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The map label for this gene is era [H]

Identifier: 187928024

GI number: 187928024

Start: 982818

End: 983756

Strand: Direct

Name: era [H]

Synonym: Rpic_0929

Alternate gene names: 187928024

Gene position: 982818-983756 (Clockwise)

Preceding gene: 187928023

Following gene: 187928025

Centisome position: 24.93

GC content: 62.62

Gene sequence:

>939_bases
ATGAGCGACACCCCATTGCAGCCTCCGCAGCCAGAATCTGGCGTGCCGGAGGGGTTCCGCTGCGGCATGGTCGCCATTGT
TGGGCGGCCGAACGTCGGCAAATCCACGCTGATGAACGCCCTCGTGGGCCAGAAAGTCAGCATCACATCGCGCAAGGCGC
AGACCACGCGCCACCGCATCACTGGCATTCAGACGACGGATGACGCGCAGTTCGTCTTCGTCGATACGCCGGGCTTCCAG
ACGCGTCACGCCACCGCGCTGAACCGGTCGCTGAACCGCGCGGTCACGTCCACGCTCACGTCGGTGGATGCCGTGTTGTT
CGTGGTCGAAGCCGGCCGCTATGGCCCGGACGACGAGAAGGTGCTCTCGCTGCTGCCGCGCGAGACGCCCGTGATCCTGA
TCGTCAATAAGGTCGACCGGCTCGATGCGTACACGCGCGCCGAGATGGTCGCCGTGTTCCTGCAGGACATGGCACAGGTG
TTTCCGTTTGCCGAAATCGTGCCGATGTCGGCCAAGAATCGCGACGACATCGACCGCTTGCTCGGCATCGTGCGCCCGTA
CCTGCCGGAAGGCGAACCGATGTACGACCCGGAAGCGCTGACCGATCGCAGCGAGCGCTTCCTGGCCGCCGAAATTGTTC
GTGAGAAGGTCTTCCGCTGGACTGGCGACGAGTTACCGTATTCCAGCACCGTCATCGTCGACAAATTCGAAACCGAAGGT
CGCCTGCGCCGCGTGTTCGTGACCATTCTGGTCGATCGCGATGCCCACAAGGCGATGATCATCGGTGCGAAGGGCGCCAA
GCTCAAGCAGATCTCCACCGAAGCCCGCATGGACATGGAAAAGCTGTTCGACGGCAAGGTGTATCTGGAGGTCTGGATCA
AGGTCAAGAGCGGTTGGGCCGACAACGAAGCCGGCCTGCGCGCCTACGGCTACGAATAA

Upstream 100 bases:

>100_bases
TCGTCAAGCGCAGCCGCGCCGAGCGCACCGGCAAGACGCGCAAGCAGGCCACGCCGCCCGATCCGCAGTTGTCTCTCAGG
TTGAAGGAATAATCAGGTAA

Downstream 100 bases:

>100_bases
CCACCTAGCCGGGCCACTCTACACACGTTCGATGGCGGGACGATCCGATCCGATTCCGGACGAGGCCGCGGAATGGCTGG
CCGAGGAGGGCGTTGCCGGC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSDTPLQPPQPESGVPEGFRCGMVAIVGRPNVGKSTLMNALVGQKVSITSRKAQTTRHRITGIQTTDDAQFVFVDTPGFQ
TRHATALNRSLNRAVTSTLTSVDAVLFVVEAGRYGPDDEKVLSLLPRETPVILIVNKVDRLDAYTRAEMVAVFLQDMAQV
FPFAEIVPMSAKNRDDIDRLLGIVRPYLPEGEPMYDPEALTDRSERFLAAEIVREKVFRWTGDELPYSSTVIVDKFETEG
RLRRVFVTILVDRDAHKAMIIGAKGAKLKQISTEARMDMEKLFDGKVYLEVWIKVKSGWADNEAGLRAYGYE

Sequences:

>Translated_312_residues
MSDTPLQPPQPESGVPEGFRCGMVAIVGRPNVGKSTLMNALVGQKVSITSRKAQTTRHRITGIQTTDDAQFVFVDTPGFQ
TRHATALNRSLNRAVTSTLTSVDAVLFVVEAGRYGPDDEKVLSLLPRETPVILIVNKVDRLDAYTRAEMVAVFLQDMAQV
FPFAEIVPMSAKNRDDIDRLLGIVRPYLPEGEPMYDPEALTDRSERFLAAEIVREKVFRWTGDELPYSSTVIVDKFETEG
RLRRVFVTILVDRDAHKAMIIGAKGAKLKQISTEARMDMEKLFDGKVYLEVWIKVKSGWADNEAGLRAYGYE
>Mature_311_residues
SDTPLQPPQPESGVPEGFRCGMVAIVGRPNVGKSTLMNALVGQKVSITSRKAQTTRHRITGIQTTDDAQFVFVDTPGFQT
RHATALNRSLNRAVTSTLTSVDAVLFVVEAGRYGPDDEKVLSLLPRETPVILIVNKVDRLDAYTRAEMVAVFLQDMAQVF
PFAEIVPMSAKNRDDIDRLLGIVRPYLPEGEPMYDPEALTDRSERFLAAEIVREKVFRWTGDELPYSSTVIVDKFETEGR
LRRVFVTILVDRDAHKAMIIGAKGAKLKQISTEARMDMEKLFDGKVYLEVWIKVKSGWADNEAGLRAYGYE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=333, Percent_Identity=25.8258258258258, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1788919, Length=293, Percent_Identity=50.8532423208191, Blast_Score=291, Evalue=3e-80,
Organism=Escherichia coli, GI87082120, Length=174, Percent_Identity=29.8850574712644, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24646434, Length=323, Percent_Identity=26.0061919504644, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34883; Mature: 34752

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTPLQPPQPESGVPEGFRCGMVAIVGRPNVGKSTLMNALVGQKVSITSRKAQTTRHRI
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEECHHHHHHHHHHH
TGIQTTDDAQFVFVDTPGFQTRHATALNRSLNRAVTSTLTSVDAVLFVVEAGRYGPDDEK
CCCEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHH
VLSLLPRETPVILIVNKVDRLDAYTRAEMVAVFLQDMAQVFPFAEIVPMSAKNRDDIDRL
HHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCCHHHHHHH
LGIVRPYLPEGEPMYDPEALTDRSERFLAAEIVREKVFRWTGDELPYSSTVIVDKFETEG
HHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCC
RLRRVFVTILVDRDAHKAMIIGAKGAKLKQISTEARMDMEKLFDGKVYLEVWIKVKSGWA
HHEEEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCC
DNEAGLRAYGYE
CCCCCCEECCCC
>Mature Secondary Structure 
SDTPLQPPQPESGVPEGFRCGMVAIVGRPNVGKSTLMNALVGQKVSITSRKAQTTRHRI
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEECHHHHHHHHHHH
TGIQTTDDAQFVFVDTPGFQTRHATALNRSLNRAVTSTLTSVDAVLFVVEAGRYGPDDEK
CCCEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHH
VLSLLPRETPVILIVNKVDRLDAYTRAEMVAVFLQDMAQVFPFAEIVPMSAKNRDDIDRL
HHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCCHHHHHHH
LGIVRPYLPEGEPMYDPEALTDRSERFLAAEIVREKVFRWTGDELPYSSTVIVDKFETEG
HHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCC
RLRRVFVTILVDRDAHKAMIIGAKGAKLKQISTEARMDMEKLFDGKVYLEVWIKVKSGWA
HHEEEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCC
DNEAGLRAYGYE
CCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]