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The map label for this gene is trxA [H]

Identifier: 187928125

GI number: 187928125

Start: 1093737

End: 1094063

Strand: Reverse

Name: trxA [H]

Synonym: Rpic_1032

Alternate gene names: 187928125

Gene position: 1094063-1093737 (Counterclockwise)

Preceding gene: 187928132

Following gene: 187928124

Centisome position: 27.75

GC content: 57.49

Gene sequence:

>327_bases
ATGAGCGAACAGATCAAGTATGTGAGCGACGCGTCCTTCGAGGCAGACGTGCTCAAGTCCGACAAACCCGTGCTGGTCGA
TTTCTGGGCCGAATGGTGCGGTCCTTGCAAAATGATCGCCCCGATCCTGGACGAGGTTTCCAAGGACTACGGCGAGAAGG
TGCAAATCGCCAAGATCAACGTCGATGAGAACCAGGGCGTGCCGGCCAAGTTCGGCATTCGCGGCATCCCAACGCTGATT
CTGTTCAAGAATGGCGCTGTGGCCGCGCAAAAGGTGGGCGCGCTGTCCAAGTCGCAACTGACTGCATTCCTGGACAGCCA
CCTGTAA

Upstream 100 bases:

>100_bases
GCGCCGACAGTGGTCTCAATGCACGCCGGTCCGTGTAATCGTGTAATGTATGGGTTCGGCGCACGTCGCCAGCTTTTACG
AAATAACAGAGGTTCCCGCC

Downstream 100 bases:

>100_bases
GCCGTTTTTCGGCTATAGGCGACCTTTCGCGTTGCCCCACACACACGCTGGCGCACTTCCGCCTGGAAGCCCGCCAGCGT
TGTGCTAAGATTGCAGCCAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSEQIKYVSDASFEADVLKSDKPVLVDFWAEWCGPCKMIAPILDEVSKDYGEKVQIAKINVDENQGVPAKFGIRGIPTLI
LFKNGAVAAQKVGALSKSQLTAFLDSHL

Sequences:

>Translated_108_residues
MSEQIKYVSDASFEADVLKSDKPVLVDFWAEWCGPCKMIAPILDEVSKDYGEKVQIAKINVDENQGVPAKFGIRGIPTLI
LFKNGAVAAQKVGALSKSQLTAFLDSHL
>Mature_107_residues
SEQIKYVSDASFEADVLKSDKPVLVDFWAEWCGPCKMIAPILDEVSKDYGEKVQIAKINVDENQGVPAKFGIRGIPTLIL
FKNGAVAAQKVGALSKSQLTAFLDSHL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=40.8602150537634, Blast_Score=79, Evalue=7e-16,
Organism=Homo sapiens, GI20070125, Length=80, Percent_Identity=36.25, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI5031973, Length=99, Percent_Identity=32.3232323232323, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=64.8148148148148, Blast_Score=155, Evalue=5e-40,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=42.3913043478261, Blast_Score=94, Evalue=2e-21,
Organism=Escherichia coli, GI87081747, Length=63, Percent_Identity=41.2698412698413, Blast_Score=64, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=40.8602150537634, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=37.9310344827586, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=75, Percent_Identity=44, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=76, Percent_Identity=39.4736842105263, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=103, Percent_Identity=29.126213592233, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=70, Percent_Identity=42.8571428571429, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=65, Percent_Identity=36.9230769230769, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=70, Percent_Identity=42.8571428571429, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=83, Percent_Identity=36.144578313253, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=70, Percent_Identity=42.8571428571429, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=77, Percent_Identity=48.0519480519481, Blast_Score=76, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=94, Percent_Identity=39.3617021276596, Blast_Score=73, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=79, Percent_Identity=32.9113924050633, Blast_Score=61, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639826, Length=91, Percent_Identity=40.6593406593407, Blast_Score=89, Evalue=5e-19,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=35.8695652173913, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24664269, Length=75, Percent_Identity=40, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=41.025641025641, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=41.025641025641, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=32.258064516129, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11784; Mature: 11652

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQIKYVSDASFEADVLKSDKPVLVDFWAEWCGPCKMIAPILDEVSKDYGEKVQIAKIN
CCCCCCCCCCCCCCHHHHCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEE
VDENQGVPAKFGIRGIPTLILFKNGAVAAQKVGALSKSQLTAFLDSHL
CCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SEQIKYVSDASFEADVLKSDKPVLVDFWAEWCGPCKMIAPILDEVSKDYGEKVQIAKIN
CCCCCCCCCCCCCHHHHCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEE
VDENQGVPAKFGIRGIPTLILFKNGAVAAQKVGALSKSQLTAFLDSHL
CCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]