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The map label for this gene is degP [H]

Identifier: 187928018

GI number: 187928018

Start: 976882

End: 978393

Strand: Direct

Name: degP [H]

Synonym: Rpic_0923

Alternate gene names: 187928018

Gene position: 976882-978393 (Clockwise)

Preceding gene: 187928017

Following gene: 187928019

Centisome position: 24.78

GC content: 64.29

Gene sequence:

>1512_bases
ATGTGTACCGCTCGATCCATTTACGCCTTGCGTCTGCTATGCGTTGCCGCCGCTGTGGCGGTTGGGAGCGCGCTGGTGCC
GGCCCACGCGCAGAATGCCACGGGCAGCGTGGCCACGGCCACGTATGGCCTGCCCGATTTTGCCGATCTGGTTGAGAAGG
TCAGTCCTGCCGTTGTCAACATCCGCACGACCGAAAAGGTCCGTATGCAGCAGGGTGGTCCGAATGATGACGACATGGCT
GAATTTTTCCGCCGCTTCTTCGGTGTACCGATGCCGGGCATGCCCGGGCAGGGCCAGAAGCGCCGCAACGCGCCGCCGCA
ACAGGAAGAGGAACAGAGCCGCGGCGTTGGTTCCGGCTTCATCATCTCGGGCGACGGCTACATCCTGACCAACGCGCATG
TGGTGGAAGGCGCGGAAACCATCTACGTCACGCTGATCGACAAACGCGAGTACAAAGCCAAGCTGATCGGCCTGGACAAA
CGCACCGATGTGGCCCTCGTCAAGGTCGAAGCGAGTGCTCTGCCGAGCCTGAAGCTGGGCGATTCCGACAAGGTGCGCGT
GGGCGAGTGGGTGCTCGCGATCGGTTCTCCGTTTGGCCTGGACAATACGGTTACGGCGGGCATTGTGTCGGCCAAGGGGC
GCGATACAGGCGACTATCTGCCGTTCATTCAATCCGACGTGGCCGTCAACCCAGGCAACTCGGGCGGCCCGCTGATCAAC
CTGCGCGGCGAGGTGATCGGCATCAACAACCAGATCTACAGCCAAAGCGGCGGCTACATGGGCATCTCGTTCTCGATCCC
GATCGACGAGGCGATGCGAGTGGCTGAGCAGTTGAAGGCGACGGGACGCGTGACACGCGGCCGCATCGGTGTGGCAATCG
ACAACGTGCCGAAGGATGCAGCGGAGTCGCTGGGTCTGGGCCGTGCGCGTGGCGCCTATGTCGGCAATGTCGAATCGGGC
GGTCCGGCGGACAAGGCAGGCATCGAGGCAGGTGACATCGTCTTGAAGTACAACGGCCGCGATGTCGAGAAGGCGGGTGA
CCTGCAGCGCCAGGTCGGCGAGACCAAGCCGGGAACGCGCGCCACCGTGCAGGTCTGGCGCAAGGGCGCAACGCGCGATC
TGGCCGTGACGGTCGCCGAGTTGCAGGCCGACACGAAGGTGGCGCAGCGTACCAAGGGCGCGCAGCCCGATAACAGCCAG
CAGGGCCCGGGCAAGCCGAACGCGCTGGGGCTCGTGGTGGCTGACTTGTCCGACGGCGCGCGTCGCGAATTCAAGACCAA
GAGTGGCGTTGAAGTGCAGGTCTCTGAAGGGCCGGCGGCGCGTGTCGGCATTCGACCGGGCGACCTGATCCTGCGTGTCG
GTGATACCGATGTCACCAACGCCAAGCAGTTCAACGAGGTGGTTGCCAAGCTTGATAAGAACCGCATGGTTGCGGTGTTC
GTCCGCCGTGGCGATGCCACCCAGGTGGTGACGCTGCGCCCGAGCGCCGCCCGTTCGGGTGGTGGTCAGTGA

Upstream 100 bases:

>100_bases
CCAGCGCGCCGCAGTAGCCGCAGAGCTGGCATCTGTCTTGGGTGCGCGGCGTTGCTGCGCAGTGCCATTTCTCTATCTGT
CCTTGTTCCGGGGAGCTTTC

Downstream 100 bases:

>100_bases
TCCAACTGACGCTCTACGGCCGCACGTACTGCCATTTGTGCGAGGACATGAAGAACGCGCTGGAGCTGCTCCGGCGCGGT
TTTTCTTTTGTGCTGCACGA

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MCTARSIYALRLLCVAAAVAVGSALVPAHAQNATGSVATATYGLPDFADLVEKVSPAVVNIRTTEKVRMQQGGPNDDDMA
EFFRRFFGVPMPGMPGQGQKRRNAPPQQEEEQSRGVGSGFIISGDGYILTNAHVVEGAETIYVTLIDKREYKAKLIGLDK
RTDVALVKVEASALPSLKLGDSDKVRVGEWVLAIGSPFGLDNTVTAGIVSAKGRDTGDYLPFIQSDVAVNPGNSGGPLIN
LRGEVIGINNQIYSQSGGYMGISFSIPIDEAMRVAEQLKATGRVTRGRIGVAIDNVPKDAAESLGLGRARGAYVGNVESG
GPADKAGIEAGDIVLKYNGRDVEKAGDLQRQVGETKPGTRATVQVWRKGATRDLAVTVAELQADTKVAQRTKGAQPDNSQ
QGPGKPNALGLVVADLSDGARREFKTKSGVEVQVSEGPAARVGIRPGDLILRVGDTDVTNAKQFNEVVAKLDKNRMVAVF
VRRGDATQVVTLRPSAARSGGGQ

Sequences:

>Translated_503_residues
MCTARSIYALRLLCVAAAVAVGSALVPAHAQNATGSVATATYGLPDFADLVEKVSPAVVNIRTTEKVRMQQGGPNDDDMA
EFFRRFFGVPMPGMPGQGQKRRNAPPQQEEEQSRGVGSGFIISGDGYILTNAHVVEGAETIYVTLIDKREYKAKLIGLDK
RTDVALVKVEASALPSLKLGDSDKVRVGEWVLAIGSPFGLDNTVTAGIVSAKGRDTGDYLPFIQSDVAVNPGNSGGPLIN
LRGEVIGINNQIYSQSGGYMGISFSIPIDEAMRVAEQLKATGRVTRGRIGVAIDNVPKDAAESLGLGRARGAYVGNVESG
GPADKAGIEAGDIVLKYNGRDVEKAGDLQRQVGETKPGTRATVQVWRKGATRDLAVTVAELQADTKVAQRTKGAQPDNSQ
QGPGKPNALGLVVADLSDGARREFKTKSGVEVQVSEGPAARVGIRPGDLILRVGDTDVTNAKQFNEVVAKLDKNRMVAVF
VRRGDATQVVTLRPSAARSGGGQ
>Mature_503_residues
MCTARSIYALRLLCVAAAVAVGSALVPAHAQNATGSVATATYGLPDFADLVEKVSPAVVNIRTTEKVRMQQGGPNDDDMA
EFFRRFFGVPMPGMPGQGQKRRNAPPQQEEEQSRGVGSGFIISGDGYILTNAHVVEGAETIYVTLIDKREYKAKLIGLDK
RTDVALVKVEASALPSLKLGDSDKVRVGEWVLAIGSPFGLDNTVTAGIVSAKGRDTGDYLPFIQSDVAVNPGNSGGPLIN
LRGEVIGINNQIYSQSGGYMGISFSIPIDEAMRVAEQLKATGRVTRGRIGVAIDNVPKDAAESLGLGRARGAYVGNVESG
GPADKAGIEAGDIVLKYNGRDVEKAGDLQRQVGETKPGTRATVQVWRKGATRDLAVTVAELQADTKVAQRTKGAQPDNSQ
QGPGKPNALGLVVADLSDGARREFKTKSGVEVQVSEGPAARVGIRPGDLILRVGDTDVTNAKQFNEVVAKLDKNRMVAVF
VRRGDATQVVTLRPSAARSGGGQ

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=357, Percent_Identity=33.6134453781513, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI22129776, Length=342, Percent_Identity=35.3801169590643, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=37.2, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI7019477, Length=280, Percent_Identity=36.7857142857143, Blast_Score=142, Evalue=6e-34,
Organism=Escherichia coli, GI1789629, Length=489, Percent_Identity=34.9693251533742, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1786356, Length=479, Percent_Identity=33.6116910229645, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1789630, Length=284, Percent_Identity=36.6197183098592, Blast_Score=167, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24646839, Length=256, Percent_Identity=35.546875, Blast_Score=148, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 52987; Mature: 52987

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTARSIYALRLLCVAAAVAVGSALVPAHAQNATGSVATATYGLPDFADLVEKVSPAVVN
CCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCEEEE
IRTTEKVRMQQGGPNDDDMAEFFRRFFGVPMPGMPGQGQKRRNAPPQQEEEQSRGVGSGF
EECCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCE
IISGDGYILTNAHVVEGAETIYVTLIDKREYKAKLIGLDKRTDVALVKVEASALPSLKLG
EECCCCEEEECCEEECCCCEEEEEEEECCCCEEEEEECCCCCCEEEEEEECCCCCCEECC
DSDKVRVGEWVLAIGSPFGLDNTVTAGIVSAKGRDTGDYLPFIQSDVAVNPGNSGGPLIN
CCCCEEECEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCEECCCEEECCCCCCCCEEE
LRGEVIGINNQIYSQSGGYMGISFSIPIDEAMRVAEQLKATGRVTRGRIGVAIDNVPKDA
ECCCEEEECCEEEECCCCEEEEEEECCHHHHHHHHHHHHHHCCEECCEEEEEECCCCCHH
AESLGLGRARGAYVGNVESGGPADKAGIEAGDIVLKYNGRDVEKAGDLQRQVGETKPGTR
HHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCH
ATVQVWRKGATRDLAVTVAELQADTKVAQRTKGAQPDNSQQGPGKPNALGLVVADLSDGA
HHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCH
RREFKTKSGVEVQVSEGPAARVGIRPGDLILRVGDTDVTNAKQFNEVVAKLDKNRMVAVF
HHHHCCCCCCEEEECCCCCEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEE
VRRGDATQVVTLRPSAARSGGGQ
EECCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MCTARSIYALRLLCVAAAVAVGSALVPAHAQNATGSVATATYGLPDFADLVEKVSPAVVN
CCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCEEEE
IRTTEKVRMQQGGPNDDDMAEFFRRFFGVPMPGMPGQGQKRRNAPPQQEEEQSRGVGSGF
EECCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCE
IISGDGYILTNAHVVEGAETIYVTLIDKREYKAKLIGLDKRTDVALVKVEASALPSLKLG
EECCCCEEEECCEEECCCCEEEEEEEECCCCEEEEEECCCCCCEEEEEEECCCCCCEECC
DSDKVRVGEWVLAIGSPFGLDNTVTAGIVSAKGRDTGDYLPFIQSDVAVNPGNSGGPLIN
CCCCEEECEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCEECCCEEECCCCCCCCEEE
LRGEVIGINNQIYSQSGGYMGISFSIPIDEAMRVAEQLKATGRVTRGRIGVAIDNVPKDA
ECCCEEEECCEEEECCCCEEEEEEECCHHHHHHHHHHHHHHCCEECCEEEEEECCCCCHH
AESLGLGRARGAYVGNVESGGPADKAGIEAGDIVLKYNGRDVEKAGDLQRQVGETKPGTR
HHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCH
ATVQVWRKGATRDLAVTVAELQADTKVAQRTKGAQPDNSQQGPGKPNALGLVVADLSDGA
HHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCH
RREFKTKSGVEVQVSEGPAARVGIRPGDLILRVGDTDVTNAKQFNEVVAKLDKNRMVAVF
HHHHCCCCCCEEEECCCCCEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEE
VRRGDATQVVTLRPSAARSGGGQ
EECCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]