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The map label for this gene is hisS [H]

Identifier: 187928153

GI number: 187928153

Start: 1126394

End: 1127746

Strand: Direct

Name: hisS [H]

Synonym: Rpic_1060

Alternate gene names: 187928153

Gene position: 1126394-1127746 (Clockwise)

Preceding gene: 187928152

Following gene: 187928154

Centisome position: 28.57

GC content: 62.45

Gene sequence:

>1353_bases
ATGCGAGAAGTCGGCTTTCAACGTGACATCATGAGCGATACACAAAAACAACGCGTGCAGAAGATCGCTGGCGTCAAAGG
CATGAACGACTTGCTGCCTGCTGATGCCCCGCTGTGGGAGCACTTTGATAACGCCGTGCGCAGCATGCTGCGCGCCTATG
GCTACCAGCAGATCCGCACGCCGATCGTTGAGCAGACGCAACTGTTTGTGCGTGGCATCGGCGAGGTGACGGACATCGTC
GAGAAGGAGATGTACACCTTCACCGATGCGTTGAACGGCGAACAACTGACCATGCGCCCCGAAGGCACCGCTGCCGCTGT
GCGCGCCGTGATCGAGCACAACCTGCTGTACGACGGCCCGAAGCGCCTGTGGTACACCGGCCCGATGTTCCGCCACGAGC
GTCCGCAGCGCGGCCGCTATCGCCAATTCCATCAGGTGGGTGTGGAAGCGCTGGGCTTTGCAGGCCCGGACATCGACGCT
GAAGTCATCCTGATGTGCCAGCGCCTGTGGGACGACCTCGGCCTGGTCGGCCTGAAGCTGGAGCTGAACTCGCTCGGACA
GGCGGAAGAGCGTGCCGCGCACCGTGCCGATCTCATCAAATATCTGGAAGGTTTCCAGGACGTTCTGGATGAGGACGGCA
AACGCCGTCTGTACACCAACCCGCTGCGCGTGCTCGACACCAAGAACCCCGCGCTGCAGGACATGGCTGCCGGCGCGCCG
AAGCTGCTCGACTACCTGGGCGACGAATCGCGCGCGCACTTTGAAGGCGTGCAGAAGCTGCTCAAGGCGAACAACATTCC
GTTCATCATCAACCCGCGTCTGGTGCGCGGGCTAGATTACTACAACCTCACGGTCTTTGAGTGGACGACCGACAAGCTGG
GCGCGCAAGGCACAGTGGCGGGGGGTGGCCGCTATGACCCGCTGATCGAGCAGATAGGCGGCAAGCCTGCCCCCGCATGC
GGCTGGGCGATGGGCGTGGAGCGCATCATCGAATTGTTGCGTGAGGAAAAGCTGGAGCCTGAAGCGCAAGGCTGTGACGT
CTACATCGTCCACCAGGGCGACGAGGCGCAGGTTCAGGCGCTGATCGCGGCAGAGCGACTGCGCGACGCCGGCCTCGACG
TCATCCTTCACGCCTCGCCGGAAGGTCGTAACGGTAGCTTCAAGTCGCAGTTCAAGCGTGCTGACGCAAGTGGCGCATCC
TATGCGGTTATCATTGGCGACGACGAAGTCACCCAAGGCGTCGCCCAGATCAAGCCGCTGCGGGGCGATCCGACCGCGGA
TGCCCAGCAGACCGTGCCGTCGGACCAACTGGTCGACCGCCTGATCGACGCCATGGTGGCCAATAACGACTAA

Upstream 100 bases:

>100_bases
CATTACGGCGCACAGACTCCTGCGACGGTCTAAAGCGACATCAGGCTTCGGAAACCAAAGCCGAAGCACGAAACGACCGG
CCGGCTCTGCATGAAGGTAG

Downstream 100 bases:

>100_bases
CAGCGGGCAGCTGACCTCGGCAGCGAACGACCGCGATTCACTCCCAATATTCAAGCTCTGCAAAGCATGGCCTACGATCT
CGAAGAACAGGAACAAATTG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MREVGFQRDIMSDTQKQRVQKIAGVKGMNDLLPADAPLWEHFDNAVRSMLRAYGYQQIRTPIVEQTQLFVRGIGEVTDIV
EKEMYTFTDALNGEQLTMRPEGTAAAVRAVIEHNLLYDGPKRLWYTGPMFRHERPQRGRYRQFHQVGVEALGFAGPDIDA
EVILMCQRLWDDLGLVGLKLELNSLGQAEERAAHRADLIKYLEGFQDVLDEDGKRRLYTNPLRVLDTKNPALQDMAAGAP
KLLDYLGDESRAHFEGVQKLLKANNIPFIINPRLVRGLDYYNLTVFEWTTDKLGAQGTVAGGGRYDPLIEQIGGKPAPAC
GWAMGVERIIELLREEKLEPEAQGCDVYIVHQGDEAQVQALIAAERLRDAGLDVILHASPEGRNGSFKSQFKRADASGAS
YAVIIGDDEVTQGVAQIKPLRGDPTADAQQTVPSDQLVDRLIDAMVANND

Sequences:

>Translated_450_residues
MREVGFQRDIMSDTQKQRVQKIAGVKGMNDLLPADAPLWEHFDNAVRSMLRAYGYQQIRTPIVEQTQLFVRGIGEVTDIV
EKEMYTFTDALNGEQLTMRPEGTAAAVRAVIEHNLLYDGPKRLWYTGPMFRHERPQRGRYRQFHQVGVEALGFAGPDIDA
EVILMCQRLWDDLGLVGLKLELNSLGQAEERAAHRADLIKYLEGFQDVLDEDGKRRLYTNPLRVLDTKNPALQDMAAGAP
KLLDYLGDESRAHFEGVQKLLKANNIPFIINPRLVRGLDYYNLTVFEWTTDKLGAQGTVAGGGRYDPLIEQIGGKPAPAC
GWAMGVERIIELLREEKLEPEAQGCDVYIVHQGDEAQVQALIAAERLRDAGLDVILHASPEGRNGSFKSQFKRADASGAS
YAVIIGDDEVTQGVAQIKPLRGDPTADAQQTVPSDQLVDRLIDAMVANND
>Mature_450_residues
MREVGFQRDIMSDTQKQRVQKIAGVKGMNDLLPADAPLWEHFDNAVRSMLRAYGYQQIRTPIVEQTQLFVRGIGEVTDIV
EKEMYTFTDALNGEQLTMRPEGTAAAVRAVIEHNLLYDGPKRLWYTGPMFRHERPQRGRYRQFHQVGVEALGFAGPDIDA
EVILMCQRLWDDLGLVGLKLELNSLGQAEERAAHRADLIKYLEGFQDVLDEDGKRRLYTNPLRVLDTKNPALQDMAAGAP
KLLDYLGDESRAHFEGVQKLLKANNIPFIINPRLVRGLDYYNLTVFEWTTDKLGAQGTVAGGGRYDPLIEQIGGKPAPAC
GWAMGVERIIELLREEKLEPEAQGCDVYIVHQGDEAQVQALIAAERLRDAGLDVILHASPEGRNGSFKSQFKRADASGAS
YAVIIGDDEVTQGVAQIKPLRGDPTADAQQTVPSDQLVDRLIDAMVANND

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788861, Length=420, Percent_Identity=54.2857142857143, Blast_Score=451, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI71993686, Length=476, Percent_Identity=24.1596638655462, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71993693, Length=476, Percent_Identity=24.1596638655462, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 50109; Mature: 50109

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREVGFQRDIMSDTQKQRVQKIAGVKGMNDLLPADAPLWEHFDNAVRSMLRAYGYQQIRT
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHC
PIVEQTQLFVRGIGEVTDIVEKEMYTFTDALNGEQLTMRPEGTAAAVRAVIEHNLLYDGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCC
KRLWYTGPMFRHERPQRGRYRQFHQVGVEALGFAGPDIDAEVILMCQRLWDDLGLVGLKL
CCEEECCCCHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCEEEEEE
ELNSLGQAEERAAHRADLIKYLEGFQDVLDEDGKRRLYTNPLRVLDTKNPALQDMAAGAP
EHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHEEECCCHHHHHHHCCCH
KLLDYLGDESRAHFEGVQKLLKANNIPFIINPRLVRGLDYYNLTVFEWTTDKLGAQGTVA
HHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCHHHHCCCEEEEEEEEEEHHHCCCCCEEC
GGGRYDPLIEQIGGKPAPACGWAMGVERIIELLREEKLEPEAQGCDVYIVHQGDEAQVQA
CCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHH
LIAAERLRDAGLDVILHASPEGRNGSFKSQFKRADASGASYAVIIGDDEVTQGVAQIKPL
HHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCC
RGDPTADAQQTVPSDQLVDRLIDAMVANND
CCCCCCCHHHCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MREVGFQRDIMSDTQKQRVQKIAGVKGMNDLLPADAPLWEHFDNAVRSMLRAYGYQQIRT
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHC
PIVEQTQLFVRGIGEVTDIVEKEMYTFTDALNGEQLTMRPEGTAAAVRAVIEHNLLYDGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCC
KRLWYTGPMFRHERPQRGRYRQFHQVGVEALGFAGPDIDAEVILMCQRLWDDLGLVGLKL
CCEEECCCCHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCEEEEEE
ELNSLGQAEERAAHRADLIKYLEGFQDVLDEDGKRRLYTNPLRVLDTKNPALQDMAAGAP
EHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHEEECCCHHHHHHHCCCH
KLLDYLGDESRAHFEGVQKLLKANNIPFIINPRLVRGLDYYNLTVFEWTTDKLGAQGTVA
HHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCHHHHCCCEEEEEEEEEEHHHCCCCCEEC
GGGRYDPLIEQIGGKPAPACGWAMGVERIIELLREEKLEPEAQGCDVYIVHQGDEAQVQA
CCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHH
LIAAERLRDAGLDVILHASPEGRNGSFKSQFKRADASGASYAVIIGDDEVTQGVAQIKPL
HHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCC
RGDPTADAQQTVPSDQLVDRLIDAMVANND
CCCCCCCHHHCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]