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The map label for this gene is lpxC [H]

Identifier: 187928236

GI number: 187928236

Start: 1219477

End: 1220370

Strand: Reverse

Name: lpxC [H]

Synonym: Rpic_1145

Alternate gene names: 187928236

Gene position: 1220370-1219477 (Counterclockwise)

Preceding gene: 187928237

Following gene: 187928235

Centisome position: 30.95

GC content: 65.77

Gene sequence:

>894_bases
ATGACCGCGCCGGGCTGGGCAAGCAATCAGGGAACACTGGCGCGCGAGCTGCGGCTGTACGGCCGCGGGCTGCACACCGG
CAAGCGCGTCAATGTCCGCGTGCATCCTGAGCGCGTCGGACACGGCATCGTGTTCCGGCGCATGCGCGGCGGCCAGCAGC
TTGCATTACTGCCCGCCTCTGCGGCGCTGCGCCTGGGGCAGCCGTTGTGCACGGCACTCCAGAATGCCGATGGCTGGCGC
GTGCGCACCGTCGAACACCTGCTGGCAGCTTTGCTGGCATGCCAGATCGACCACGCCACCGTCGAGATCGATGCCGAAGA
GGTGCCGATCCTGGATGGCAGCGCACAGCCCTGGCTGCAGGCGATCGAGGCCTGTGGACGCCTCCCGCTGGATGCACCCA
AGCGCTTCCTGCGGATTCTCAAGACGGTTGCTGTGGAAGATGGCGGCATGCATCGCACGATCATCGAACCGGCCGACCAC
TATGCGATGTCCGTAACCAACGACCTCAAGGGGTTCGGCGAGATGAACTGGCAGGGCATCATCGACCCCGTTTCGTTCGC
TTCCGACATCGCGCCATCGCGCTCATATGGCCGCCTGCGCTGGGCGGTGCCAGCCATCTTGTTTGGCTATCTGCGGGGCC
AACCGATTCTGCGCGGCGCGAGGCCGTCATGCACCGCTACCATTGTCGGCTCCGGCGTGATCGGCGGCATGCGCCTGCCG
ATGGAGTTCGTGCGGCACCGCGTGCTTGATCTAATCGGCGACCTAGCTCTGCTGGGCGCGCCGCTGTTAGGCAAGGTCAC
AGCCTTGCGCCCCAGCCACGAAATGAATTACCGGCTTTGTGCCGCCCTGCTCGCCCGGCCCGATGCCTGGGAATGGGCAT
ACCCCACACACTGA

Upstream 100 bases:

>100_bases
TCCATGGCTCGGAAATCAGCAGCGACGAACTGCAACGCATGGCACGCGAAATGACCGCCAACCGAGCAGTCGCAGATGTC
CTCACTGAGACGACCTCGTG

Downstream 100 bases:

>100_bases
CGAAGGAATCCGCAGTATGAGACTGGGCGACCAGTTGCGACAGCAGCTTGCTGCTAAGGCCCTGAAGCGGCAGCTTGATC
GGGTCACGAAAGAAATGGAG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine; Acetate. [C]

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MTAPGWASNQGTLARELRLYGRGLHTGKRVNVRVHPERVGHGIVFRRMRGGQQLALLPASAALRLGQPLCTALQNADGWR
VRTVEHLLAALLACQIDHATVEIDAEEVPILDGSAQPWLQAIEACGRLPLDAPKRFLRILKTVAVEDGGMHRTIIEPADH
YAMSVTNDLKGFGEMNWQGIIDPVSFASDIAPSRSYGRLRWAVPAILFGYLRGQPILRGARPSCTATIVGSGVIGGMRLP
MEFVRHRVLDLIGDLALLGAPLLGKVTALRPSHEMNYRLCAALLARPDAWEWAYPTH

Sequences:

>Translated_297_residues
MTAPGWASNQGTLARELRLYGRGLHTGKRVNVRVHPERVGHGIVFRRMRGGQQLALLPASAALRLGQPLCTALQNADGWR
VRTVEHLLAALLACQIDHATVEIDAEEVPILDGSAQPWLQAIEACGRLPLDAPKRFLRILKTVAVEDGGMHRTIIEPADH
YAMSVTNDLKGFGEMNWQGIIDPVSFASDIAPSRSYGRLRWAVPAILFGYLRGQPILRGARPSCTATIVGSGVIGGMRLP
MEFVRHRVLDLIGDLALLGAPLLGKVTALRPSHEMNYRLCAALLARPDAWEWAYPTH
>Mature_296_residues
TAPGWASNQGTLARELRLYGRGLHTGKRVNVRVHPERVGHGIVFRRMRGGQQLALLPASAALRLGQPLCTALQNADGWRV
RTVEHLLAALLACQIDHATVEIDAEEVPILDGSAQPWLQAIEACGRLPLDAPKRFLRILKTVAVEDGGMHRTIIEPADHY
AMSVTNDLKGFGEMNWQGIIDPVSFASDIAPSRSYGRLRWAVPAILFGYLRGQPILRGARPSCTATIVGSGVIGGMRLPM
EFVRHRVLDLIGDLALLGAPLLGKVTALRPSHEMNYRLCAALLARPDAWEWAYPTH

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=289, Percent_Identity=33.2179930795848, Blast_Score=154, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 32529; Mature: 32398

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPGWASNQGTLARELRLYGRGLHTGKRVNVRVHPERVGHGIVFRRMRGGQQLALLPAS
CCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECHHHHCCHHHHHHHCCCCEEEEECHH
AALRLGQPLCTALQNADGWRVRTVEHLLAALLACQIDHATVEIDAEEVPILDGSAQPWLQ
HHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHH
AIEACGRLPLDAPKRFLRILKTVAVEDGGMHRTIIEPADHYAMSVTNDLKGFGEMNWQGI
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCC
IDPVSFASDIAPSRSYGRLRWAVPAILFGYLRGQPILRGARPSCTATIVGSGVIGGMRLP
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCC
MEFVRHRVLDLIGDLALLGAPLLGKVTALRPSHEMNYRLCAALLARPDAWEWAYPTH
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TAPGWASNQGTLARELRLYGRGLHTGKRVNVRVHPERVGHGIVFRRMRGGQQLALLPAS
CCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECHHHHCCHHHHHHHCCCCEEEEECHH
AALRLGQPLCTALQNADGWRVRTVEHLLAALLACQIDHATVEIDAEEVPILDGSAQPWLQ
HHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHH
AIEACGRLPLDAPKRFLRILKTVAVEDGGMHRTIIEPADHYAMSVTNDLKGFGEMNWQGI
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCC
IDPVSFASDIAPSRSYGRLRWAVPAILFGYLRGQPILRGARPSCTATIVGSGVIGGMRLP
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCC
MEFVRHRVLDLIGDLALLGAPLLGKVTALRPSHEMNYRLCAALLARPDAWEWAYPTH
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine; H2O [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine + H2O = UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine + Acetate. [C]

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA