914, Length=361, Percent_Identity=33.7950138504155, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17560912, Length=361, Percent_Identity=33.7950138504155, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI71994529, Length=371, Percent_Identity=30.7277628032345, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71982617, Length=356, Percent_Identity=28.9325842696629, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71982625, Length=356, Percent_Identity=28.9325842696629, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320267, Length=365, Percent_Identity=29.3150684931507, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6320438, Length=354, Percent_Identity=28.8135593220339, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=257, Percent_Identity=28.4046692607004, Blast_Score=109, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24662918, Length=358, Percent_Identity=30.4469273743017, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI17136286, Length=363, Percent_Identity=30.0275482093664, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17137420, Length=349, Percent_Identity=29.2263610315186, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24653280, Length=290, Percent_Identity=28.6206896551724, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24653276, Length=290, Percent_Identity=28.6206896551724, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24653278, Length=290, Percent_Identity=28.6206896551724, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 49052; Mature: 49052

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLGDQLRQQLAAKALKRQLDRVTKEMETGAERAAVAAHTGEASAAQPVNPADYAALCRF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEECCCCCCCCCCCCHHHHHHHHH
DTLPAYQQVSIIREVSERLGIASPFFRVHEGVAGATTQINGQSYINFANYNYLGLSGDAE
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEECCCCEEEECCCEEEECCCCCC
VSASAKAAVDQYGTSASASRMVAGERPVQRELERALASVYEVDDCVAFVSGHATNVTVIG
CCCHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
CLFGPGDLIVHDALAHNSIVQGAQLSGAKRLNFPHNDWAALDALLTRVRRDYRRVLIAVE
EEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GIYSMDGDFPELERFIDIKRRHGAFLMVDEAHSFGVLGATGKGIREHFGLAGRDVDIWMG
HHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEECCCCCHHHHHCCCCCCCHHHHHH
TFSKTLAGCGGYIAGEQALIDILRHLAPGFLYSVGLSPVLAATSLTALRRMLDEPQRVAK
HHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHH
LRERGRQFLDAAREAGLNTGLSAGYSVVPVIIGSSLKAAQWANALFEKGINTQPIFYPAV
HHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHCCCCHHHHHHHHHHHCCCCCCCEEECHH
EEKAARLRFFICSTHTPEQIAYTIASVAQLARR
HHHHHHEEEEEECCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLGDQLRQQLAAKALKRQLDRVTKEMETGAERAAVAAHTGEASAAQPVNPADYAALCRF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEECCCCCCCCCCCCHHHHHHHHH
DTLPAYQQVSIIREVSERLGIASPFFRVHEGVAGATTQINGQSYINFANYNYLGLSGDAE
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEECCCCEEEECCCEEEECCCCCC
VSASAKAAVDQYGTSASASRMVAGERPVQRELERALASVYEVDDCVAFVSGHATNVTVIG
CCCHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
CLFGPGDLIVHDALAHNSIVQGAQLSGAKRLNFPHNDWAALDALLTRVRRDYRRVLIAVE
EEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GIYSMDGDFPELERFIDIKRRHGAFLMVDEAHSFGVLGATGKGIREHFGLAGRDVDIWMG
HHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEECCCCCHHHHHCCCCCCCHHHHHH
TFSKTLAGCGGYIAGEQALIDILRHLAPGFLYSVGLSPVLAATSLTALRRMLDEPQRVAK
HHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHH
LRERGRQFLDAAREAGLNTGLSAGYSVVPVIIGSSLKAAQWANALFEKGINTQPIFYPAV
HHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHCCCCHHHHHHHHHHHCCCCCCCEEECHH
EEKAARLRFFICSTHTPEQIAYTIASVAQLARR
HHHHHHEEEEEECCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA