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The map label for this gene is atoC [H]

Identifier: 187928123

GI number: 187928123

Start: 1090643

End: 1092016

Strand: Reverse

Name: atoC [H]

Synonym: Rpic_1030

Alternate gene names: 187928123

Gene position: 1092016-1090643 (Counterclockwise)

Preceding gene: 187928124

Following gene: 187928121

Centisome position: 27.7

GC content: 65.14

Gene sequence:

>1374_bases
ATGCGCGAAGAGTCGCTGGAATGTACTGCCGCGTGCCGAACCGTCGTAGTGGCGTCACGCGCGGGGATGGGGGAGATCGA
CGAGACGATTTTGGGTGCGGACTGGCACGTGCGACGCGTAGCGTCGATGCGCGAACTGGGCTGTGCCATTCGTGACGGCG
TTCCCAAGGCGGGCTTGGTCGATTTCGGCAGCGCGTTCTCTGCTGCGGAGTTGGATTTGCTCGAGCGCTGCATGCAAGTC
TCGCATGTGGGCTGGGTGGCGGCCCTGCCGCCGGCCATGCTGAACCACGAACGCGTGCGCCAGCTCGTGCGCGATTACTG
CGTGGACTACGTGCAGATGCCGCTGCGCACGGACGAGGCTGCGTATTCGCTGCGTCACGCCTGGGGCATGGCCTCGCTCG
CGCAGGAAGTCACGCCAGCGCCGAAGGCCAATCATGCGCGCATGCTGGGCGAGTGCCCTGCCATGCACGGCCTGTTTCGC
GCCATCCGCAAGGTCGCGCAGAACAGCGCGCCAGCCTTCATCGCGGGGGAGTCAGGCACGGGCAAGGAGCTGACTGCCCA
GGCCATTCACGAGGCTTCCTCGCGCGCAGGCGGGCCGTTCATCGCCATCAATTGCGGGGCGATTCCGCCGCACCTGATCC
AGTCCGAATTGTTTGGCTACGAAAAAGGCGCGTTTACCGGCGCGCATCAGCGTCATATCGGCTGGGTCGAGCATGCCAAC
GGCGGCACGCTGTTCCTCGATGAAATCGGCGACCTGCCGCTTGAGAGCCAAGTCAGCCTGCTGCGCTTCCTGCAACAAGG
CACGATTACGCGGCTTGGCGGGCACCAGGCGATTCCGCTGGACATCCGCATCATTTCGGCAACGCACGTGGATCTGGAAG
CCGCCCAACACCACGGCGGATTTCGCACCGATCTGTTTCATCGACTGTGCGTGCTCACCTTGTCGGTGCCACCGCTTCGC
GAGCGCGGCAGCGACATCGTGCTGCTGGCCCAACACATCCTGGCCCAGCATGCCAGCGAGGCGTCGCACCGGATCCGCGG
GTTCACGCCCTGCGCGCTGCACGCGATGATGCATTACCCGTGGCCGGGCAACGTGCGCGAACTCATCAACCGCGTGCGCC
GCGCGCTGGTGATGACCGACAACCGCAAGATCTCCGCGGCCGACCTGCACCTCGAAGGCTATGCATCCGTCTCGGGCCAG
ACACTGGAGGAAGCGCGCGAGGGTGCAGAGTCCGATGCCATCCGCACGGCCATCGCCCGCAACGGCTTCCATATGGGCAT
GACCGCGCGCGAATTGGCGGTGTCTCGCGTCACGCTGTATCGGTTGATGCAGAAGCACGGCATTCGAGCAGAGCATCCAC
TGCACCCGGCCTAG

Upstream 100 bases:

>100_bases
TCATCGCAAAAGAGAAACCCGGCAACCATACTGCAAGCCTGCCCTGGCCGGGCCGCCTCGGCAAAGAACGAACCACACGA
AAAATCGAACGGGGGAAACC

Downstream 100 bases:

>100_bases
GCCTGGGCTCATCGTTTTCATTCCGATCGGCGGGGGCATAGCGTGGGTGCTATGCCCCCCCGGATGCGCTTTTTTTTGGG
CAAGCCGAAGGAATGGCGCC

Product: Fis family sigma54 specific transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MREESLECTAACRTVVVASRAGMGEIDETILGADWHVRRVASMRELGCAIRDGVPKAGLVDFGSAFSAAELDLLERCMQV
SHVGWVAALPPAMLNHERVRQLVRDYCVDYVQMPLRTDEAAYSLRHAWGMASLAQEVTPAPKANHARMLGECPAMHGLFR
AIRKVAQNSAPAFIAGESGTGKELTAQAIHEASSRAGGPFIAINCGAIPPHLIQSELFGYEKGAFTGAHQRHIGWVEHAN
GGTLFLDEIGDLPLESQVSLLRFLQQGTITRLGGHQAIPLDIRIISATHVDLEAAQHHGGFRTDLFHRLCVLTLSVPPLR
ERGSDIVLLAQHILAQHASEASHRIRGFTPCALHAMMHYPWPGNVRELINRVRRALVMTDNRKISAADLHLEGYASVSGQ
TLEEAREGAESDAIRTAIARNGFHMGMTARELAVSRVTLYRLMQKHGIRAEHPLHPA

Sequences:

>Translated_457_residues
MREESLECTAACRTVVVASRAGMGEIDETILGADWHVRRVASMRELGCAIRDGVPKAGLVDFGSAFSAAELDLLERCMQV
SHVGWVAALPPAMLNHERVRQLVRDYCVDYVQMPLRTDEAAYSLRHAWGMASLAQEVTPAPKANHARMLGECPAMHGLFR
AIRKVAQNSAPAFIAGESGTGKELTAQAIHEASSRAGGPFIAINCGAIPPHLIQSELFGYEKGAFTGAHQRHIGWVEHAN
GGTLFLDEIGDLPLESQVSLLRFLQQGTITRLGGHQAIPLDIRIISATHVDLEAAQHHGGFRTDLFHRLCVLTLSVPPLR
ERGSDIVLLAQHILAQHASEASHRIRGFTPCALHAMMHYPWPGNVRELINRVRRALVMTDNRKISAADLHLEGYASVSGQ
TLEEAREGAESDAIRTAIARNGFHMGMTARELAVSRVTLYRLMQKHGIRAEHPLHPA
>Mature_457_residues
MREESLECTAACRTVVVASRAGMGEIDETILGADWHVRRVASMRELGCAIRDGVPKAGLVDFGSAFSAAELDLLERCMQV
SHVGWVAALPPAMLNHERVRQLVRDYCVDYVQMPLRTDEAAYSLRHAWGMASLAQEVTPAPKANHARMLGECPAMHGLFR
AIRKVAQNSAPAFIAGESGTGKELTAQAIHEASSRAGGPFIAINCGAIPPHLIQSELFGYEKGAFTGAHQRHIGWVEHAN
GGTLFLDEIGDLPLESQVSLLRFLQQGTITRLGGHQAIPLDIRIISATHVDLEAAQHHGGFRTDLFHRLCVLTLSVPPLR
ERGSDIVLLAQHILAQHASEASHRIRGFTPCALHAMMHYPWPGNVRELINRVRRALVMTDNRKISAADLHLEGYASVSGQ
TLEEAREGAESDAIRTAIARNGFHMGMTARELAVSRVTLYRLMQKHGIRAEHPLHPA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=356, Percent_Identity=41.8539325842697, Blast_Score=260, Evalue=2e-70,
Organism=Escherichia coli, GI1790437, Length=338, Percent_Identity=42.8994082840237, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI1788905, Length=305, Percent_Identity=43.6065573770492, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1790299, Length=376, Percent_Identity=39.0957446808511, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87082117, Length=273, Percent_Identity=45.4212454212454, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI87082152, Length=333, Percent_Identity=40.5405405405405, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1786524, Length=320, Percent_Identity=41.5625, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1789233, Length=336, Percent_Identity=40.4761904761905, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1789087, Length=307, Percent_Identity=39.0879478827362, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=36.4779874213836, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1787583, Length=336, Percent_Identity=34.5238095238095, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI87081858, Length=318, Percent_Identity=33.6477987421384, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789828, Length=243, Percent_Identity=34.156378600823, Blast_Score=129, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50004; Mature: 50004

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREESLECTAACRTVVVASRAGMGEIDETILGADWHVRRVASMRELGCAIRDGVPKAGLV
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
DFGSAFSAAELDLLERCMQVSHVGWVAALPPAMLNHERVRQLVRDYCVDYVQMPLRTDEA
CCCCCCCHHHHHHHHHHHHHHHCCHHHHCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCHH
AYSLRHAWGMASLAQEVTPAPKANHARMLGECPAMHGLFRAIRKVAQNSAPAFIAGESGT
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEECCCCC
GKELTAQAIHEASSRAGGPFIAINCGAIPPHLIQSELFGYEKGAFTGAHQRHIGWVEHAN
CHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCEEECC
GGTLFLDEIGDLPLESQVSLLRFLQQGTITRLGGHQAIPLDIRIISATHVDLEAAQHHGG
CCEEEEECCCCCCCHHHHHHHHHHHHCCEEECCCCEECEEEEEEEEEECCHHHHHHHCCC
FRTDLFHRLCVLTLSVPPLRERGSDIVLLAQHILAQHASEASHRIRGFTPCALHAMMHYP
CHHHHHHHHHHHHCCCCCHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
WPGNVRELINRVRRALVMTDNRKISAADLHLEGYASVSGQTLEEAREGAESDAIRTAIAR
CCCCHHHHHHHHHHHHEECCCCEEEEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHH
NGFHMGMTARELAVSRVTLYRLMQKHGIRAEHPLHPA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MREESLECTAACRTVVVASRAGMGEIDETILGADWHVRRVASMRELGCAIRDGVPKAGLV
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
DFGSAFSAAELDLLERCMQVSHVGWVAALPPAMLNHERVRQLVRDYCVDYVQMPLRTDEA
CCCCCCCHHHHHHHHHHHHHHHCCHHHHCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCHH
AYSLRHAWGMASLAQEVTPAPKANHARMLGECPAMHGLFRAIRKVAQNSAPAFIAGESGT
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEECCCCC
GKELTAQAIHEASSRAGGPFIAINCGAIPPHLIQSELFGYEKGAFTGAHQRHIGWVEHAN
CHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCEEECC
GGTLFLDEIGDLPLESQVSLLRFLQQGTITRLGGHQAIPLDIRIISATHVDLEAAQHHGG
CCEEEEECCCCCCCHHHHHHHHHHHHCCEEECCCCEECEEEEEEEEEECCHHHHHHHCCC
FRTDLFHRLCVLTLSVPPLRERGSDIVLLAQHILAQHASEASHRIRGFTPCALHAMMHYP
CHHHHHHHHHHHHCCCCCHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
WPGNVRELINRVRRALVMTDNRKISAADLHLEGYASVSGQTLEEAREGAESDAIRTAIAR
CCCCHHHHHHHHHHHHEECCCCEEEEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHH
NGFHMGMTARELAVSRVTLYRLMQKHGIRAEHPLHPA
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]